Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function

scientific article published on 16 August 2006

Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1091/MBC.E06-07-0579
P3181OpenCitations bibliographic resource ID4987143
P932PMC publication ID1635371
P698PubMed publication ID16914514

P50authorConly RiederQ5161252
William Charles EarnshawQ21004362
Mariana Lince-FariaQ47503272
António PereiraQ58322657
Ana L PereiraQ59830128
Cristina DuqueQ64481785
Niels GaljartQ93079424
Helder MaiatoQ43208331
P2093author name stringPolla J Hergert
Irina Matos
Tatiana Stepanova
Ana R R Maia
C Laura Sayas
Ksenija Drabek
P2860cites workIdentification of APC2, a homologue of the adenomatous polyposis coli tumour suppressorQ22008756
EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologueQ22011153
A role for the Adenomatous Polyposis Coli protein in chromosome segregationQ24291074
Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblastsQ24291093
Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms.Q24294556
Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamicsQ24306616
Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's diseaseQ24307611
CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortexQ24337317
APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignmentQ24536199
Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochoresQ24555706
Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organizationQ24631567
Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpointQ24648791
Drosophila CLASP is required for the incorporation of microtubule subunits into fluxing kinetochore fibresQ24649746
How do kinetochores CLASP dynamic microtubules?Q28204481
Localization of CENP-E in the fibrous corona and outer plate of mammalian kinetochores from prometaphase through anaphaseQ28255991
Inhibition of spindle elongation by taxol.Q52480136
Spindle microtubules in flux.Q52655927
Aneuploidy and cancerQ56224730
Mutations in the APC tumour suppressor gene cause chromosomal instabilityQ62024148
Microtubule dynamics during the cell cycle: the effects of taxol and nocodazole on the microtubule system of Pt K2 cells at different stages of the mitotic cycleQ69880238
Nucleotide requirements for anaphase chromosome movements in permeabilized mitotic cells: anaphase B but not anaphase A requires ATPQ70567813
Correlative light and electron microscopy of mitotic cells in monolayer culturesQ77801971
Efficient mitosis in human cells lacking poleward microtubule fluxQ28278497
EB1 and EB3 control CLIP dissociation from the ends of growing microtubulesQ28506248
Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cellsQ29617924
Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome IIIQ29618444
Measuring the stoichiometry and physical interactions between components elucidates the architecture of the vertebrate kinetochoreQ30437662
CLIP-170 facilitates the formation of kinetochore-microtubule attachmentsQ30476694
Xorbit/CLASP links dynamic microtubules to chromosomes in the Xenopus meiotic spindleQ30480345
Centrosomes enhance the fidelity of cytokinesis in vertebrates and are required for cell cycle progressionQ30662520
MAST/Orbit has a role in microtubule-kinetochore attachment and is essential for chromosome alignment and maintenance of spindle bipolarityQ30695098
Model for anaphase B: role of three mitotic motors in a switch from poleward flux to spindle elongationQ30835545
Studies on the ejection properties of asters: astral microtubule turnover influences the oscillatory behavior and positioning of mono-oriented chromosomesQ33250756
The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesisQ34084142
The dynamic kinetochore-microtubule interfaceQ34362671
Microtubule plus-end-tracking proteins: mechanisms and functions.Q34386396
Transient production of retroviral- and lentiviral-based vectors for the transduction of Mammalian cellsQ35843034
The adenomatous polyposis coli protein: the Achilles heel of the gut epithelium.Q35912806
Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpointQ35938685
Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death.Q36197250
Aneuploidy: a matter of bad connections.Q36197388
A permeabilized cell model for studying cell division: a comparison of anaphase chromosome movement and cleavage furrow constriction in lysed PtK1 cellsQ36208705
Biotin-tubulin incorporates into kinetochore fiber microtubules during early but not late anaphaseQ36221845
Chromosomes move poleward in anaphase along stationary microtubules that coordinately disassemble from their kinetochore endsQ36225263
STU1, a suppressor of a beta-tubulin mutation, encodes a novel and essential component of the yeast mitotic spindleQ36234943
Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APCQ36324684
Orbit, a novel microtubule-associated protein essential for mitosis in Drosophila melanogasterQ36328234
KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegansQ36335836
Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrationsQ36598611
MLL is fused to EB1 (MAPRE1), which encodes a microtubule-associated protein, in a patient with acute lymphoblastic leukemiaQ38329677
Successful treatment of UGT1A1 deficiency in a rat model of Crigler-Najjar disease by intravenous administration of a liver-specific lentiviral vectorQ40342200
Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability.Q40488542
The checkpoint control for anaphase onset does not monitor excess numbers of spindle poles or bipolar spindle symmetry.Q41129904
Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells.Q41445584
Mutations in orbit/mast reveal that the central spindle is comprised of two microtubule populations, those that initiate cleavage and those that propagate furrow ingression.Q42915467
Regulation of microtubule assembly by human EB1 family proteinsQ43652188
Interzonal microtubules are dynamic during spindle elongationQ43863333
The CENP-F-like proteins HCP-1 and HCP-2 target CLASP to kinetochores to mediate chromosome segregation.Q46810631
P4510describes a project that usesImageJQ1659584
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
kinetochoreQ908912
Cytoplasmic linker associated protein 1Q21114179
P304page(s)4526-4542
P577publication date2006-08-16
P1433published inMolecular Biology of the CellQ2338259
P1476titleMammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function
P478volume17

