The safety and efficacy of {+/-}3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study

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The safety and efficacy of {+/-}3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study is …
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scholarly articleQ13442814

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P356DOI10.1177/0269881110378371
P3181OpenCitations bibliographic resource ID2628116
P932PMC publication ID3122379
P698PubMed publication ID20643699
P5875ResearchGate publication ID45274868

P2093author name stringLisa Jerome
Mark T Wagner
Ann T Mithoefer
Michael C Mithoefer
Rick Doblin
P2860cites workPrevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey ReplicationQ22253031
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in HumansQ22255501
Oxytocin increases trust in humansQ28254266
The origin of MDMA (ecstasy) revisited: the true story reconstructed from the original documentsQ28257990
Oxytocin is associated with human trustworthinessQ28267939
Efficacy and safety of sertraline treatment of posttraumatic stress disorder: a randomized controlled trialQ28377040
A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy")Q28577690
A method of conducting therapeutic sessions with MDMA.Q30432617
Pharmacotherapy for post-traumatic stress disorder - a systematic review and meta-analysis.Q33266344
Human pharmacology of 3,4-methylenedioxymethamphetamine ("ecstasy"): psychomotor performance and subjective effectsQ33911701
Gender differences in the subjective effects of MDMA.Q33943522
Clinician-administered PTSD scale: a review of the first ten years of researchQ33949505
Efficacy and safety of paroxetine treatment for chronic PTSD: a fixed-dose, placebo-controlled studyQ33956204
What is a "mood stabilizer"? An evidence-based responseQ33974918
Combat duty in Iraq and Afghanistan, mental health problems, and barriers to careQ34330469
The epidemiology of posttraumatic stress disorder: what is the extent of the problem?Q34331013
Practice guideline for the treatment of patients with acute stress disorder and posttraumatic stress disorderQ34379429
Ecstasy (MDMA) mimics the post-orgasmic state: impairment of sexual drive and function during acute MDMA-effects may be due to increased prolactin secretionQ34404887
The early history of "Ecstasy"Q34482355
The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): preliminary clinical validityQ34482688
Oxytocin improves "mind-reading" in humansQ34586095
The relative efficacy of bona fide psychotherapies for treating post-traumatic stress disorder: a meta-analysis of direct comparisonsQ34720881
Oxytocin shapes the neural circuitry of trust and trust adaptation in humansQ34781060
Effective psychotherapies for posttraumatic stress disorder: a review and critique.Q34929778
Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration.Q34989613
Do patients drop out prematurely from exposure therapy for PTSD?Q35613612
Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research--past, present, and futureQ36571175
Combining pharmacotherapy with cognitive behavioral therapy: traditional and new approachesQ36639956
Plasma pharmacokinetics of 3,4-methylenedioxymethamphetamine after controlled oral administration to young adultsQ37146495
Pharmacotherapy of posttraumatic stress disorder: a review of meta-analyses and treatment guidelines.Q37377379
Common mental disorders in postconflict settingsQ38965688
Posttraumatic stress disorder in an urban population of young adults: risk factors for chronicityQ39238863
The subjective effects of MDMA and mCPP in moderate MDMA usersQ43803511
Subjective and hormonal effects of 3,4-methylenedioxymethamphetamine (MDMA) in humansQ43841637
Acute psychological effects of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") are attenuated by the serotonin uptake inhibitor citalopramQ43842041
3,4-Methylenedioxymethamphetamine (MDMA) modulates cortical and limbic brain activity as measured by [H(2)(15)O]-PET in healthy humansQ43842046
Paced auditory serial-addition task: a measure of recovery from concussionQ43974735
The experimental use of psychedelic (LSD) psychotherapyQ45078230
Association of cardiovascular risk factors with mental health diagnoses in Iraq and Afghanistan war veterans using VA health careQ45331383
Pharmacological interaction between 3,4-methylenedioxymethamphetamine (ecstasy) and paroxetine: pharmacological effects and pharmacokinetics.Q46985552
