Effects of developmental exposure to 2,2 ,4,4 ,5-pentabromodiphenyl ether (PBDE-99) on sex steroids, sexual development, and sexually dimorphic behavior in rats

scientific article

Effects of developmental exposure to 2,2 ,4,4 ,5-pentabromodiphenyl ether (PBDE-99) on sex steroids, sexual development, and sexually dimorphic behavior in rats is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1289/EHP.8391
P932PMC publication ID1367831
P698PubMed publication ID16451854
P5875ResearchGate publication ID7322086

P2093author name stringHellmuth Lilienthal
Chris E Talsness
Simone Wichert Grande
Alfons Hack
Astrid Roth-Härer
P2860cites workBrominated flame retardants: cause for concern?Q24810610
Retrospective time-trend study of polybrominated diphenyl ether and polybrominated and polychlorinated biphenyl levels in human serum from the United StatesQ24812068
Brominated flame retardants: a novel class of developmental neurotoxicants in our environment?Q24813240
Differential effects of two lots of aroclor 1254: congener-specific analysis and neurochemical end pointsQ24813557
Cognitive effects of endocrine-disrupting chemicals in animalsQ24813727
Developmental exposure to low dose PBDE 99: effects on male fertility and neurobehavior in rat offspringQ24814138
Polybrominated diphenyl ethers (PBDEs) in U.S. mothers' milkQ24816676
Effects of acute exposure to PCBs 126 and 153 on anterior pituitary and thyroid hormones and FSH isoforms in adult Sprague Dawley male rats.Q33178175
Differential in vitro neurotoxicity of the flame retardant PBDE-99 and of the PCB Aroclor 1254 in human astrocytoma cells.Q33207794
Steroid metabolising enzymes in the determination of brain genderQ33694917
Certain organochlorine and organobromine contaminants in Swedish human milk in perspective of past 20-30 yearsQ33896004
Thyroidal dysfunction and environmental chemicals--potential impact on brain developmentQ33905546
Developmental and reproductive toxicity of dioxins and related compounds: cross-species comparisonsQ34346310
A review on human exposure to brominated flame retardants--particularly polybrominated diphenyl ethersQ35172732
Sexual differentiation of the brain: role of testosterone and its active metabolitesQ35916997
Environmental toxicant effects on neuroendocrine functionQ39570051
In vivo and in vitro anti-androgenic effects of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture.Q40400078
Functional aspects of developmental toxicity of polyhalogenated aromatic hydrocarbons in experimental animals and human infantsQ40404012
Developmental neurotoxicity of PCBs in humans: what do we know and where do we go from here?Q41048667
Reduced thyroxine levels in mice perinatally exposed to polybrominated diphenyl ethersQ42729968
Polybrominated diphenyl ethers in Swedish human liver and adipose tissueQ43721821
Effects of maternal exposure to a reconstituted mixture of polychlorinated biphenyls on sex-dependent behaviors and steroid hormone concentrations in rats: dose-response relationshipQ43868424
Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruptionQ43893639
Neonatal exposure to the brominated flame retardant 2,2',4,4',5-pentabromodiphenyl ether causes altered susceptibility in the cholinergic transmitter system in the adult mouseQ43964839
Methoxychlor may cause ovarian follicular atresia and proliferation of the ovarian epithelium in the mouseQ44085284
Effects of perinatal exposure to a polybrominated diphenyl ether (PBDE 99) on mouse neurobehavioural developmentQ44184712
Neonatal exposure to polybrominated diphenyl ether (PBDE 153) disrupts spontaneous behaviour, impairs learning and memory, and decreases hippocampal cholinergic receptors in adult miceQ44612642
Modulation of ovarian follicle maturation in Long–Evans rats exposed to polychlorinated biphenyls (PCBs) in-utero and lactationallyQ44614736
Assessment of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture, in the EDSP male and female pubertal protocolsQ44785548
Investigations of strain and/or gender differences in developmental neurotoxic effects of polybrominated diphenyl ethers in miceQ44969061
A possible mechanism for decrease in serum thyroxine level by polychlorinated biphenyls in Wistar and Gunn ratsQ44978811
Effects of gestational and lactational exposure to low doses of PCBs 126 and 153 on anterior pituitary and gonadal hormones and on puberty in female goatsQ45036159
Early developmental exposure to BDE 99 or Aroclor 1254 affects neurobehavioural profile: interference from the administration routeQ45266743
