Luzp4 defines a new mRNA export pathway in cancer cells

scientific article

Luzp4 defines a new mRNA export pathway in cancer cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/NAR/GKV070
P3181OpenCitations bibliographic resource ID2464530
P932PMC publication ID4344508
P698PubMed publication ID25662211
P5875ResearchGate publication ID272019631

P50authorStuart A WilsonQ56506558
James CattoQ56934355
Nicolas ViphakoneQ56956886
Mark J DickmanQ61160847
P2093author name stringPaul R Heath
Marcus G Cumberbatch
Michaela J Livingstone
P2860cites workNIH Image to ImageJ: 25 years of image analysisQ23319322
TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architectureQ24290505
TREX is a conserved complex coupling transcription with messenger RNA exportQ24295211
Hypophosphorylated ASF/SF2 binds TAP and is present in messenger ribonucleoproteinsQ24295302
ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complexQ24299834
Linking transcriptional elongation and messenger RNA export to metastatic breast cancersQ24300178
Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factorsQ24301347
Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNAQ24305433
BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.Q50455260
A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5.Q54479973
Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8Q24306711
Recruitment of the human TREX complex to mRNA during splicingQ24306879
Chtop is a component of the dynamic TREX mRNA export complexQ24307827
Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNAQ24320299
UIF, a New mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNAQ24336514
Cytoscape: a software environment for integrated models of biomolecular interaction networksQ24515682
The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substratesQ24539652
A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4AQ24615463
Cancer cells and normal cells differ in their requirements for Thoc1Q24647728
Postage for the messenger: designating routes for nuclear mRNA exportQ26998427
Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA exportQ27677076
U2AF participates in the binding of TAP (NXF1) to mRNAQ28207777
Mutually exclusive interactions drive handover of mRNA from export adaptors to TAPQ28512678
Cancer/testis antigens, gametogenesis and cancerQ29616129
Towards a knowledge-based Human Protein AtlasQ29617987
Using ProHits to store, annotate, and analyze affinity purification-mass spectrometry (AP-MS) dataQ30561141
Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancersQ33823134
A novel tumour associated leucine zipper protein targeting to sites of gene transcription and splicingQ34130453
Genome-wide analysis of nuclear mRNA export pathways in DrosophilaQ35016875
The solution structure of REF2-I reveals interdomain interactions and regions involved in binding mRNA export factors and RNA.Q35110861
High throughput quantitative reverse transcription PCR assays revealing over-expression of cancer testis antigen genes in multiple myeloma stem cell-like side population cellsQ35194860
Fragile X mental retardation protein FMRP and the RNA export factor NXF2 associate with and destabilize Nxf1 mRNA in neuronal cellsQ35840450
Cancer/testis antigens and urological malignanciesQ36337004
Human TREX component Thoc5 affects alternative polyadenylation site choice by recruiting mammalian cleavage factor I.Q37080336
mRNA export and cancerQ37907202
The oncogene eIF4E reprograms the nuclear pore complex to promote mRNA export and oncogenic transformationQ39295500
TREX exposes the RNA-binding domain of Nxf1 to enable mRNA exportQ40711565
Cotranscriptional recruitment of the mRNA export factor Yra1 by direct interaction with the 3' end processing factor Pcf11.Q41920187
Shotgun proteome analysis utilising mixed mode (reversed phase-anion exchange chromatography) in conjunction with reversed phase liquid chromatography mass spectrometry analysisQ42956738
SR splicing factors serve as adapter proteins for TAP-dependent mRNA exportQ44384538
Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completionQ46686083
Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA exportQ50336101
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
CytoscapeQ3699942
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectmRNA export from nucleusQ15334263
Aly/REF export factorQ21102370
P1104number of pages14
P304page(s)2353-2366
P577publication date2015-02-27
P1433published inNucleic Acids ResearchQ135122
P1476titleLuzp4 defines a new mRNA export pathway in cancer cells
P478volume43

Reverse relations

cites work (P2860)
Q52322083A meta-analysis of public microarray data identifies biological regulatory networks in Parkinson's disease.
Q39142495A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs
Q64264933Bilateral striatal necrosis due to homoplasmic mitochondrial 3697G>A mutation presents with incomplete penetrance and sex bias
Q92143116Co-transcriptional Loading of RNA Export Factors Shapes the Human Transcriptome
Q36370196Differentially expressed proteins in glioblastoma multiforme identified with a nanobody-based anti-proteome approach and confirmed by OncoFinder as possible tumor-class predictive biomarker candidates
Q57190617Emerging Contributions of Cancer/Testis Antigens to Neoplastic Behaviors
Q91771228It's Not the Destination, It's the Journey: Heterogeneity in mRNA Export Mechanisms
Q91771220Mechanism and Regulation of Co-transcriptional mRNP Assembly and Nuclear mRNA Export
Q26783595Multiple Export Mechanisms for mRNAs
Q28081155Nuclear export of messenger RNA
Q49941000Proteomic Analysis of the Serum of Patients with Stable Vitiligo and Progressive Vitiligo
Q89146094RNA Degradation in Neurodegenerative Disease
Q47907249RNA Nuclear Export: From Neurological Disorders to Cancer
Q100750569RNA in cancer
Q38788828SR proteins are NXF1 adaptors that link alternative RNA processing to mRNA export.
Q33891056SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits
Q58050321Severe neurocognitive and growth disorders due to variation in THOC2 , an essential component of nuclear mRNA export machinery
Q100378834Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma
Q37568186Structural and biochemical analyses of the DEAD-box ATPase Sub2 in association with THO or Yra1.
Q50295510TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally
Q64295454The UAP56-Interacting Export Factors UIEF1 and UIEF2 Function in mRNA Export
Q58740715The mA-methylase complex recruits TREX and regulates mRNA export
Q57043820The mA‑methylase complex and mRNA export
Q26751488The new (dis)order in RNA regulation
Q28078160The role of TREX in gene expression and disease
Q96222254The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer
Q37428430Transcriptional Network Architecture of Breast Cancer Molecular Subtypes

Search more.