| scholarly article | Q13442814 |
| P2093 | author name string | John Papaconstantinou | |
| Ching-Chyuan Hsieh | |||
| P2860 | cites work | Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways | Q24309037 |
| Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation | Q24532201 | ||
| Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. | Q24533236 | ||
| Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation | Q24533258 | ||
| Aging and resistance to oxidative damage in Caenorhabditis elegans | Q24561446 | ||
| Oxidants, antioxidants, and the degenerative diseases of aging | Q24561734 | ||
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| The p66shc adaptor protein controls oxidative stress response and life span in mammals | Q29614553 | ||
| MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo | Q29615244 | ||
| The free radical theory of aging matures | Q29618019 | ||
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| Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin. | Q33786987 | ||
| Protein phosphatases and the regulation of mitogen-activated protein kinase signalling. | Q33860531 | ||
| The role of the redox protein thioredoxin in cell growth and cancer | Q34062727 | ||
| Protein oxidation and aging | Q34243989 | ||
| The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts | Q34356250 | ||
| Oxidative stress and aging: beyond correlation | Q35185561 | ||
| Role of oxidative stress in Drosophila aging | Q35341166 | ||
| Evidence for posttranscriptional regulation of C/EBPalpha and C/EBPbeta isoform expression during the lipopolysaccharide-mediated acute-phase response | Q36559345 | ||
| Effects of age on the posttranscriptional regulation of CCAAT/enhancer binding protein alpha and CCAAT/enhancer binding protein beta isoform synthesis in control and LPS-treated livers | Q36878810 | ||
| Distinct cellular functions of MK2. | Q39675050 | ||
| Unifying model of the programmed (intrinsic) and stochastic (extrinsic) theories of aging. The stress response genes, signal transduction-redox pathways and aging | Q40660440 | ||
| Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria | Q41829151 | ||
| Production of reactive oxygen species by mitochondria: central role of complex III. | Q42163292 | ||
| Oxidative stress and ageing in Caenorhabditis elegans | Q42239558 | ||
| Age-specific changes in expression, activity, and activation of the c-Jun NH(2)-terminal kinase and p38 mitogen-activated protein kinases by methyl methanesulfonate in rats | Q43737676 | ||
| Extension of life span and stress resistance of Drosophila melanogaster by long-term supplementation with melatonin | Q43928110 | ||
| Mitochondrial ROS initiate phosphorylation of p38 MAP kinase during hypoxia in cardiomyocytes | Q43988501 | ||
| Implications for the insulin signaling pathway in Snell dwarf mouse longevity: a similarity with the C. elegans longevity paradigm | Q44000418 | ||
| Antioxidant enzymes, free-radical damage, and response to paraquat in liver and kidney of long-living growth hormone receptor/binding protein gene-disrupted mice | Q44183231 | ||
| The effect of aging on p38 signaling pathway activity in the mouse liver and in response to ROS generated by 3-nitropropionic acid | Q44212182 | ||
| Age-associated changes in SAPK/JNK and p38 MAPK signaling in response to the generation of ROS by 3-nitropropionic acid | Q44462914 | ||
| Thioredoxin-2 inhibits mitochondria-located ASK1-mediated apoptosis in a JNK-independent manner. | Q44875157 | ||
| Altered oxidative stress response of the long-lived Snell dwarf mouse | Q44899540 | ||
| Age-associated differences in cardiovascular inflammatory gene induction during endotoxic stress. | Q52134751 | ||
| Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. | Q52543010 | ||
| Oxidative stress in Caenorhabditis elegans: protective effects of superoxide dismutase/catalase mimetics. | Q53908583 | ||
| Multiplex stress resistance in cells from long-lived dwarf mice. | Q53925947 | ||
| ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis | Q57267073 | ||
| Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics | Q62472542 | ||
| Akt/PKB and p38 MAPK signaling, translational initiation and longevity in Snell dwarf mouse livers | Q80997328 | ||
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 259-68 | |
| P577 | publication date | 2006-02-01 | |
| P1433 | published in | FASEB Journal | Q520194 |
| P1476 | title | Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice | |
| P478 | volume | 20 |
| Q33983226 | Acidic environment leads to ROS-induced MAPK signaling in cancer cells |
| Q34286319 | Activation of senescence and aging characteristics by mitochondrially generated ROS: How are they linked? |
| Q54981824 | Age-dependent regulation of antioxidant genes by p38α MAPK in the liver. |
| Q39499185 | Antioxidative effects of cherry leaves extract on tert-butyl hydroperoxide-mediated cytotoxicity through regulation of thioredoxin-2 protein expression levels |
