Mutant Lrp1 knock-in mice generated by recombinase-mediated cassette exchange reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development

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Mutant Lrp1 knock-in mice generated by recombinase-mediated cassette exchange reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.26.2.605-616.2006
P932PMC publication ID1346909
P698PubMed publication ID16382151

P2093author name stringDieter Hartmann
Anton J M Roebroek
Annick Lauwers
Sara Reekmans
Liesbet Smeijers
Nathalie Feyaerts
P2860cites workInteractions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transductionQ22254170
Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP)Q24291952
Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptorQ24297663
Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartmentQ24556547
Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnantsQ24564846
Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretaseQ28188278
Use of mutated FLP recognition target (FRT) sites for the exchange of expression cassettes at defined chromosomal lociQ28239813
Elk-1 knock-out mice engineered by Flp recombinase-mediated cassette exchangeQ28247895
Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor proteinQ28290411
Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor moleculesQ28566437
Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low Density lipoprotein receptor-related protein in caveolaeQ28570390
LRP: a multifunctional scavenger and signaling receptorQ30004206
Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF.Q34114977
LRP: role in vascular wall integrity and protection from atherosclerosisQ34190034
v-Src induces Shc binding to tyrosine 63 in the cytoplasmic domain of the LDL receptor-related protein 1.Q34203422
Diverse role of LDL receptor-related protein in the clearance of proteases and in signalingQ35181677
Genomic cloning of the mouse LDL receptor related protein/alpha 2-macroglobulin receptor geneQ36713195
Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice.Q37527495
The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processingQ39665687
Functional expression of murine LRP1 requires correction of Lrp1 cDNA sequencesQ40714057
Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domainQ40743382
Tyrosine-phosphorylated low density lipoprotein receptor-related protein 1 (Lrp1) associates with the adaptor protein SHC in SRC-transformed cellsQ40819741
Mutation at the processing site of chicken low density lipoprotein receptor-related protein impairs efficient endoplasmic reticulum exit, but proteolytic cleavage is not essential for its endocytic functionsQ41002620
Double-reciprocal crossover mediated by FLP-recombinase: a concept and an assayQ41127146
Genetic deficiency in low density lipoprotein receptor-related protein confers cellular resistance to Pseudomonas exotoxin A. Evidence that this protein is required for uptake and degradation of multiple ligandsQ42807171
FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein.Q46004266
Sustained somatic gene inactivation by viral transfer of Cre recombinase.Q47948186
Efficient FLP recombination in mouse ES cells and oocytesQ48875650
LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantationQ52478181
Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.Q53233510
The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65.Q53255682
Targetted correction of a mutant HPRT gene in mouse embryonic stem cellsQ59085795
Correction: LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantationQ70709189
The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low density lipoprotein receptor-related proteinQ73626284
DNA cassette exchange in ES cells mediated by Flp recombinase: an efficient strategy for repeated modification of tagged loci by marker-free constructsQ74510986
Identification of a major cyclic AMP-dependent protein kinase A phosphorylation site within the cytoplasmic tail of the low-density lipoprotein receptor-related protein: implication for receptor-mediated endocytosisQ95751077
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
P304page(s)605-616
P577publication date2006-01-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleMutant Lrp1 knock-in mice generated by recombinase-mediated cassette exchange reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development
P478volume26

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cites work (P2860)
Q24620548A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death
Q40055466Conditional transgene expression mediated by the mouse beta-actin locus
Q33871111Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps
Q33488082Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates
Q47743028Endothelial LRP1 - A Potential Target for the Treatment of Alzheimer's Disease : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla.
Q36626421Functional role of the low-density lipoprotein receptor-related protein in Alzheimer's disease
Q64945588Generation of a Series of Knock-In Alleles Using RMCE in ES Cells
Q34305393Impaired LDL receptor-related protein 1 translocation correlates with improved dyslipidemia and atherosclerosis in apoE-deficient mice
Q84781583Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis
Q82467955Knock-In Approaches
Q90026999LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer's Disease
Q30541787LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype
Q36486210Lipoprotein receptors – an evolutionarily ancient multifunctional receptor family
Q54979105Liver-enriched transcription factor expression relates to chronic hepatic failure in humans.
Q64086638Low Density Receptor-Related Protein 1 Interactions With the Extracellular Matrix: More Than Meets the Eye
Q86815127Low density lipoprotein receptor-related protein 1 mediated endocytosis of β1-integrin influences cell adhesion and cell migration
Q39374128Low-Density Lipoprotein Receptor-Related Proteins in Skeletal Development and Disease
Q41161172Low-density lipoprotein receptor-related protein 1 is a novel modulator of radial glia stem cell proliferation, survival, and differentiation.
Q30481360Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia
Q37250051Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior
Q37035085Polarized traffic of LRP1 involves AP1B and SNX17 operating on Y-dependent sorting motifs in different pathways
Q41900942RMCE-ASAP: a gene targeting method for ES and somatic cells to accelerate phenotype analyses
Q54573062Recombinase-mediated cassette exchange to rapidly and efficiently generate mice with human cardiac sodium channels.
Q24627796Recommended Method for Chromosome Exploitation: RMCE-based Cassette-exchange Systems in Animal Cell Biotechnology
Q34348612Signaling through LRP1: Protection from atherosclerosis and beyond
Q24644020Structural and functional consequences of tyrosine phosphorylation in the LRP1 cytoplasmic domain
Q36801117The LDL receptor-related protein (LRP) family: an old family of proteins with new physiological functions
Q26776179The Matricellular Receptor LRP1 Forms an Interface for Signaling and Endocytosis in Modulation of the Extracellular Tumor Environment
Q90444043The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM
Q40005626The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors

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