Mutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise.

scientific article

Mutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise. is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2013PNAS..110.2228Y
P356DOI10.1073/PNAS.1222285110
P3181OpenCitations bibliographic resource ID839122
P932PMC publication ID3568371
P698PubMed publication ID23345450
P5875ResearchGate publication ID235368007

P50authorMary-Claire KingQ437741
Mustafa TekinQ58979405
Mhamed GratiQ64672038
Ann Chi Yan WongQ83393913
Tze Ling LohQ84520365
Tom WalshQ37380700
Srdjan M. VlajkovicQ43136351
Peter R. ThorneQ43136362
Gary D. HousleyQ43136372
P2093author name stringYan Zhu
Asli Sirmaci
Xue Z Liu
Zheng-Yi Chen
Bechara Kachar
Dinghua Xie
Allen F Ryan
Hong-Bo Zhao
Taro Fujikawa
Huijun Yuan
Denise Yan
Lilin Du
Susan Blanton
P2860cites workPrevalence of hearing loss in the United States by industryQ23912485
Americans Hear as Well or Better Today Compared With 40 Years Ago: Hearing Threshold Levels in the Unscreened Adult Population of the United States, 1959–1962 and 1999–2004Q23913674
A method and server for predicting damaging missense mutationsQ27860835
Molecular physiology of P2X receptorsQ28203477
Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransductionQ28569812
P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATPQ28585703
Assessment of hearing in 80 inbred strains of mice by ABR threshold analysesQ29619783
A novel locus for autosomal dominant non-syndromic deafness (DFNA41) maps to chromosome 12q24-qterQ30309691
Immunohistochemical localization of adenosine 5'-triphosphate-gated ion channel P2X(2) receptor subunits in adult and developing rat cochleaQ73798323
Lighting up the senses: FM1-43 loading of sensory cells through nonselective ion channels.Q30310868
Music exposure and hearing disorders: an overview.Q30383356
ATP activates P2X receptors to mediate gap junctional coupling in the cochleaQ30448478
Differential actions of isoflurane and ketamine-based anaesthetics on cochlear function in the mouseQ30454970
Gap junctional hemichannel-mediated ATP release and hearing controls in the inner earQ30476549
Noise in a laboratory animal facility from the human and mouse perspectivesQ30476669
Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filamentsQ30490501
Purinergic modulation of cochlear partition resistance and its effect on the endocochlear potential in the Guinea pig.Q30492676
Damage-induced cell-cell communication in different cochlear cell types via two distinct ATP-dependent Ca wavesQ30495799
ATP-mediated potassium recycling in the cochlear supporting cellsQ30495802
Acceleration of age-related hearing loss by early noise exposure: evidence of a misspent youthQ30499044
Whole exome sequencing and homozygosity mapping identify mutation in the cell polarity protein GPSM2 as the cause of nonsyndromic hearing loss DFNB82.Q33960515
New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptorQ34292603
Potential role of purinergic signalling in cochlear pathologyQ34674998
Contributions of mouse models to understanding of age- and noise-related hearing lossQ36456347
Ageing and hearing lossQ36698257
Genetic studies on noise-induced hearing loss: a reviewQ37385754
Purinergic signaling in special sensesQ37397945
Global and regional hearing impairment prevalence: an analysis of 42 studies in 29 countriesQ37971242
Subunit Arrangement in P2X ReceptorsQ40629382
Pore dilation of neuronal P2X receptor channelsQ40960421
ATP activates P2x receptors and requires extracellular Ca(++) participation to modify outer hair cell nonlinear capacitanceQ41153004
Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds.Q41646184
Reduced P2x2 receptor-mediated regulation of endocochlear potential in the ageing mouse cochleaQ41834757
Purinergic regulation of sound transduction and auditory neurotransmission.Q43933322
Noise induces up-regulation of P2X2 receptor subunit of ATP-gated ion channels in the rat cochleaQ44511290
Effects of adenosine 5'-triphosphate and related agonists on cochlear functionQ46856372
Expression of the P2X(2) receptor subunit of the ATP-gated ion channel in the cochlea: implications for sound transduction and auditory neurotransmission.Q46944206
Expression and distribution of creatine transporter and creatine kinase (brain isoform) in developing and mature rat cochlear tissues.Q48673078
Refinement of the DFNA41 locus and candidate genes analysis.Q50470214
PresbycusisQ56475342
P433issue6
P407language of work or nameEnglishQ1860
P921main subjecthearing lossQ16035842
Purinergic receptor P2X 2Q21118924
Purinergic receptor P2X, ligand-gated ion channel, 2Q21985923
P304page(s)2228-2233
P577publication date2013-01-23
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleMutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise
P478volume110

