Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen

scientific article

Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2006PNAS..10318107U
P356DOI10.1073/PNAS.0608595103
P932PMC publication ID1838714
P698PubMed publication ID17108083
P5875ResearchGate publication ID6689842

P50authorLouise PrakashQ28323954
P2093author name stringJerard Hurwitz
Lajos Haracska
Satya Prakash
Vladimir Bermudez
Károly Fátyol
András Blastyák
Ildikó Hajdú
Ildiko Unk
Barnabás Szakál
P2860cites workhRAD30 mutations in the variant form of xeroderma pigmentosumQ22010237
RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitinationQ22010577
Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13Q24291487
Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA.Q24537135
Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitinationQ24563236
Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligasesQ27626747
Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair.Q27935427
Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, PoletaQ27935465
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.Q27937465
The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanismQ27938714
Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin conjugating, DNA binding, and ATP hydrolytic activitiesQ27938794
Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sitesQ27938885
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase etaQ28115711
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligaseQ28145635
Eukaryotic translesion synthesis DNA polymerases: specificity of structure and functionQ29617871
Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugationQ29619155
Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesionsQ29619958
Lysine 63-polyubiquitination guards against translesion synthesis-induced mutationsQ33247452
Identification of a protein essential for a major pathway used by human cells to avoid UV- induced DNA damageQ34048520
The error-free component of the RAD6/RAD18 DNA damage tolerance pathway of budding yeast employs sister-strand recombinationQ34115863
Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region.Q34210489
Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases eta and REV1Q34234530
Requirement of RAD5 and MMS2 for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiaeQ34276876
Ubiquitylation of yeast proliferating cell nuclear antigen and its implications for translesion DNA synthesisQ34597716
Mms2-Ubc13-dependent and -independent roles of Rad5 ubiquitin ligase in postreplication repair and translesion DNA synthesis in Saccharomyces cerevisiaeQ35131692
Saccharomyces cerevisiae RAD5-encoded DNA repair protein contains DNA helicase and zinc-binding sequence motifs and affects the stability of simple repetitive sequences in the genomeQ36699247
Opposing effects of ubiquitin conjugation and SUMO modification of PCNA on replicational bypass of DNA lesions in Saccharomyces cerevisiaeQ37731934
Requirement of DNA polymerase eta for error-free bypass of UV-induced CC and TC photoproductsQ39468393
Role of DNA polymerase eta in the UV mutation spectrum in human cellsQ40663020
The influence of the proliferating cell nuclear antigen-interacting domain of p21(CIP1) on DNA synthesis catalyzed by the human and Saccharomyces cerevisiae polymerase delta holoenzymesQ71985237
Yeast DNA repair protein RAD5 that promotes instability of simple repetitive sequences is a DNA-dependent ATPaseQ72808754
Requirement of DNA polymerase activity of yeast Rad30 protein for its biological functionQ77808091
Yeast and human translesion DNA synthesis polymerases: expression, purification, and biochemical characterizationQ79773215
P433issue48
P407language of work or nameEnglishQ1860
P921main subjectubiquitin protein ligase activityQ21095456
SNF2 histone linker PHD RING helicaseQ21100915
P304page(s)18107-12
P577publication date2006-11-28
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleHuman SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen
P478volume103

