NF-κB-mediated repression of growth arrest- and DNA-damage-inducible proteins 45α and γ is essential for cancer cell survival

scientific article

NF-κB-mediated repression of growth arrest- and DNA-damage-inducible proteins 45α and γ is essential for cancer cell survival is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2004PNAS..10113618Z
P356DOI10.1073/PNAS.0402069101
P932PMC publication ID518803
P698PubMed publication ID15353598
P5875ResearchGate publication ID8359538

P50authorLuiz ZerbiniQ72622624
Towia A LibermannQ44211169
Mary B GoldringQ52565525
Ricardo G CorreaQ59555225
P2093author name stringXuesong Gu
Franck Grall
Akos Czibere
Yihong Wang
Je-Yoel Cho
Jin-Rong Zhou
Kosei Ijiri
Marie Joseph
Wanjang Wei
P2860cites workEffective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of matrix metalloproteinases and proinflammatory cytokines is nuclear factor-kappaB dependentQ64380458
Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa BQ70903372
GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cellsQ73923485
GADD45-induced cell cycle G2-M arrest associates with altered subcellular distribution of cyclin B1 and is independent of p38 kinase activityQ78666533
A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKKQ22008047
Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 bindingQ24299183
Signal transduction by tumor necrosis factor mediated by JNK protein kinasesQ24308037
NF-kappaB regulation in the immune systemQ28205043
GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stressQ28215088
Genotoxic-stress-response genes and growth-arrest genes. gadd, MyD, and other genes induced by treatments eliciting growth arrestQ28243439
Characterisation of the interaction between PCNA and Gadd45Q28303473
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vectorQ29547503
NF-kappaB in cancer: from innocent bystander to major culpritQ29614603
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathwayQ29616436
Gene therapy: promises and problems.Q34101058
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.Q34131747
Marine ecosystems: bacterial photosynthesis genes in a virusQ34222352
A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA.Q34762243
Inhibition of orthotopic growth and metastasis of androgen-sensitive human prostate tumors in mice by bioactive soybean componentsQ37422017
Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.Q40767950
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.Q41218044
Characterization of p21Cip1/Waf1 peptide domains required for cyclin E/Cdk2 and PCNA interaction.Q41233614
c-Myc represses the proximal promoters of GADD45a and GADD153 by a post-RNA polymerase II recruitment mechanismQ42458575
Inhibition of JNK activation through NF-kappaB target genesQ43802523
Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer.Q47938173
Increased nuclear factor-kappa B activation is related to the tumor development of renal cell carcinoma.Q53381334
Cell survival and a Gadd45-factor deficiencyQ59065679
Life-or-death decisionsQ59078427
P2507corrigendum / erratumCorrection to "NF-κB-mediated repression of growth arrest- and DNA-damage-inducible proteins 45α and γ is essential for cancer cell survival"Q118228299
P433issue37
P407language of work or nameEnglishQ1860
P921main subjectDNA damageQ5205747
NF-κBQ411114
P304page(s)13618-13623
P577publication date2004-09-07
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleNF-κB-mediated repression of growth arrest- and DNA-damage-inducible proteins 45α and γ is essential for cancer cell survival
P478volume101

