IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration

scientific article

IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/EMBOJ.2013.191
P8608Fatcat IDrelease_ejlicsajfnez5cwuuixqgvvz3a
P3181OpenCitations bibliographic resource ID4230472
P932PMC publication ID3791370
P698PubMed publication ID23982733
P5875ResearchGate publication ID256189265

P50authorZhigang LiQ42884334
P2093author name stringNarendra Thapa
Andrew C Hedman
David B Sacks
Richard A Anderson
Suyong Choi
P2860cites workThe effect of IQGAP1 on Xenopus embryonic ectoderm requires Cdc42Q74587695
IQGAP1 integrates Ca2+/calmodulin and Cdc42 signalingQ77732943
An emerging role for IQGAP1 in regulating protein trafficQ84286071
Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDIQ24292355
Type I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activationQ24293175
IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent mannerQ24294255
IQGAP1 modulates activation of B-RafQ24309982
IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain foldQ24312786
PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functionsQ24314508
Dia1 and IQGAP1 interact in cell migration and phagocytic cup formationQ24318404
Phosphoinositide signaling regulates the exocyst complex and polarized integrin trafficking in directionally migrating cellsQ24602665
Scaffold proteins: hubs for controlling the flow of cellular informationQ24611517
Get to grips: steering local actin dynamics with IQGAPsQ24645636
IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesisQ24655426
Critical role of PIP5KI{gamma}87 in InsP3-mediated Ca(2+) signalingQ24676005
Type I gamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with mu 1B adaptinQ24683598
Cell migration: integrating signals from front to backQ27860670
Phosphoinositides in cell regulation and membrane dynamicsQ27861051
Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesionQ27939824
IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulinQ28209157
Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170Q28213976
Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesionsQ28214350
Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1Q28215755
IQGAP1 regulation and roles in cancerQ28237517
Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosisQ28240831
IQGAP1: a key regulator of adhesion and migrationQ28250427
IQGAP1 stimulates proliferation and enhances tumorigenesis of human breast epithelial cellsQ28256129
Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migrationQ28295800
PIP2 and PIP3: complex roles at the cell surfaceQ28609413
Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphateQ28647599
Conserved microtubule-actin interactions in cell movement and morphogenesisQ29615212
Cell adhesion: integrating cytoskeletal dynamics and cellular tensionQ29618066
The Nck-interacting kinase phosphorylates ERM proteins for formation of lamellipodium by growth factorsQ30477995
Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytesQ30481021
Phosphatidylinositol phosphate kinases, a multifaceted family of signaling enzymes.Q33584871
Type I gamma phosphatidylinositol phosphate kinase modulates invasion and proliferation and its expression correlates with poor prognosis in breast cancer.Q33892896
IQGAP1 stimulates actin assembly through the N-WASP-Arp2/3 pathwayQ34579326
PIP(2) and proteins: interactions, organization, and information flowQ34623576
PIP5KI gamma is required for cardiovascular and neuronal developmentQ34645669
A screen for novel phosphoinositide 3-kinase effector proteins.Q34751632
Phosphoinositide regulation of the actin cytoskeletonQ35019759
IQGAP1 and its binding proteins control diverse biological functionsQ35713259
Regulation of microtubules in cell migrationQ36032502
Type I gamma phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migrationQ36118826
Plasma membrane phosphoinositide organization by protein electrostaticsQ36327803
IQGAP1 in cellular signaling: bridging the GAP.Q36440667
Movin' on up: the role of PtdIns(4,5)P(2) in cell migration.Q36450231
PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membraneQ36630120
The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA.Q36718374
A conspicuous connection: structure defines function for the phosphatidylinositol-phosphate kinase family.Q36761494
Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinasesQ36829577
Two novel phosphatidylinositol-4-phosphate 5-kinase type Igamma splice variants expressed in human cells display distinctive cellular targetingQ37434355
Life at the leading edgeQ37894186
Phosphatidylinositol 4, 5 bisphosphate and the actin cytoskeletonQ37989034
Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of rho-GTPase regulatorQ38336933
Involvement of IQGAP1, an effector of Rac1 and Cdc42 GTPases, in cell-cell dissociation during cell scatteringQ39458563
Rac controls PIP5K localisation and PtdIns(4,5)P₂ synthesis, which modulates vinculin localisation and neurite dynamics.Q39655961
The PI(3,5)P2 and PI(4,5)P2 interactomesQ39860903
Fibroblast adaptation and stiffness matching to soft elastic substratesQ40787799
Binding of neomycin to phosphatidylinositol 4,5-bisphosphate (PIP2).Q41268508
PIPKIγ regulates β-catenin transcriptional activity downstream of growth factor receptor signaling.Q41818593
PI(4,5)P2-dependent microdomain assemblies capture microtubules to promote and control leading edge motilityQ42145207
Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migrationQ42448806
IQGAP1 promotes cell motility and invasionQ42798469
Localization of the PAK1-, WASP-, and IQGAP1-specifying regions of Cdc42.Q42810090
A polybasic motif allows N-WASP to act as a sensor of PIP(2) densityQ45233508
Ras and Rho protein induction of motility and invasion in T47D breast adenocarcinoma cells.Q53398246
P4510describes a project that usesImageJQ1659584
P433issue19
P407language of work or nameEnglishQ1860
P921main subjectcell migrationQ189092
P304page(s)2617-2630
P577publication date2013-08-27
P1433published inThe EMBO JournalQ1278554
P1476titleIQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration
P478volume32

