Structural and functional impairment of endocytic pathways by retinitis pigmentosa mutant rhodopsin-arrestin complexes

scientific article

Structural and functional impairment of endocytic pathways by retinitis pigmentosa mutant rhodopsin-arrestin complexes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI21136
P3181OpenCitations bibliographic resource ID435021
P932PMC publication ID437971
P698PubMed publication ID15232620

P2093author name stringChing-Hwa Sung
Jen-Zen Chuang
Carrie Vega
Wenjin Jun
P2860cites workRhodopsin mutants that bind but fail to activate transducinQ24300261
The fate of the phagosome: conversion to 'age pigment' and impact in human retinal pigment epitheliumQ70950495
A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in cultureQ71307582
A rhodopsin gene mutation responsible for autosomal dominant retinitis pigmentosa results in a protein that is defective in localization to the photoreceptor outer segmentQ71651373
Monoclonal antibodies to rhodopsin: characterization, cross-reactivity, and application as structural probesQ72694659
Transferrin is made and bound by photoreceptor cellsQ72865534
Autosomal dominant retinitis pigmentosa with a rhodopsin mutation (Arg-135-Trp). Disease phenotype in a Swedish familyQ73445994
Iron, ferritin, transferrin, and transferrin receptor in the adult rat retinaQ73991088
Iron-induced apoptosis in the photoreceptor cells of ratsQ74313038
Photoreceptor autophagy: effects of light history on number and opsin content of degradative vacuolesQ78221895
Rhodopsin mutations responsible for autosomal dominant retinitis pigmentosa. Clustering of functional classes along the polypeptide chainQ24321952
Rhodopsin mutations in autosomal dominant retinitis pigmentosaQ24564252
A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activationQ28252768
Identification of novel rhodopsin mutations responsible for retinitis pigmentosa: implications for the structure and function of rhodopsinQ30445562
Visualization of TGN to endosome trafficking through fluorescently labeled MPR and AP-1 in living cellsQ30476964
Profile of the genes expressed in the human peripheral retina, macula, and retinal pigment epithelium determined through serial analysis of gene expression (SAGE).Q32051276
Constitutively active mutants of rhodopsinQ34244263
A six-generation family with autosomal dominant retinitis pigmentosa and a rhodopsin gene mutation (arginine-135-leucine)Q34296603
The endocytic pathway: a mosaic of domainsQ34389525
Autosomal-dominant retinitis pigmentosa associated with an Arg-135-Trp point mutation of the rhodopsin gene. Clinical features and longitudinal observationsQ34400676
Beta-Arrestins: new roles in regulating heptahelical receptors' functionsQ34401868
Constitutive activation of phototransduction by K296E opsin is not a cause of photoreceptor degenerationQ34453852
Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidusQ34584278
Retinal function and rhodopsin levels in autosomal dominant retinitis pigmentosa with rhodopsin mutationsQ34842125
Functional heterogeneity of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosaQ34951881
Electroporation and RNA interference in the rodent retina in vivo and in vitroQ35120935
Sequence alignment of the G-protein coupled receptor superfamilyQ35225323
Iterative fractionation of recycling receptors from lysosomally destined ligands in an early sorting endosomeQ36222118
Efficient photoreceptor-targeted gene expression in vivo by recombinant adeno-associated virusQ36242842
An endocytosed TGN38 chimeric protein is delivered to the TGN after trafficking through the endocytic recycling compartment in CHO cells.Q36255652
Delivery of ligands from sorting endosomes to late endosomes occurs by maturation of sorting endosomesQ36531233
SARA, a FYVE domain protein, affects Rab5-mediated endocytosis.Q40690087
Endocytosis of ligand-human parathyroid hormone receptor 1 complexes is protein kinase C-dependent and involves beta-arrestin2. Real-time monitoring by fluorescence microscopyQ40924347
Rhodopsin arginine-135 mutants are phosphorylated by rhodopsin kinase and bind arrestin in the absence of 11-cis-retinalQ41043592
Constitutive activation of opsin: interaction of mutants with rhodopsin kinase and arrestinQ41294623
Characterization of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa. Mutations on the cytoplasmic surface affect transducin activation.Q41554234
Deferoxamine (Desferal)-induced toxic retinal pigmentary degeneration and presumed optic neuropathy.Q42256501
A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome systemQ44045954
Evidence for two apoptotic pathways in light-induced retinal degenerationQ44130152
Expression of photoreceptor-associated molecules during human fetal eye development.Q44569355
Selective illumination of single photoreceptors in the house fly retina: local membrane turnover and uptake of extracellular horseradish peroxidase (HRP) and lucifer yellow.Q52455397
The formation of stable rhodopsin-arrestin complexes induces apoptosis and photoreceptor cell degeneration.Q52584172
A molecular pathway for light-dependent photoreceptor apoptosis in Drosophila.Q52584174
Ca(2+)-dependent interaction of recoverin with rhodopsin kinase.Q55064223
Two phases of rod photoreceptor differentiation during rat retinal developmentQ57742125
Development of the light response in neonatal mammalian rodsQ58792304
Structure and function in rhodopsin. Studies of the interaction between the rhodopsin cytoplasmic domain and transducinQ68214782
Endocytosis in the inner segment of rod photoreceptors: analysis of Xenopus laevis retinas using horseradish peroxidaseQ68535556
Endocytosis of cationized ferritin by rat photoreceptorsQ69388496
Development of lipofuscin-like fluorescence in the retinal pigment epithelium in response to protease inhibitor treatmentQ69656173
Nephrogenic diabetes insipidus. A V2 vasopressin receptor unable to stimulate adenylyl cyclaseQ70769648
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectretinitis pigmentosaQ847057
P304page(s)131-40
P577publication date2004-07-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleStructural and functional impairment of endocytic pathways by retinitis pigmentosa mutant rhodopsin-arrestin complexes
P478volume114

