The sec14 homology module of neurofibromin binds cellular glycerophospholipids: mass spectrometry and structure of a lipid complex

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The sec14 homology module of neurofibromin binds cellular glycerophospholipids: mass spectrometry and structure of a lipid complex is …
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scholarly articleQ13442814

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P356DOI10.1016/J.JMB.2006.11.055
P698PubMed publication ID17187824

P50authorKlaus ScheffzekQ30169968
Stefan WeltiQ30170019
Matthias WilmQ63409908
P2093author name stringIgor D'Angelo
Sven Fraterman
P2860cites workBipartite interaction between neurofibromatosis type I protein (neurofibromin) and syndecan transmembrane heparan sulfate proteoglycansQ24291240
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Yeast Sec14p deficient in phosphatidylinositol transfer activity is functional in vivo.Q27934421
Role of the Sec14-like domain of Dbl family exchange factors in the regulation of Rho family GTPases in different subcellular sitesQ28116887
Human RhoGAP domain-containing proteins: structure, function and evolutionary relationshipsQ28203687
NF1 tumor suppressor gene function: narrowing the GAPQ28203741
Dbl family guanine nucleotide exchange factorsQ28209857
Neurofibromin: a general outlookQ28249551
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Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of RasQ28646214
Sec14 homology domain targets p50RhoGAP to endosomes and provides a link between Rab and Rho GTPasesQ28910420
Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constantsQ29546524
Selective disactivation of neurofibromin GAP activity in neurofibromatosis type 1.Q30431017
Structural analysis of the GAP-related domain from neurofibromin and its implicationsQ33889193
Neurofibromin, a tumor suppressor in the nervous systemQ34174300
Homotypic secretory vesicle fusion induced by the protein tyrosine phosphatase MEG2 depends on polyphosphoinositides in T cellsQ34282084
Adult-onset spinocerebellar dysfunction caused by a mutation in the gene for the alpha-tocopherol-transfer proteinQ34296084
Ataxia with isolated vitamin E deficiency is caused by mutations in the alpha-tocopherol transfer proteinQ34308654
The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs.Q34365918
Bacterial Membrane Lipids: Where Do We Stand?Q35550561
Mass spectrometric approaches using electrospray ionization charge states and hydrogen-deuterium exchange for determining protein structures and their conformational changesQ35587004
Biological functions of phosphatidylinositol transfer proteinsQ35723532
Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometryQ36040256
The diverse biological functions of phosphatidylinositol transfer proteins in eukaryotes.Q36385399
Sec14p-like proteins regulate phosphoinositide homoeostasis and intracellular protein and lipid trafficking in yeast.Q36482034
Phosphatidylinositol-transfer protein and its homologues in yeast.Q36482067
Spatial segregation of Ras signaling: new evidence from fission yeastQ36576725
Lipids of mitochondriaQ38148540
Minor lesion mutational spectrum of the entire NF1 gene does not explain its high mutability but points to a functional domain upstream of the GAP-related domainQ39814751
PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.Q40315264
Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.Q40459310
Specific interaction of protein tyrosine phosphatase-MEG2 with phosphatidylserineQ40654185
Phosphorylation of neurofibromatosis type 1 gene product (neurofibromin) by cAMP-dependent protein kinaseQ41216932
The spectrum of NF1 mutations in Korean patients with neurofibromatosis type 1.Q42286021
Neurofibromin colocalizes with mitochondria in cultured cellsQ42834856
A novel bipartite phospholipid-binding module in the neurofibromatosis type 1 protein.Q43205712
Lateral sequestration of phosphatidylinositol 4,5-bisphosphate by the basic effector domain of myristoylated alanine-rich C kinase substrate is due to nonspecific electrostatic interactionsQ44049943
Mutations in a novel gene encoding a CRAL-TRIO domain cause human Cayman ataxia and ataxia/dystonia in the jittery mouse.Q44615423
PKA phosphorylation and 14-3-3 interaction regulate the function of neurofibromatosis type I tumor suppressor, neurofibromin.Q44740786
Lipid composition of neuronal cell bodies and neurites from cultured dorsal root gangliaQ45084515
Phosphorylation of neurofibromin by PKC is a possible molecular switch in EGF receptor signaling in neural cellsQ46825369
Rescue of a Drosophila NF1 mutant phenotype by protein kinase A.Q47070480
Lipid composition of subcellular membranes from larvae and prepupae of Drosophila melanogaster.Q52228981
Phospholipids in Drosophila heads: effects of visual mutants and phototransduction manipulations.Q52545828
Expression, purification and preliminary crystallographic characterization of a novel segment from the neurofibromatosis type 1 protein.Q52653823
Evaluation of denaturing high performance liquid chromatography (DHPLC) for the mutational analysis of the neurofibromatosis type 1 ( NF1) gene.Q53676718
XX. On the equilibrium of liquid conducting masses charged with electricityQ56269185
Sec14p-like domains in NF1 and Dbl-like proteins indicate lipid regulation of Ras and Rho signalingQ57025048
Identification of forty-five novel and twenty-three knownNF1 mutations in Chinese patients with neurofibromatosis type 1Q62723435
Kinetic analysis of phospholipase C beta isoforms using phospholipid-detergent mixed micelles. Evidence for interfacial catalysis involving distinct micelle binding and catalytic stepsQ72223417
Six novel mutations in the neurofibromatosis type 1 (NF1) geneQ73701714
Phosphorylation of neurofibromin by cAMP-dependent protein kinase is regulated via a cellular association of N(G),N(G)-dimethylarginine dimethylaminohydrolaseQ73739300
Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1Q81420599
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectmass spectrometryQ180809
Neurofibromin 1Q411610
glycerophospholipidsQ420004
phosphatidylcholine bindingQ14878186
P304page(s)551-62
P577publication date2007-02-16
P1433published inJournal of Molecular BiologyQ925779
P1476titleThe sec14 homology module of neurofibromin binds cellular glycerophospholipids: mass spectrometry and structure of a lipid complex
P478volume366

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