Topical administration of lacritin is a novel therapy for aqueous-deficient dry eye disease

scientific article

Topical administration of lacritin is a novel therapy for aqueous-deficient dry eye disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1167/IOVS.14-13924
P3181OpenCitations bibliographic resource ID3218032
P932PMC publication ID4148924
P698PubMed publication ID25034600

P2093author name stringGordon W Laurie
Robert L McKown
Suganthalakshmi Balasubbu
Marianne Gallup
Nancy A McNamara
Trinka Vijmasi
Feeling Y T Chen
P2860cites workThe important role of T cells and receptor expression in Sjögren's syndromeQ35535169
Interleukin-1 receptor mediates the interplay between CD4+ T cells and ocular resident cells to promote keratinizing squamous metaplasia in Sjögren's syndromeQ37050342
Immune profile of squamous metaplasia development in autoimmune regulator-deficient dry eye.Q37139290
Topical administration of interleukin-1 receptor antagonist as a therapy for aqueous-deficient dry eye in autoimmune disease.Q37195776
Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. CsA Phase 3 Study GroupQ41730611
Alterations in expression of mucin, tenascin-c and syndecan-1 in the conjunctiva following retinal surgery and plaque radiotherapyQ43718947
A link between tear instability and hyperosmolarity in dry eye.Q46072952
Syndecan regulates cell migration and axon guidance in C. elegansQ46715063
Influence of the eye-associated lymphoid tissue (EALT) on inflammatory ocular surface disease.Q52928043
Hyperosmolarity-Induced Cornification of Human Corneal Epithelial Cells Is Regulated by JNK MAPKQ56775881
The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007)Q80347907
Tear osmolarity in the diagnosis and management of dry eye diseaseQ83395082
Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndromeQ21133793
cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal glandQ24291355
Establishment of an appropriate animal model for lacritin studies: cloning and characterization of lacritin in monkey eyesQ24293443
Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathwaysQ24300470
Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritinQ24303785
Lacritin and other new proteins of the lacrimal functional unitQ24320688
Lacritin and the tear proteome as natural replacement therapy for dry eyeQ24594010
Tissue transglutaminase is a negative regulator of monomeric lacritin bioactivityQ24594029
Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolismQ24609781
Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivityQ24631177
Lacritin, a novel human tear glycoprotein, promotes sustained basal tearing and is well tolerated.Q24635929
Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseasesQ28241769
Comparative analysis of the tear protein expression in blepharitis patients using two-dimensional electrophoresisQ28256113
Mass spectrometry-based proteomic analyses in contact lens-related dry eyeQ28259300
Lacritin-induced secretion of tear proteins from cultured monkey lacrimal acinar cellsQ28287063
Tear lacritin levels by age, sex, and time of day in healthy adultsQ30422186
Interleukin-1 as a phenotypic immunomodulator in keratinizing squamous metaplasia of the ocular surface in Sjögren's syndromeQ34086947
American College of Rheumatology classification criteria for Sjögren's syndrome: a data-driven, expert consensus approach in the Sjögren's International Collaborative Clinical Alliance cohortQ34260251
Dry eye as a mucosal autoimmune diseaseQ34647761
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectLacritinQ1759126
eye diseaseQ3041498
tear secretionQ12153824
P304page(s)5401-5409
P577publication date2014-07-17
P1433published inInvestigative Ophthalmology Visual ScienceQ6060707
P1476titleTopical administration of lacritin is a novel therapy for aqueous-deficient dry eye disease
P478volume55

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cites work (P2860)
Q28115093A thermo-responsive protein treatment for dry eyes
Q92442286Advances in dry eye disease treatment
Q41677137Aire-deficient mice provide a model of corneal and lacrimal gland neuropathy in Sjögren's syndrome
Q38875664Development of Causative Treatment Strategies for Lacrimal Gland Insufficiency by Tissue Engineering and Cell Therapy. Part 1: Regeneration of Lacrimal Gland Tissue: Can We Stimulate Lacrimal Gland Renewal In Vivo?
Q90153796Development of lacrimal gland inflammation in the mouse model of herpes stromal keratitis
Q64244837Effect of topical 0.05% cyclosporine A on the tear protein lacritin in a rat model of dry eye
Q28119133Lacritin Salvages Human Corneal Epithelial Cells from Lipopolysaccharide Induced Cell Death
Q30278788Lacritin and other autophagy associated proteins in ocular surface health
Q34542159Reduced Levels of Tear Lacritin Are Associated With Corneal Neuropathy in Patients With the Ocular Component of Sjögren's Syndrome
Q38652990TFOS DEWS II Tear Film Report.
Q50039889[Novel current and future therapy options for treatment of dry eye disease].

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