Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases

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Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases is …
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scholarly articleQ13442814

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P356DOI10.1016/J.FEBSLET.2006.07.046
P698PubMed publication ID16884718
P5875ResearchGate publication ID6901542

P50authorRudi BeyaertQ37382622
P2093author name stringSophie Janssens
Reinout Schauvliege
P2860cites workTollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptorQ22254266
TAK1 is a ubiquitin-dependent kinase of MKK and IKKQ24291454
IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa BQ24291605
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signallingQ24299573
Pellino2 activates the mitogen activated protein kinase pathwayQ24305052
Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosolQ24307324
Characterization of Pellino2, a substrate of IRAK1 and IRAK4Q24308089
A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteinsQ24312808
Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complexQ24337456
Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaBQ24531441
IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinaseQ24534145
The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligasesQ28139237
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chainQ28142613
Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signalingQ28207396
Negative regulation of toll-like receptor-mediated signaling by TollipQ28212686
Cutting edge: mouse pellino-2 modulates IL-1 and lipopolysaccharide signalingQ28511311
Proteasomes and their kin: proteases in the machine ageQ29614359
Ubiquitin: structures, functions, mechanismsQ29616462
Pellino-related sequences from Caenorhabditis elegans and Homo sapiens.Q33929295
Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent mannerQ34421538
A universal role for MyD88 in TLR/IL-1R-mediated signalingQ34825992
Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family membersQ35079256
A20 inhibits NF-kappaB activation by dual ubiquitin-editing functionsQ36011021
How Toll-like receptors signal: what we know and what we don't knowQ36339101
Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signalingQ40615423
The RING finger. A novel protein sequence motif related to the zinc finger.Q40818998
Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding proteinQ42152339
Does this have a familiar RING?Q55920907
The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylationQ73596405
P433issue19
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
P304page(s)4697-4702
P577publication date2006-07-24
P1433published inFEBS LettersQ1388051
P1476titlePellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases
P478volume580