Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis

scientific article

Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M203619200
P698PubMed publication ID12163485

P50authorHisashi NarimatsuQ55486826
Akira TogayachiQ60169463
P2093author name stringAkihiko Kameyama
Hiroko Iwasaki
Takashi Kudo
Takashi Sato
Yan Zhang
Koji Kimata
Hideto Watanabe
Shoko Nishihara
Masanori Gotoh
Norihiro Kikuchi
Toshikazu Yada
Yeon-Dae Kwon
Hideo Mochizuki
Niro Inaba
Tomohiro Akashima
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Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycansQ22010476
Cloning and expression of a proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I. A seventh member of the human beta4-galactosyltransferase gene familyQ22010511
A novel human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substratesQ22010732
Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-IIQ24290566
Molecular cloning and expression of a human chondroitin synthaseQ24291588
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???Q24292160
Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6)Q24291678
Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc-peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycansQ24292241
A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3Q24314565
The expanding beta 4-galactosyltransferase gene family: messages from the databanksQ24318549
cDNA cloning and expression of a novel human UDP-N-acetyl-alpha-D-galactosamine. Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3Q24321336
3'-minor groove binder-DNA probes increase sequence specificity at PCR extension temperaturesQ24515326
The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesisQ24522477
Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesisQ24631229
Crystal structures of the bovine beta 4galactosyltransferase catalytic domain and its complex with uridine diphosphogalactoseQ27618915
Crystal structure of lactose synthase reveals a large conformational change in its catalytic component, the beta1,4-galactosyltransferase-IQ27632731
Purification and cDNA Cloning of a Human UDP-N-acetyl-α- D-galactosamine:polypeptide N-AcetylgalactosaminyltransferaseQ28114903
Cloning of a human UDP-N-acetyl-alpha-D-Galactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeatQ28118379
Cloning and characterization of a close homologue of human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase-T3, designated GalNAc-T6. Evidence for genetic but not functional redundancyQ28118938
Versican interacts with chemokines and modulates cellular responsesQ28138079
Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functionsQ28139075
The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfateQ28284035
Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipidsQ28573246
Real time quantitative PCRQ29616373
First isolation of human UDP-D-xylose: proteoglycan core protein beta-D-xylosyltransferase secreted from cultured JAR choriocarcinoma cellsQ30967075
Molecular interactions of neural chondroitin sulfate proteoglycans in the brain developmentQ33820542
rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfateQ33928505
Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine.Q34141550
Cloning and sequencing of cDNA of bovine N-acetylglucosamine (beta 1-4)galactosyltransferaseQ35614333
Regulation of chondroitin sulfate biosynthesis by specific sulfation: acceptor specificity of serum beta-GalNAc transferase revealed by structurally defined oligosaccharidesQ38345546
Changes in sulfated mucopolysaccharide composition of mammalian tissues during growth and in cancer tissuesQ39820747
Glycosyl transferases in chondroitin sulphate biosynthesis. Effect of acceptor structure on activityQ42849254
A novel method for real time quantitative RT-PCR.Q46544663
Decorin-type I collagen interaction. Presence of separate core protein-binding domains.Q54613919
Changes in glycosaminoglycan composition of normal human placentas with maturationQ71527087
P433issue41
P407language of work or nameEnglishQ1860
P921main subjectchondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic processQ21154682
Chondroitin sulfate N-acetylgalactosaminyltransferase 1Q21154687
P304page(s)38189-38196
P577publication date2002-08-05
P1433published inJournal of Biological ChemistryQ867727
P1476titleEnzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis
P478volume277

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cites work (P2860)
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Q39469213Chondroitin 4-O-sulfotransferase-2 regulates the number of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-1.
Q28594403Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is necessary for normal endochondral ossification and aggrecan metabolism
Q28588112Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning
Q34199064Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities
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Q35042618Comparison of microarray expression profiles between follicular variant of papillary thyroid carcinomas and follicular adenomas of the thyroid
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Q59335441Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1
Q36943360Effect of Angelica sinensis Polysaccharides on Osteoarthritis In Vivo and In Vitro: A Possible Mechanism to Promote Proteoglycans Synthesis
Q26995332Human genetic disorders and knockout mice deficient in glycosaminoglycan
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Q50335972Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members
Q58427278Increased Synthesis of Chondroitin Sulfate Proteoglycan Promotes Adult Hippocampal Neurogenesis in Response to Enriched Environment
Q42155968Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor
Q41595190Mass spectrometry for the characterization of unsulfated chondroitin oligosaccharides from 2-mers to 16-mers. Comparison with hyaluronic acid oligomers
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Q34141550Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine.
Q24321810Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc
Q42688017Molecular cloning and expression of a second chondroitin N-acetylgalactosaminyltransferase involved in the initiation and elongation of chondroitin/dermatan sulfate
Q48168194Nematode chondroitin polymerizing factor showing cell-/organ-specific expression is indispensable for chondroitin synthesis and embryonic cell division
Q48330762Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2.
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Q38973334Sulfated glycosaminoglycans: their distinct roles in stem cell biology
Q50293296The addition of GalNAc to the terminal glucuronate residue forms chondroitin

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