Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase

scientific article

Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase is …
instance of (P31):
scholarly articleQ13442814

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P3181OpenCitations bibliographic resource ID1332470
P932PMC publication ID398258
P698PubMed publication ID7737118

P2093author name stringM Winey
F C Luca
E Weiss
A R Schutz
B Stoelcker
E Lauzé
P2860cites workExpression of TTK, a novel human protein kinase, is associated with cell proliferationQ24300491
The protein kinase family: conserved features and deduced phylogeny of the catalytic domainsQ27860528
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiaeQ27860636
2 New M13 vectors for cloningQ27861042
Direct interaction between yeast spindle pole body components: Kar1p is required for Cdc31p localization to the spindle pole bodyQ27933029
NDC1: a nuclear periphery component required for yeast spindle pole body duplicationQ27933112
The essential mitotic target of calmodulin is the 110-kilodalton component of the spindle pole body in Saccharomyces cerevisiaeQ27933219
MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplicationQ27934422
KAR1, a gene required for function of both intranuclear and extranuclear microtubules in yeastQ27936118
Genetic interactions between CDC31 and KAR1, two genes required for duplication of the microtubule organizing center in Saccharomyces cerevisiae.Q27938282
The calcium-binding protein cell division cycle 31 of Saccharomyces cerevisiae is a component of the half bridge of the spindle pole bodyQ27938729
A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vectorQ28131601
Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeastQ28131609
A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coliQ28131613
5-Fluoroorotic acid as a selective agent in yeast molecular geneticsQ28131614
Multiple cDNAs encoding the esk kinase predict transmembrane and intracellular enzyme isoformsQ28586050
Behavior of spindles and spindle plaques in the cell cycle and conjugation of Saccharomyces cerevisiaeQ29618381
Vectors for the inducible overexpression of glutathione S-transferase fusion proteins in yeastQ29618547
Physical maps of the six smallest chromosomes of Saccharomyces cerevisiae at a resolution of 2.6 kilobase pairsQ29618575
Detection and quantification of phosphotyrosine in proteinsQ29620010
The NUF1 gene encodes an essential coiled-coil related protein that is a potential component of the yeast nucleoskeletonQ31116099
Characterization of a human protein threonine kinase isolated by screening an expression library with antibodies to phosphotyrosineQ34305703
Dual-specificity protein kinases: will any hydroxyl do?Q35429941
Nucleotide sequence and transcriptional mapping of the yeast pet56-his3-ded1 gene regionQ35565697
Centrosome assembly in vitro: role of gamma-tubulin recruitment in Xenopus sperm aster formationQ36233614
In vitro microtubule-nucleating activity of spindle pole bodies in fission yeast Schizosaccharomyces pombe: cell cycle-dependent activation in xenopus cell-free extractsQ36531430
IL-2-induced expression of TTK, a serine, threonine, tyrosine kinase, correlates with cell cycle progression.Q36757266
Fused protein domains inhibit DNA binding by LexAQ40655370
Saccharomyces cerevisiae nuclear fusion requires prior activation by alpha factorQ40667349
Regulation of the microtubule nucleating activity of centrosomes in Xenopus egg extracts: role of cyclin A-associated protein kinaseQ41846033
A spacer protein in the Saccharomyces cerevisiae spindle poly body whose transcript is cell cycle-regulatedQ42036502
Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactionsQ46112210
RPK1, an essential yeast protein kinase involved in the regulation of the onset of mitosis, shows homology to mammalian dual-specificity kinasesQ48081745
New yeast actin-like gene required late in the cell cycleQ48189700
Microtubule nucleating activity of centrosomes in cell-free extracts from Xenopus eggs: involvement of phosphorylation and accumulation of pericentriolar material.Q49158166
Assembly and functions of the spindle pole body in budding yeast.Q52223252
Acid and base hydrolysis of phosphoproteins bound to immobilon facilitates analysis of phosphoamino acids in gel-fractionated proteins.Q53518465
Nucleation of microtubules from mitotic centrosomes is modulated by a phosphorylated epitopeQ67667092
Asymmetric mitotic segregation of the yeast spindle pole bodyQ68119514
Labeling of RNA and phosphoproteins in Saccharomyces cerevisiaeQ70120838
Cell cycle dependent regulation of the protein kinase TTKQ72760076
Molecular components of the centrosomeQ75293454
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectmitotic spindle organizationQ14878173
TTK protein kinaseQ21125520
Serine/threonine/tyrosine protein kinase MPS1 YDL028CQ27547692
P304page(s)1655-63
P577publication date1995-04-18
P1433published inThe EMBO JournalQ1278554
P1476titleYeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase
P478volume14

