Trimethoprim-sulfamethoxazole versus trimethoprim-sulfamethoxazole plus doxycycline as oral eradicative treatment for melioidosis (MERTH): a multicentre, double-blind, non-inferiority, randomised controlled trial

scientific article

Trimethoprim-sulfamethoxazole versus trimethoprim-sulfamethoxazole plus doxycycline as oral eradicative treatment for melioidosis (MERTH): a multicentre, double-blind, non-inferiority, randomised controlled trial is …
instance of (P31):
scholarly articleQ13442814
comparative studyQ58901591

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P356DOI10.1016/S0140-6736(13)61951-0
P3181OpenCitations bibliographic resource ID5125801
P932PMC publication ID3939931
P698PubMed publication ID24284287

P50authorNicholas P J DayQ28033668
Vanaporn WuthiekanunQ28321762
Wirongrong ChierakulQ28321766
Direk LimmathurotsakulQ28321770
Ploenchan ChetchotisakdQ41653531
Siriluck AnunnatsiriQ41653621
Sharon PeacockQ44172566
Narisara ChantratitaQ52730888
Janjira ThaipadungpanitQ56133645
Wipada ChaowagulQ114417982
Kriangsak PhimdaQ114433980
Piroon MootsikapunQ114433981
Seksan ChaisuksantQ114433982
P2093author name stringBandit Thinkhamrop
Wattanachai Susaengrat
Chalongchai Toondee
Jiraporn Pilaikul
Sunchai Phiphitaporn
Surasakdi Wongrattanacheewin
P2860cites workGenetic diversity and microevolution of Burkholderia pseudomallei in the environmentQ21144556
Melioidosis: epidemiology, pathophysiology, and managementQ24522461
Recurrent melioidosis in patients in northeast Thailand is frequently due to reinfection rather than relapseQ24535314
Outcomes of patients with melioidosis treated with cotrimoxazole alone for eradication therapyQ24602857
Increasing incidence of human melioidosis in Northeast ThailandQ24605111
Consensus guidelines for dosing of amoxicillin-clavulanate in melioidosisQ24630305
Dosing regimens of cotrimoxazole (trimethoprim-sulfamethoxazole) for melioidosisQ24651516
Multilocus Sequence Typing and Evolutionary Relationships among the Causative Agents of Melioidosis and Glanders, Burkholderia pseudomallei and Burkholderia malleiQ28202846
Trimethoprim/sulfamethoxazole resistance in clinical isolates of Burkholderia pseudomalleiQ28249826
Burkholderia Pseudomallei is genetically diverse in agricultural land in Northeast ThailandQ28475834
The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective studyQ33769912
A comparison of chloramphenicol, trimethoprim-sulfamethoxazole, and doxycycline with doxycycline alone as maintenance therapy for melioidosisQ33873221
Maintenance therapy of melioidosis with ciprofloxacin plus azithromycin compared with cotrimoxazole plus doxycyclineQ33952994
Open-label randomized trial of oral trimethoprim-sulfamethoxazole, doxycycline, and chloramphenicol compared with trimethoprim-sulfamethoxazole and doxycycline for maintenance therapy of melioidosisQ34077038
A prospective comparison of co-amoxiclav and the combination of chloramphenicol, doxycycline, and co-trimoxazole for the oral maintenance treatment of melioidosisQ34371469
Risk factors for recurrent melioidosis in northeast ThailandQ34567077
Activities of daily living associated with acquisition of melioidosis in northeast Thailand: a matched case-control studyQ34600705
GeoSentinel surveillance of illness in returned travelers, 2007-2011Q36239501
Simultaneous infection with more than one strain of Burkholderia pseudomallei is uncommon in human melioidosisQ36314343
Workshop on treatment of and postexposure prophylaxis for Burkholderia pseudomallei and B. mallei Infection, 2010Q36570592
Melioidosis: acute and chronic disease, relapse and re-activationQ38958161
The antimicrobial susceptibility of Pseudomonas pseudomallei. Emergence of resistance in vitro and during treatmentQ38961152
A comparison of antibiotic susceptibility testing methods for cotrimoxazole with Burkholderia pseudomallei.Q39356268
The pros and cons of noninferiority trialsQ39361105
Non-inferiority trials: design concepts and issues - the encounters of academic consultants in statisticsQ57506046
MelioidosisQ84964739
P433issue9919
P407language of work or nameEnglishQ1860
P921main subjectantibioticQ12187
doxycyclineQ422442
sulfamethoxazole/trimethoprimQ898623
melioidosisQ963944
multicenter clinical trialQ6934595
P304page(s)807-14
P577publication date2014-03-01
P1433published inThe LancetQ939416
P1476titleTrimethoprim-sulfamethoxazole versus trimethoprim-sulfamethoxazole plus doxycycline as oral eradicative treatment for melioidosis (MERTH): a multicentre, double-blind, non-inferiority, randomised controlled trial
P478volume383