Reverse relations

cites work (P2860)
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Q35948366Bioinformatic analyses in early host response to Porcine Reproductive and Respiratory Syndrome virus (PRRSV) reveals pathway differences between pigs with alternate genotypes for a major host response QTL
Q38861831Control of diverse subcellular processes by a single multi-functional lipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2].
Q37579110HECTD1 controls the protein level of IQGAP1 to regulate the dynamics of adhesive structures
Q97532061Hyperplasia suppressor gene inhibits the proliferation and metastasis of glioma cells by targeting rho family proteins
Q55462178IQ Domain-Containing GTPase-Activating Protein 1 Regulates Cytoskeletal Reorganization and Facilitates NKG2D-Mediated Mechanistic Target of Rapamycin Complex 1 Activation and Cytokine Gene Translation in Natural Killer Cells.
Q39294242IQGAP1 is a key node within the small GTPase network
Q38629482IQGAP1 is a phosphoinositide effector and kinase scaffold
Q51297968IQGAP1 makes PI(3)K signalling as easy as PIP, PIP2, PIP3.
Q38367073IQGAP1: insights into the function of a molecular puppeteer
Q35132297IQGAPs choreograph cellular signaling from the membrane to the nucleus
Q36098641Limb body wall complex, amniotic band sequence, or new syndrome caused by mutation in IQ Motif containing K (IQCK)?
Q33738762PI(3,4)P2 plays critical roles in the regulation of focal adhesion dynamics of MDA-MB-231 breast cancer cells
Q28083975PIP kinases define PI4,5P₂signaling specificity by association with effectors
Q48144836PIPKIγ and talin couple phosphoinositide and adhesion signaling to control the epithelial to mesenchymal transition.
Q50077060PLD and PA Take MT1-MMP for a Metastatic Ride.
Q91962766Phosphatidic acid generated by PLD2 promotes the plasma membrane recruitment of IQGAP1 and neointima formation
Q37348955Phosphatidylinositol phosphate 5-kinase Iγi2 in association with Src controls anchorage-independent growth of tumor cells.
Q53971924Phosphoinositide 3-kinase pathways and autophagy require phosphatidylinositol phosphate kinases.
Q47147567Ras GAP-related and C-terminal domain-dependent localization and tumorigenic activities of IQGAP1 in melanoma cells
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Q95266089The Prediction and Prognostic Significance of INPP5K Expression in Patients with Liver Cancer
Q93000654The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif
Q27023065The biology of IQGAP proteins: beyond the cytoskeleton
Q33830545The coordinating role of IQGAP1 in the regulation of local, endosome-specific actin networks
Q59793515The phosphorylation status of PIP5K1C at serine 448 can be predictive for invasive ductal carcinoma of the breast
Q92143850Type Iγ phosphatidylinositol phosphate kinase promotes tumor growth by facilitating Warburg effect in colorectal cancer