Next generation sequencing of prostate cancer from a patient identifies a deficiency of methylthioadenosine phosphorylase, an exploitable tumor target

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Next generation sequencing of prostate cancer from a patient identifies a deficiency of methylthioadenosine phosphorylase, an exploitable tumor target is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/1535-7163.MCT-11-0826
P932PMC publication ID3691697
P698PubMed publication ID22252602

P50authorArul ChinnaiyanQ4802034
Martin HirstQ30421490
Mark RubinQ37375521
Francesca DemichelisQ42532145
Himisha BeltranQ90576129
Christopher A MaherQ94483659
Colin CollinsQ104143274
P2093author name stringLadan Fazli
Martin Gleave
Yuwei Wang
Hui Xue
Peter W Gout
Marco Marra
Martin Lubin
Chunxiao Wu
Yuzhuo Wang
Joseph R Bertino
Hongwei Cheng
Sonal Brahmbhatt
Antonio Hurtado-Coll
Stanislav V Volik
Shawn Anderson
Robert H Bell
Anne Haegert
Anna V Lapuk
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Mapping short DNA sequencing reads and calling variants using mapping quality scoresQ24644612
Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanomaQ24685552
Methylthioadenosine phosphorylase, a gene frequently codeleted with p16(cdkN2a/ARF), acts as a tumor suppressor in a breast cancer cell lineQ28215271
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolutionQ29619477
Integrative genomic profiling of human prostate cancerQ29619905
Brain metastasis from prostate small cell carcinoma: not to be neglectedQ30751480
Results of a phase II study with doxorubicin, etoposide, and cisplatin in patients with fully characterized small-cell carcinoma of the prostateQ33343227
Selective killing of tumors deficient in methylthioadenosine phosphorylase: a novel strategyQ33455616
Neuroendocrine differentiation in prostatic carcinomaQ33604393
Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancerQ33730189
Neuroendocrine differentiation in carcinoma of the prostate. Diagnostic, prognostic, and therapeutic implicationsQ34243006
Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer modelsQ34266365
Histologic variants of adenocarcinoma and other carcinomas of prostate: pathologic criteria and clinical significance.Q34429946
Establishment in severe combined immunodeficiency mice of subrenal capsule xenografts and transplantable tumor lines from a variety of primary human lung cancers: potential models for studying tumor progression-related changesQ34544350
Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase.Q34575673
Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancerQ34728470
Down-regulation of methylthioadenosine phosphorylase (MTAP) induces progression of hepatocellular carcinoma via accumulation of 5'-deoxy-5'-methylthioadenosine (MTA).Q34756307
Small cell carcinoma of prostate: Effectiveness of hormonal versus chemotherapyQ35227930
The mighty mouse: genetically engineered mouse models in cancer drug developmentQ36568461
Advances in whole genome sequencing technology.Q37807055
Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity: current strategiesQ37837359
Diagnosing and treating small-cell carcinomas of prostatic originQ39411095
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Insulin receptor expression by human prostate cancersQ39941083
ASAP1, a gene at 8q24, is associated with prostate cancer metastasisQ39976234
A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancersQ40124146
Lack of methylthioadenosine phosphorylase expression in mantle cell lymphoma is associated with shorter survival: implications for a potential targeted therapyQ40267159
An orthotopic metastatic prostate cancer model in SCID mice via grafting of a transplantable human prostate tumor line.Q40374898
Small cell carcinoma of the bladder and prostateQ40379901
Development and characterization of efficient xenograft models for benign and malignant human prostate tissueQ42473593
CDKN2A and MTAP deletions in peritoneal mesotheliomas are correlated with loss of p16 protein expression and poor survivalQ43191497
Homozygous deletion of MTAP gene as a poor prognosticator in gastrointestinal stromal tumorsQ43249140
A phase II multicenter study of L-alanosine, a potent inhibitor of adenine biosynthesis, in patients with MTAP-deficient cancerQ46490111
Neuroendocrine cells in benign and malignant prostate tissue: morphogenesis, proliferation, and androgen receptor status.Q47740760
Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xenograftsQ64387019
The CDKN2A tumor-suppressor locus--a tale of two proteinsQ74357703
Progression of prostate cancer to neuroendocrine cell tumorQ74507669
Morphology and therapeutic strategies for neuroendocrine tumors of the genitourinary tractQ74802832
Neuroendocrine differentiated small cell carcinoma presenting as recurrent prostate cancer after androgen deprivation therapyQ77651935
Establishment of subrenal capsule xenografts of primary human ovarian tumors in SCID mice: potential modelsQ81120942
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectprostate cancerQ181257
patientQ181600
P304page(s)775-83
P577publication date2012-03-01
P1433published inMolecular Cancer TherapeuticsQ2363144
P1476titleNext generation sequencing of prostate cancer from a patient identifies a deficiency of methylthioadenosine phosphorylase, an exploitable tumor target
P478volume11

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