| Q37645147 | Apoptosis signal regulating kinase 1 (ASK1): potential as a therapeutic target for Alzheimer's disease |
| Q52329051 | Apoptosis signal regulating kinase-1 and NADPH oxidase mediate human amylin evoked redox stress and apoptosis in pancreatic beta-cells. |
| Q36145408 | Attenuation of p38α MAPK stress response signaling delays the in vivo aging of skeletal muscle myofibers and progenitor cells |
| Q39579957 | Bz-423 superoxide signals apoptosis via selective activation of JNK, Bak, and Bax |
| Q58119900 | Continuous overexpression of thioredoxin 1 enhances cancer development and does not extend maximum lifespan in male C57BL/6 mice |
| Q64271087 | Curcuminoid WZ35 synergize with cisplatin by inducing ROS production and inhibiting TrxR1 activity in gastric cancer cells |
| Q26823299 | Decoding cell death signals in liver inflammation |
| Q35348072 | Deletion of thioredoxin interacting protein (TXNIP) augments hyperoxia-induced vaso-obliteration in a mouse model of oxygen induced-retinopathy. |
| Q33627882 | Dermal fibroblasts from long-lived Ames dwarf mice maintain their in vivo resistance to mitochondrial generated reactive oxygen species (ROS) |
| Q40223933 | Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation |
| Q38032609 | Eat-me: autophagy, phagocytosis, and reactive oxygen species signaling |
| Q42224148 | Effect of silibinin and vitamin E on the ASK1-p38 MAPK pathway in D-galactosamine/lipopolysaccharide induced hepatotoxicity. |
| Q39590493 | Epigallocatechin-3-gallate induces cell apoptosis of human chondrosarcoma cells through apoptosis signal-regulating kinase 1 pathway |
| Q47136971 | Essential role of mitochondrial Stat3 in p38MAPK mediated apoptosis under oxidative stress. |
| Q42524269 | Evidence that age-related changes in p38 MAP kinase contribute to the decreased steroid production by the adrenocortical cells from old rats |
| Q37169564 | Heat shock protein gp96 interacts with protein phosphatase 5 and controls toll-like receptor 2 (TLR2)-mediated activation of extracellular signal-regulated kinase (ERK) 1/2 in post-hypoxic kidney cells |
| Q35635366 | Hepatitis B virus x protein induces perinuclear mitochondrial clustering in microtubule- and Dynein-dependent manners |
| Q36745795 | Human umbilical cord blood mesenchymal stem cell transplantation suppresses inflammatory responses and neuronal apoptosis during early stage of focal cerebral ischemia in rabbits |
| Q36807584 | Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance |
| Q39269737 | Implication of 14-3-3ε and 14-3-3θ/τ in proteasome inhibition-induced apoptosis of glioma cells |
| Q28388335 | Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases |
| Q39848103 | Japanese encephalitis virus NS2B-NS3 protease induces caspase 3 activation and mitochondria-mediated apoptosis in human medulloblastoma cells |
| Q35801816 | Klotho Protects Dopaminergic Neuron Oxidant-Induced Degeneration by Modulating ASK1 and p38 MAPK Signaling Pathways |
| Q35827257 | Klotho Regulates 14-3-3ζ Monomerization and Binding to the ASK1 Signaling Complex in Response to Oxidative Stress |
| Q37621156 | Kolaviron, a biflavonoid of Garcinia kola seed mitigates ischemic/reperfusion injury by modulation of pro-survival and apoptotic signaling pathways. |
| Q41439241 | Linking Klotho, Nrf2, MAP kinases and aging |
| Q90602682 | Liver ASK1 protects from non-alcoholic fatty liver disease and fibrosis |
| Q33915561 | Longevity is impacted by growth hormone action during early postnatal period |
| Q46974309 | Low utilization of circulating glucose after food withdrawal in Snell dwarf mice |
| Q36452761 | Lower levels of F2-isoprostanes in serum and livers of long-lived Ames dwarf mice |
| Q34186406 | Luteolin inhibits pyrogallol-induced apoptosis through the extracellular signal-regulated kinase signaling pathway. |
| Q34085212 | Methylglyoxal increases cardiomyocyte ischemia-reperfusion injury via glycative inhibition of thioredoxin activity |
| Q45060086 | Mitochondrial Dysfunction in Cardiovascular Aging |
| Q28388306 | Mitochondrial Metabolism in Aging Heart |
| Q63090506 | Mitochondrial ROS generated at the complex-II matrix or intermembrane space microdomain have distinct effects on redox signaling and stress sensitivity in C. elegans |
| Q35254777 | Mitochondrial electron transport chain functions in long-lived Ames dwarf mice |
| Q42226736 | Modulation of ASK1 expression during overexpression of Trx and HSP70 in stressed fish liver mitochondria |
| Q39759995 | Modulation of the ASK1-MKK3/6-p38/MAPK signalling pathway mediates sildenafil protection against chemical hypoxia caused by malonate. |
| Q28730442 | MyD88 associated ROS generation is crucial for Lactobacillus induced IL-12 production in macrophage |
| Q37342232 | NADPH oxidases and angiotensin II receptor signaling |
| Q39202038 | NLRP3 inflammasome: Its regulation and involvement in atherosclerosis |