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cites work (P2860)
Q37609049A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation
Q37706969Activating transcription factor 3 is crucial for antitumor activity and to strengthen the antiviral properties of Onconase
Q43782517Apoptosis of glomerular mesangial cells induced by sublytic C5b-9 complexes in rats with Thy-1 nephritis is dependent on Gadd45 gamma upregulation
Q37478131Cadmium induces intracellular Ca2+- and H2O2-dependent apoptosis through JNK- and p53-mediated pathways in skin epidermal cell line
Q23923998Characterization of an alternatively spliced GADD45 alpha, GADD45 alpha 1 isoform, inarsenic-treated epithelial cells
Q53707055Co-inhibition of BET proteins and NF-κB as a potential therapy for colorectal cancer through synergistic inhibiting MYC and FOXM1 expressions.
Q34023344Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-κB inhibitors in ovarian cancer therapy
Q37290391Comprehensive evaluation of a novel nuclear factor-kappaB inhibitor, quinoclamine, by transcriptomic analysis
Q49470056Curcumol potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer
Q23923999Deficiency in Ikk beta gene enhances arsenic-induced gadd45alpha expression
Q37331102Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism
Q33346368Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes.
Q64258088Dihydroartemisinin inhibits prostate cancer via JARID2/miR-7/miR-34a-dependent downregulation of Axl
Q40349623Escherichia coli verotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest
Q38172363Fucoxanthin: a marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms
Q24608649GADD45 proteins: central players in tumorigenesis
Q37159197GADD45a is a novel candidate gene in inflammatory lung injury via influences on Akt signaling
Q37046475GADD45α and γ interaction with CDK11p58 regulates SPDEF protein stability and SPDEF-mediated effects on cancer cell migration
Q35860643GADD45α inhibition of DNMT1 dependent DNA methylation during homology directed DNA repair
Q39635948GADD45βDetermines Chemoresistance and Invasive Growth of Side Population Cells of Human Embryonic Carcinoma
Q39321571GADD45γ regulates TNF-α and IL-6 synthesis in THP-1 cells
Q24600470GADD45γ: a New Vitamin D-Regulated Gene that Is Antiproliferative in Prostate Cancer Cells
Q42824286Gadd45 beta is a pro-survival factor associated with stress-resistant tumors
Q24600659Gadd45 in the response of hematopoietic cells to genotoxic stress
Q28388105Gadd45 proteins as critical signal transducers linking NF-kappaB to MAPK cascades
Q34222845Gadd45 proteins: relevance to aging, longevity and age-related pathologies
Q24600698Gadd45 stress sensors in malignancy and leukemia
Q39910112Gadd45-alpha and Gadd45-gamma utilize p38 and JNK signaling pathways to induce cell cycle G2/M arrest in Hep-G2 hepatoma cells
Q53625972Gadd45a and Gadd45b protect hematopoietic cells from UV-induced apoptosis via distinct signaling pathways, including p38 activation and JNK inhibition.
Q41950183Gadd45α activity is the principal effector of Shigella mitochondria-dependent epithelial cell death in vitro and ex vivo.
Q36413954Growth arrest DNA damage-inducible gene 45 gamma expression as a prognostic and predictive biomarker in hepatocellular carcinoma
Q64115434Growth arrest and DNA damage 45γ is required for caspase-dependent renal tubular cell apoptosis
Q42804452Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells
Q46709860Hematopoietic cells from Gadd45a- and Gadd45b-deficient mice are sensitized to genotoxic-stress-induced apoptosis
Q34131115Hepatocyte proliferation/growth arrest balance in the liver of mice during E. multilocularis infection: a coordinated 3-stage course
Q46259543Human accelerated regions and other human-specific sequence variations in the context of evolution and their relevance for brain development
Q24625593Human-specific loss of regulatory DNA and the evolution of human-specific traits
Q36119216IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response
Q35125173Inactivation of GSK3β and activation of NF-κB pathway via Axl represents an important mediator of tumorigenesis in esophageal squamous cell carcinoma.
Q23923964Inhibition of NF-kappa B stabilizes gadd45 alpha mRNA
Q36447432Interplay of nuclear factor-kappaB and B-myb in the negative regulation of androgen receptor expression by tumor necrosis factor alpha
Q35232584JunD-mediated repression of GADD45α and γ regulates escape from cell death in prostate cancer
Q47106153Long noncoding RNA SFTA1P promoted apoptosis and increased cisplatin chemosensitivity via regulating the hnRNP-U-GADD45A axis in lung squamous cell carcinoma
Q45875678Methylation mediated Gadd45β enhanced the chemosensitivity of hepatocellular carcinoma by inhibiting the stemness of liver cancer cells
Q31051711Mining microarray data at NCBI's Gene Expression Omnibus (GEO)*.
Q27301986Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury
Q24320004Mutant telomerase RNAs induce DNA damage and apoptosis via the TRF2-ATM pathway in telomerase-overexpressing primary fibroblasts
Q37184393NAC-1, a potential stem cell pluripotency factor, contributes to paclitaxel resistance in ovarian cancer through inactivating Gadd45 pathway
Q38773619New role and molecular mechanism of Gadd45a in hepatic fibrosis
Q37332664Oligonucleotide microarray analysis of apoptosis induced by 15-methoxypinusolidic acid in microglial BV2 cells
Q36099676Opposite Effects of M1 and M2 Macrophage Subtypes on Lung Cancer Progression.
Q52887370Oxidative stress-induced Gadd45α inhibits trophoblast invasion and increases sFlt1/sEng secretions via p38 MAPK involving in the pathology of pre-eclampsia.
Q40100857Probiotic Lactobacillus reuteri suppress proinflammatory cytokines via c-Jun
Q48266344Redistribution of cell cycle by arsenic trioxide is associated with demethylation and expression changes of cell cycle related genes in acute promyelocytic leukemia cell line (NB4).
Q34524224Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding
Q36778892Role of activated nuclear factor-kappaB in the pathogenesis and therapy of squamous cell carcinoma of the head and neck
Q37609032Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis.
Q36907129SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κB/STAT3 complex to its promoter in malignant lymphoid cells
Q49604295Single-Base Resolution Map of Evolutionary Constraints and Annotation of Conserved Elements across Major Grass Genomes
Q33723689Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair
Q49364990Sodium fluoride induces apoptosis in mouse splenocytes by activating ROS-dependent NF-κB signaling
Q34382716TAp73-mediated the activation of c-Jun N-terminal kinase enhances cellular chemosensitivity to cisplatin in ovarian cancer cells.
Q64122028The IAP antagonist birinapant potentiates bortezomib anti-myeloma activity in vitro and in vivo
Q36798094The RUNX1 transcription factor is expressed in serous epithelial ovarian carcinoma and contributes to cell proliferation, migration and invasion.
Q27650481The crystal structure and dimerization interface of GADD45γ
Q92151215The expression of mouse double minute 2 homolog and P73 had no correlation with growth arrest DNA damage-inducible gene 45α in patients with non-small-cell lung carcinoma: A STROBE-compliant study
Q33955558The non-steroidal anti-inflammatory drugs Sulindac sulfide and Diclofenac induce apoptosis and differentiation in human acute myeloid leukemia cells through an AP-1 dependent pathway.
Q39515645The novel compound OSI-461 induces apoptosis and growth arrest in human acute myeloid leukemia cells
Q39381139The receptor tyrosine kinase Axl is an essential regulator of prostate cancer proliferation and tumor growth and represents a new therapeutic target.
Q38107999The role of ubiquitin-proteasome system in glioma survival and growth
Q35076646The stress granule protein G3BP1 recruits protein kinase R to promote multiple innate immune antiviral responses
Q40211693Unr, a cytoplasmic RNA-binding protein with cold-shock domains, is involved in control of apoptosis in ES and HuH7 cells
Q39266738cIAP2 represses IKKα/β-mediated activation of MDM2 to prevent p53 degradation
Q37006736p53 controls hepatitis C virus non-structural protein 5A-mediated downregulation of GADD45α expression via the NF-κB and PI3K-Akt pathways

Q118228299Correction to "NF-κB-mediated repression of growth arrest- and DNA-damage-inducible proteins 45α and γ is essential for cancer cell survival"main subjectP921

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