Arf, Arl, Arp and Sar proteins: a family of GTP-binding proteins with a structural device for 'front-back' communication

scientific article

Arf, Arl, Arp and Sar proteins: a family of GTP-binding proteins with a structural device for 'front-back' communication is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1093/EMBO-REPORTS/KVF221
P8608Fatcat IDrelease_ssx5ap3clzf7doawyjbpysc6ue
P3181OpenCitations bibliographic resource ID4721473
P932PMC publication ID1307594
P698PubMed publication ID12429613
P5875ResearchGate publication ID11036878

P50authorJacqueline CherfilsQ28037089
Sebastiano PasqualatoQ28946363
P2093author name stringLouis Renault
Jacqueline Cherfils
P2860cites workADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signalQ22003823
ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulinQ22254219
ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoliQ24290214
The complex of Arl2-GTP and PDE delta: from structure to functionQ24295264
Phospholipid- and GTP-dependent activation of cholera toxin and phospholipase D by human ADP-ribosylation factor-like protein 1 (HARL1)Q24324892
Structure of Arf6-GDP suggests a basis for guanine nucleotide exchange factors specificityQ27625191
Structural and biochemical properties show ARL3-GDP as a distinct GTP binding proteinQ27629740
The structural GDP/GTP cycle of human Arf6Q27630787
Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPasesQ27634686
Crystal structure of Sar1-GDP at 1.7 Å resolution and the role of the NH 2 terminus in ER exportQ27636702
The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal formsQ27729475
Structure of the human ADP-ribosylation factor 1 complexed with GDPQ27730791
An extensively modified version of MolScript that includes greatly enhanced coloring capabilitiesQ27860594
COPII: a membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulumQ27930804
SEC12 encodes a guanine-nucleotide-exchange factor essential for transport vesicle budding from the ER.Q27937857
Yeast Ysl2p, homologous to Sec7 domain guanine nucleotide exchange factors, functions in endocytosis and maintenance of vacuole integrity and interacts with the Arf-Like small GTPase Arl1pQ27939201
Dynamics of the COPII coat with GTP and stable analoguesQ27939261
The guanine nucleotide-binding switch in three dimensionsQ28131710
The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase DQ28139704
GEFs: structural basis for their activation of small GTP-binding proteinsQ28141028
The mammalian guanine nucleotide exchange factor mSec12 is essential for activation of the Sar1 GTPase directing endoplasmic reticulum exportQ28568377
Regulation of Golgi structure and function by ARF-like protein 1 (Arl1)Q28574316
Structural basis for activation of ARF GTPase: mechanisms of guanine nucleotide exchange and GTP-myristoyl switchingQ29620513
A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70.Q30176478
The role of ARF and Rab GTPases in membrane transportQ33712473
Regulators and effectors of the ARF GTPases.Q33954573
The C. elegans evl-20 gene is a homolog of the small GTPase ARL2 and regulates cytoskeleton dynamics during cytokinesis and morphogenesisQ34128948
The many faces of Ras: recognition of small GTP-binding proteinsQ34460152
A novel GTP-binding protein, Sar1p, is involved in transport from the endoplasmic reticulum to the Golgi apparatus.Q36222049
Myristoylation is not required for GTP-dependent binding of ADP-ribosylation factor ARF1 to phospholipidsQ38314148
The Arabidopsis PILZ group genes encode tubulin-folding cofactor orthologs required for cell division but not cell growthQ39742711
Molecules in the ARF orbitQ47682640
The yeast Sar exchange factor Sec12, and its higher organism orthologs, fold as beta-propellers.Q52598219
Structural Basis for Activation of ARF GTPaseQ56288670
N-terminal hydrophobic residues of the G-protein ADP-ribosylation factor-1 insert into membrane phospholipids upon GDP to GTP exchangeQ73244046
Dual interaction of ADP ribosylation factor 1 with Sec7 domain and with lipid membranes during catalysis of guanine nucleotide exchangeQ73297506
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)1035-1041
P577publication date2002-11-01
P1433published inEMBO ReportsQ5323356
P1476titleArf, Arl, Arp and Sar proteins: a family of GTP-binding proteins with a structural device for 'front-back' communication
P478volume3

Reverse relations

cites work (P2860)
Q42785130A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins
Q47358887A hereditary spastic paraplegia-associated atlastin variant exhibits defective allosteric coupling in the catalytic core