Traumatic events and post-traumatic stress disorder in the community: prevalence, risk factors and comorbidityQ47685826
Psychological and cardiovascular effects and short-term sequelae of MDMA ("ecstasy") in MDMA-naïve healthy volunteersQ48788983
The effects of fluoxetine on the subjective and physiological effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans.Q50921579
Emotional processing of fear: exposure to corrective information.Q51217642
The serotonin uptake inhibitor citalopram reduces acute cardiovascular and vegetative effects of 3,4-methylenedioxymethamphetamine ('Ecstasy') in healthy volunteers.Q51971591
Post-traumatic stress reactions in children of war.Q51985926
Burden of medical illness in women with depression and posttraumatic stress disorder.Q51995264
Psychiatric consequences of "ethnic cleansing": clinical assessments and trauma testimonies of newly resettled Bosnian refugeesQ52017354
Vasopressin and oxytocin secretion in response to the consumption of ecstasy in a clubbing population.Q52289049
Psychological and Cardiovascular Effects and Short-Term Sequelae of MDMA (“Ecstasy”) in MDMA-Naïve Healthy VolunteersQ54297095
Psychobiologic effects of 3,4-methylenedioxymethamphetamine in humans: methodological considerations and preliminary observationsQ71489898
Cardiovascular and neuroendocrine effects and pharmacokinetics of 3, 4-methylenedioxymethamphetamine in humansQ77921465
Augmentation of sertraline with prolonged exposure in the treatment of posttraumatic stress disorderQ79318217
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)439-52
P577publication date2011-04-01
P1433published inJournal of PsychopharmacologyQ6295819
P1476titleThe safety and efficacy of {+/-}3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study
P478volume25

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cites work (P2860)
Q47777762(±)-MDMA and its enantiomers: potential therapeutic advantages of R(-)-MDMA.
Q932398103,4-Methylenedioxymethamphetamine (MDMA; ecstasy) use and transitions to injection drug use among street-involved youth
Q388291903,4-Methylenedioxymethamphetamine Increases Affiliative Behaviors in Squirrel Monkeys in a Serotonin 2A Receptor-Dependent Manner.
Q373477193,4-Methylenedioxymethamphetamine facilitates fear extinction learning
Q222992433,4-Methylenedioxymethamphetamine's (MDMA's) Impact on Posttraumatic Stress Disorder
Q581048493,4-Methylenedioxymethamphetamine-assisted psychotherapy for treatment of chronic posttraumatic stress disorder: A randomized phase 2 controlled trial
Q903574903,4-methylenedioxymethamphetamine (MDMA) impairs the extinction and reconsolidation of fear memory in rats
Q885733263,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder in military veterans, firefighters, and police officers: a randomised, double-blind, dose-response, phase 2 clinical trial
Q246027623,4-methylenedioxymethamphetamine (MDMA): current perspectives
Q64070251A Review of 3,4-methylenedioxymethamphetamine (MDMA)-Assisted Psychotherapy
Q46847604A proposal to evaluate mechanistic efficacy of hallucinogens in addiction treatment
Q34309474A randomized, controlled pilot study of MDMA (± 3,4-Methylenedioxymethamphetamine)-assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD).
Q38192959A reconsideration and response to Parrott AC (2013) "Human psychobiology of MDMA or 'Ecstasy': an overview of 25 years of empirical research".
Q28484011A systematic prediction of multiple drug-target interactions from chemical, genomic, and pharmacological data
Q57177225A translational perspective on neural circuits of fear extinction: Current promises and challenges
Q30404060A window into the intoxicated mind? Speech as an index of psychoactive drug effects
Q34674320Acute Effects of the Novel Psychoactive Drug 2C-B on Emotions
Q33635662Acute effects of LSD on amygdala activity during processing of fearful stimuli in healthy subjects.
Q36253278Acute effects of MDMA on autonomic cardiac activity and their relation to subjective prosocial and stimulant effects.
Q30544870Acute prosocial effects of oxytocin and vasopressin when given alone or in combination with 3,4-methylenedioxymethamphetamine in rats: involvement of the V1A receptor
Q38962662Altered Insula Connectivity under MDMA.
Q38015058Amphetamines, the pregnant woman and her children: a review
Q38160918Anxiolytic drug discovery: what are the novel approaches and how can we improve them?
