Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway

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Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.271.21.12129
P698PubMed publication ID8647802
P5875ResearchGate publication ID14552366

P2093author name stringJ Ni
G S Feng
Y B Ouyang
Z Q Shi
R Gentz
D P Hu
P2860cites workBcr-Abl oncoproteins bind directly to activators of the Ras signalling pathwayQ24324144
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signalingQ24337017
The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5.Q24337241
Binding of Vav to Grb2 through dimerization of Src homology 3 domainsQ24564126
SH2 domains recognize specific phosphopeptide sequencesQ27860748
An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitroQ28267609
Sequence identification of 2,375 human brain genesQ28283772
SH3 domain-mediated interaction of dystroglycan and Grb2Q28301162
Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinaseQ28302000
The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1Q28511655
Molecular Cloning of the Mousegrb2Gene: Differential Interaction of the Grb2 Adaptor Protein with Epidermal Growth Factor and Nerve Growth Factor ReceptorsQ28592605
p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinaseQ28610005
Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factorQ29616395
Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformationQ29616396
Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on RasQ29617087
Complementary DNA sequencing: expressed sequence tags and human genome projectQ29618255
Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinasesQ29618331
C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domainsQ29618334
Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila.Q30193377
BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor proteinQ30194769
A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.Q30195071
SH2 domain specificity and activity modified by a single residueQ34057752
Signal transduction--a conserved pathway from the membrane to the nucleusQ34348625
A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinaseQ36643931
SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinasesQ41566173
Signal transduction. How receptors turn Ras on.Q55066288
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectcell-cell signalingQ14758911
GRB2 related adaptor proteinQ21103288
SH3 domainQ24771787
P304page(s)12129-32
P577publication date1996-05-24
P1433published inJournal of Biological ChemistryQ867727
P1476titleGrap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway
P478volume271