Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3

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Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M807526200
P932PMC publication ID2631951
P698PubMed publication ID19008232

P2093author name stringHong Zhang
Ed Stavnezer
P2860cites workSki is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptorQ22008813
The Ski protein family is required for MeCP2-mediated transcriptional repressionQ24291417
Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signalingQ24296714
SKI activates Wnt/beta-catenin signaling in human melanomaQ24298640
Interaction with Smad4 is indispensable for suppression of BMP signaling by c-SkiQ24303530
The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42Q24311912
Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissuesQ24337448
Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding proteinQ24537783
Cooperation of six and eya in activation of their target genes through nuclear translocation of EyaQ24554423
Ski interacts with the evolutionarily conserved SNW domain of SkipQ24555232
Tight control of gene expression in mammalian cells by tetracycline-responsive promotersQ24564850
Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factorsQ24594377
The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signalingQ24599753
SnoI, a novel alternatively spliced isoform of the ski protooncogene homolog, sno.Q24617524
A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genesQ24631256
Isolation of human cDNA clones of ski and the ski-related gene, snoQ24635631
c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smadsQ28138749
Molecular mechanisms regulating myogenic determination and differentiationQ28145088
Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signalingQ28146183
Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesisQ28185761
Altered myogenesis in Six1-deficient miceQ28187781
Impaired interactions between mouse Eyal harboring mutations found in patients with branchio-oto-renal syndrome and Six, Dach, and G proteinsQ28214522
Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerizationQ28239333
The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye developmentQ28258959
Crystal structure of the dachshund homology domain of human SKIQ28260495
Probing tumor phenotypes using stable and regulated synthetic microRNA precursorsQ28275174
Second-generation shRNA libraries covering the mouse and human genomesQ28275183
Mammalian and Drosophila dachshund genes are related to the Ski proto-oncogene and are expressed in eye and limbQ28275505
Human SRF-related proteins: DNA-binding properties and potential regulatory targetsQ28300739
Activation of a muscle-specific enhancer by the Ski proto-oncogeneQ28505793
Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle developmentQ28507155
Corl1, a novel neuronal lineage-specific transcriptional corepressor for the homeodomain transcription factor Lbx1Q28508618
Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- miceQ28510846
c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylasesQ28589107
Tissue-specific regulation of retinal and pituitary precursor cell proliferationQ28589859
Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding siteQ28589912
ski can cause selective growth of skeletal muscle in transgenic miceQ68624469
A carboxyl-terminal region of the ski oncoprotein mediates homodimerization as well as heterodimerization with the related protein SnoNQ72724829
Dedifferentiation of mammalian myotubes induced by msx1Q73406479
Thymus, kidney and craniofacial abnormalities in Six 1 deficient miceQ73593261
Dachshund and eyes absent proteins form a complex and function synergistically to induce ectopic eye development in DrosophilaQ74037490
Viral ski inhibits retinoblastoma protein (Rb)-mediated transcriptional repression in a dominant negative fashionQ78168212
Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selectionQ29617433
Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formationQ33885274
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cellsQ33938488
Six family genes--structure and function as transcription factors and their roles in developmentQ33957333
Mechanisms underlying the transcriptional regulation of skeletal myogenesis.Q34131477
Ski/Sno and TGF-beta signaling.Q34225107
Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placodeQ34414173
MyoD and the transcriptional control of myogenesisQ34442774
Myogenic regulatory factors and the specification of muscle progenitors in vertebrate embryosQ34762477
Activation of the myogenin promoter during mouse embryogenesis in the absence of positive autoregulationQ34779892
Generation of transforming viruses in cultures of chicken fibroblasts infected with an avian leukosis virusQ35241487
Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type beta transforming growth factorQ35754725
Requirement of protein co-factor for the DNA-binding function of the human ski proto-oncogene productQ35827450
Transformation of hematopoietic cells by the Ski oncoprotein involves repression of retinoic acid receptor signalingQ36308232
Myogenin expression, cell cycle withdrawal, and phenotypic differentiation are temporally separable events that precede cell fusion upon myogenesis.Q36382342
Transformation-defective v-ski induces MyoD and myogenin expression but not myotube formationQ36685768
Analysis of the myogenin promoter reveals an indirect pathway for positive autoregulation mediated by the muscle-specific enhancer factor MEF-2Q36698404
Activation of the c-ski oncogene by overexpressionQ36797799
Unique sequence, ski, in Sloan-Kettering avian retroviruses with properties of a new cell-derived oncogeneQ36859974
Transforming Sloan-Kettering viruses generated from the cloned v-ski oncogene by in vitro and in vivo recombinationsQ36859994
Skeletal muscle satellite cells and adult myogenesis.Q36998129
The emerging biology of satellite cells and their therapeutic potentialQ37064632
Paired MyoD-binding sites regulate myosin light chain gene expressionQ37399134
Structure and activities of the ski oncogeneQ37805045
Binding of C/EBPbeta to the C-reactive protein (CRP) promoter in Hep3B cells is associated with transcription of CRP mRNA.Q39953275
Regulation of Muscle Differentiation by the MEF2 Family of MADS Box Transcription FactorsQ40432858
A highly conserved enhancer downstream of the human MLC1/3 locus is a target for multiple myogenic determination factorsQ40525469
Repression of endogenous Smad7 by Ski.Q40558828
Trans-regulation of myogenin promoter/enhancer activity by c-ski during skeletal-muscle differentiation: the C-terminus of the c-Ski protein is essential for transcriptional regulatory activity in myotubesQ41070504
Enhanced expression of mouse c-ski accompanies terminal skeletal muscle differentiation in vivo and in vitroQ41275887
Determinants of myogenic specificity within MyoD are required for noncanonical E box bindingQ42412056
Identification of a new class of PAX3-FKHR target promoters: a role of the Pax3 paired box DNA binding domainQ42703157
Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potentialQ42828894
Oxidative stress is the new stressQ46839696
Mouse Dach, a homologue of Drosophila dachshund, is expressed in the developing retina, brain and limbsQ47925213
Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development.Q48068853
The regulation of myogenin gene expression during the embryonic development of the mouseQ48112077
The Msh-like homeobox genes define domains in the developing vertebrate eye.Q48217316
The ski oncogene induces muscle differentiation in quail embryo cells.Q51173935
Identification of a core functional and structural domain of the v-Ski oncoprotein responsible for both transformation and myogenesis.Q53441456
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
myotube differentiationQ14762267
SKI proto-oncogeneQ14913250
EYA transcriptional coactivator and phosphatase 3Q21981870
Sine oculis-related homeobox 1Q21981883
Ski oncogeneQ21990617
P304page(s)2867-79
P577publication date2009-01-30
P1433published inJournal of Biological ChemistryQ867727
P1476titleSki regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3
P478volume284

