Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells

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Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M310876200
P698PubMed publication ID14660579

P2093author name stringSusumu Ohwada
Tetsu Akiyama
Yusuke Nakamura
Yoichi Furukawa
Tsutomu Nakamura
Kazuyoshi Kohu
Kousuke Tashiro
Satoru Kuhara
Tatsuya Yamada
Osamu Higuchi
Takashi Sekiya
Shungo Adachi
P2860cites workElevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumorsQ33952813
Synergistic induction of tumor antigens by Wnt-1 signaling and retinoic acid revealed by gene expression profilingQ34113095
Mutated APC and Asef are involved in the migration of colorectal tumour cellsQ34179068
Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanismQ34235866
Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcriptionQ35977699
The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.Q36237136
Deletion of an amino-terminal sequence beta-catenin in vivo and promotes hyperphosporylation of the adenomatous polyposis coli tumor suppressor proteinQ36561208
The adenomatous polyposis coli gene and human cancersQ40413967
Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cellsQ40901818
Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-cateninQ41036974
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.Q45345819
Zebrafish nma is involved in TGFbeta family signalingQ47073698
Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axinQ47981369
Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.Q52547859
Asef, a link between the tumor suppressor APC and G-protein signalingQ24290104
Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signalingQ24293496
Identification of c-MYC as a target of the APC pathwayQ24310637
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assemblyQ24312910
The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICATQ24314421
ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modulesQ24314463
p15INK4B is a potential effector of TGF-beta-induced cell cycle arrestQ24319021
Association of the APC gene product with beta-cateninQ24322359
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APCQ24336321
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cellsQ27860717
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Lessons from hereditary colorectal cancerQ28131788
TGF-beta signaling by Smad proteinsQ28139850
TGFbeta signaling in growth control, cancer, and heritable disordersQ28142605
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1Q28145752
The ABC of APCQ28205388
Improving the efficacy of antibody-based cancer therapiesQ28208361
Identification of a link between the tumour suppressor APC and the kinesin superfamilyQ28209996
Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomasQ28213290
Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during developmentQ28216579
Association of the APC tumor suppressor protein with cateninsQ28257313
Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin levelQ28282155
Actin-dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cellsQ28363074
Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3betaQ28505773
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumorsQ28640916
Wnt signaling: a common theme in animal developmentQ29547527
beta-catenin is a target for the ubiquitin-proteasome pathwayQ29547589
TGF-beta signaling in tumor suppression and cancer progressionQ29615427
Linking colorectal cancer to Wnt signalingQ29619810
Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleusQ29620188
DBTSS: DataBase of human Transcriptional Start Sites and full-length cDNAsQ30782690
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectBMP and activin membrane bound inhibitorQ4834576
catenin beta 1Q1634046
colonic neoplasmQ3542029
negative regulation of transforming growth factor beta receptor signaling pathwayQ14818046
P304page(s)6840-6
P577publication date2004-02-20
P1433published inJournal of Biological ChemistryQ867727
P1476titleIdentification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells
P478volume279