A Rab-GAP TBC domain protein binds hepatitis C virus NS5A and mediates viral replication

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A Rab-GAP TBC domain protein binds hepatitis C virus NS5A and mediates viral replication is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.01249-07
P932PMC publication ID2045567
P698PubMed publication ID17686842
P5875ResearchGate publication ID6152423

P50authorMark A WintersQ115268118
P2093author name stringBenjamin Aroeti
Ella H Sklan
Jeffrey S Glenn
Menashe Elazar
Tsafi Danieli
Kirk Staschke
Tina M Oakes
P2860cites workDifferential Requirements of Rab5 and Rab7 for Endocytosis of Influenza and Other Enveloped VirusesQ47953724
NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signalingQ22009551
Hepatitis C virus RNA polymerase and NS5A complex with a SNARE-like proteinQ22010735
Identification and characterization of amphiphysin II as a novel cellular interaction partner of the hepatitis C virus NS5A proteinQ24295396
Raf-1 kinase associates with Hepatitis C virus NS5A and regulates viral replicationQ24300700
Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replicationQ24302046
The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activityQ24313430
Rab9 GTPase is required for replication of human immunodeficiency virus type 1, filoviruses, and measles virusQ24533383
Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complexQ24537657
Interaction of rotavirus polymerase VP1 with nonstructural protein NSP5 is stronger than that with NSP2Q24672464
Rab 5 is required for the cellular entry of dengue and West Nile virusesQ24683001
Rab7 associates with early endosomes to mediate sorting and transport of Semliki forest virus to late endosomesQ24810483
Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replicationQ27472912
Hepatitis C Virus Entry Depends on Clathrin-Mediated EndocytosisQ27473290
Amphipathic Helix-Dependent Localization of NS5A Mediates Hepatitis C Virus RNA ReplicationQ27473477
Participation of Rab5, an Early Endosome Protein, in Hepatitis C Virus RNA Replication MachineryQ27480343
Efficient initiation of HCV RNA replication in cell cultureQ27860520
Complete replication of hepatitis C virus in cell cultureQ27860934
Unravelling hepatitis C virus replication from genome to functionQ29620056
An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5AQ29620628
Hepatitis C virus NS5A colocalizes with the core protein on lipid droplets and interacts with apolipoproteinsQ30824009
Interactions of rotavirus VP4 spike protein with the endosomal protein Rab5 and the prenylated Rab acceptor PRA1.Q31143299
Infrared fluorescent immunofocus assay (IR-FIFA) for the quantitation of non-cytopathic and minimally cytopathic virusesQ33227589
TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism.Q34549396
Invasion of host cells by JC virus identifies a novel role for caveolae in endosomal sorting of noncaveolar ligandsQ35101449
Pathophysiology of hepatitis C virus infection and related liver diseaseQ35703872
Targeting Rab GTPases to distinct membrane compartmentsQ35936418
Molecular cloning of a cDNA with a novel domain present in the tre-2 oncogene and the yeast cell cycle regulators BUB2 and cdc16.Q36682467
A nucleotide binding motif in hepatitis C virus (HCV) NS4B mediates HCV RNA replicationQ40162438
Inhibition of hepatitis C virus replication and expression by small interfering RNA targeting host cellular genesQ40175518
Hepatitis C virus core protein associates with detergent-resistant membranes distinct from classical plasma membrane raftsQ40213539
Mouse polyomavirus enters early endosomes, requires their acidic pH for productive infection, and meets transferrin cargo in Rab11-positive endosomes.Q40292963
Rab5 and Rab7, but not ARF6, govern the early events of HIV-1 infection in polarized human placental cellsQ40354283
Hepatitis C virus (HCV) NS5A protein: role in HCV replication and resistance to interferon-alphaQ42998178
Pre- and post-Golgi vacuoles operate in the transport of Semliki Forest virus membrane glycoproteins to the cell surfaceQ45795762
P433issue20
P407language of work or nameEnglishQ1860
P921main subjecthepatitis CQ154869
Hepatitis C virusQ708693
viral genome replicationQ3933202
positive regulation by virus of viral protein levels in host cellQ21103150
TBC1 domain family member 20Q21119749
P304page(s)11096-105
P577publication date2007-10-01
P1433published inJournal of VirologyQ1251128
P1476titleA Rab-GAP TBC domain protein binds hepatitis C virus NS5A and mediates viral replication
P478volume81

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cites work (P2860)
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