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cites work (P2860)
Q42646846A homolog of ScRAD5 is involved in DNA repair and homologous recombination in Arabidopsis
Q49988792A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis.
Q35586040A novel ubiquitin binding mode in the S. cerevisiae translesion synthesis DNA polymerase η
Q47396526A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair.
Q34526170Analysis of CPD ultraviolet lesion bypass in chicken DT40 cells: polymerase η and PCNA ubiquitylation play identical roles
Q40898008Asymmetric nature of two subunits of RAD18, a RING-type ubiquitin ligase E3, in the human RAD6A-RAD18 ternary complex.
Q51616204AtRAD5A is a DNA translocase harboring a HIRAN domain which confers binding to branched DNA structures and is required for DNA repair in vivo.
Q37200030Axitinib blocks Wnt/β-catenin signaling and directs asymmetric cell division in cancer
Q37104072BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade
Q28070584Balancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too?
Q28275269Characterization of human Spartan/C1orf124, an ubiquitin-PCNA interacting regulator of DNA damage tolerance
Q34227706Chronic treatment with cisplatin induces replication-dependent sister chromatid recombination to confer cisplatin-resistant phenotype in nasopharyngeal carcinoma
Q92345645Circular RNA hsa_circ_0001649 inhibits hepatocellular carcinoma progression via multiple miRNAs sponge
Q41905451Constitutive fusion of ubiquitin to PCNA provides DNA damage tolerance independent of translesion polymerase activities
Q33973384Coordinated protein and DNA remodeling by human HLTF on stalled replication fork
Q35205030Crosstalk between translesion synthesis, Fanconi anemia network, and homologous recombination repair pathways in interstrand DNA crosslink repair and development of chemoresistance
Q40854358Crystallographic study of a novel DNA-binding domain of human HLTF involved in the template-switching pathway to avoid the replication arrest caused by DNA damage.
Q35391240DGCR14 induces Il17a gene expression through the RORγ/BAZ1B/RSKS2 complex
Q60909331DNA Damage Tolerance Mechanisms Revealed from the Analysis of Immunoglobulin V Gene Diversification in Avian DT40 Cells
Q41860261DNA damage tolerance: when it's OK to make mistakes
Q24652996DNA damage-induced ubiquitylation of RFC2 subunit of replication factor C complex
Q28119166DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis
Q38853445Different types of interaction between PCNA and PIP boxes contribute to distinct cellular functions of Y-family DNA polymerases
Q35211243Dynamic regulation of PCNA ubiquitylation/deubiquitylation
Q36368763En bloc transfer of polyubiquitin chains to PCNA in vitro is mediated by two different human E2-E3 pairs.
Q57972039Error-free DNA damage tolerance pathway is facilitated by the Irc5 translocase through cohesin
Q37044564Eukaryotic DNA damage tolerance and translesion synthesis through covalent modifications of PCNA.
Q42380577FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2
Q47735296Functions of SMARCAL1, ZRANB3, and HLTF in maintaining genome stability
Q27013707Genomic instability in cancer
Q34159143Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling
Q36054241HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligase
Q35762843HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal.
Q39695095Helicase-like transcription factor confers radiation resistance in cervical cancer through enhancing the DNA damage repair capacity.
Q24652076Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination
Q36891684Integrating S-phase checkpoint signaling with trans-lesion synthesis of bulky DNA adducts
Q61813569Mechanisms of DNA Damage Tolerance: Post-Translational Regulation of PCNA
Q37676241Mechanisms of Post-Replication DNA Repair
Q42600350Mechanistic analysis of PCNA poly-ubiquitylation by the ubiquitin protein ligases Rad18 and Rad5.
Q33921111Multiple Rad5 activities mediate sister chromatid recombination to bypass DNA damage at stalled replication forks
Q80805356Neurosprora crassa RAD5 homologue, mus-41, inactivation results in higher sensitivity to mutagens but has little effect on PCNA-ubiquitylation in response to UV-irradiation
Q36899005Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly
Q47781755Nuclear insulin-like growth factor 1 receptor phosphorylates proliferating cell nuclear antigen and rescues stalled replication forks after DNA damage.
Q36456075PCNA modifications for regulation of post-replication repair pathways
Q38740304PCNA-Ub polyubiquitination inhibits cell proliferation and induces cell-cycle checkpoints
Q27679322PHD domain from human SHPRH
Q28509424PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage
Q92221511Peptides encoded by noncoding genes: challenges and perspectives
Q37233382Polyubiquitination by HECT E3s and the determinants of chain type specificity
Q24642282Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks
Q24304915Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate
Q47570425Progress and prospects of circular RNAs in Hepatocellular carcinoma: Novel insights into their function
Q47342186Proteasome-independent functions of lysine-63 polyubiquitination in plants
Q45412951RAD5A, RECQ4A, and MUS81 have specific functions in homologous recombination and define different pathways of DNA repair in Arabidopsis thaliana
Q50316149RTEL1 inhibits trinucleotide repeat expansions and fragility.