Q34102695A host small GTP-binding protein ARL8 plays crucial roles in tobamovirus RNA replication
Q44591639A structural model for actin-induced nucleotide release in myosin
Q27642224A structural state of the myosin V motor without bound nucleotide
Q28472424ACAP-A/B are ArfGAP homologs in dictyostelium involved in sporulation but not in chemotaxis
Q64227339ADP-ribosylation factor-like 4A interacts with Robo1 to promote cell migration by regulating Cdc42 activation
Q50075772ADP-ribosylation factor-like 4C binding to filamin-A modulates filopodium formation and cell migration
Q91988971ARF GTPases and their GEFs and GAPs: concepts and challenges
Q29618078ARF proteins: roles in membrane traffic and beyond
Q34695889ARF-like protein 16 (ARL16) inhibits RIG-I by binding with its C-terminal domain in a GTP-dependent manner
Q41569807ARF6 mediates nephrin tyrosine phosphorylation-induced podocyte cellular dynamics
Q92568985ARL4C is associated with initiation and progression of lung adenocarcinoma and represents a therapeutic target
Q36113106ARLTS1 germline variants and the risk for breast, prostate, and colorectal cancer
Q28489019ATP-driven self-assembly of a morphogenetic protein in Bacillus subtilis
Q78761464Activation of G-protein Galpha subunits by receptors through Galpha-Gbeta and Galpha-Ggamma interactions
Q52720447Activators and Effectors of the Small G Protein Arf1 in Regulation of Golgi Dynamics During the Cell Division Cycle.
Q37457340Allosteric regulation of Arf GTPases and their GEFs at the membrane interface.
Q30503993An Arf-like small G protein, ARL-8, promotes the axonal transport of presynaptic cargoes by suppressing vesicle aggregation
Q34502171An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility
Q91535489An influenza-derived membrane tension-modulating peptide regulates cell movement and morphology via actin remodeling
Q90639267Architecture of human Rag GTPase heterodimers and their complex with mTORC1
Q28191279Arf and its many interactors
Q28073244Arf-like GTPase Arl8: Moving from the periphery to the center of lysosomal biology
Q42268960ArfGAP1 responds to membrane curvature through the folding of a lipid packing sensor motif.
Q27934287Arl1p regulates spatial membrane organization at the trans-Golgi network through interaction with Arf-GEF Gea2p and flippase Drs2p.
Q53673633Arl4c expression in colorectal and lung cancers promotes tumorigenesis and may represent a novel therapeutic target.
Q39067513Arl4c is a key regulator of tubulogenesis and tumourigenesis as a target gene of Wnt-β-catenin and growth factor-Ras signalling
Q50504325Arl5b is a Golgi-localised small G protein involved in the regulation of retrograde transport.
Q24301800Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling
Q34447982Bayesian classification of residues associated with protein functional divergence: Arf and Arf-like GTPases
Q24315733Biochemical and structural characterization of the gem GTPase
Q33793277Building a fission machine--structural insights into dynamin assembly and activation
Q37435112Chapter 5: rab proteins and their interaction partners
Q42092525Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiation
Q42159319Combining NMR and molecular dynamics studies for insights into the allostery of small GTPase-protein interactions
Q49923865Comparative Phylogenetic and Expression Analysis of Small GTPases Families in Legume and Non-Legume Plants.
Q24533582Comparative genomic analysis identifies an ADP-ribosylation factor-like gene as the cause of Bardet-Biedl syndrome (BBS3)
Q57247018Conditional inactivation ofAspergillus nidulans sarASAR1uncovers the morphogenetic potential of regulating endoplasmic reticulum (ER) exit
Q44739114Conformational states of the small G protein Arf-1 in complex with the guanine nucleotide exchange factor ARNO-Sec7.
Q28588828Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target
Q27681461Crystal Structure of aSchistosoma mansoniSeptin Reveals the Phenomenon of Strand Slippage in Septins Dependent on the Nature of the Bound Nucleotide
Q27664210Crystal structure of Leishmania major ADP-ribosylation factor-like 1 and a classification of related GTPase family members in this Kinetoplastid
Q24315920Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector
Q37164450Defining potential roles of Pb(2+) in neurotoxicity from a calciomics approach
Q37292838Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopia
Q35746723Domains of the TGN: coats, tethers and G proteins.