Reverse relations

cites work (P2860)
Q24294298A cryptic TOG domain with a distinct architecture underlies CLASP-dependent bipolar spindle formation
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Q88932494An isolated CLASP TOG domain suppresses microtubule catastrophe and promotes rescue
Q28078705Anaphase B
Q60954706BUB-1 promotes amphitelic chromosome biorientation via multiple activities at the kinetochore
Q36733674Building Blocks of Functioning Brain: Cytoskeletal Dynamics in Neuronal Development
Q90729150CLASP promotes microtubule bundling in metaphase spindle independently of Ase1/PRC1 in fission yeast
Q34622487CLASP promotes microtubule rescue by recruiting tubulin dimers to the microtubule
Q24300214CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity
Q38912588CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development
Q36692554CLASPs function redundantly to regulate astral microtubules in the C. elegans embryo
Q39401246CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment.
Q36317230Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore-microtubule attachments
Q52715877Chromosome Segregation Is Biased by Kinetochore Size.
Q37165291Chromosomes and cancer cells.
Q37684057Clasp2 ensures mitotic fidelity and prevents differentiation of epidermal keratinocytes
Q26785528Connections between cadherin-catenin proteins, spindle misorientation, and cancer
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Q34012798Dynamic regulation of Oct1 during mitosis by phosphorylation and ubiquitination
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Q42984053Evidence for a vast peptide overlap between West Nile virus and human proteomes
Q39772876FEZ1 interacts with CLASP2 and NEK1 through coiled-coil regions and their cellular colocalization suggests centrosomal functions and regulation by PKC.
Q38715110GSK3-mediated CLASP2 phosphorylation modulates kinetochore dynamics.
Q24304441Global profiling of co- and post-translationally N-myristoylated proteomes in human cells
Q47921014How Kinetochore Architecture Shapes the Mechanisms of Its Function
Q88058993Human CLASP2 specifically regulates microtubule catastrophe and rescue
Q55687877Identification and Functional Characterization of a Microtubule-Associated Protein, GhCLASP2, From Upland Cotton (Gossypium hirsutum L.).
Q54456913Identification of complex relationship between protein kinases and substrates during the cell cycle of HeLa cells by phosphoproteomic analysis.
Q34698732Length-dependent anisotropic scaling of spindle shape
Q47446718Linking site-specific loss of histone acetylation to repression of gene expression by the mycotoxin ochratoxin A.
Q24319920MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis
Q37728193Mechanisms of Chromosome Congression during Mitosis.
Q37193068Mechanisms of chromosomal instability.
Q37671350Mechanisms of force generation by end-on kinetochore-microtubule attachments.
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Q30491189Motor-independent targeting of CLASPs to kinetochores by CENP-E promotes microtubule turnover and poleward flux.
Q30514537Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1).
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Q24679500The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.
Q37715836The perpetual movements of anaphase.

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