Reverse relations

cites work (P2860)
Q88962073A dominant variant in the PDE1C gene is associated with nonsyndromic hearing loss
Q30454581ATP-gated ion channels mediate adaptation to elevated sound levels.
Q38732061AUNA2: A Novel Type of Non-Syndromic Slowly Progressive Auditory Synaptopathy/Auditory Neuropathy with Autosomal-Dominant Inheritance
Q27318173Activation of SIRT3 by the NAD⁺ precursor nicotinamide riboside protects from noise-induced hearing loss
Q28829682Adenosine Triphosphate (ATP) Inhibits Voltage-Sensitive Potassium Currents in Isolated Hensen's Cells and Nifedipine Protects Against Noise-Induced Hearing Loss in Guinea Pigs
Q37219569Aging of perennial cells and organ parts according to the programmed aging paradigm.
Q46450559Cellular mechanisms of noise-induced hearing loss.
Q38527697Cellular signaling protective against noise-induced hearing loss – A role for novel intrinsic cochlear signaling involving corticotropin-releasing factor?
Q27307804Characterization of ATPase Activity of P2RX2 Cation Channel
Q45864470Close-field electroporation gene delivery using the cochlear implant electrode array enhances the bionic ear.
Q42027805Contribution of the Juxtatransmembrane Intracellular Regions to the Time Course and Permeation of ATP-gated P2X7 Receptor Ion Channels
Q30830670Critical role of ATP-induced ATP release for Ca2+ signaling in nonsensory cell networks of the developing cochlea
Q41863359Direct gating of ATP-activated ion channels (P2X2 receptors) by lipophilic attachment at the outer end of the second transmembrane domain
Q64089470Efficient introduction of an isogenic homozygous mutation to induced pluripotent stem cells from a hereditary hearing loss family using CRISPR/Cas9 and single-stranded donor oligonucleotides
Q36031223Expression and function of pannexins in the inner ear and hearing
Q38393019Gene expression profiles of the cochlea and vestibular endorgans: localization and function of genes causing deafness
Q97587562Gene therapy development in hearing research in China
Q30355940Genetics of Tinnitus: Still in its Infancy.
Q30411041Hearing loss caused by a P2RX2 mutation identified in a MELAS family with a coexisting mitochondrial 3243AG mutation
Q30354613Hypothesis of K+-Recycling Defect Is Not a Primary Deafness Mechanism for Cx26 (GJB2) Deficiency
Q26771359Insights into the channel gating of P2X receptors from structures, dynamics and small molecules
Q30365562Loss of Myh14 Increases Susceptibility to Noise-Induced Hearing Loss in CBA/CaJ Mice.
Q36803634MYO3A Causes Human Dominant Deafness and Interacts with Protocadherin 15-CD2 Isoform
Q30412447Mechanisms of sensorineural cell damage, death and survival in the cochlea.
Q38655779Molecular Structure and Regulation of P2X Receptors With a Special Emphasis on the Role of P2X2 in the Auditory System.
Q37067040Next-generation sequencing in genetic hearing loss
Q60307553Non-Syndromic Hearing Loss and High-Throughput Strategies to Decipher Its Genetic Heterogeneity
Q34158330Non-synonymous single nucleotide polymorphisms in the P2X receptor genes: association with diseases, impact on receptor functions and potential use as diagnosis biomarkers
Q34464511Nucleotide signalling during inflammation
Q38820111On the permeation of large organic cations through the pore of ATP-gated P2X receptors.
Q92391586Onset kinetics of noise-induced purinergic adaptation of the 'cochlear amplifier'
Q38885828P2X receptors
Q44801039P2X2 Dominant Deafness Mutations Have No Negative Effect on Wild-Type Isoform: Implications for Functional Rescue and in Deafness Mechanism
Q30387364Properties of ATP-gated ion channels assembled from P2X2 subunits in mouse cochlear Reissner's membrane epithelial cells
Q92879640Purinergic Signaling and Cochlear Injury-Targeting the Immune System?
Q42367885Purinergic Signalling: Therapeutic Developments
Q92490326Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space
Q30404370Quantitative trait loci on chromosome 5 for susceptibility to frequency-specific effects on hearing in DBA/2J mice
Q39015106Signaling in the Auditory System: Implications in Hair Cell Regeneration and Hearing Function
Q89734622Small fish, big prospects: using zebrafish to unravel the mechanisms of hereditary hearing loss
Q30367228Sound-Induced Intracellular Ca2+ Dynamics in the Adult Hearing Cochlea
Q34035042Targeted high-throughput sequencing identifies pathogenic mutations in KCNQ4 in two large Chinese families with autosomal dominant hearing loss
Q38925903Temporary and Permanent Noise-induced Threshold Shifts: A Review of Basic and Clinical Observations.
Q30431019Water permeability of the mammalian cochlea: functional features of an aquaporin-facilitated water shunt at the perilymph-endolymph barrier.
Q28117356Whole Exome Sequencing Identified MCM2 as a Novel Causative Gene for Autosomal Dominant Nonsyndromic Deafness in a Chinese Family
Q33889479Whole-exome sequencing and its impact in hereditary hearing loss

Search more.