The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through Toll-like receptors 2 and 4 in human monocytes

scientific article

The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through Toll-like receptors 2 and 4 in human monocytes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/IAI.74.5.2686-2696.2006
P8608Fatcat IDrelease_5vbj3cebm5f6vlcaju2uq3sqpy
P3181OpenCitations bibliographic resource ID3115812
P932PMC publication ID1459749
P698PubMed publication ID16622205

P2093author name stringClifford V Harding
Eun-Kyeong Jo
Hwa-Jung Kim
Ji-Sook Lee
Chang-Hwa Song
Chul-Su Yang
Jeong-Kyu Park
Tae-Hyun Paik
Saet-Byel Jung
Sung-Soo Jung
A-Rum Shin
Ji Woong Son
P2860cites workHost defense mechanisms triggered by microbial lipoproteins through toll-like receptorsQ22010442
Role of mitogen-activated protein kinase pathways in the production of tumor necrosis factor-alpha, interleukin-10, and monocyte chemotactic protein-1 by Mycobacterium tuberculosis H37Rv-infected human monocytes.Q53654719
Toll-like receptorsQ55867091
Mycobacterium bovis bacille Calmette Guerin infection of human neutrophils induces CXCL8 secretion by MyD88-dependent TLR2 and TLR4 activationQ62061192
The nature of the immunogen determines the specificity of antibodies and T cells to selected peptides of the 38 kDa mycobacterial antigenQ71714663
Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammationQ73407117
Functions and specificity of T cells following nucleic acid vaccination of mice against Mycobacterium tuberculosis infectionQ73433289
Inhibition of IFN-gamma-induced class II transactivator expression by a 19-kDa lipoprotein from Mycobacterium tuberculosis: a potential mechanism for immune evasionQ73552827
Toll-like receptorsQ77627452
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 GeneQ22299417
MAP kinase activation in macrophagesQ23923208
The 19-kDa Mycobacterium tuberculosis protein induces macrophage apoptosis through Toll-like receptor-2Q24295054
A family of human receptors structurally related to Drosophila TollQ24321888
Toll-like receptorsQ27860671
Effect of deletion or overexpression of the 19-kilodalton lipoprotein Rv3763 on the innate response to Mycobacterium tuberculosisQ28486872
The immunodominant 38-kDa lipoprotein antigen of Mycobacterium tuberculosis is a phosphate-binding proteinQ28486986
Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosisQ28646111
Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinasesQ29614338
Acylation state of the phosphatidylinositol hexamannosides from Mycobacterium bovis bacillus Calmette Guerin and mycobacterium tuberculosis H37Rv and its implication in Toll-like receptor responseQ30939823
Specificity of antibodies and tuberculin response after occupational exposure to tuberculosisQ30989682
The acylation state of mycobacterial lipomannans modulates innate immunity response through toll-like receptor 2.Q33232176
The biology of Toll-like receptorsQ33922391
Induction of cell-mediated immunity against Mycobacterium tuberculosis using DNA vaccines encoding cytotoxic and helper T-cell epitopes of the 38-kilodalton proteinQ34008526
Isolation and partial purification of macrophage- and dendritic cell-activating components from Mycoplasma arthritidis: association with organism virulence and involvement with Toll-like receptor 2.Q34033844
The many faces of host responses to tuberculosisQ34266438
MAP kinases in the immune responseQ34542231
Protective immunity against tuberculosis induced by vaccination with major extracellular proteins of Mycobacterium tuberculosisQ34629227
Macrophage signalling upon mycobacterial infection: the MAP kinases lead the way.Q35076743
Dynamics of cytokine generation in patients with active pulmonary tuberculosisQ35160616
The significance of proteins actively secreted by Mycobacterium tuberculosis in relation to immunity and complications of mycobacterial diseasesQ35638117
Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteinsQ35782886
The 38-kDa protein of Mycobacterium tuberculosis: a reviewQ35845697
Manipulation of mitogen-activated protein kinase/nuclear factor-kappaB-signaling cascades during intracellular Toxoplasma gondii infectionQ35884234
Immunological activity of a 38-kilodalton protein purified from Mycobacterium tuberculosisQ37012176
Control of mycobacterial replication in human macrophages: roles of extracellular signal-regulated kinases 1 and 2 and p38 mitogen-activated protein kinase pathwaysQ39656080
Mycobacterium tuberculosis triggers apoptosis in peripheral neutrophils involving toll-like receptor 2 and p38 mitogen protein kinase in tuberculosis patientsQ40015293
Mycobacterium tuberculosis 19-kDa lipoprotein inhibits IFN-gamma-induced chromatin remodeling of MHC2TA by TLR2 and MAPK signalingQ40302381
The protective immune response to Mycobacterium tuberculosisQ40380470
Mycobacterium tuberculosis heat shock proteins use diverse Toll-like receptor pathways to activate pro-inflammatory signalsQ40439026
The T cell response to secreted antigens of Mycobacterium tuberculosisQ40505189
Factors associated with humoral response to ESAT-6, 38 kDa and 14 kDa in patients with a spectrum of tuberculosisQ40587417
Differential roles of Toll-like receptors in the elicitation of proinflammatory responses by macrophages.Q40745157
Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19-kDa lipoprotein of Mycobacterium tuberculosisQ43664763
Pharmacological analysis of signal transduction pathways required for mycobacterium tuberculosis-induced IL-8 and MCP-1 production in human peripheral monocytesQ44189298
The production of tumour necrosis factor-alpha is decreased in peripheral blood mononuclear cells from multidrug-resistant tuberculosis patients following stimulation with the 30-kDa antigen of Mycobacterium tuberculosis.Q44516775
T cell repertoire in tuberculosis: selective anergy to an immunodominant epitope of the 38-kDa antigen in patients with active diseaseQ44752213
Increased expression of Mycobacterium tuberculosis 19 kDa lipoprotein obliterates the protective efficacy of BCG by polarizing host immune responses to the Th2 subtype.Q46939320
Toll-like receptor 2 (TLR2)-dependent-positive and TLR2-independent-negative regulation of proinflammatory cytokines by mycobacterial lipomannansQ47914814
Mycobacterium tuberculosis LprG (Rv1411c): a novel TLR-2 ligand that inhibits human macrophage class II MHC antigen processing.Q51824924
P433issue5
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
P304page(s)2686-96
P577publication date2006-05-01
P1433published inInfection and ImmunityQ6029193
P1476titleThe mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through Toll-like receptors 2 and 4 in human monocytes
P478volume74

