Chimaeric HPV E6 proteins allow dissection of the proteolytic pathways regulating different E6 cellular target proteins

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Chimaeric HPV E6 proteins allow dissection of the proteolytic pathways regulating different E6 cellular target proteins is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1018303143
P356DOI10.1038/SJ.ONC.1206026
P698PubMed publication ID12444549
P5875ResearchGate publication ID11023489

P2093author name stringLawrence Banks
Miranda Thomas
David Pim
P2860cites workBinding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor proteinQ24311317
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53Q24317677
Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1Q24328861
Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteinsQ24527216
Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligaseQ24551145
PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membraneQ24563377
Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteinsQ24622878
Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor proteinQ24654803
Solution structure determination and mutational analysis of the papillomavirus E6 interacting peptide of E6APQ27629403
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferaseQ27860571
PDZ domains: targeting signalling molecules to sub-membranous sitesQ28242408
MAGI-1, a membrane-associated guanylate kinase with a unique arrangement of protein-protein interaction domainsQ28256306
HPV E6 and MAGUK protein interactions: determination of the molecular basis for specific protein recognition and degradationQ28360379
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53Q29547773
Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epitheliaQ30176838
Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradationQ33292379
The role of the E6-p53 interaction in the molecular pathogenesis of HPV.Q33807833
Targeted degradation of the retinoblastoma protein by human papillomavirus E7-E6 fusion proteinsQ33937962
Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradationQ34141231
The human papillomavirus E6 protein and its contribution to malignant progressionQ34468780
Inhibition of patterned cell shape change and cell invasion by Discs large during Drosophila oogenesisQ35192400
Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.Q36660357
Possible prognostic significance of human papillomavirus type in cervical cancerQ39184697
Identification of a second transforming function in bovine papillomavirus type 1 E6 and the role of E6 interactions with paxillin, E6BP, and E6APQ39588970
Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteinsQ40445624
Comparison of human papillomavirus type 18 (HPV-18) E6-mediated degradation of p53 in vitro and in vivo reveals significant differences based on p53 structure and cell type but little difference with respect to mutants of HPV-18 E6.Q41014430
Mutational analysis of human papillomavirus type 16 E6 protein: transforming function for human cells and degradation of p53 in vitroQ41290315
PDZ domains bind carboxy-terminal sequences of target proteinsQ41331117
Analysis of individual human papillomavirus types in cervical neoplasia: a possible role for type 18 in rapid progressionQ41336297
Prognostic significance of polymerase chain reaction detected human papillomavirus of tumors and lymph nodes in surgically treated stage IB cervical cancerQ41955314
A comparative analysis of the interactions of the E6 proteins from cutaneous and genital papillomaviruses with p53 and E6AP in correlation to their transforming potentialQ42833219
Association of human papillomavirus types 16 and 18 E6 proteins with p53.Q43701619
PDZ proteins organize synaptic signaling pathwaysQ46332824
Cooperative regulation of cell polarity and growth by Drosophila tumor suppressorsQ47070295
Associations between oncogenic human papillomaviruses and local invasive patterns in cervical cancer.Q53375847
Malignant transformation of recurrent respiratory papillomatosis associated with integrated human papillomavirus type 11 DNA and mutation of p53.Q53434597
Dispensability of p53 degradation for tumorigenicity and decreased serum requirement of human papillomavirus type 16 E6.Q53435589
Degradation of p53 only is not sufficient for the growth stimulatory effect of human papillomavirus 16 E6 oncoprotein in human embryonic fibroblasts.Q53469153
Human papillomavirus-11-associated recurrent respiratory papillomatosis is more aggressive than human papillomavirus-6-associated diseaseQ73493346
HPV E6 targeted degradation of the discs large protein: evidence for the involvement of a novel ubiquitin ligaseQ73501403
P433issue53
P407language of work or nameEnglishQ1860
P921main subjectproteolysisQ33123
P304page(s)8140-8
P577publication date2002-11-21
P1433published inOncogeneQ1568657
P1476titleChimaeric HPV E6 proteins allow dissection of the proteolytic pathways regulating different E6 cellular target proteins
P478volume21

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cites work (P2860)
Q446352631H and 15N resonance assignment, secondary structure and dynamic behaviour of the C-terminal domain of human papillomavirus oncoprotein E6.
Q81204537Analysis of specificity determinants in the interactions of different HPV E6 proteins with their PDZ domain-containing substrates
Q39605811Analysis of the PDZ binding specificities of Influenza A virus NS1 proteins.
Q24305966Association of E6AP (UBE3A) with human papillomavirus type 11 E6 protein
Q36409895Cell polarity proteins: common targets for tumorigenic human viruses
Q36989890Cellular transformation by human papillomaviruses: lessons learned by comparing high- and low-risk viruses
Q51489521Crosstalk between the human papillomavirus E2 transcriptional activator and the E6 oncoprotein.
Q34243863Differential regulation of cutaneous oncoprotein HPVE6 by wtp53, mutant p53R248W and ΔNp63α is HPV type dependent
Q34980270Human papillomavirus E6 and E7 oncoproteins as risk factors for tumorigenesis
Q30443519Human papillomavirus E6 regulates the cytoskeleton dynamics of keratinocytes through targeted degradation of p53
Q54243472Human papillomavirus type 16 E5-mediated upregulation of Met in human keratinocytes.
Q85597772Interactions between E6AP and E6 proteins from alpha and beta HPV types
Q33620876New generic primer system targeting mucosal/genital and cutaneous human papillomaviruses leads to the characterization of HPV 115, a novel Beta-papillomavirus species 3
Q24298153Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses
Q24309432Role of the PDZ domain-binding motif of the oncoprotein E6 in the pathogenesis of human papillomavirus type 31
Q24294963Structures of a human papillomavirus (HPV) E6 polypeptide bound to MAGUK proteins: mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein
Q35895297The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy
Q40444191The Interaction Between Human Papillomaviruses and the Stromal Microenvironment
Q24315710The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins
Q33292139The human papillomavirus 16 E6 protein binds to Fas-associated death domain and protects cells from Fas-triggered apoptosis.
Q40211890The role of the ubiquitin ligase E6-AP in human papillomavirus E6-mediated degradation of PDZ domain-containing proteins
Q44310046Viruses and the 26S proteasome: hacking into destruction

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