| Q42470643 | Neurovascular protective effect of FeTPPs in N-methyl-D-aspartate model: similarities to diabetes |
| Q35942706 | Nitrative thioredoxin inactivation as a cause of enhanced myocardial ischemia/reperfusion injury in the aging heart |
| Q36727329 | Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes. |
| Q54976426 | Oxidative Stress-Induced TGF-beta/TAB1-mediated p38MAPK activation in human amnion epithelial cells. |
| Q33694284 | Oxidative modification and aggregation of creatine kinase from aged mouse skeletal muscle |
| Q36225827 | PX-12 inhibits the growth of hepatocelluar carcinoma by inducing S-phase arrest, ROS-dependent apoptosis and enhances 5-FU cytotoxicity |
| Q54392986 | Preventive effect of total flavones of Choerospondias axillaries on ischemia/reperfusion-induced myocardial infarction-related MAPK signaling pathway. |
| Q33804075 | Proteomic analysis of mesenchymal stem-like cells derived from ovarian teratoma: potential role of glutathione S-transferase M2 in ovarian teratoma |
| Q37179493 | Proximal inhibition of p38 MAPK stress signaling prevents distal axonopathy |
| Q26781179 | ROS mediated MAPK signaling in abiotic and biotic stress- striking similarities and differences |
| Q24322530 | Reactive oxygen species and hyaluronidase 2 regulate airway epithelial hyaluronan fragmentation |
| Q39172724 | Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21(Cip1) downregulation are required for shikonin-induced apoptosis |
| Q46359476 | Recombinant Human Thioredoxin-1 Protects Macrophages from Oxidized Low-Density Lipoprotein-Induced Foam Cell Formation and Cell Apoptosis |
| Q51564092 | Redox Remodeling Is Pivotal in Murine Diaphragm Muscle Adaptation to Chronic Sustained Hypoxia. |
| Q92631111 | Redox Signaling from Mitochondria: Signal Propagation and Its Targets |
| Q34734032 | Retracted: Novel Insights into the Synergistic Interaction of a Thioredoxin Reductase Inhibitor and TRAIL: The Activation of the ASK1-ERK-Sp1 Pathway |
| Q92661639 | Role of Cytosolic 2-Cys Prx1 and Prx2 in Redox Signaling |
| Q28594591 | Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock |
| Q36759868 | SCO2 induces p53-mediated apoptosis by Thr845 phosphorylation of ASK-1 and dissociation of the ASK-1-Trx complex. |
| Q38281761 | SIRT1 regulates MAPK pathways in vitiligo skin: insight into the molecular pathways of cell survival |
| Q39831884 | SOCS1 protects protein tyrosine phosphatases by thioredoxin upregulation and attenuates Jaks to suppress ROS-mediated apoptosis. |
| Q47068957 | SOD-1 deletions in Caenorhabditis elegans alter the localization of intracellular reactive oxygen species and show molecular compensation |
| Q35109528 | San-Huang-Xie-Xin-Tang Prevents Rat Hearts from Ischemia/Reperfusion-Induced Apoptosis through eNOS and MAPK Pathways |
| Q35585586 | Selenium alleviates porcine nephrotoxicity of ochratoxin A by improving selenoenzyme expression in vitro |
| Q36569550 | Selenium-dependent regulation of oxidative stress and immunity in periparturient dairy cattle |
| Q35070003 | Skeletal cell differentiation is enhanced by atmospheric dielectric barrier discharge plasma treatment |
| Q37000173 | Stem cells, phenotypic inversion, and differentiation. |
| Q34110540 | Systems biology modeling reveals a possible mechanism of the tumor cell death upon oncogene inactivation in EGFR addicted cancers |
| Q59791111 | TGF-β downregulation-induced cancer cell death is finely regulated by the SAPK signaling cascade |
| Q35346731 | Targeting apoptosis signalling kinase-1 (ASK-1) does not prevent the development of neuropathy in streptozotocin-induced diabetic mice |
| Q34322396 | The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging |
| Q46282033 | The Molecular Physiopathogenesis of Islet Amyloidosis |
| Q90231797 | The Thioredoxin System is Regulated by the ASK-1/JNK/p38/Survivin Pathway During Germ Cell Apoptosis |
| Q89777608 | The lipid peroxidation product 4-hydroxy-2-nonenal induces tissue factor decryption via ROS generation and the thioredoxin system |
| Q36514605 | The pharmokinetic limitations of antioxidant treatment for COPD. |
| Q35535899 | Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice |
| Q56418741 | Thioredoxin overexpression in both the cytosol and mitochondria accelerates age-related disease and shortens lifespan in male C57BL/6 mice |
| Q37455458 | Thioredoxin, oxidative stress, cancer and aging |
| Q37179758 | Up-regulation of thioredoxin interacting protein (Txnip) by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose-treated endothelial cells |
| Q35001920 | Vitamin C restores healthy aging in a mouse model for Werner syndrome |
| Q28384606 | p27 suppresses cyclooxygenase-2 expression by inhibiting p38β and p38δ-mediated CREB phosphorylation upon arsenite exposure |
| Q38908783 | p38 Mitogen activated protein kinase (MAPK): a new therapeutic target for reducing the risk of adverse pregnancy outcomes |
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