Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway

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Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway is …
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scholarly articleQ13442814

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P356DOI10.1158/0008-5472.CAN-10-0697
P3181OpenCitations bibliographic resource ID1495919
P932PMC publication ID2940956
P698PubMed publication ID20668064

P50authorGuohui WanQ82663678
P2093author name stringXinna Zhang
Xiongbin Lu
Franklin G Berger
Hexin Chen
Sizolwenkosi Mlotshwa
Vicki Vance
P2860cites workRole of Notch signaling in cell-fate determination of human mammary stem/progenitor cellsQ21195157
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loopQ24297633
Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repairQ24297983
Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent mannerQ24336721
PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpointsQ24527393
miR-15 and miR-16 induce apoptosis by targeting BCL2Q24536069
Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle controlQ24537538
p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiationQ24596239
Prospective identification of tumorigenic breast cancer cellsQ24683474
Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23Q28218453
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activityQ28218469
Causes and consequences of microRNA dysregulation in cancerQ28258994
The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repairQ28278532
The serine-threonine protein phosphatase PPM1D is frequently activated through amplification in aggressive primary breast tumoursQ28279346
Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphataseQ28283888
Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcomeQ28283932
Comprehensive genomic analysis of desmoplastic medulloblastomas: identification of novel amplified genes and separate evaluation of the different histological componentsQ28290477
The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activitiesQ28297958
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cellsQ29616498
Modulation of microRNA processing by p53Q29620776
A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.Q33294239
ATM is down-regulated by N-Myc-regulated microRNA-421.Q33667539
Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiationQ33726581
Stem cells in normal breast development and breast cancerQ35548236
Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expressionQ35568362
Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1DQ36326949
The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.Q36617172
Identification of tumor-initiating cells in a p53-null mouse model of breast cancerQ36762011
Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sitesQ37014644
Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibitionQ39747969
Tiling path genomic profiling of grade 3 invasive ductal breast cancersQ39868704
Increased wild-type p53-induced phosphatase 1 (Wip1 or PPM1D) expression correlated with downregulation of checkpoint kinase 2 in human gastric carcinomaQ40096682
Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D.Q40406429
MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage responseQ41911349
Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage responseQ41967616
An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancersQ42458622
Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targetsQ47848630
Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathwayQ48022280
PPM1D is a potential target for 17q gain in neuroblastomaQ52828743
The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis.Q53595739
Wip1 Phosphatase Modulates ATM-Dependent Signaling PathwaysQ61849111
Stem cell characteristics of transplanted rat mammary clonogensQ73018903
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectDNA damageQ5205747
P304page(s)7176-7186
P577publication date2010-07-28
P1433published inCancer ResearchQ326097
P1476titleOncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway
P478volume70