Q21093333EST analysis of the scaly green flagellate Mesostigma viride (Streptophyta): implications for the evolution of green plants (Viridiplantae).
Q41977426Effect of the N-Terminal Helix and Nucleotide Loading on the Membrane and Effector Binding of Arl2/3.
Q42316725Epigenetic upregulation of ARL4C, due to DNA hypomethylation in the 3'-untranslated region, promotes tumorigenesis of lung squamous cell carcinoma
Q28651540Eukaryotic cells and their cell bodies: Cell Theory revised
Q90707721Function of Arl4aa in the Initiation of Hematopoiesis in Zebrafish by Maintaining Golgi Complex Integrity in Hemogenic Endothelium
Q41898582Functional analysis of TbARL1, an N-myristoylated Golgi protein essential for viability in bloodstream trypanosomes
Q30585204Functional characterization of Prickle2 and BBS7 identify overlapping phenotypes yet distinct mechanisms.
Q34395820GTP-binding-defective ARL4D alters mitochondrial morphology and membrane potential.
Q37800644GTPases involved in vesicular trafficking: Structures and mechanisms
Q27865202Galpha Gbetagamma dissociation may be due to retraction of a buried lysine and disruption of an aromatic cluster by a GTP-sensing Arg Trp pair
Q33979104Genetic interaction between Bardet-Biedl syndrome genes and implications for limb patterning
Q38695238Genetics of human Bardet-Biedl syndrome, an updates
Q28383704Genomic copy number variants: evidence for association with antibody response to anthrax vaccine adsorbed
Q27936914Golgi recruitment of GRIP domain proteins by Arf-like GTPase 1 is regulated by Arf-like GTPase 3.
Q39686074High yield production of myristoylated Arf6 small GTPase by recombinant N-myristoyl transferase
Q57453319IQSEC2 mutation update and review of the female-specific phenotype spectrum including intellectual disability and epilepsy
Q27347938Identification and functional analysis of the vision-specific BBS3 (ARL6) long isoform
Q54100467Identification of ARL4C as a Peritoneal Dissemination-Associated Gene and Its Clinical Significance in Gastric Cancer.
Q48609190Identification of genes co-upregulated with Arc during BDNF-induced long-term potentiation in adult rat dentate gyrus in vivo
Q30497467Insight into the role of dynamics in the conformational switch of the small GTP-binding protein Arf1
Q24599535Insights into the classification of small GTPases
Q27680018Integrated Conformational and Lipid-Sensing Regulation of Endosomal ArfGEF BRAG2
Q36521968Involvement of a novel ADP-ribosylation factor GTPase-activating protein, SMAP, in membrane trafficking: implications in cancer cell biology
Q28239006JM4 is a four-transmembrane protein binding to the CCR5 receptor
Q39078976KRAS, NRAS and BRAF mutations in colorectal cancer and melanoma
Q24316429Large nucleotide-dependent conformational change in Rab28
Q43882986Light on the structural communication in Ras GTPases.
Q44879164Localization and Trafficking of an Isoform of the AtPRA1 Family to the Golgi Apparatus Depend on Both N‐ and C‐Terminal Sequence Motifs
Q36217305Lysosomal membrane proteomics and biogenesis of lysosomes
Q35189394Mechanisms of membrane deformation
Q35161989Membrane binding by MinD involves insertion of hydrophobic residues within the C-terminal amphipathic helix into the bilayer
Q73086504Membrane traffic: Arl GTPases get a GRIP on the Golgi
Q36375740Membrane-bending proteins
Q30432201Modifications to the C-terminus of Arf1 alter cell functions and protein interactions
Q27935099Molecular interactions of yeast Neo1p, an essential member of the Drs2 family of aminophospholipid translocases, and its role in membrane trafficking within the endomembrane system
Q46328382Multiple interactions between an Arf/GEF complex and charged lipids determine activation kinetics on the membrane
Q27919661Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome
Q47662340N-terminal acetylation targets GTPases to membranes.
