Development of lacosamide for the treatment of partial-onset seizures

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Development of lacosamide for the treatment of partial-onset seizures is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1111/NYAS.12213
P932PMC publication ID3759704
P698PubMed publication ID23859801
P5875ResearchGate publication ID249965205

P2093author name stringPamela Doty
William Byrnes
David Hebert
Francois-Xavier Mathy
James Zackheim
Kelly Simontacchi
P2860cites workPharmacodynamic and pharmacokinetic evaluation of coadministration of lacosamide and an oral contraceptive (levonorgestrel plus ethinylestradiol) in healthy female volunteersQ43587289
Adjunctive lacosamide for partial-onset seizures: Efficacy and safety results from a randomized controlled trialQ46138712
The novel antiepileptic drug lacosamide blocks behavioral and brain metabolic manifestations of seizure activity in the 6 Hz psychomotor seizure modelQ46743536
The social and economic consequences of epilepsy: a controlled national studyQ48319363
EpilepsyQ55899118
Lacosamide neurotoxicity associated with concomitant use of sodium channel-blocking antiepileptic drugs: A pharmacodynamic interaction?Q58449801
Tolerability, pharmacokinetics, and bioequivalence of the tablet and syrup formulations of lacosamide in plasma, saliva, and urine: saliva as a surrogate of pharmacokinetics in the central compartment.Q64984039
Epilepsy after the first drug fails: substitution or add-on?Q73085681
No pharmacokinetic interaction between lacosamide and valproic acid in healthy volunteersQ82918294
Rational polytherapy with lacosamide in clinical practice: results of a Spanish cohort analysis RELACOVAQ83523024
Add-on lacosamide: a retrospective study on the relationship between serum concentration, dosage, and adverse eventsQ85025187
The adverse event profile of lacosamide: a systematic review and meta-analysis of randomized controlled trialsQ27026195
Safety and tolerability of adjunctive lacosamide intravenous loading dose in lacosamide-naive patients with partial-onset seizuresQ30455664
Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy SocietyQ33202108
ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromesQ33252737
A Pooled Analysis of Lacosamide Clinical Trial Data Grouped by Mechanism of Action of Concomitant Antiepileptic DrugsQ33751484
In silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivationQ34055749
Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsyQ34618958
Lacosamide: a review of preclinical properties.Q34623155
Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizuresQ34652020
Intravenous lacosamide as replacement for oral lacosamide in patients with partial-onset seizuresQ34691856
The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels.Q34701722
Disparities in NIH funding for epilepsy researchQ35691548
Combination therapy in epilepsy: when and what to use.Q36622991
Quality-of-life trajectories in epilepsy: a review of the literatureQ37044834
Antiepileptic drug therapy: does mechanism of action matter?Q37901704
Adjunctive lacosamide in clinical practice: sodium blockade with a difference?Q37926255
Sodium channels and the neurobiology of epilepsyQ38035905
Drug binding assays do not reveal specific binding of lacosamide to collapsin response mediator protein 2 (CRMP-2).Q39336259
Long-term safety and efficacy in patients with uncontrolled partial-onset seizures treated with adjunctive lacosamide: results from a Phase III open-label extension trialQ42638125
Intravenous lacosamide as short-term replacement for oral lacosamide in partial-onset seizuresQ42644393
Examining the clinical utility of lacosamide: pooled analyses of three phase II/III clinical trialsQ42797086
Lacosamide as adjunctive therapy for partial-onset seizures: a randomized controlled trialQ43173503
No pharmacokinetic interaction between lacosamide and carbamazepine in healthy volunteersQ43258641
P275copyright licenseCreative Commons Attribution 2.5 GenericQ18810333
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectcarboxylic acidQ134856
amidesQ188777
anticonvulsant agentQ576618
focal epilepsyQ7140388
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)56-68
P577publication date2013-07-01
P1433published inAnnals of the New York Academy of SciencesQ2431664
P1476titleDevelopment of lacosamide for the treatment of partial-onset seizures
P478volume1291

Reverse relations

cites work (P2860)
Q33167023A long-term noninterventional safety study of adjunctive lacosamide therapy in patients with epilepsy and uncontrolled partial-onset seizures
Q40651545Acute or chronic use of lacosamide does not alter its distribution between serum and cerebrospinal fluid
Q51744039Adjunctive Eslicarbazepine Acetate in Pediatric Patients with Focal Epilepsy: A Systematic Review and Meta-Analysis.
Q38244248Advances in epilepsy treatment: lacosamide pharmacokinetic profile
Q38468591Clinical pharmacokinetic and pharmacodynamic profile of lacosamide
Q50599628Cognitive effects of lacosamide as adjunctive therapy in refractory epilepsy.
Q39989931Efficacy and Tolerability of Lacosamide in the Treatment of Children With Refractory Generalized Epilepsy
Q50883978Female anorgasmia induced by lacosamide: Rare or neglected side effect?
Q30399934Lacosamide in status epilepticus: Systematic review of current evidence.
Q49053027Lacosamide inhibits calcitonin gene-related peptide production and release at trigeminal level in the rat.
Q50201563Lacosamide treatment of childhood refractory focal epilepsy: the first reported side effect in paediatric patients
Q52696502Lacosamide-Induced Recurrent Ventricular Tachycardia in the Acute Care Setting.
Q88766207Lacosamide: A Review in Focal-Onset Seizures in Patients with Epilepsy
Q38160816Lacosamide: a review of its use as adjunctive therapy in the management of partial-onset seizures
Q64120050Preparation, Characterization, and Stability Evaluation of Taste-Masking Lacosamide Microparticles
Q87189649Sexual dysfunction induced by lacosamide: An underreported side effect?
Q47419334The effects of lacosamide on cognition, quality-of-life measures, and quality of life in patients with refractory partial epilepsy
Q37722778The efficacy of lacosamide as monotherapy and adjunctive therapy in focal epilepsy and its use in status epilepticus: clinical trial evidence and experience
Q51823925Treatment with lacosamide impedes generalized seizures in a rodent model of cortical dysplasia.

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