Q64087722Aromatic Bromination Abolishes the Psychomotor Features and Pro-social Responses of MDMA ("Ecstasy") in Rats and Preserves Affinity for the Serotonin Transporter (SERT)
Q90120348Association between posttraumatic stress disorder and nonfatal drug overdose
Q64983258Augmentation of Extinction and Inhibitory Learning in Anxiety and Trauma-Related Disorders.
Q90400310Breakthrough for Trauma Treatment: Safety and Efficacy of MDMA-Assisted Psychotherapy Compared to Paroxetine and Sertraline
Q37337904Carvedilol inhibits the cardiostimulant and thermogenic effects of MDMA in humans: Lost in translation.
Q34535259Clinical applications of hallucinogens: A review
Q37458263Clinically Relevant Pharmacological Strategies That Reverse MDMA-Induced Brain Hyperthermia Potentiated by Social Interaction.
Q52300416Commentary on Coulson & Caulkins (2012): Optimizing drug scheduling.
Q52298270Commentary on Halpern et al. (2011): strengthening the case against functionally significant serotonergic neurotoxicity in human MDMA (ecstasy) users.
Q53449696Considering the context: social factors in responses to drugs in humans.
Q55007454Crime and Violence among MDMA Users in the United States.
Q52803481Current Perspective on MDMA-Assisted Psychotherapy for Posttraumatic Stress Disorder.
Q57176236Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine
Q34544993Decision-making in chronic ecstasy users: a systematic review.
Q47551565Depressive mood ratings are reduced by MDMA in female polydrug ecstasy users homozygous for the l-allele of the serotonin transporter
Q35965775Differences in the locomotor-activating effects of indirect serotonin agonists in habituated and non-habituated rats
Q43842167Differential effects of MDMA and methylphenidate on social cognition.
Q59131907Diminished positive affect and traumatic stress: A biobehavioral review and commentary on trauma affective neuroscience
Q47318737Direct comparison of the acute subjective, emotional, autonomic, and endocrine effects of MDMA, methylphenidate, and modafinil in healthy subjects.
Q93135591Do adjuvant interventions improve treatment outcome in adult patients with posttraumatic stress disorder receiving trauma-focused psychotherapy? A systematic review
Q41932270Does psychedelic drug use reduce risk of suicidality? Evidence from a longitudinal community-based cohort of marginalised women in a Canadian setting
Q24620135Durability of improvement in post-traumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3,4-methylenedioxymethamphetamine-assisted psychotherapy: a prospective long-term follow-up study
Q50574947Effects of MDMA alone and after pretreatment with reboxetine, duloxetine, clonidine, carvedilol, and doxazosin on pupillary light reflex.
Q64217983Effects of MDMA on attention to positive social cues and pleasantness of affective touch
Q53694581Effects of N, N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression.
Q48463442Effects of Schedule I drug laws on neuroscience research and treatment innovation
Q45950720Effects of ecstasy on cooperative behaviour and perception of trustworthiness: a naturalistic study.
Q38966221Electrophysiological Actions of Synthetic Cathinones on Monoamine Transporters
Q34634128Evidence for chronically altered serotonin function in the cerebral cortex of female 3,4-methylenedioxymethamphetamine polydrug users
Q53091817Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: a revision of the 2005 guidelines from the British Association for Psychopharmacology.
Q48105789Experienced drug users assess the relative harms and benefits of drugs: a web-based survey
Q91130379Fear expression is suppressed by tyrosine administration
Q47675823Forbidden therapies: Santo Daime, ayahuasca, and the prohibition of entheogens in Western society
Q58803214Gene expression analysis indicates reduced memory and cognitive functions in the hippocampus and increase in synaptic reorganization in the frontal cortex 3 weeks after MDMA administration in Dark Agouti rats
Q47312691High ambient temperature facilitates the acquisition of 3,4-methylenedioxymethamphetamine (MDMA) self-administration
Q34420092History and future of the Multidisciplinary Association for Psychedelic Studies (MAPS).
Q34359604Human psychobiology of MDMA or 'Ecstasy': an overview of 25 years of empirical research
Q90667604Inclusion of people of color in psychedelic-assisted psychotherapy: a review of the literature
Q38652284Inhibition of serotonin transporters disrupts the enhancement of fear memory extinction by 3,4-methylenedioxymethamphetamine (MDMA).
