Role of the malate-aspartate shuttle on the metabolic response to myocardial ischemia

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Role of the malate-aspartate shuttle on the metabolic response to myocardial ischemia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JTBI.2008.05.033
P932PMC publication ID2572303
P698PubMed publication ID18603266
P5875ResearchGate publication ID5248348
P894zbMATH Open document ID1400.92192

P2093author name stringXin Yu
Gerald M Saidel
Lufang Zhou
Marco E Cabrera
Ming Lu
William C Stanley
P2860cites workSubcellular metabolite transport and carbon isotope kinetics in the intramyocardial glutamate poolQ52304898
Alanine, glutamate, and ammonia exchanges in acutely ischemic swine myocardiumQ52479405
Evidence for electrogenic aspartate transport in rat liver mitochondriaQ54180396
Mechanism of the exchanges catalysed by the oxoglutarate translocatory of rat-heart mitochondria. Kinetics of the exchange reactions between 2-oxoglutarate, malate and malonate.Q54286664
Active downregulation of myocardial energy requirements during prolonged moderate ischemia in swineQ68062806
Intramitochondrial localization of palmityl-CoA dehydrogenase, beta-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase in guinea-pig heartQ68621392
Control of the transport of reducing equivalents across the mitochondrial membrane in perfused rat heartQ68631989
Regulation of glutamate metabolism and interactions with the citric acid cycle in rat heart mitochondriaQ68668871
Electrogenic characteristics of the mitochondrial glutamate-aspartate antiporterQ68844273
Kinetic advantages of hetero-enzyme complexes with glutamate dehydrogenase and the alpha-ketoglutarate dehydrogenase complexQ69652309
Reducing equivalent shuttles in developing porcine myocardium: enhanced capacity in the newborn heartQ71527760
Tricarboxylic acid cycle metabolites during ischemia in isolated perfused rat heartQ71658190
Partitioning of pyruvate between oxidation and anaplerosis in swine heartsQ73112783
Postnatal expression and activity of the mitochondrial 2-oxoglutarate-malate carrier in intact heartsQ73190908
Tricarboxylic acid cycle intermediates in human muscle at rest and during prolonged cyclingQ73281266
Metabolic adaptation of the hypertrophied heart: role of the malate/aspartate and alpha-glycerophosphate shuttlesQ73288483
Ca(2+) activation of heart mitochondrial oxidative phosphorylation: role of the F(0)/F(1)-ATPaseQ73426632
Altered Metabolite Exchange Between Subcellular Compartments in Intact Postischemic Rabbit HeartsQ73554708
The relation between intra- and extramitochondrial pyridine nucleotidesQ79057999
Characterization of a second member of the subfamily of calcium-binding mitochondrial carriers expressed in human non-excitable tissuesQ22011108
Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondriaQ24291715
Characterization of the human heart mitochondrial proteomeQ24294999
Molecular cloning of Aralar, a new member of the mitochondrial carrier superfamily that binds calcium and is present in human muscle and brainQ24309242
The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier proteinQ28137643
Regulation of malate dehydrogenase activity by glutamate, citrate, alpha-ketoglutarate, and multienzyme interactionQ28283642
Ca2+ Activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin: role in the heart malate-aspartate NADH shuttleQ28512011
The Metabolic Significance of the Malate-Aspartate Cycle in HeartQ36709174
Physiological significance of metabolic channellingQ36835187
Cellular magnesium and Na/Mg exchange in heart cellsQ37739410
Effects of Ca2+ on the activities of the calcium-sensitive dehydrogenases within the mitochondria of mammalian tissuesQ38201920
The role of Ca2+ ions in the regulation of intramitochondrial metabolism and energy production in rat heartQ38715240
Microcompartmentation, metabolic channelling and carbohydrate metabolismQ39191800
Metabolite Transport in MitochondriaQ39267391
Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. Potential for pharmacological interventionsQ41387610
Acute hibernation decreases myocardial pyruvate carboxylation and citrate releaseQ43737901
Expression of the aspartate/glutamate mitochondrial carriers aralar1 and citrin during development and in adult rat tissues.Q44041432
Acute myocardial ischemia causes a transmural gradient in glucose extraction but not glucose uptakeQ44075026
Effect of inhibition of Na(+)/Ca(2+) exchanger at the time of myocardial reperfusion on hypercontracture and cell deathQ44100828
Post-ischemic treatment with dipyruvyl-acetyl-glycerol decreases myocardial infarct size in the pigQ44628712
Interrelationships between malate-aspartate shuttle and citric acid cycle in rat heart mitochondriaQ44833779
Step and ramp induction of myocardial ischemia: comparison of in vivo and in silico results.Q45069734
Mechanistic model of cardiac energy metabolism predicts localization of glycolysis to cytosolic subdomain during ischemiaQ45244970
Regulation of lactate production at the onset of ischaemia is independent of mitochondrial NADH/NAD+: insights from in silico studies.Q46751817
A series of cases in which metabolic channelling can decrease the pool size at constant net flux in a simple dynamic channelQ47354574
Warm blood hyperkalaemic reperfusion ('hot shot') prevents myocardial substrate derangement in patients undergoing coronary artery bypass surgeryQ47849050
Ontogeny of malate-aspartate shuttle capacity and gene expression in cardiac mitochondriaQ48039112
Regulation of myocardial substrate metabolism during increased energy expenditure: insights from computational studiesQ51230126
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectapplied mathematicsQ33521
myocardial ischemiaQ6947906
P6104maintained by WikiProjectWikiProject MathematicsQ8487137
P304page(s)466-75
P577publication date2008-09-21
P1433published inJournal of Theoretical BiologyQ2153724
P1476titleRole of the malate-aspartate shuttle on the metabolic response to myocardial ischemia
P478volume254

