Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells

scientific article

Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1523/JNEUROSCI.4441-10.2011
P3181OpenCitations bibliographic resource ID1384582
P932PMC publication ID3091622
P698PubMed publication ID21508222
P5875ResearchGate publication ID51065699

P50authorChristine KleinQ21257320
P2093author name stringDimitri Krainc
Filip Simunovic
Hyun Jeong
Philip Seibler
John Graziotto
P2860cites workFeeder-free growth of undifferentiated human embryonic stem cellsQ34093315
Generation of human-induced pluripotent stem cellsQ34792230
Description of Parkinson's disease as a clinical syndrome.Q35170978
Update on the genetics of Parkinson's diseaseQ37050631
NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCsQ37377843
Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.Q37444336
Derivation of midbrain dopamine neurons from human embryonic stem cellsQ37493958
Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesisQ38344199
Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patientsQ39699315
Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1.Q40051916
Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6.Q40201823
Co-amplification of nuclear pseudogenes and assessment of heteroplasmy of mitochondrial DNA mutationsQ41031930
Retrovirus silencing, variegation, extinction, and memory are controlled by a dynamic interplay of multiple epigenetic modificationsQ44963495
Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.Q45302702
Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegenerationQ45302924
Production and purification of lentiviral vectorsQ46172190
Directed differentiation and transplantation of human embryonic stem cell-derived motoneurons.Q51986995
Biological effects of the PINK1 c.1366C>T mutation: implications in Parkinson disease pathogenesis.Q54562638
Clinical Spectrum of Homozygous and Heterozygous PINK1 Mutations in a Large German Family With Parkinson DiseaseQ60332322
PINK1 is selectively stabilized on impaired mitochondria to activate ParkinQ21145802
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonismQ24309753
Parkin is recruited selectively to impaired mitochondria and promotes their autophagyQ24317471
PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neuronsQ24322788
Hereditary early-onset Parkinson's disease caused by mutations in PINK1Q24337084
PGC-1 coactivators: inducible regulators of energy metabolism in health and diseaseQ24541524
PGC-1α, a potential therapeutic target for early intervention in Parkinson's diseaseQ24597726
CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cellsQ24600745
PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementiaQ24604133
Disease-specific induced pluripotent stem cellsQ24641981
Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cellsQ24676703
Induction of pluripotent stem cells from adult human fibroblasts by defined factorsQ27860967
Reprogramming of human somatic cells to pluripotency with defined factorsQ28262710
Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factorsQ28749672
A guided tour into subcellular colocalization analysis in light microscopyQ29547199
Induced pluripotent stem cells from a spinal muscular atrophy patientQ29614340
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signalingQ29615601
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkinQ29615684
Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neuronsQ29616199
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2Q29617098
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivatorsQ29617353
PINK1-dependent recruitment of Parkin to mitochondria in mitophagyQ29620567
Dynamics of three-dimensional replication patterns during the S-phase, analysed by double labelling of DNA and confocal microscopyQ31042736
Parkinson disease, 10 years after its genetic revolution: multiple clues to a complex disorderQ33344464
Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cellsQ33415997
P4510describes a project that usesImageJQ1659584
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectmitochondrionQ39572
regulation of protein targeting to mitochondrionQ21106655
P304page(s)5970-6
P577publication date2011-04-20
P1433published inJournal of NeuroscienceQ1709864
P1476titleMitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells
P478volume31