Phospholipid scramblase 1 is secreted by a lipid raft-dependent pathway and interacts with the extracellular matrix protein 1 in the dermal epidermal junction zone of human skin

scientific article

Phospholipid scramblase 1 is secreted by a lipid raft-dependent pathway and interacts with the extracellular matrix protein 1 in the dermal epidermal junction zone of human skin is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M110.136408
P932PMC publication ID2988386
P698PubMed publication ID20870722

P50authorXaveer Van OstadeQ50999001
Uwe HansenQ91531516
Peter PonsaertsQ37831161
P2093author name stringEllen Steenackers
Joseph Merregaert
Abdoelwaheb El Ghalbzouri
Johanna Van Langen
Sandy Sercu
P2860cites workThe phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membraneQ21143809
Recombinant human extracellular matrix protein 1 inhibits alkaline phosphatase activity and mineralization of mouse embryonic metatarsals in vitroQ24290795
Extracellular matrix protein 1 (ECM1) has angiogenic properties and is expressed by breast tumor cellsQ24291100
Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesisQ24295251
Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptorQ24297409
Phospholipid scramblase 1 potentiates the antiviral activity of interferonQ24301128
Extracellular matrix protein 1 inhibits the activity of matrix metalloproteinase 9 through high-affinity protein/protein interactionsQ24306471
Phospholipid scramblase 1 binds to the promoter region of the inositol 1,4,5-triphosphate receptor type 1 gene to enhance its expressionQ24314365
ECM1 interacts with fibulin-3 and the beta 3 chain of laminin 332 through its serum albumin subdomain-like 2 domainQ24319670
The human extracellular matrix gene 1 (ECM1): genomic structure, cDNA cloning, expression pattern, and chromosomal localizationQ24336159
Cytokine secretion via cholesterol-rich lipid raft-associated SNAREs at the phagocytic cup.Q46972979
Extracellular matrix protein 1 interacts with the domain III of fibulin-1C and 1D variants through its central tandem repeat 2.Q52045588
Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids.Q54067088
Autoantibodies to extracellular matrix protein 1 in lichen sclerosusQ59406032
Co-culture of human keratinocytes on post-mitotic human dermal fibroblast feeder cells: production of large amounts of interleukin 6Q68101385
The formation of competent barrier lipids in reconstructed human epidermis requires the presence of vitamin CQ73666847
Phospholipid scramblase 1Q79436900
Characterization of IgG autoantibodies to extracellular matrix protein 1 in lichen sclerosusQ80525778
Nuclear and cell membrane effects contribute independently to the induction of apoptosis in human cells exposed to UVB radiationQ24644671
Phospholipid scramblases and Tubby-like proteins belong to a new superfamily of membrane tethered transcription factorsQ24655395
A novel genetic system to detect protein-protein interactionsQ27860915
Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptorQ28188289
Role of MmTRA1b/phospholipid scramblase1 gene expression in the induction of differentiation of human myeloid leukemia cells into granulocytesQ28198210
Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membraneQ28206954
Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrilsQ28208101
Phospholipid scramblases: an overviewQ28300611
Molecular cloning, characterization, and genetic mapping of the cDNA coding for a novel secretory protein of mouse. Demonstration of alternative splicing in skin and cartilageQ28508650
Proteomics analysis of A33 immunoaffinity-purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signatureQ33697715
Interaction between cartilage oligomeric matrix protein and extracellular matrix protein 1 mediates endochondral bone growth.Q33823788
Differentiation-dependent alternative splicing and expression of the extracellular matrix protein 1 gene in human keratinocytes.Q33895655
Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1).Q33958324
Extracellular matrix protein 1 gene (ECM1) mutations in lipoid proteinosis and genotype-phenotype correlation.Q34179586
Paracrine regulation of keratinocyte proliferation and differentiationQ34221187
Development of antigen-specific ELISA for circulating autoantibodies to extracellular matrix protein 1 in lichen sclerosusQ34327999
Characterization of the human extracellular matrix protein 1 gene on chromosome 1q21.Q34460341
A novel splice-site mutation in ECM-1 gene in a consanguineous family with lipoid proteinosisQ34465817
Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationshipQ34899429
Mechanisms of regulated unconventional protein secretionQ34915147
The molecular basis of lipoid proteinosis: mutations in extracellular matrix protein 1.Q36967337
The extracellular matrix protein 1: its molecular interaction and implication in tumor progressionQ37150091
Single proteins might have dual but related functions in intracellular and extracellular microenvironmentsQ37351491
Phospholipid scramblase: an updateQ37715024
Clinical and molecular characterization of lipoid proteinosis in Namaqualand, South AfricaQ39550958
Human papillomavirus type 16 infection of human keratinocytes requires clathrin and caveolin-1 and is brefeldin a sensitiveQ39843190
Supramolecular interactions in the dermo-epidermal junction zone: anchoring fibril-collagen VII tightly binds to banded collagen fibrilsQ40454600
Resistance to UV-induced apoptosis in Chinese-hamster ovary cells overexpressing phosphatidylserine synthases.Q40564576
Basement membrane reconstruction in human skin equivalents is regulated by fibroblasts and/or exogenously activated keratinocytesQ42472962
Expression of extracellular matrix protein 1 (ECM1) in human skin is decreased by age and increased upon ultraviolet exposureQ42489873
Mutual induction of growth factor gene expression by epidermal-dermal cell interactionQ42769779
Role of fibroblasts in the regulation of proinflammatory interleukin IL-1, IL-6 and IL-8 levels induced by keratinocyte-derived IL-1.Q42812381
Effect of fibroblasts on epidermal regenerationQ44099052
Messenger RNA electroporation is highly efficient in mouse embryonic stem cells: successful FLPe- and Cre-mediated recombination.Q45877070
Interaction of extracellular matrix protein 1 with extracellular matrix components: ECM1 is a basement membrane protein of the skin.Q46804676
P433issue48
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
membrane raftQ424178
extracellular matrixQ193825
Phospholipid scramblase 1Q21130721
Extracellular matrix protein 1Q21201768
P304page(s)37823-37
P577publication date2010-11-26
P1433published inJournal of Biological ChemistryQ867727
P1476titlePhospholipid scramblase 1 is secreted by a lipid raft-dependent pathway and interacts with the extracellular matrix protein 1 in the dermal epidermal junction zone of human skin
P478volume285