Differential effects of commercial polybrominated diphenyl ether and polychlorinated biphenyl mixtures on intracellular signaling in rat brain in vitroQ46384504
Developmental exposure of rats to a reconstituted PCB mixture or aroclor 1254: effects on organ weights, aromatase activity, sex hormone levels, and sweet preference behaviorQ48142345
Neurotoxic effects in adult mice neonatally exposed to 3,3'4,4'5-pentachlorobiphenyl or 2,3,3'4,4'-pentachlorobiphenyl. Changes in brain nicotinic receptors and behaviourQ48573447
Ultrastructural evaluation of oocytes during atresia in rat ovarian follicles.Q50721832
Growth and development in rats given recombinant human epidermal growth factor(1-48) as neonates.Q52134103
Gestational and lactational exposure to TCDD or coplanar PCBs alters adult expression of saccharin preference behavior in female rats.Q53958801
Polybrominated diphenyl ethers detected in human adipose tissue from SpainQ57266576
Effect of hypothyroidism on ovarian follicular development, granulosa cell proliferation and peripheral hormone levels in the prepubertal ratQ71147108
Effect of hypothyroidism induced by propylthiouracil and thiourea on male and female reproductive systems of neonatal miceQ71831836
Proposal for a classification of oocytes and follicles in the mouse ovaryQ72204415
Sex differences in taste preference for glucose and saccharin solutionsQ72216407
Reduced levels of 1,25-dihydroxyvitamin D(3) in rat dams and offspring after exposure to a reconstituted PCB mixtureQ73006896
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) increases release of luteinizing hormone and follicle-stimulating hormone from the pituitary of immature female rats in vivo and in vitroQ73155190
Epidermal growth factor tyrosine kinase receptors and the neuroendocrine control of mammalian pubertyQ77169869
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectsexual dimorphismQ181497
P1104number of pages8
P304page(s)194-201
P577publication date2006-02-01
P1433published inEnvironmental Health PerspectivesQ1345904
P1476titleEffects of developmental exposure to 2,2 ,4,4 ,5-pentabromodiphenyl ether (PBDE-99) on sex steroids, sexual development, and sexually dimorphic behavior in rats
P478volume114

Reverse relations

cites work (P2860)
Q390386971,2-Dibromo-4-(1,2 dibromoethyl) cyclohexane (TBECH)-mediated steroid hormone receptor activation and gene regulation in chicken LMH cells.
Q40180857A Case-Control Study of Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Cryptorchidism in Canadian Populations
Q38316962A review on the effects of PBDEs on thyroid and reproduction systems in fish
Q38069134A three-generational study of In ovo exposure to PBDE-99 in the zebra finch
Q37296844Adipocytes under assault: environmental disruption of adipose physiology.
Q47884731Adipose Tissue as a Site of Toxin Accumulation
Q44080707Adverse effects of 2,2',4,4'-tetrabromodiphenyl ether on semen quality and spermatogenesis in male mice
Q46858199An assessment of the developmental toxicity of BDE-99 in the European starling using an integrated laboratory and field approach.
Q36093139Association between levels of persistent organic pollutants in adipose tissue and cryptorchidism in early childhood: a case-control study
Q29248101Association of prenatal and childhood PBDE exposure with timing of puberty in boys and girls
Q28393780Association of prenatal exposure to polybrominated diphenyl ethers and infant birth weight
Q64137664Associations between prenatal and childhood PBDE exposure and early adolescent visual, verbal and working memory
Q33563004Behavioral changes in aging but not young mice after neonatal exposure to the polybrominated flame retardant decaBDE.
Q28390051Brominated Flame Retardants and Other Persistent Organohalogenated Compounds in Relation to Timing of Puberty in a Longitudinal Study of Girls
Q37720065Brominated flame retardants in breast milk and behavioural and cognitive development at 36 months
Q40022813Bromination pattern of hydroxylated metabolites of BDE-47 affects their potency to release calcium from intracellular stores in PC12 cells.
Q34789938Childhood obesity and environmental chemicals
Q33862225Components of plastic: experimental studies in animals and relevance for human health
Q49348502Comprehensive Screening Links Halogenated Organic Compounds with Testosterone Levels in Male Delphinus delphis from the Southern California Bight.
