Structural basis for induced formation of the inflammatory mediator prostaglandin E2.

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Structural basis for induced formation of the inflammatory mediator prostaglandin E2. is …
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scholarly articleQ13442814

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P819ADS bibcode2008PNAS..10511110J
P356DOI10.1073/PNAS.0802894105
P8608Fatcat IDrelease_kwa7p4oxh5fhbe7dpwg27q3df4
P3181OpenCitations bibliographic resource ID3278518
P932PMC publication ID2516235
P698PubMed publication ID18682561
P5875ResearchGate publication ID23151547

P2093author name stringCaroline Jegerschöld
Hans Hebert
Kaoru Mitsuoka
Karina Roxana Gheorghe
Nobuhiko Gyobu
Pasi Purhonen
Per-Johan Jakobsson
Priyaranjan Bhakat
Ralf Morgenstern
Sven-Christian Pawelzik
P2860cites workCoordinate up- and down-regulation of glutathione-dependent prostaglandin E synthase and cyclooxygenase-2 in A549 cells. Inhibition by NS-398 and leukotriene C4Q73072346
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The projection structure of the membrane protein microsomal glutathione transferase at 3 A resolution as determined from two-dimensional hexagonal crystalsQ77753697
Location of substrate binding sites within the integral membrane protein microsomal glutathione transferase-1Q79768541
Trehalose embedding technique for high-resolution electron crystallography: application to structural study on bacteriorhodopsinQ81155004
Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug targetQ22010153
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceQ24286950
Crystal structure of inhibitor-bound human 5-lipoxygenase-activating proteinQ24315769
Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolismQ24672755
Improved methods for building protein models in electron density maps and the location of errors in these modelsQ26776980
PROCHECK: a program to check the stereochemical quality of protein structuresQ26778411
Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthaseQ27646754
Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesisQ27646755
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
Comparative protein modelling by satisfaction of spatial restraintsQ27860866
Structural basis for detoxification and oxidative stress protection in membranesQ28578847
Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2Q28585904
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Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination.Q34188046
Crystal structure and possible catalytic mechanism of microsomal prostaglandin E synthase type 2 (mPGES-2).Q34413989
Membrane prostaglandin E synthase-1: a novel therapeutic targetQ34690079
The induced prostaglandin E2 pathway is a key regulator of the respiratory response to infection and hypoxia in neonates.Q35812765
A twisted base? The role of arginine in enzyme-catalyzed proton abstractions.Q35974369
Coupling between cyclooxygenases and terminal prostanoid synthasesQ36248286
The structure of membrane associated proteins in eicosanoid and glutathione metabolism as determined by electron crystallography.Q36942843
Effects of immunosuppressive treatment on microsomal prostaglandin E synthase 1 and cyclooxygenases expression in muscle tissue of patients with polymyositis or dermatomyositisQ36971146
Structural and functional characterization of human microsomal prostaglandin E synthase-1 by computational modeling and site-directed mutagenesisQ40355515
Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamidesQ40702429
Human leukotriene C(4) synthase at 4.5 A resolution in projectionQ41792370
Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cellsQ43648210
Stress sensor triggers conformational response of the integral membrane protein microsomal glutathione transferase 1.Q45058608
Bioinformatic and enzymatic characterization of the MAPEG superfamilyQ46407773
Effects of antirheumatic treatments on the prostaglandin E2 biosynthetic pathwayQ57349940
P433issue32
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
prostaglandin E2Q416554
prostaglandin-E synthase activityQ21130569
Prostaglandin E synthaseQ22676692
P304page(s)11110-11115
P577publication date2008-08-05
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleStructural basis for induced formation of the inflammatory mediator prostaglandin E2.
P478volume105