Reverse relations

cites work (P2860)
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Q30502592Chromosomal instability in mouse embryonic fibroblasts null for the transcriptional co-repressor Ski.
Q35207442Excitation‐transcription coupling in skeletal muscle: the molecular pathways of exercise
Q39188632Expression of Ski can act as a negative feedback mechanism on retinoic acid signaling.
Q33883339Kruppel-like factor 4 inhibits epithelial-to-mesenchymal transition through regulation of E-cadherin gene expression
Q35639937Mitogen-activated protein kinase extracellular signal-regulated kinase 2 phosphorylates and promotes Pin1 protein-dependent promyelocytic leukemia protein turnover
Q39256753Overexpression of Six1 leads to retardation of myogenic differentiation in C2C12 myoblasts
Q35562803Peroxisome proliferator-activated receptor γ (PPARγ) mediates a Ski oncogene-induced shift from glycolysis to oxidative energy metabolism
Q33744538Promyelocytic leukemia protein controls cell migration in response to hydrogen peroxide and insulin-like growth factor-1
Q84759300SKI knockdown inhibits human melanoma tumor growth in vivo
Q28589792Six family genes control the proliferation and differentiation of muscle satellite cells
Q84381185Six1 and Six1 cofactor expression is altered during early skeletal muscle overload in mice
Q38184513Six1: a critical transcription factor in tumorigenesis
Q33569692The Notch effector Hey1 associates with myogenic target genes to repress myogenesis.
Q38248282The role of Six1 in the genesis of muscle cell and skeletal muscle development
Q40637660Time course and side-by-side analysis of mesodermal, pre-myogenic, myogenic and differentiated cell markers in the chicken model for skeletal muscle formation
Q38337450Transcriptional analysis of the titin cap gene
Q62060038Transcriptional cofactors Ski and SnoN are major regulators of the TGF-β/Smad signaling pathway in health and disease
Q37885788c-Ski in health and disease
Q90577000miR-23a-3p/SIX1 regulates glucose uptake and proliferation through GLUT3 in head and neck squamous cell carcinomas

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