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cites work (P2860)
Q50109311A case report of Tubo-ovarian abscess caused by Burkholderia pseudomallei
Q57193551A case report of melioidosis complicated by infective sacroiliitis in Sri Lanka
Q53679268A man with unsuspected marine eosinophilic gastritis.
Q40542863Antibiotic resistance in Burkholderia species
Q61803231Clinical Manifestations, Antimicrobial Drug Susceptibility Patterns, and Outcomes in Melioidosis Cases, India
Q38598756Clinical Outcomes in Musculoskeletal Involvement of Burkholderia Pseudomallei Infection
Q39263011Correlation between biofilm production, antibiotic susceptibility and exopolysaccharide composition in Burkholderia pseudomallei bpsI, ppk, and rpoS mutant strains
Q90817977Cranial Melioidosis Presenting as Osteomyelitis and/or Extra-Axial Abscess: Literature Review
Q35015687Cutaneous melioidosis in a healthy Danish man after travelling to South-East Asia
Q33843665Demonstrating the Protective Efficacy of the Novel Fluoroquinolone Finafloxacin against an Inhalational Exposure to Burkholderia pseudomallei
Q58695264Factors affecting clinical outcomes in the management of melioidosis in Singapore: a 16-year case series
Q58761277Feasibility and initial outcomes of a multifaceted prevention programme of melioidosis in diabetic patients in Ubon Ratchathani, northeast Thailand
Q35116418Functional characterization and evaluation of in vitro protective efficacy of murine monoclonal antibodies BURK24 and BURK37 against Burkholderia pseudomallei
Q36361693Hematopoietic lineage skewing and intestinal epithelia degeneration in aged mice with telomerase RNA component deletion
Q90243749Human Melioidosis
Q35219793Intravenous therapy duration and outcomes in melioidosis: a new treatment paradigm
Q36958444Investigation of Recurrent Melioidosis in Lao People's Democratic Republic by Multilocus Sequence Typing.
Q39582866Loss of Methyltransferase Function and Increased Efflux Activity Leads to Doxycycline Resistance in Burkholderia pseudomallei
Q57094969Melioidosis
Q61699558Melioidosis
Q43126480Melioidosis diagnostic workshop, 2013.
Q57147972Melioidosis in Brunei Darussalam
Q64239581Melioidosis with a subdural collection - a case report
Q64238619Melioidosis, an emerging infectious disease in the Midwest Brazil: A case report
Q33663333Melioidosis: Clinical impact and public health threat in the tropics.
Q64095025Melioidosis: The hazards of incomplete peer-review
Q33816438New insights from the 7th World Melioidosis Congress 2013.
Q97566851Prolonged intermittent fever and massive splenomegaly in a miner working in the tropical jungle, China
Q38690224Pulmonary melioidosis presenting with pleural effusion: A case report and review of literature
Q39307381Splenic abscesses in a returning traveler
Q90232462Successful Treatments and Management of A Case of Canine Melioidosis
Q39446204Susceptibility of Clinical Isolates of Burkholderia pseudomallei to a Lipid A Biosynthesis Inhibitor
Q38330997The expanding role of co-trimoxazole in developing countries
Q34538191Treatment and prophylaxis of melioidosis
Q47876732Treatment of diseases acquired abroad
Q42942530Trimethoprim/sulfamethoxazole resistance in Burkholderia pseudomallei.
Q42534233Trimethoprim/sulfamethoxazole resistance in clinical isolates of Burkholderia pseudomallei from Thailand
Q37685353Two fatal cases of melioidosis on the Thai-Myanmar border

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