Regional and cellular distribution patterns of insulin-degrading enzyme in the adult human brain and pituitary

scientific article

Regional and cellular distribution patterns of insulin-degrading enzyme in the adult human brain and pituitary is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JCHEMNEU.2007.12.001
P3181OpenCitations bibliographic resource ID4637128
P698PubMed publication ID18226493

P50authorJohann SteinerQ42319648
P2093author name stringBernhard Bogerts
Siegfried Ansorge
Uwe Lendeckel
Alicja Bukowska
Hans-Gert Bernstein
Henrik Dobrowolny
Renate Stauch
Kurt Trübner
Theresia Ernst
P2860cites workReduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 alleleQ24684471
Regional and cellular distribution of neural visinin-like protein immunoreactivities (VILIP-1 and VILIP-3) in human brainQ28138174
Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzymeQ28254283
The insulysin (insulin degrading enzyme) enigmaQ28261817
Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brainsQ28281534
Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease familiesQ28284636
Insulin degrading enzyme is expressed in the human cerebrovascular endothelium and in cultured human cerebrovascular endothelial cellsQ33208160
Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease.Q34400472
A reduced number of cortical neurons show increased Caldendrin protein levels in chronic schizophreniaQ34667313
Macromolecules involved in production and metabolism of beta-amyloid at the brain barriersQ35946613
Dysregulation of the hypothalamic-pituitary-gonadal axis with menopause and andropause promotes neurodegenerative senescenceQ36063538
Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.Q36363015
Molecular connexions between dementia and diabetes.Q36837972
Shifts in metabolic parameters surrounding glucose homoeostasis resulting from tricyclic antidepressant therapy: implications of insulin resistance?Q40182599
Identification of gamma-endorphin-generating enzyme as insulin-degrading enzymeQ41151622
Lack of neuronal NOS has consequences for the expression of POMC and POMC-derived peptides in the mouse pituitaryQ43793830
Insulin receptors in the pituitary gland: morphological evidence for influence on opioid peptide-synthesizing cellsQ44345620
Insulin-degrading enzyme in the Alzheimer's disease brain: prominent localization in neurons and senile plaquesQ48230458
Brain insulin and insulin receptors in aging and sporadic Alzheimer's diseaseQ48404181
Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathologyQ48404243
Regional specificity in the neuropathologic substrates of schizophrenia: a morphometric analysis of Broca's area 44 and area 9.Q48413933
Nitric oxide synthase-containing neurons in the human hypothalamus: reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenicsQ48522635
Density of Sgt1-immunopositive neurons is decreased in the cerebral cortex of Alzheimer's disease brainQ48541135
Increased number of nitric oxide synthase immunoreactive Purkinje cells and dentate nucleus neurons in schizophreniaQ48548523
Insulin receptor deficits in schizophrenia and in cellular and animal models of insulin receptor dysfunctionQ48596589
Atrial natriuretic peptide (ANP) is a high-affinity substrate for rat insulin-degrading enzymeQ48611951
Insulin- and glucagonlike peptides in the brainQ48749412
The amyloid-beta precursor-like protein APLP2 and its relative APP are differentially regulated during neuroendocrine cell activationQ48773295
Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzymeQ48812317
Desensitization of the neuronal insulin receptor: a new approach in the etiopathogenesis of late-onset sporadic dementia of the Alzheimer type (SDAT)?Q53264266
Effects of chronic treatment with haloperidol and bromocriptine on the processing of beta-endorphin to gamma- and alpha-endorphin in discrete regions of the rat pituitary gland and brainQ67654313
Degradation of insulin-like growth factors I and II by a human insulin degrading enzymeQ70395087
44 Insulysin and pitrilysin: Insulin-degrading enzymes of mammals and bacteriaQ72059284
Identification and isolation of a cytosolic proteolytic complex containing insulin degrading enzyme and the multicatalytic proteinaseQ72102224
Non-covalent interaction of ubiquitin with insulin-degrading enzymeQ73633793
Reduced sarcoplasmic reticulum Ca(2+)-uptake and expression of phospholamban in left ventricular myocardium of dogs with heart failureQ77994741
Insulin-degrading enzyme in brain microvessels: proteolysis of amyloid {beta} vasculotropic variants and reduced activity in cerebral amyloid angiopathyQ80872424
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectbrainQ1073
Insulin degrading enzymeQ1225690
preproinsulinQ7240673
P304page(s)216-224
P577publication date2007-12-14
P1433published inJournal of Chemical NeuroanatomyQ15766107
P1476titleRegional and cellular distribution patterns of insulin-degrading enzyme in the adult human brain and pituitary
P478volume35

Reverse relations

cites work (P2860)
Q37303380Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide.
Q90701915Autoimmune antibodies correlate with immune checkpoint therapy-induced toxicities
Q42563794Chronic airway-induced allergy in mice modifies gene expression in the brain toward insulin resistance and inflammatory responses.
Q26866392Insulin in the brain: its pathophysiological implications for States related with central insulin resistance, type 2 diabetes and Alzheimer's disease
Q26741609Mechanisms of Aβ Clearance and Degradation by Glial Cells
Q92384162Oxidative inactivation of amyloid beta-degrading proteases by cholesterol-enhanced mitochondrial stress
Q55383585Proteomic Analysis of Hippocampus and Cortex in Streptozotocin-Induced Diabetic Model Mice Showing Dementia.
Q35027962Vascular and extravascular distribution of the ATP-binding cassette transporters ABCB1 and ABCC1 in aged human brain and pituitary.

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