Induction of senescence-like phenotypes by forced expression of hic-5, which encodes a novel LIM motif protein, in immortalized human fibroblasts

scientific article

Induction of senescence-like phenotypes by forced expression of hic-5, which encodes a novel LIM motif protein, in immortalized human fibroblasts is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.17.3.1224
P8608Fatcat IDrelease_kuvkaa7cwvdbjm4w5waopeq4mu
P932PMC publication ID231847
P698PubMed publication ID9032249
P5875ResearchGate publication ID14178638

P2093author name stringT Takano
M Oshimura
J Mashimo
K Nose
M Shibanuma
S Imai
E Mochizuki
N Nishiya
R Maniwa
P2860cites workMolecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABLQ24306777
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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinasesQ24319848
Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescenceQ24323214
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Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteinsQ27861094
Existence of high abundance antiproliferative mRNA's in senescent human diploid fibroblastsQ46687908
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screenQ48084448
1.5 kb mRNA abundantly expressed in rat tumors encodes a 37 kilodalton protein in vitroQ48375291
Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma.Q50586207
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Multistep carcinogenesis of normal human fibroblasts. Human fibroblasts immortalized by repeated treatment with Co-60 gamma rays were transformed into tumorigenic cells with Ha-ras oncogenesQ53520574
Copy number of a human type I alpha 2 collagen geneQ67235562
Telomere positional effects and the regulation of cellular senescenceQ68007322
Contact-inhibition-induced quiescent state is marked by intense nuclear expression of statinQ68195923
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Evidence for the recessive nature of cellular immortalityQ71810575
WAF1, a potential mediator of p53 tumor suppressionQ27861121
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p21 is a universal inhibitor of cyclin kinasesQ28257305
The growth arrest-specific gene, gas1, is involved in growth suppressionQ28587372
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pEF-BOS, a powerful mammalian expression vectorQ29547606
E2F: a link between the Rb tumor suppressor protein and viral oncoproteinsQ29618375
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The LIM domain is a modular protein-binding interfaceQ34325141
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Human fibronectin: cell specific alternative mRNA splicing generates polypeptide chains differing in the number of internal repeats.Q35433852
Senescence of immortal human fibroblasts by the introduction of normal human chromosome 6Q35472884
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Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferationQ35614668
Cloning and sequence of a cDNA coding for the human beta-migrating endothelial-cell-type plasminogen activator inhibitorQ36430764
A gene involved in control of human cellular senescence on human chromosome 1qQ36649408
Loss of serum response element-binding activity and hyperphosphorylation of serum response factor during cellular agingQ36658009
Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexesQ36686434
Diverse gene sequences are overexpressed in werner syndrome fibroblasts undergoing premature replicative senescenceQ36727404
The LIM domain: a new structural motif found in zinc-finger-like proteins.Q36728285
Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agentsQ36761728
Growth of immortal simian virus 40 tsA-transformed human fibroblasts is temperature dependentQ36770140
Antisense RNA of proto-oncogene c-fos blocks renewed growth of quiescent 3T3 cellsQ36834831
Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblastsQ36914342
Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cellsQ36958660
Genetic analysis of indefinite division in human cells: evidence for a cell senescence-related gene(s) on human chromosome 4.Q37540466
Senescent cells fail to express cdc2, cycA, and cycB in response to mitogen stimulationQ37639646
Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyreneQ37684502
Replicative senescence: the human fibroblast comes of age.Q37951214
Molecular Genetic Approaches to the Study of Cellular SenescenceQ40431282
Molecular and Cell Biology of Replicative SenescenceQ40431309
Why are human cells resistant to malignant cell transformation in vitro?Q40798787
Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activityQ41272633
Evidence for multiple pathways to cellular senescence.Q41418473
Immortalization-susceptible elements and their binding factors mediate rejuvenation of regulation of the type I collagenase gene in simian virus 40 large T antigen-transformed immortal human fibroblastsQ41431649
Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1.Q41668628
Changes in fibronectin mRNA splicing with in vitro passageQ41673671
Fibronectin expression increases during in vitro cellular senescence: correlation with increased cell areaQ41675923
Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblastsQ41725165
Induction of cellular senescence in immortalized cells by human chromosome 1.Q41744236
Repression of c-fos transcription and an altered genetic program in senescent human fibroblastsQ41748100
The alternative splicing of fibronectin pre-mRNA is altered during aging and in response to growth factorsQ43965576
Regulation of two E2F-related genes in presenescent and senescent human fibroblastsQ44141795
Regulation of collagenase and collagenase mRNA production in early- and late-passage human diploid fibroblastsQ44234904
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)1224-35
P577publication date1997-03-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleInduction of senescence-like phenotypes by forced expression of hic-5, which encodes a novel LIM motif protein, in immortalized human fibroblasts
P478volume17

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cites work (P2860)
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Q37763785Bypassing cellular senescence by genetic screening tools
Q34474505Cbl-c Ubiquitin Ligase Activity Is Increased via the Interaction of Its RING Finger Domain with a LIM Domain of the Paxillin Homolog, Hic 5
Q24318621Cell Adhesion Kinase β Forms a Complex with a New Member, Hic-5, of Proteins Localized at Focal Adhesions
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Q34200801Expression of androgen receptor coactivators in normal and cancer prostate tissues and cultured cell lines
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Q39489450HIC-5: A Mobile Molecular Scaffold Regulating the Anchorage Dependence of Cell Growth
Q36008830Hic-5 Regulates Actin Cytoskeletal Reorganization and Expression of Fibrogenic Markers and Myocilin in Trabecular Meshwork Cells
Q39739902Hic-5 communicates between focal adhesions and the nucleus through oxidant-sensitive nuclear export signal
Q35923246Hic-5 controls BMP4 responses in prostate cancer cells through interacting with Smads 1, 5 and 8
Q35925292Hic-5 promotes invadopodia formation and invasion during TGF-β-induced epithelial-mesenchymal transition.
Q41143061Hic-5 promotes the hypertrophic scar myofibroblast phenotype by regulating the TGF-beta1 autocrine loop.
Q28139714Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain
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Q35618697Lepidopteran DALP, and its mammalian ortholog HIC-5, function as negative regulators of muscle differentiation
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Q46719817Tyrosine-phosphorylated Hic-5 inhibits epidermal growth factor-induced lamellipodia formation

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