Q36845704New insights into membrane trafficking and protein sorting.
Q36117175Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins
Q47712841Nucleotide Binding to ARL2 in the TBCD∙ARL2∙β-Tubulin Complex Drives Conformational Changes in β-Tubulin.
Q33913562Nucleotide-dependent farnesyl switch orchestrates polymerization and membrane binding of human guanylate-binding protein 1.
Q36327799Organelle identity and the signposts for membrane traffic
Q28607547Paths and determinants for Penicillium janthinellum to resist low and high copper
Q28488987Peptide anchoring spore coat assembly to the outer forespore membrane in Bacillus subtilis
Q24610396Phylogenetic analysis of Sec7-domain-containing Arf nucleotide exchangers
Q36761229Prediction of contact matrix for protein-protein interaction
Q42168173Preparation of myristoylated Arf1 and Arf6.
Q39128436Quantitative proteomic and phosphoproteomic analysis of Trypanosoma cruzi amastigogenesis.
Q36291656Ras-like family small GTPases genes in Nilaparvata lugens: Identification, phylogenetic analysis, gene expression and function in nymphal development
Q26827528Regulating the large Sec7 ARF guanine nucleotide exchange factors: the when, where and how of activation
Q26825750Regulation of small GTPases by GEFs, GAPs, and GDIs
Q27931167Role for Gcs1p in regulation of Arl1p at trans-Golgi compartments
Q36336697Role of tethering factors in secretory membrane traffic.
Q57805499SHOC2-MRAS-PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis
Q42782864Sorting of lipidated cargo by the Arl2/Arl3 system
Q24336820Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex
Q42408680Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi
Q90636682Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes
Q27671802Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity
Q24299379Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes
Q24316285Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis.
Q24298505Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus
Q90638886Structural basis for the docking of mTORC1 on the lysosomal surface
Q27640772Structural basis for the function of the beta subunit of the eukaryotic signal recognition particle receptor
Q27687376Structural insights into the small G-protein Arl13B and implications for Joubert syndrome
Q24301031Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor
Q38947857Structure and content of the Entamoeba histolytica genome
Q35592558Structure of an ADP-ribosylation factor, ARF1, from Entamoeba histolytica bound to Mg(2+)-GDP.
Q36167110Structure-activity relationship studies of QS11, a small molecule Wnt synergistic agonist.
Q90730511System-Wide Characterization of MoArf GTPase Family Proteins and Adaptor Protein MoGga1 Involved in the Development and Pathogenicity of Magnaporthe oryzae
Q27939495Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p
Q27933615The ARF-like GTPases Arl1p and Arl3p act in a pathway that interacts with vesicle-tethering factors at the Golgi apparatus.
Q47660256The Arf GEF GBF1 and Arf4 synergize with the sensory receptor cargo, rhodopsin, to regulate ciliary membrane trafficking.
Q33613339The Arf family G protein Arl1 is required for secretory granule biogenesis in Drosophila
Q24301385The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane
Q35939493The BBSome Controls Energy Homeostasis by Mediating the Transport of the Leptin Receptor to the Plasma Membrane
Q38828900The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function
Q36478004The RGK family of GTP-binding proteins: regulators of voltage-dependent calcium channels and cytoskeleton remodeling
Q24603374The Ras protein superfamily: evolutionary tree and role of conserved amino acids
Q35189409The apical compartment: trafficking pathways, regulators and scaffolding proteins
Q37235510The charge-dipole pocket: a defining feature of signaling pathway GTPase on/off switches
Q35827688The epigenetic processes of meiosis in male mice are broadly affected by the widely used herbicide atrazine.
Q33320526The leishmania ARL-1 and Golgi traffic
Q24315798The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3
Q38258807The roles of monomeric GTP-binding proteins in macroautophagy in Saccharomyces cerevisiae
Q35020039The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans
Q35744541The small G protein Arl1 directs the trans-Golgi-specific targeting of the Arf1 exchange factors BIG1 and BIG2.
Q27652747The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function
Q24310659Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis
Q48232874Unexpected protein families including cell defense components feature in the N-myristoylome of a higher eukaryote
Q24322663Yeast and human Ysl2p/hMon2 interact with Gga adaptors and mediate their subcellular distribution

Search more.