Reverse relations

cites work (P2860)
Q54565102A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic mice.
Q35590766A mycobacterial phosphoribosyltransferase promotes bacillary survival by inhibiting oxidative stress and autophagy pathways in macrophages and zebrafish
Q39133864A role for interleukin-17A in modulating intracellular survival of Mycobacterium bovis bacillus Calmette-Guérin in murine macrophages
Q40047410ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling
Q92962372ATP-binding cassette (ABC) import systems of Mycobacterium tuberculosis: target for drug and vaccine development
Q36321894Anti-epidermal growth factor receptor (EGFR) antibodies overcome resistance of ovarian cancer cells to targeted therapy and natural cytotoxicity
Q47096875Antimycobacterial and Anti-inflammatory Mechanisms of Baicalin via Induced Autophagy in Macrophages Infected with Mycobacterium tuberculosis.
Q34565300Apoptosis-associated biomarkers in tuberculosis: promising for diagnosis and prognosis prediction.
Q35684805Arc of a vicious circle: pathways activated by Mycobacterium tuberculosis that target the HIV-1 long terminal repeat
Q95362569Cell death at the cross roads of host-pathogen interaction in Mycobacterium tuberculosis infection
Q34765627Characterization of Proinflammatory Responses and Innate Signaling Activation in Macrophages Infected with Mycobacterium scrofulaceum
Q33634527Differential expression of Toll-like receptors on human alveolar macrophages and autologous peripheral monocytes.
Q24303632Eis (enhanced intracellular survival) protein of Mycobacterium tuberculosis disturbs the cross regulation of T-cells
Q41488141Expression of proinflammatory and regulatory cytokines via NF-κB and MAPK-dependent and IFN regulatory factor-3-independent mechanisms in human primary monocytes infected by Mycobacterium tuberculosis
Q26863391Host immune responses to mycobacterial antigens and their implications for the development of a vaccine to control tuberculosis
Q38106740Influence of Toll-like receptor gene polymorphisms to tuberculosis susceptibility in humans
Q36759549Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
Q98630214Is targeting dysregulation in apoptosis splice variants in Mycobacterium tuberculosis (MTB) host interactions and splicing factors resulting in immune evasion by MTB strategies a possibility?
Q46933779Leishmania mexicana lipophosphoglycan activates ERK and p38 MAP kinase and induces production of proinflammatory cytokines in human macrophages through TLR2 and TLR4.
Q37519338Leptospira surface adhesin (Lsa21) induces Toll like receptor 2 and 4 mediated inflammatory responses in macrophages
Q35039679Macrophage immunoregulatory pathways in tuberculosis
Q79258484Mammalian cell entry protein of Mycobacterium tuberculosis induces the proinflammatory response in RAW 264.7 murine macrophage-like cells
Q81687586Molecular signatures distinguishing active from latent tuberculosis in peripheral blood mononuclear cells, after in vitro antigenic stimulation with purified protein derivative of tuberculin (PPD) or Candida: a preliminary report
Q34433649Monocytes and the 38kDa-antigen of mycobacterium tuberculosis modulate natural killer cell activity and their cytolysis directed against ovarian cancer cell lines
Q39434579Monocytes from tuberculosis patients that exhibit cleaved caspase 9 and denaturalized cytochrome c are more susceptible to death mediated by Toll-like receptor 2.
Q38151096Multifaceted Impact of Host C-C Chemokine CCL2 in the Immuno-Pathogenesis of HIV-1/M. tuberculosis Co-Infection
Q35000960Mycobacterial Heparin-binding Hemagglutinin Antigen Activates Inflammatory Responses through PI3-K/Akt, NF-κB, and MAPK Pathways
Q37075508Mycobacterium leprae Activates Toll-Like Receptor-4 Signaling and Expression on Macrophages Depending on Previous Bacillus Calmette-Guerin Vaccination
Q46793529Mycobacterium tuberculosis 38-kDa antigen induces endoplasmic reticulum stress-mediated apoptosis via toll-like receptor 2/4.
Q38716100Mycobacterium tuberculosis EsxL inhibits MHC-II expression by promoting hypermethylation in class-II transactivator loci in macrophages
Q50058300Mycobacterium tuberculosis H37Rv infection regulates alternative splicing in Macrophages