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cites work (P2860)
Q39204652ALG-2-interacting Tubby-like protein superfamily member PLSCR3 is secreted by an exosomal pathway and taken up by recipient cultured cells
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Q36862693Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease.
Q33902557Membrane lipid interactions in intestinal ischemia/reperfusion-induced Injury
Q39999453N-terminal proline-rich domain is required for scrambling activity of human phospholipid scramblases
Q40617807Phosphatidylserine externalization and membrane blebbing are involved in the nonclassical export of FGF1
Q35888851Phospholipid Scramblase 1 Modulates FcR-Mediated Phagocytosis in Differentiated Macrophages
Q38283758Roles and regulation of phospholipid scramblases
Q42124126Skin basement membrane: the foundation of epidermal integrity--BM functions and diverse roles of bridging molecules nidogen and perlecan
Q43672114The C-terminal transmembrane domain of human phospholipid scramblase 1 is essential for the protein flip-flop activity and Ca²⁺-binding.
Q46092293The single C-terminal helix of human phospholipid scramblase 1 is required for membrane insertion and scrambling activity.
Q36299524mRNA N6-methyladenosine methylation of postnatal liver development in pig.
Q40235577mRNA and protein expression of the angiogenesis-related genes EDIL3, AMOT and ECM1 in mesenchymal stem cells in psoriatic dermis

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