Q36421673Intimate insight: MDMA changes how people talk about significant others
Q24630561Is ecstasy an "empathogen"? Effects of ±3,4-methylenedioxymethamphetamine on prosocial feelings and identification of emotional states in others
Q38986358Keto amphetamine toxicity-focus on the redox reactivity of the cathinone designer drug mephedrone.
Q47206849Key interindividual determinants in MDMA pharmacodynamics.
Q37262799LSD Acutely Impairs Fear Recognition and Enhances Emotional Empathy and Sociality
Q26799231Legal highs: staying on top of the flood of novel psychoactive substances
Q26859367Lost in translation: preclinical studies on 3,4-methylenedioxymethamphetamine provide information on mechanisms of action, but do not allow accurate prediction of adverse events in humans
Q56961628MDMA
Q37149027MDMA (3,4-Methylenedioxymethamphetamine) Analogues as Tools to Characterize MDMA-Like Effects: An Approach to Understand Entactogen Pharmacology
Q93220727MDMA Increases Cooperation and Recruitment of Social Brain Areas When Playing Trustworthy Players in an Iterated Prisoner's Dilemma
Q34325163MDMA alters emotional processing and facilitates positive social interaction
Q47901966MDMA does not alter responses to the Trier Social Stress Test in humans
Q50592804MDMA enhances "mind reading" of positive emotions and impairs "mind reading" of negative emotions.
Q34375625MDMA enhances emotional empathy and prosocial behavior
Q46749663MDMA enhances hippocampal-dependent learning and memory under restrictive conditions, and modifies hippocampal spine density
Q92483926MDMA enhances pleasantness of affective touch
Q21558551MDMA for the treatment of mood disorder: all talk no substance?
Q59068914MDMA keeps severe stress at bay
Q91839166MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials
Q102379345MDMA-assisted psychotherapy for treatment of anxiety and other psychological distress related to life-threatening illnesses: a randomized pilot study
Q35626948Manganese-enhanced magnetic resonance imaging reveals differential long-term neuroadaptation after methamphetamine and the substituted cathinone 4-methylmethcathinone (mephedrone).
Q39548034Measuring the subjective: revisiting the psychometric properties of three rating scales that assess the acute effects of hallucinogens.
Q55043421Methylenedioxymethamphetamine (MDMA, ‘Ecstasy’): Neurodegeneration versus Neuromodulation.
Q51482161Neurochemical binding profiles of novel indole and benzofuran MDMA analogues.
Q26770106Neuroimaging in moderate MDMA use: A systematic review
Q59791313Neuroscience Informed Prolonged Exposure Practice: Increasing Efficiency and Efficacy Through Mechanisms
Q38191529New phenethylamines in Europe
Q48190285No major role of norepinephrine transporter gene variations in the cardiostimulant effects of MDMA.
Q37422671Nonlinear pharmacokinetics of (+/-)3,4-methylenedioxymethamphetamine (MDMA) and its pharmacodynamic consequences in the rat.
Q34521723Novel psychopharmacological therapies for psychiatric disorders: psilocybin and MDMA.
Q37184290Oxytocin receptor gene variation predicts subjective responses to MDMA.
Q55264971Oxytocin receptor gene variations and socio-emotional effects of MDMA: A pooled analysis of controlled studies in healthy subjects.
Q38442124Oxytocin: parallel processing in the social brain?
Q28070159PTSD: from neurobiology to pharmacological treatments
Q37113859Perspectives on zebrafish models of hallucinogenic drugs and related psychotropic compounds
Q22305514Pharmacological enhancement of exposure-based treatment in PTSD: a qualitative review
Q36851442Pharmacological examination of trifluoromethyl ring-substituted methcathinone analogs
Q27006437Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders
Q26776489Post-traumatic stress disorder
Q93181348Post-traumatic stress disorder: a state-of-the-art review of evidence and challenges
Q89774560Posttraumatic Growth After MDMA-Assisted Psychotherapy for Posttraumatic Stress Disorder
Q58213889Posttraumatic Stress Disorder: An Integrated Overview of the Neurobiological Rationale for Pharmacology
Q47963200Progress and promise for the MDMA drug development program
Q41307521Prosocial effects of MDMA: A measure of generosity.
Q55381227Psilocybin and MDMA reduce costly punishment in the Ultimatum Game.