Reverse relations

cites work (P2860)
Q91626621A Small Chaperone Improves Folding and Routing of Rhodopsin Mutants Linked to Inherited Blindness
Q38657660Aberrant protein trafficking in retinal degenerations: The initial phase of retinal remodeling.
Q21145009Accumulation of rhodopsin in late endosomes triggers photoreceptor cell degeneration
Q35844863Alternative pathway of cell death in Drosophila mediated by NF-κB transcription factor Relish
Q33879152Arrestin can act as a regulator of rhodopsin photochemistry
Q42089456Arrestins in apoptosis
Q41941697Assessing the correlation between mutant rhodopsin stability and the severity of retinitis pigmentosa
Q42940253Autophagy-dependent rhodopsin degradation prevents retinal degeneration in Drosophila.
Q34569418Beta-arrestin2-mediated internalization of mammalian odorant receptors.
Q36502943Cell-nonautonomous function of ceramidase in photoreceptor homeostasis
Q93051388Characterizing variants of unknown significance in rhodopsin: A functional genomics approach
Q90258074Coupling of Human Rhodopsin to a Yeast Signaling Pathway Enables Characterization of Mutations Associated with Retinal Disease
Q36928951Detection of G protein-selective G protein-coupled receptor (GPCR) conformations in live cells
Q35662681Effect of rapamycin on the fate of P23H opsin associated with retinitis pigmentosa (an American Ophthalmological Society thesis).
Q37044506Functional map of arrestin binding to phosphorylated opsin, with and without agonist
Q35621624G protein-coupled receptor kinases: more than just kinases and not only for GPCRs
Q28083847Hsp90 as a Potential Therapeutic Target in Retinal Disease
Q37649115Hsp90 inhibition protects against inherited retinal degeneration
Q35218045Light regulates the ciliary protein transport and outer segment disc renewal of mammalian photoreceptors
Q27322196Negative regulation of the novel norpA(P24) suppressor, diehard4, in the endo-lysosomal trafficking underlies photoreceptor cell degeneration
Q35593740Novel rhodopsin mutations and genotype-phenotype correlation in patients with autosomal dominant retinitis pigmentosa
Q36814854Phototransduction and retinal degeneration in Drosophila.
Q42060854ROM-1 potentiates photoreceptor specific membrane fusion processes
Q37089132Regulation of arrestin binding by rhodopsin phosphorylation level
Q24337262SARA-regulated vesicular targeting underlies formation of the light-sensing organelle in mammalian rods
Q34581973Stable rhodopsin/arrestin complex leads to retinal degeneration in a transgenic mouse model of autosomal dominant retinitis pigmentosa.
Q36914861Structure and activation of rhodopsin
Q58700462Targeted disruption of the endogenous zebrafish locus as models of rapid rod photoreceptor degeneration
Q36610331The Disease Protein Tulp1 Is Essential for Periactive Zone Endocytosis in Photoreceptor Ribbon Synapses
Q45873271The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy
Q30619897Ultrastructural visualization of trans-ciliary rhodopsin cargoes in mammalian rods
Q36915521Visual arrestin interaction with clathrin adaptor AP-2 regulates photoreceptor survival in the vertebrate retina