Novel small molecule activators of the Trk family of receptor tyrosine kinases

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Novel small molecule activators of the Trk family of receptor tyrosine kinases is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BBAPAP.2012.08.021
P932PMC publication ID3602283
P698PubMed publication ID22982231

P2093author name stringKeqiang Ye
Obiamaka Obianyo
P2860cites workDeoxygedunin, a natural product with potent neurotrophic activity in miceQ21136320
Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activityQ24615575
Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell deathQ24674099
Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behaviorQ24679793
Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 AQ27732820
Signal transduction by receptors with tyrosine kinase activityQ27860624
Protein modules and signalling networksQ27860694
Trk receptors: roles in neuronal signal transductionQ27919636
Structural analysis of receptor tyrosine kinasesQ28198048
Interactions between brain-derived neurotrophic factor and the TRKB receptor. Identification of two ligand binding domains in soluble TRKB by affinity separation and chemical cross-linkingQ28249975
A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant EffectQ28298196
Design of Potent Peptide Mimetics of Brain-derived Neurotrophic FactorQ48318337
Focal cerebral ischemia in rats induces expression of P75 neurotrophin receptor in resistant striatal cholinergic neuronsQ48475009
Structure-activity relationships of conformationally constrained peptide analogues of loop 2 of brain-derived neurotrophic factorQ48497521
Watching the brain remake itself.Q51129398
p75-mediated neuroprotection by NGF against glutamate cytotoxicity in cortical culturesQ60688389
Neurotrophic factors in Alzheimer's and Parkinson's disease brainQ64768197
Isolation and characterization of an antimalarial agent of the neem tree Azadirachta indicaQ69418510
Nerve growth factor (NGF)-mediated protection of neural crest cells from antimitotic agent-induced apoptosis: the role of the low-affinity NGF receptorQ71132186
Monoclonal antibody to human Trk-A: diagnostic and therapeutic potential in neuroblastomaQ74360653
7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in ratsQ28566697
Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learningQ30544629
A peptidomimetic of NT-3 acts as a TrkC antagonistQ33489168
Bivalent peptidomimetic ligands of TrkC are biased agonists and selectively induce neuritogenesis or potentiate neurotrophin-3 trophic signalsQ33500614
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone.Q33664194
BDNF and activity-dependent synaptic modulationQ33820669
Activation of Trk neurotrophin receptors in the absence of neurotrophinsQ33937877
An extended surface of binding to Trk tyrosine kinase receptors in NGF and BDNF allows the engineering of a multifunctional pan-neurotrophin.Q34052239
Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodentsQ34111160
7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndromeQ34242515
Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene.Q34338664
TrkA cross-linking mimics neuronal responses to nerve growth factorQ34442757
Nerve growth factor for the treatment of diabetic neuropathy: what went wrong, what went right, and what does the future hold?Q34800447
Functional validation of ligand mimicry by anti-receptor antibodies: structural and therapeutic implicationsQ35232317
7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's diseaseQ35622640
Receptor tyrosine kinases: mechanisms of activation and signalingQ36738608
Differential regional expression of brain-derived neurotrophic factor following olfactory fear learningQ36745105
Peptide agonist of the thrombopoietin receptor as potent as the natural cytokineQ36864987
Growth-stimulatory monoclonal antibodies against human insulin-like growth factor I receptorQ37056292
TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatmentQ37127162
Cholinergic system during the progression of Alzheimer's disease: therapeutic implicationsQ37318152
The neurotrophin family of neurotrophic factors: an overviewQ37988419
Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitroQ40142745
Novel agonist monoclonal antibodies activate TrkB receptors and demonstrate potent neurotrophic activities.Q40232259
Differential regulation of the intrinsic pathway of apoptosis in brain and liver during ageingQ40267501
Functional Interactions of Neurotrophins and Neurotrophin ReceptorsQ40441056
The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmissionQ40513169
Role of neurotrophins and trk receptors in the development and maintenance of sensory neurons: an overviewQ41055284
Neurotrophic factors and amyotrophic lateral sclerosisQ41096229
Potent human p140-TrkA agonists derived from an anti-receptor monoclonal antibody.Q41227716
Loss of NGF receptor immunoreactivity in basal forebrain neurons of aged rats: correlation with spatial memory impairmentQ41272547
Mice lacking brain-derived neurotrophic factor develop with sensory deficitsQ41481309
Blood-brain barrier penetration and in vivo activity of an NGF conjugateQ41578400
Effect of neem limonoids on lactate dehydrogenase (LDH) of the rice leaffolder, Cnaphalocrocis medinalis (Guenée) (Insecta: Lepidoptera: Pyralidae).Q42039853
Vulnerability to depression: from brain neuroplasticity to identification of biomarkers.Q42494002
Transplants of cholinergic septal explants reinnervate adult rodent hippocampusQ42522806
A novel family of cyclic peptide antagonists suggests that N-cadherin specificity is determined by amino acids that flank the HAV motifQ42805775
Alzheimer's Therapeutics: Neurotrophin Domain Small Molecule MimeticsQ43477496
Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects.Q44270223
Transactivation of Trk neurotrophin receptors by G-protein-coupled receptor ligands occurs on intracellular membranes.Q44999225
Serum concentrations of nerve growth factor and brain-derived neurotrophic factor in depressed patients before and after antidepressant treatmentQ46724820
Nerve growth factor increases extracellular acetylcholine levels in the parietal cortex and hippocampus of aged rats and restores object recognitionQ48154484
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectbiophysicsQ7100
P304page(s)2213-8
P577publication date2013-10-01
P1433published inBiochimica et Biophysica ActaQ864239
P1476titleNovel small molecule activators of the Trk family of receptor tyrosine kinases
P478volume1834

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cites work (P2860)
Q285472057, 8-Dihydroxyflavone Protects an Endothelial Cell Line from H2O2 Damage
Q47308989Antidepressant Imipramine Protects Bupivacaine-Induced Neurotoxicity in Dorsal Root Ganglion Neurons Through Coactivation of TrkA and TrkB.
Q37479544BDNF mediates neuroprotection against oxygen-glucose deprivation by the cardiac glycoside oleandrin
Q37599609Chronic TrkB agonist treatment in old age does not mitigate diaphragm neuromuscular dysfunction
Q38252739Dynamic nature of the p75 neurotrophin receptor in response to injury and disease
Q92982652Effects of the selective TrkA agonist gambogic amide on pigmentation and growth of human hair follicles in vitro
Q34478681Gram-scale, chemoselective synthesis of N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide (HIOC).
Q94544744Histone Deacetylases Inhibitors in Neurodegenerative Diseases, Neuroprotection and Neuronal Differentiation
Q47280331Modulating Neurotrophin Receptor Signaling as a Therapeutic Strategy for Huntington's Disease
Q47652702Natural product modulators of human sensations and mood: molecular mechanisms and therapeutic potential
Q97882922Neuroprotection Against Oxidative Stress: Phytochemicals Targeting TrkB Signaling and the Nrf2-ARE Antioxidant System
Q35984583Neuroprotective role of an N-acetyl serotonin derivative via activation of tropomyosin-related kinase receptor B after subarachnoid hemorrhage in a rat model
Q38736357Neurotrophin-mimicking peptides at the biointerface with gold respond to copper ion stimuli.

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