Q37791999Cryptorchidism and hypospadias as a sign of testicular dysgenesis syndrome (TDS): Environmental connection
Q27314776Cytochrome P450 3A1 mediates 2,2',4,4'-tetrabromodiphenyl ether-induced reduction of spermatogenesis in adult rats
Q39471895Cytotoxic effects and oxidative stress response of six PBDE metabolites on human L02 cells
Q46840403Developmental exposure to decabrominated diphenyl ether (BDE-209): effects on sperm oxidative stress and chromatin DNA damage in mouse offspring
Q24678057Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants
Q38319957Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents
Q39428097Differences in the mechanisms of action of BDE-47 and its metabolites on OVCAR-3 and MCF-7 cell apoptosis
Q42721359Early exposure to 2,2',4,4',5-pentabromodiphenyl ether (BDE-99) affects mating behavior of zebra finches
Q37285986Effect of brazilian propolis on exacerbation of respiratory syncytial virus infection in mice exposed to tetrabromobisphenol a, a brominated flame retardant
Q58802846Effects of Polybrominated Diphenyl Ethers on Child Cognitive, Behavioral, and Motor Development
Q51579237Effects of chronic polybrominated diphenyl ether exposure on gonadal development in the northern leopard frog, Rana pipiens.
Q35920244Effects of decabrominated diphenyl ether (PBDE-209) in regulation of growth and apoptosis of breast, ovarian, and cervical cancer cells
Q44354230Effects of dietary exposure to brominated flame retardant BDE-47 on thyroid condition, gonadal development and growth of zebrafish
Q43193571Effects of gestational exposure to decabromodiphenyl ether on reproductive parameters, thyroid hormone levels, and neuronal development in Sprague-Dawley rats offspring
Q37005915Effects of maternal dietary exposure to cadmium during pregnancy on mammary cancer risk among female offspring
Q42696532Effects on the reproductive parameters of two generations of Rattus norvegicus offspring from dams exposed to heptachlor during gestation and lactation.
Q88771076Embryonic exposure to environmentally relevant concentrations of a brominated flame retardant reduces the size of song-control nuclei in a songbird
Q48607227Endocrine disruption and reproduction impairment in zebrafish after long-term exposure to DE-71.
Q28388657Endocrine-disrupting chemicals: associated disorders and mechanisms of action
Q38172050Environmental toxins: alarming impacts of pesticides on male fertility
Q36900958Estrogenic environmental endocrine-disrupting chemical effects on reproductive neuroendocrine function and dysfunction across the life cycle.
Q38779608Evaluation of Polybrominated Diphenyl Ether Toxicity on HepG2 Cells - Hexabrominated Congener (BDE-154) Is Less Toxic than Tetrabrominated Congener (BDE-47).
Q39850392Evaluation of liver and thyroid toxicity in Sprague-Dawley rats after exposure to polybrominated diphenyl ether BDE-209
Q46196549Evaluation of surfactants as solubilizing agents in microsomal metabolism reactions with lipophilic substrates
Q30354590Exposure of Female Rats to an Environmentally Relevant Mixture of Brominated Flame Retardants Targets the Ovary, Affecting Folliculogenesis and Steroidogenesis.
Q50968690Exposure of pregnant women to persistent organic pollutants and cord sex hormone levels.
Q37464654Expression of obesity markers and Persistent Organic Pollutants levels in adipose tissue of obese patients: reinforcing the obesogen hypothesis?
Q43020915Fate of microconstituents in biosolids composted in an aerated silage bag.
Q36064953Flame retardants in placenta and breast milk and cryptorchidism in newborn boys
Q47641113From the Cover: Exposure to an Environmentally Relevant Mixture of Brominated Flame Retardants Decreased p-β-Cateninser675 Expression and Its Interaction With E-Cadherin in the Mammary Glands of Lactating Rats
Q42721301Gestational exposure to BDE-99 produces toxicity through upregulation of CYP isoforms and ROS production in the fetal rat liver.
Q33702926Global gene expression analysis in the livers of rat offspring perinatally exposed to low doses of 2,2',4,4'-tetrabromodiphenyl ether.
Q34160878Halogenated flame retardants: do the fire safety benefits justify the risks?
Q37007964Hormone disruption by PBDEs in adult male sport fish consumers
Q88782377Hydroxylated Polybrominated Diphenyl Ethers Exert Estrogenic Effects via Non-Genomic G Protein-Coupled Estrogen Receptor Mediated Pathways
Q36940841Hydroxylated metabolites of the polybrominated diphenyl ether mixture DE-71 are weak estrogen receptor-alpha ligands
Q90618239In Utero and Lactational Exposure to Flame Retardants Disrupts Rat Ovarian Follicular Development and Advances Puberty
Q38791866In utero and childhood DDT, DDE, PBDE and PCBs exposure and sex hormones in adolescent boys: The CHAMACOS study
Q24656316In utero and lactational exposures to low doses of polybrominated diphenyl ether-47 alter the reproductive system and thyroid gland of female rat offspring
Q45932228In vitro effects of environmentally relevant polybrominated diphenyl ether (PBDE) congeners on calcium buffering mechanisms in rat brain.