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cites work (P2860)
Q38747766A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect
Q43283596Amino acid transamination is crucial for ischaemic cardioprotection in normal and preconditioned isolated rat hearts--focus on L-glutamate.
Q92681362Bi-allelic GOT2 Mutations Cause a Treatable Malate-Aspartate Shuttle-Related Encephalopathy
Q48681715Cytosolic Ca2+ regulates the energization of isolated brain mitochondria by formation of pyruvate through the malate–aspartate shuttle
Q39692392Differential susceptibility of mitochondrial complex II to inhibition by oxaloacetate in brain and heart.
Q94672643Distinct pattern of one-carbon metabolism, a nutrient-sensitive pathway, in invasive breast cancer: A metabolomic study
Q37130658Ethanol exposure decreases mitochondrial outer membrane permeability in cultured rat hepatocytes
Q92728754From nutritional wealth to autophagy: In vivo metabolic dynamics in the cytosol, mitochondrion and shuttles of IgG producing CHO cells
Q42371059In vivo analysis of NH4+ transport and central N-metabolism of Saccharomyces cerevisiae under aerobic N-limited conditions.
Q43012366Inhibition of the malate-aspartate shuttle by pre-ischaemic aminooxyacetate loading of the heart induces cardioprotection.
Q41624197Kinetic simulation of malate-aspartate and citrate-pyruvate shuttles in association with Krebs cycle
Q59794815Metabolic engineering of the thermophilic filamentous fungus to produce fumaric acid
Q37846991Metabolic fingerprint of ischaemic cardioprotection: importance of the malate-aspartate shuttle.
Q90608253Metabolomic Fingerprinting of Infants Undergoing Cardiopulmonary Bypass: Changes in Metabolic Pathways and Association With Mortality and Cardiac Intensive Care Unit Length of Stay
Q37373389Modeling cardiac action potential shortening driven by oxidative stress-induced mitochondrial oscillations in guinea pig cardiomyocytes
Q46291291Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses
Q37627779Propofol compared with isoflurane inhibits mitochondrial metabolism in immature swine cerebral cortex
Q94512218Proteomic and metabolomic characterization of cardiac tissue in acute myocardial ischemia injury rats
Q35870299Regulation of Cytosolic and Mitochondrial Oxidation via Malate-Aspartate Shuttle: An Observation Using Dynamic 13C NMR Spectroscopy
Q39637618Sex differences in the regulation of spatially distinct cardiac mitochondrial subpopulations
Q64975929mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function.

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