A high level of mutation tolerance in the multifunctional sequence encoding the RNA encapsidation signal of an avian hepatitis B virus and slow evolution rate revealed by in vivo infection

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A high level of mutation tolerance in the multifunctional sequence encoding the RNA encapsidation signal of an avian hepatitis B virus and slow evolution rate revealed by in vivo infection is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.05005-11
P932PMC publication ID3165760
P698PubMed publication ID21752921

P50authorMichael NassalQ55979346
P2093author name stringChristine Rösler
Bernadette Schmid
P2860cites workFitness and its role in evolutionary geneticsQ22122004
Hepatitis B virus replicationQ24563894
Viral mutation ratesQ24611162
Sequence- and structure-specific determinants in the interaction between the RNA encapsidation signal and reverse transcriptase of avian hepatitis B virusesQ24673641
Thermodynamics and NMR studies on Duck, Heron and Human HBV encapsidation signalsQ24677917
Heterologous replacement of the supposed host determining region of avihepadnaviruses: high in vivo infectivity despite low infectivity for hepatocytesQ27318278
A bulged region of the hepatitis B virus RNA encapsidation signal contains the replication origin for discontinuous first-strand DNA synthesisQ28775714
Locating proteins in the cell using TargetP, SignalP and related toolsQ29547300
Rates of evolutionary change in viruses: patterns and determinantsQ29616174
A structural model for duck hepatitis B virus core protein derived by extensive mutagenesis.Q30364727
SELEX-derived aptamers of the duck hepatitis B virus RNA encapsidation signal distinguish critical and non-critical residues for productive initiation of reverse transcriptionQ33206025
Low dynamic state of viral competition in a chronic avian hepadnavirus infectionQ33787127
Frequency of spontaneous mutations in an avian hepadnavirus infectionQ33846377
Nature, position, and frequency of mutations made in a single cycle of HIV-1 replicationQ34120857
Efficient Hsp90-independent in vitro activation by Hsc70 and Hsp40 of duck hepatitis B virus reverse transcriptase, an assumed Hsp90 client protein.Q34212832
In vitro reconstitution of functional hepadnavirus reverse transcriptase with cellular chaperone proteinsQ34327359
Half-life of the duck hepatitis B virus covalently closed circular DNA pool in vivo following inhibition of viral replicationQ34339400
cis -Acting Sequences That Contribute to Synthesis of Minus-Strand DNA Are Not Conserved between HepadnavirusesQ34416515
Hepatitis B virus reverse transcriptase and epsilon RNA sequences required for specific interaction in vitroQ34434801
Conditional replication of duck hepatitis B virus in hepatoma cellsQ34466545
Base pairing between the 5' half of epsilon and a cis-acting sequence, phi, makes a contribution to the synthesis of minus-strand DNA for human hepatitis B virusQ34647380
Base pairing among three cis-acting sequences contributes to template switching during hepadnavirus reverse transcriptionQ34762794
Solution structure of the apical stem-loop of the human hepatitis B virus encapsidation signalQ35130364
Rapid production of neutralizing antibody leads to transient hepadnavirus infectionQ35543965
RNA sequences controlling the initiation and transfer of duck hepatitis B virus minus-strand DNA.Q35841519
A splice hepadnavirus RNA that is essential for virus replication.Q35850499
A novel transcriptional element in circular DNA monomers of the duck hepatitis B virusQ35896223
pet, a small sequence distal to the pregenome cap site, is required for expression of the duck hepatitis B virus pregenome.Q36629024
Novel mechanism for reverse transcription in hepatitis B virusesQ36654275
The duck hepatitis B virus pre-C region encodes a signal sequence which is essential for synthesis and secretion of processed core proteins but not for virus formationQ36919777
Hepatocyte turnover in transient and chronic hepadnavirus infections.Q36980713
A mechanism to explain the selection of the hepatitis e antigen-negative mutant during chronic hepatitis B virus infectionQ37051594
The Conformation of the 3′ End of the Minus-Strand DNA Makes Multiple Contributions to Template Switches during Plus-Strand DNA Synthesis of Duck Hepatitis B VirusQ37060241
Hepatitis B viruses: reverse transcription a different way.Q37109700
Immune selection during chronic hepadnavirus infectionQ37278170
The size of the viral inoculum contributes to the outcome of hepatitis B virus infectionQ37356013
RNA polymerase active center: the molecular engine of transcriptionQ37505069
A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigenQ37571503
Hepatitis B virus resistance to nucleos(t)ide analogues.Q37593697
HIV-1 evolution: frustrating therapies, but disclosing molecular mechanismsQ37755873
Chaperones activate hepadnavirus reverse transcriptase by transiently exposing a C-proximal region in the terminal protein domain that contributes to epsilon RNA bindingQ38297666