Q37746498Independent Maternal and Fetal Genetic Effects on Midgestational Circulating Levels of Environmental Pollutants
Q35059912Innovative application of fluoro tagging to trace airborne particulate and gas-phase polybrominated diphenyl ether exposures
Q49118120Internal exposure to pollutants and sex hormone levels in Flemish male adolescents in a cross-sectional study: associations and dose-response relationships
Q38087229Molecular toxicology of polybrominated diphenyl ethers: nuclear hormone receptor mediated pathways
Q42915419Multi-generational effects of polybrominated diphenylethers exposure: embryonic exposure of male American kestrels (Falco sparverius) to DE-71 alters reproductive success and behaviors
Q43043410Natural mixtures of persistent organic pollutants (POP) increase weight gain, advance puberty, and induce changes in gene expression associated with steroid hormones and obesity in female zebrafish.
Q35842517Neonatal exposure to brominated flame retardant BDE-47 reduces long-term potentiation and postsynaptic protein levels in mouse hippocampus
Q37080743Neurotoxicity of a polybrominated diphenyl ether mixture (DE-71) in mouse neurons and astrocytes is modulated by intracellular glutathione levels
Q37905814Nitric oxide signaling as a common target of organohalogens and other neuroendocrine disruptors
Q42717232Oxidative metabolism of BDE-99 by human liver microsomes: predominant role of CYP2B6.
Q24624417PBDE concentrations in women's serum and fecundability
Q37112190Participant experiences in a breastmilk biomonitoring study: a qualitative assessment
Q34487815Perinatal exposure to low-dose DE-71 increases serum thyroid hormones and gonadal osteopontin gene expression
Q34069591Perinatal exposure to polychlorinated biphenyls alters social behaviors in rats.
Q24611244Phthalates and other additives in plastics: human exposure and associated health outcomes
Q46748151Physiological effects of polybrominated diphenyl ether (PBDE-47) on pregnant gartersnakes and resulting offspring
Q37344551Polybrominated diphenyl ether (PBDE) concentrations in house dust are related to hormone levels in men.
Q57798298Polybrominated diphenyl ether (PBDE) neurotoxicity: a systematic review and meta-analysis of animal evidence
Q37494996Polybrominated diphenyl ether exposure and reproductive hormones in North American men.
Q43328399Polybrominated diphenyl ethers in chicken tissues and eggs from an electronic waste recycling area in southeast China
Q35011367Polybrominated diphenyl ethers in marine ecosystems of the American continents: foresight from current knowledge
Q37494990Polybrominated diphenyl ethers, 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153), and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) concentrations in sera collected in 2009 from Texas children
Q33263713Polybrominated diphenyl ethers: a case study for using biomonitoring data to address risk assessment questions
Q35030343Polychlorinated biphenyl (PCB) exposure in mothers and time to pregnancy in daughters.
Q82647899Porphyrogenic effect of pentabromodiphenyl ether after repeated administration to rats
Q46166292Prenatal Serum Concentrations of Brominated Flame Retardants and Autism Spectrum Disorder and Intellectual Disability in the Early Markers of Autism Study: A Population-Based Case-Control Study in California
Q50957987QSAR prediction of the competitive interaction of emerging halogenated pollutants with human transthyretin.
Q47149952Scientific Opinion on Polybrominated Diphenyl Ethers (PBDEs) in Food
Q35127130Serum PBDEs and age at menarche in adolescent girls: analysis of the National Health and Nutrition Examination Survey 2003-2004
Q36003966Serum and follicular fluid concentrations of polybrominated diphenyl ethers and in-vitro fertilization outcome
Q38211782The added value of proteomics for toxicological studies.
Q39692914The cytotoxic effects of synthetic 6-hydroxylated and 6-methoxylated polybrominated diphenyl ether 47 (BDE47).
Q36633056The polybrominated diphenyl ether mixture DE-71 is mildly estrogenic
Q36522635The steroid hormone biosynthesis pathway as a target for endocrine-disrupting chemicals.
Q36602294Toxicological function of adipose tissue: focus on persistent organic pollutants.
Q51659431Transcriptional regulation in liver and testis associated with developmental and reproductive effects in male zebrafish exposed to natural mixtures of persistent organic pollutants (POP).
Q89892693Transcriptomic profiling of PBDE-exposed HepaRG cells unveils critical lncRNA- PCG pairs involved in intermediary metabolism
Q23915392Transgenerational exposures: persistent chemical pollutants in the environment and breast milk
Q50483139miR-21 is involved in skeletal deficiencies of zebrafish embryos exposed to polychlorinated biphenyls.

Search more.