DLX5 (distal-less homeobox 5) promotes tumor cell proliferation by transcriptionally regulating MYC

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DLX5 (distal-less homeobox 5) promotes tumor cell proliferation by transcriptionally regulating MYC is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M109.021477
P3181OpenCitations bibliographic resource ID3044043
P932PMC publication ID2742824
P698PubMed publication ID19497851
P5875ResearchGate publication ID26268076

P2093author name stringJinfei Xu
Joseph R Testa
P2860cites workIdentification of c- MYC as a Target of the APC PathwayQ24310637
The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal developmentQ24675473
Inhibition of DLX-7 homeobox gene causes decreased expression of GATA-1 and c-myc genes and apoptosisQ24677909
Specification of jaw subdivisions by Dlx genesQ28218878
Physical mapping of the split hand/split foot locus on chromosome 7 and implication in syndromic ectrodactylyQ28242341
Bone morphogenetic protein-2-induced alkaline phosphatase expression is stimulated by Dlx5 and repressed by Msx2Q28586077
Abnormal urethra formation in mouse models of split-hand/split-foot malformation type 1 and type 4Q28588793
Reversible tumorigenesis by MYC in hematopoietic lineagesQ33874286
c-Myc target genes involved in cell growth, apoptosis, and metabolismQ33956988
Chromosome-mediated alterations of the MYC gene in human cancer.Q34778071
Modelling Myc inhibition as a cancer therapyQ34811008
Deregulated homeobox gene expression in cancer: cause or consequence?Q34932292
The many faces of c-MYC.Q35189740
Detection of the c-myc oncogene product in testicular cancerQ35992310
Homeobox gene expression in cancer: insights from developmental regulation and deregulationQ36274462
Ovarian cancer: homeobox genes, autocrine/paracrine growth, and kinase signalingQ36472003
Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoterQ38321841
Activation of placenta-specific transcription factor distal-less homeobox 5 predicts clinical outcome in primary lung cancer patientsQ38426930
Small-molecule c-Myc inhibitor, 10058-F4, inhibits proliferation, downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cellsQ40198255
A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemiaQ40219227
Transcriptional activation of c-myc proto-oncogene by WT1 proteinQ40529835
Reversible lymphomagenesis in conditionally c-MYC expressing miceQ40565007
Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.Q40731052
Identification of a homeodomain binding element in the bone sialoprotein gene promoter that is required for its osteoblast-selective expressionQ40883137
Reciprocal regulation of osteocalcin transcription by the homeodomain proteins Msx2 and Dlx5.Q42464095
A BMP-inducible gene, dlx5, regulates osteoblast differentiation and mesoderm inductionQ42818472
Abnormalities of protooncogenes in non-small cell lung cancer. Correlations with tumor type and clinical characteristics.Q45946068
Regulatory elements that modulate expression of human c-mycQ46101026
A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic miceQ46721107
Dlx homeobox gene control of mammalian limb and craniofacial developmentQ52018151
Amplifications of both c-Ki-ras with a point mutation and c-myc in a primary pancreatic cancer and its metastatic tumors in lymph nodes.Q52834018
Association of amplified oncogene c-myc with an abnormally banded chromosome 8 in a human leukaemia cell lineQ54486682
Chromosome translocation can occur on either side of the c-myc oncogene in Burkitt lymphoma cellsQ58420444
Expressing the human genomeQ59066512
c-myc oncogene expression in colorectal cancerQ68933915
Stimulation of c-myc oncogene expression associated with estrogen-induced proliferation of human breast cancer cellsQ69442688
c-myc oncoprotein levels in bladder cancerQ70231308
Sustained loss of a neoplastic phenotype by brief inactivation of MYCQ74413944
Chromosome 8 copy numbers and the c-myc gene amplification in non-small cell lung cancer. Analysis by interphase cytogeneticsQ77786601
FOXM1c transactivates the human c-myc promoter directly via the two TATA boxes P1 and P2Q80241527
P433issue31
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
positive regulation of transcription, DNA-templatedQ14818066
Distal-less homeobox 5Q21102620
P304page(s)20593-601
P577publication date2009-07-31
P1433published inJournal of Biological ChemistryQ867727
P1476titleDLX5 (distal-less homeobox 5) promotes tumor cell proliferation by transcriptionally regulating MYC
P478volume284

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cites work (P2860)
Q35623134Adaptation of ovarian cancer cells to the peritoneal environment: Multiple mechanisms of the developmental patterning gene HOXA9
Q64059376Allelic Switching of , , and during Colorectal Cancer Tumorigenesis
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Q36214162Co-targeting of Akt and Myc inhibits viability of lymphoma cells from Lck-Dlx5 mice
Q58570118Comparative mRNA and miRNA transcriptome analysis of a mouse model of IGFIR-driven lung cancer
Q91817021DLX5 gene regulates the Notch signaling pathway to promote glomerulosclerosis and interstitial fibrosis in uremic rats
Q61851740Depot-specific gene expression profiles during differentiation and transdifferentiation of bovine muscle satellite cells, and differentiation of preadipocytes
Q46534463Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker
Q31041624Dlx5 Homeodomain:DNA Complex: Structure, Binding and Effect of Mutations Related to Split Hand and Foot Malformation Syndrome
Q28554645Early Transcriptomic Response to LDL and oxLDL in Human Vascular Smooth Muscle Cells
Q34055794Exome sequencing reveals a heterozygous DLX5 mutation in a Chinese family with autosomal-dominant split-hand/foot malformation.
Q35690891Expression of long non-coding RNA DLX6-AS1 in lung adenocarcinoma
Q33596707GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt.
Q38206779Homeobox Gene Deregulation: Impact on the Hallmarks of Cancer
Q35235227Homeobox gene Dlx-2 is implicated in metabolic stress-induced necrosis
Q96167143Identification and validation of prognosis-related DLX5 methylation as an epigenetic driver in myeloid neoplasms
Q40201604Increased copy number of the DLX4 homeobox gene in breast axillary lymph node metastasis
Q100407688KDM4A promotes the growth of non-small cell lung cancer by mediating the expression of Myc via DLX5 through the Wnt/β-catenin signaling pathway
Q42314702The homeoprotein Dlx5 drives murine T-cell lymphomagenesis by directly transactivating Notch and upregulating Akt signaling
Q34287705Transcription Factor DLX5 As a New Target for Promising Antitumor Agents

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