Q38695050Mycobacterium tuberculosis MymA is a TLR2 agonist that activate macrophages and a TH1 response
Q39386686Mycobacterium tuberculosis Rv0652 stimulates production of tumour necrosis factor and monocytes chemoattractant protein-1 in macrophages through the Toll-like receptor 4 pathway.
Q36155020Mycobacterium tuberculosis Rv2882c Protein Induces Activation of Macrophages through TLR4 and Exhibits Vaccine Potential
Q35145130Mycobacterium tuberculosis Rv3402c enhances mycobacterial survival within macrophages and modulates the host pro-inflammatory cytokines production via NF-kappa B/ERK/p38 signaling
Q64105435Mycobacterium tuberculosis Rv3463 induces mycobactericidal activity in macrophages by enhancing phagolysosomal fusion and exhibits therapeutic potential
Q27663955Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2
Q42909598Mycobacterium tuberculosis-induced gamma interferon production by natural killer cells requires cross talk with antigen-presenting cells involving Toll-like receptors 2 and 4 and the mannose receptor in tuberculous pleurisy
Q34419185New approaches in the diagnosis and treatment of latent tuberculosis infection
Q40131760New findings of Toll-like receptors involved in Mycobacterium tuberculosis infection
Q38225182Outcome of Mycobacterium tuberculosis and Toll-like receptor interaction: immune response or immune evasion?
Q21296755Pathogenesis, immunology, and diagnosis of latent Mycobacterium tuberculosis infection
Q42236324Pattern recognition receptors and cytokines in Mycobacterium tuberculosis infection--the double-edged sword?
Q40240877Protein kinase C zeta plays an essential role for Mycobacterium tuberculosis-induced extracellular signal-regulated kinase 1/2 activation in monocytes/macrophages via Toll-like receptor 2.
Q38921251Recombinant TB9.8 of Mycobacterium bovis Triggers the Production of IL-12 p40 and IL-6 in RAW264.7 Macrophages via Activation of the p38, ERK, and NF-κB Signaling Pathways
Q34229621Regulation of Mycobacterium tuberculosis-dependent HIV-1 transcription reveals a new role for NFAT5 in the toll-like receptor pathway
Q34104329Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors
Q37595801Rhodococcus erythropolis as a host for expression, secretion and glycosylation of Mycobacterium tuberculosis proteins.
Q37021687Role of toll-like receptors in multiple sclerosis
Q39952436Roles of reactive oxygen species in CXCL8 and CCL2 expression in response to the 30-kDa antigen of Mycobacterium tuberculosis
Q28085251Sensing of Mycobacterium tuberculosis and consequences to both host and bacillus
Q37935325Serodiagnosis of tuberculosis: due to shift track
Q37315298TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.
Q40559584TLR2 signaling depletes IRAK1 and inhibits induction of type I IFN by TLR7/9.
Q37039006TLR4-mediated activation of dendritic cells by the heat shock protein DnaK from Francisella tularensis.
Q31140592The 30-kDa and 38-kDa antigens from Mycobacterium tuberculosis induce partial maturation of human dendritic cells shifting CD4(+) T cell responses towards IL-4 production
Q89967181The Heparin-Binding Hemagglutinin of Nocardia cyriacigeorgica GUH-2 Stimulates Inflammatory Cytokine Secretion Through Activation of Nuclear Factor κB and Mitogen-Activated Protein Kinase Pathways via TLR4
Q36044999Therapeutic effects of mycobacterial secretory proteins against established asthma in BALB/c mice
Q38871816Toll-like receptor 2 in host defense against Mycobacterium tuberculosis: to be or not to be-that is the question
Q40104128Toll-like receptor genes are differentially expressed at the sites of infection during the progression of Johne's disease in outbred sheep.
Q41570545Transcriptome changes upon in vitro challenge with Mycobacterium bovis in monocyte-derived macrophages from bovine tuberculosis-infected and healthy cows
Q90726349Unmethylated CpG motif-containing genomic DNA fragment of Bacillus calmette-guerin promotes macrophage functions through TLR9-mediated activation of NF-κB and MAPKs signaling pathways
Q57458673Upregulation of miR-196b-5p attenuates BCG uptake via targeting SOCS3 and activating STAT3 in macrophages from patients with long-term cigarette smoking-related active pulmonary tuberculosis
Q38053069Virulence factors of the Mycobacterium tuberculosis complex

Search more.