Q34493217Psychedelic medicine: a re-emerging therapeutic paradigm
Q57309250Psychedelic-Assisted Psychotherapy: A Paradigm Shift in Psychiatric Research and Development
Q30359998Psychedelics
Q89091482Psychedelics Promote Structural and Functional Neural Plasticity
Q47410020Psychedelics and reconsolidation of traumatic and appetitive maladaptive memories: focus on cannabinoids and ketamine
Q29398415Psychoactive Substances and the English Language: “Drugs,” Discourses, and Public Policy
Q24201806Psychological therapies for chronic post-traumatic stress disorder (PTSD) in adults
Q47697448Recreational 3,4-methylenedioxy-N-methylamphetamine (MDMA) or 'ecstasy' and self-focused compassion: Preliminary steps in the development of a therapeutic psychopharmacology of contemplative practices
Q58757402Reduction in social anxiety after MDMA-assisted psychotherapy with autistic adults: a randomized, double-blind, placebo-controlled pilot study
Q91665835Regular MDMA use is associated with decreased risk of drug injection among street-involved youth who use illicit drugs
Q43740653Reply to the letter to the editor by H Chabrol
Q48420021Research on psychedelic substances
Q34645841Residual neurocognitive features of long-term ecstasy users with minimal exposure to other drugs
Q90318457Reviewing the Potential of Psychedelics for the Treatment of PTSD
Q38819567Safety pharmacology of acute MDMA administration in healthy subjects.
Q90400382Self-Rated Effectiveness of Microdosing With Psychedelics for Mental and Physical Health Problems Among Microdosers
Q47769685Self-experimentations with psychedelics among mental health professionals: LSD in the former Czechoslovakia
Q47662199Separating the agony from ecstasy: R(-)-3,4-methylenedioxymethamphetamine has prosocial and therapeutic-like effects without signs of neurotoxicity in mice
Q38600048Serotonin and brain function: a tale of two receptors
Q34640595Shaping the renaissance of psychedelic research
Q48292506Should addiction researchers be interested in psychedelic science?
Q45053309Single oral doses of (±) 3,4-methylenedioxymethamphetamine ('Ecstasy') produce lasting serotonergic deficits in non-human primates: relationship to plasma drug and metabolite concentrations
Q60619766Social Cognition
Q37899850Social, policy, and public health perspectives on new psychoactive substances.
Q27016155Targeting memory processes with drugs to prevent or cure PTSD
Q47640031The 21st century psychedelic renaissance: heroic steps forward on the back of an elephant
Q34659485The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level-Dependent Resting State Functional Connectivity
Q34502080The Psychopharmacology of ±3,4 Methylenedioxymethamphetamine and its Role in the Treatment of Posttraumatic Stress Disorder
Q28806840The association of psychedelic use and opioid use disorders among illicit users in the United States
Q34392399The effect of acutely administered MDMA on subjective and BOLD-fMRI responses to favourite and worst autobiographical memories
Q38937390The effects of MDMA on socio-emotional processing: Does MDMA differ from other stimulants?
Q49357192The hidden therapist: evidence for a central role of music in psychedelic therapy
Q51339121The intersection of structurally traumatized communities and substance use treatment: Dominant discourses and hidden themes.
Q28240897The norepinephrine transporter inhibitor reboxetine reduces stimulant effects of MDMA ("ecstasy") in humans
Q34495787The prosocial effects of 3,4-methylenedioxymethamphetamine (MDMA): Controlled studies in humans and laboratory animals.
Q41254417Therapeutic effect of increased openness: Investigating mechanism of action in MDMA-assisted psychotherapy
Q38023813Therapeutic mechanisms of classic hallucinogens in the treatment of addictions: from indirect evidence to testable hypotheses
Q89716254Translating molecular and neuroendocrine findings in posttraumatic stress disorder and resilience to novel therapies
Q59132161Treating PTSD: A Review of Evidence-Based Psychotherapy Interventions
Q34523797Treating posttraumatic stress disorder with MDMA-assisted psychotherapy: A preliminary meta-analysis and comparison to prolonged exposure therapy
Q38687081Why Psychiatry Needs 3,4-Methylenedioxymethamphetamine: A Child Psychiatrist's Perspective

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