Enrichment of a precore-minus mutant of duck hepatitis B virus in experimental mixed infectionsQ39550275
Formation of a functional hepatitis B virus replication initiation complex involves a major structural alteration in the RNA template.Q39576399
A secondary structure that contains the 5' and 3' splice sites suppresses splicing of duck hepatitis B virus pregenomic RNA.Q39685114
New hepatitis B virus of cranes that has an unexpected broad host rangeQ39699896
Evidence for activation of the hepatitis B virus polymerase by binding of its RNA template.Q39875943
Insertions within epsilon affect synthesis of minus-strand DNA before the template switch for duck hepatitis B virusQ39880270
Two regions of an avian hepadnavirus RNA pregenome are required in cis for encapsidation.Q40039911
The sequence of the RNA primer and the DNA template influence the initiation of plus-strand DNA synthesis in hepatitis B virusQ40127432
The encapsidation signal on the hepatitis B virus RNA pregenome forms a stem-loop structure that is critical for its functionQ40409530
Hepatitis B virus nucleocapsids formed by carboxy-terminally mutated core proteins contain spliced viral genomes but lack full-size DNA.Q40487914
Chimeras of duck and heron hepatitis B viruses provide evidence for functional interactions between viral components of pregenomic RNA encapsidationQ40530743
Underrepresentation of the 3' region of the capsid pregenomic RNA of duck hepatitis B virusQ40590011
A pregenomic RNA sequence adjacent to DR1 and complementary to epsilon influences hepatitis B virus replication efficiency.Q40683446
Superinfection exclusion in duck hepatitis B virus infection is mediated by the large surface antigenQ41039030
The reverse transcriptase of hepatitis B virus acts as a protein primer for viral DNA synthesisQ41838728
Chaperone activation of the hepadnaviral reverse transcriptase for template RNA binding is established by the Hsp70 and stimulated by the Hsp90 systemQ41933522
Monoclonal antibodies providing topological information on the duck hepatitis B virus core protein and avihepadnaviral nucleocapsid structure.Q42910725
The persistence in the liver of residual duck hepatitis B virus covalently closed circular DNA is not dependent upon new viral DNA synthesisQ42939279
Sequence comparison of an Australian duck hepatitis B virus strain with other avian hepadnavirusesQ45738931
A small 2'-OH- and base-dependent recognition element downstream of the initiation site in the RNA encapsidation signal is essential for hepatitis B virus replication initiationQ45745460
Competition in vivo between a cytopathic variant and a wild-type duck hepatitis B virusQ45752875
Characterization of age- and dose-related outcomes of duck hepatitis B virus infection.Q45755958
Experimental confirmation of a hepatitis B virus (HBV) epsilon-like bulge-and-loop structure in avian HBV RNA encapsidation signalsQ45764925
Kinetics of duck hepatitis B virus infection following low dose virus inoculation: one virus DNA genome is infectious in neonatal ducksQ45765889
The early host innate immune response to duck hepatitis B virus infectionQ84761188
P4510describes a project that usesImageQuantQ112270642
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectHepatitis B virusQ6844
virologyQ7215
P1104number of pages14
P304page(s)9300-9313
P577publication date2011-07-13
P1433published inJournal of VirologyQ1251128
P1476titleA high level of mutation tolerance in the multifunctional sequence encoding the RNA encapsidation signal of an avian hepatitis B virus and slow evolution rate revealed by in vivo infection
P478volume85

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cites work (P2860)
Q34085801A SELEX-screened aptamer of human hepatitis B virus RNA encapsidation signal suppresses viral replication.
Q41392402Cloning, expression and purification of duck hepatitis B virus (DHBV) core protein and its use in the development of an indirect ELISA for serologic detection of DHBV infection
Q28730089Distinct families of cis-acting RNA replication elements epsilon from hepatitis B viruses
Q34974070Evidence for multiple distinct interactions between hepatitis B virus P protein and its cognate RNA encapsidation signal during initiation of reverse transcription
Q36086762Extensive mutagenesis of the conserved box E motif in duck hepatitis B virus P protein reveals multiple functions in replication and a common structure with the primer grip in HIV-1 reverse transcriptase
Q38645882Few basepairing-independent motifs in the apical half of the avian HBV ε RNA stem-loop determine site-specific initiation of protein-priming.
Q27013849Hepatitis B virus reverse transcriptase: diverse functions as classical and emerging targets for antiviral intervention
Q98469304Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability

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