Q57753536Rad5, HLTF, and SHPRH: A Fresh View of an Old Story
Q36137333Rad5-dependent DNA repair functions of the Saccharomyces cerevisiae FANCM protein homolog Mph1.
Q34285356Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway
Q64989576Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes.
Q33547722Regulation of PCNA polyubiquitination in human cells
Q28289142Regulation of PCNA-protein interactions for genome stability
Q28087183Regulation of translesion DNA synthesis: Posttranslational modification of lysine residues in key proteins
Q37340387Replicating damaged DNA in eukaryotes
Q28067138Replication stress: getting back on track
Q35974065Requirement of Rad18 protein for replication through DNA lesions in mouse and human cells
Q24310657Role of PCNA-dependent stimulation of 3'-phosphodiesterase and 3'-5' exonuclease activities of human Ape2 in repair of oxidative DNA damage
Q39372569Role of SUMO modification of human PCNA at stalled replication fork
Q64387319Role of Y-family translesion DNA polymerases in replication stress: Implications for new cancer therapeutic targets
Q33614018Role of double-stranded DNA translocase activity of human HLTF in replication of damaged DNA
Q36976726Roles of PCNA-binding and ubiquitin-binding domains in human DNA polymerase eta in translesion DNA synthesis
Q37871124Roles of sequential ubiquitination of PCNA in DNA-damage tolerance
Q29871514SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis
Q50296606SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N
Q50296608SHPRH polyubiquitinates monoubiquitinated PCNA
Q43100862SHPRH regulates rRNA transcription by recognizing the histone code in an mTOR-dependent manner
Q33796994SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination
Q52648065Salivary gland cancer patient-derived xenografts enable characterization of cancer stem cells and new gene fusions associated with tumor progression.
Q37192014Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells
Q90076665Sex-dependent and -independent transcriptional changes during haploid phase gametogenesis in the sugar kelp Saccharina latissima
Q34925644Single cell analysis of human RAD18-dependent DNA post-replication repair by alkaline bromodeoxyuridine comet assay
Q38290540Solution NMR structure of the HLTF HIRAN domain: a conserved module in SWI2/SNF2 DNA damage tolerance proteins.
Q24296499Spartan/C1orf124 is important to prevent UV-induced mutagenesis
Q30373537Structure of a Novel DNA-binding Domain of Helicase-like Transcription Factor (HLTF) and Its Functional Implication in DNA Damage Tolerance
Q90480198Structure, Regulation, and Function of Linear and Circular Long Non-Coding RNAs
Q37034923The DNA damage response pathways: at the crossroad of protein modifications
Q92755025The DNA repair protein SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase
Q48137956The DNA translocase RAD5A acts independently of the other main DNA repair pathways, and requires both its ATPase and RING domain for activity in Arabidopsis thaliana
Q55404189The Emerging Role of Circular RNAs in Hepatocellular Carcinoma.
Q60932044The Emerging Role of Cohesin in the DNA Damage Response
Q104101497The HLTF-PARP1 interaction in the progression and stability of damaged replication forks caused by methyl methanesulfonate
Q90749291The Mechanistic Differences in HLA-Associated Carbamazepine Hypersensitivity
Q36406986The RAD5-dependent postreplication repair pathway is important to suppress gross chromosomal rearrangements
Q24616365The Role of PCNA Posttranslational Modifications in Translesion Synthesis
Q49724590The inhibition of UBC13 expression and blockage of the DNMT1-CHFR-Aurora A pathway contribute to paclitaxel resistance in ovarian cancer.
Q42065210The ubiquitin E3 ligase activity of BRCA1 and its biological functions.
Q37878585Timing and spacing of ubiquitin-dependent DNA damage bypass
Q92383542TonEBP Regulates PCNA Polyubiquitination in Response to DNA Damage through Interaction with SHPRH and USP1
Q57803942Transcriptional and Epigenetic Regulation by the Mechanistic Target of Rapamycin Complex 1 Pathway
Q37952001Translesion DNA synthesis in the context of cancer research
Q42419243Translesion synthesis polymerases in the prevention and promotion of carcinogenesis
Q46928613Two Mms2 residues cooperatively interact with ubiquitin and are critical for Lys63 polyubiquitination in vitro and in vivo
Q37918601Ub-family modifications at the replication fork: Regulating PCNA-interacting components
Q26739716Ubc13: the Lys63 ubiquitin chain building machine
Q37871655Ubiquitin family modifications and template switching
Q36416228Ubiquitin pathway and ovarian cancer
Q37894280Ubiquitin-family modifications in the replication of DNA damage
Q37861006Ubiquitination of PCNA and its essential role in eukaryotic translesion synthesis
Q59138263Ubiquitylation at the Fork: Making and Breaking Chains to Complete DNA Replication
Q33528989Visualisation of PCNA monoubiquitination in vivo by single pass spectral imaging FRET microscopy
Q36023692What a difference a decade makes: insights into translesion DNA synthesis
Q27931722Yeast Rad5 protein required for postreplication repair has a DNA helicase activity specific for replication fork regression
Q21262982hMMS2 serves a redundant role in human PCNA polyubiquitination
Q90129510ncRNA-Encoded Peptides or Proteins and Cancer

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