The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.

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The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1036945455
P356DOI10.1038/NATURE03966
P3181OpenCitations bibliographic resource ID131015
P932PMC publication ID1636584
P698PubMed publication ID16177794
P5875ResearchGate publication ID7585775

P50authorMichael S KapiloffQ56529035
P2093author name stringJohn D Scott
Lorene K Langeberg
Kimberly L Dodge-Kafka
Joseph Soughayer
Jennifer J Carlisle Michel
Genevieve C Pare
P2860cites workEpac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMPQ22008544
A family of cAMP-binding proteins that directly activate Rap1Q22008551
mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytesQ22010409
Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesteraseQ24290674
PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complexQ24295192
Components of a new human protein kinase signal transduction pathwayQ24319086
The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579.Q24533566
mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling moduleQ24535019
Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy.Q24535352
Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domainsQ27729819
Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1Q28115929
ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regionsQ28145238
Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activationQ28282018
Isolation of MEK5 and differential expression of alternatively spliced formsQ28285099
Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestinsQ28578546
Protein kinase A-independent activation of ERK and H,K-ATPase by cAMP in native kidney cells: role of Epac IQ28582549
AKAP signalling complexes: focal points in space and timeQ29618533
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tetheringQ30857018
A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.Q34156405
PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalizationQ35005680
B-Raf-dependent regulation of the MEK-1/mitogen-activated protein kinase pathway in PC12 cells and regulation by cyclic AMP.Q36666870
Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytesQ40370148
Inhibition by cAMP of Ras-Dependent Activation of RafQ41514458
Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterasesQ42462628
Cell condition-dependent regulation of ERK5 by cAMP.Q42810032
Epac: a new cAMP target and new avenues in cAMP researchQ43859972
Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytesQ43901717
Cyclic nucleotide research -- still expanding after half a centuryQ44123887
Preparation of homogeneous cyclic AMP-dependent protein kinase(s) and its subunits from rabbit skeletal muscleQ44848566
An adenosine 3',5'-monophosphate-dependant protein kinase from rabbit skeletal muscleQ68579160
Significance of ERK cascade compared with JAK/STAT and PI3-K pathway in gp130-mediated cardiac hypertrophyQ73015180
P433issue7058
P407language of work or nameEnglishQ1860
P921main subjectnegative regulation of cyclic-nucleotide phosphodiesterase activityQ21105003
Phosphodiesterase 4DQ21106795
A-kinase anchoring protein 6Q21108172
Rap guanine nucleotide exchange factor 3Q21123225
mitogen-activated protein kinase 7Q21156654
P304page(s)574-578
P577publication date2005-09-01
P1433published inNatureQ180445
P1476titleThe protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways
P478volume437