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cites work (P2860)
Q24320294A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators.
Q24608914A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes
Q36273802A role for mitogen-activated protein kinase in the spindle assembly checkpoint in XTC cells
Q24671750Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry
Q24538743Ascospore formation in the yeast Saccharomyces cerevisiae
Q27936853Associations among PH and SH3 domain-containing proteins and Rho-type GTPases in Yeast
Q34888095Bub1, Sgo1, and Mps1 mediate a distinct pathway for chromosome biorientation in budding yeast
Q33786507Bub1p kinase activates the Saccharomyces cerevisiae spindle assembly checkpoint
Q34352444Cellular Abundance of Mps1 and the Role of Its Carboxyl Terminal Tail in Substrate Recruitment
Q35657719Centromere-tethered Mps1 pombe homolog (Mph1) kinase is a sufficient marker for recruitment of the spindle checkpoint protein Bub1, but not Mad1.
Q28540742Characterization of a putative spindle assembly checkpoint kinase Mps1, suggests its involvement in cell division, morphogenesis and oxidative stress tolerance in Candida albicans
Q33995013DBF2 protein kinase binds to and acts through the cell cycle-regulated MOB1 protein
Q30438021Diverse functions of spindle assembly checkpoint genes in Saccharomyces cerevisiae
Q38146494Dual personality of Mad1: regulation of nuclear import by a spindle assembly checkpoint protein
Q37022622Evolutionary Turnover of Kinetochore Proteins: A Ship of Theseus?
Q41768740Fine structure analysis of the yeast centrin, Cdc31p, identifies residues specific for cell morphology and spindle pole body duplication
Q37730163Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer
Q24682987Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores
Q24536263Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication
Q24569635Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression
Q58753054Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N-neopentyl
Q42116229Kinase activity of fission yeast Mph1 is required for Mad2 and Mad3 to stably bind the anaphase promoting complex
Q90430597LMO1 functions as an oncogene by regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer
Q57173343Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis
Q38232315Lessons from yeast: the spindle pole body and the centrosome
Q36848040MOB1, an essential yeast gene required for completion of mitosis and maintenance of ploidy
Q27938932Mimicking Ndc80 phosphorylation triggers spindle assembly checkpoint signalling
Q35002027Mip1 associates with both the Mps1 kinase and actin, and is required for cell cortex stability and anaphase spindle positioning.
Q42254103Mitotic Kinases and p53 Signaling
Q94046103Mitotic Protein Kinase 1: Role in Spindle Assembly Checkpoint Revisited
Q39131699Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores.
Q34768220Mps1p regulates meiotic spindle pole body duplication in addition to having novel roles during sporulation
Q41876971Mutation of a phosphorylatable residue in Put3p affects the magnitude of rapamycin-induced PUT1 activation in a Gat1p-dependent manner
Q33788429N-terminal regions of Mps1 kinase determine functional bifurcation
Q36864195New alleles of the yeast MPS1 gene reveal multiple requirements in spindle pole body duplication
Q36236630Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae
Q30452748Recognizing chromosomes in trouble: association of the spindle checkpoint protein Bub3p with altered kinetochores and a unique defective centromere
Q27940146Role of calmodulin and Spc110p interaction in the proper assembly of spindle pole body compenents
Q27930257Saccharomyces cerevisiae MPS2 encodes a membrane protein localized at the spindle pole body and the nuclear envelope
Q34012498Saccharomyces cerevisiae Mob1p is required for cytokinesis and mitotic exit
Q27931564Saccharomyces cerevisiae genes required in the absence of the CIN8-encoded spindle motor act in functionally diverse mitotic pathways
Q27678136Scaffold-Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitors
Q27660495Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function
Q42771999Spc42p: a phosphorylated component of the S. cerevisiae spindle pole body (SPD) with an essential function during SPB duplication
Q38611058Spc98p directs the yeast gamma-tubulin complex into the nucleus and is subject to cell cycle-dependent phosphorylation on the nuclear side of the spindle pole body
Q28484055Structural and functional characterization of the protein kinase Mps1 in Arabidopsis thaliana
Q27653321Structural and mechanistic insights into Mps1 kinase activation
Q27680652Structure-Based Design of Orally Bioavailable 1 H -Pyrrolo[3,2- c ]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)
Q39696988Synthetic Physical Interactions Map Kinetochore-Checkpoint Activation Regions.
Q33602466Systematic analysis of essential genes reveals important regulators of G protein signaling
Q38904176TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability
Q37697225TTK is a favorable prognostic biomarker for triple-negative breast cancer survival
Q31109693TagSmart: analysis and visualization for yeast mutant fitness data measured by tag microarrays
Q27936569The Bbp1p-Mps2p complex connects the SPB to the nuclear envelope and is essential for SPB duplication
Q33632369The MPS1 family of protein kinases
Q27939738The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint
Q24683919The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex
Q27937845The yeast CDC37 gene interacts with MPS1 and is required for proper execution of spindle pole body duplication
Q27937301The yeast centrin, cdc31p, and the interacting protein kinase, Kic1p, are required for cell integrity
Q27938020The yeast protein kinase Mps1p is required for assembly of the integral spindle pole body component Spc42p
Q36895837Yeast Dam1p is required to maintain spindle integrity during mitosis and interacts with the Mps1p kinase
Q27935457Yeast Mps1p phosphorylates the spindle pole component Spc110p in the N-terminal domain

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