| scholarly article | Q13442814 |
| P50 | author | Ettore Appella | Q28468958 |
| P2093 | author name string | Makoto Nagashima | |
| Seiichi Takenoshita | |||
| Kensuke Kumamoto | |||
| Jun Yokota | |||
| Taro Yamashita | |||
| Izumi Horikawa | |||
| Curtis C Harris | |||
| Kaori Fujita | |||
| Elisa A Spillare | |||
| P2860 | cites work | Oncogene-Induced Senescence: Putting the Brakes on Tumor Development | Q22065360 |
| ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation | Q24300142 | ||
| ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways | Q24321528 | ||
| Mdm2 promotes the rapid degradation of p53 | Q24322597 | ||
| Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a | Q24324559 | ||
| ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression | Q24338124 | ||
| ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation | Q24529998 | ||
| DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53 | Q24555770 | ||
| A biomarker that identifies senescent human cells in culture and in aging skin in vivo | Q24562644 | ||
| Induction of p53-dependent senescence by the MDM2 antagonist nutlin-3a in mouse cells of fibroblast origin. | Q53536765 | ||
| Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription | Q64380818 | ||
| In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 | Q27642888 | ||
| Transcriptional regulation of the human DNA polymerase delta catalytic subunit gene POLD1 by p53 tumor suppressor and Sp1 | Q28190792 | ||
| The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53 | Q28266637 | ||
| Amplification of a gene encoding a p53-associated protein in human sarcomas | Q28270924 | ||
| A microRNA component of the p53 tumour suppressor network | Q28305330 | ||
| The serial cultivation of human diploid cell strains | Q29547356 | ||
| Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis | Q29547575 | ||
| Active genes are tri-methylated at K4 of histone H3 | Q29547668 | ||
| Genomic maps and comparative analysis of histone modifications in human and mouse | Q29614418 | ||
| Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark | Q29614516 | ||
| Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2 | Q29614519 | ||
| Transcriptional activation of miR-34a contributes to p53-mediated apoptosis | Q29619556 | ||
| p53 in health and disease | Q29619939 | ||
| Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding | Q33895689 | ||
| Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence | Q34196515 | ||
| Regulation of cellular senescence by p53. | Q34254621 | ||
| Phylogenetic analysis of the ING family of PHD finger proteins | Q34346845 | ||
| Tumor suppressor p53 represses transcription of RECQ4 helicase | Q34388704 | ||
| Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy | Q34478557 | ||
| The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress. | Q34498861 | ||
| Transcriptional repression mediated by the p53 tumour suppressor | Q35116644 | ||
| Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. | Q35207550 | ||
| Roles of cyclin D1 and related genes in growth inhibition, senescence and apoptosis | Q35591569 | ||
| p53 Activation by small molecules: application in oncology | Q36184746 | ||
| Chromatin modification and senescence: linkage by tumor suppressors? | Q36445499 | ||
| MDM2 inhibitors for cancer therapy | Q36663493 | ||
| Global genechip profiling to identify genes responsive to p53-induced growth arrest and apoptosis in human lung carcinoma cells | Q38350034 | ||
| Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression | Q38353894 | ||
| Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1alpha and Hdm2. | Q40181750 | ||
| Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1. | Q40200606 | ||
| MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells. | Q40324423 | ||
| Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis | Q40506599 | ||
| Limited role of N-terminal phosphoserine residues in the activation of transcription by p53. | Q40570035 | ||
| Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers | Q40938040 | ||
| Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53. | Q41004423 | ||
| p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1. | Q41061353 | ||
| Enhanced expression of cyclin D1 in senescent human fibroblasts | Q41325876 | ||
| Overexpression of Cyclin D1 Blocks Proliferation of Normal Diploid Fibroblasts | Q41354691 | ||
| Microarray analysis of replicative senescence | Q41693910 | ||
| Tumour biology: senescence in premalignant tumours | Q42802962 | ||
| ING1 represses transcription by direct DNA binding and through effects on p53 | Q44605115 | ||
| Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest | Q48078984 | ||
| P433 | issue | 9 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 3193-203 | |
| P577 | publication date | 2008-05-01 | |
| P1433 | published in | Cancer Research | Q326097 |
| P1476 | title | Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence | |
| P478 | volume | 68 |
| Q43229947 | 'Junk' DNA meets the p53 network |
| Q32174267 | 11q deletion in neuroblastoma: a review of biological and clinical implications. |
| Q64275042 | 5p and 3p Strands of miR-34 Family Members Have Differential Effects in Cell Proliferation, Migration, and Invasion in Cervical Cancer Cells |
| Q37037314 | A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis. |
| Q35503722 | A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition. |
| Q39530180 | Acquisition of p53 mutations in response to the non-genotoxic p53 activator Nutlin-3. |
| Q37706842 | Activation of lung p53 by Nutlin-3a prevents and reverses experimental pulmonary hypertension |
| Q57801328 | Age-related microRNAs in older breast cancer patients: biomarker potential and evolution during adjuvant chemotherapy |
| Q37480646 | Alterations in microRNA expression in stress-induced cellular senescence |
| Q36464573 | Amelioration of radiation esophagitis by orally administered p53/Mdm2/Mdm4 inhibitor (BEB55) or GS-nitroxide |
| Q36023740 | An evaluation of small-molecule p53 activators as chemoprotectants ameliorating adverse effects of anticancer drugs in normal cells |
| Q89718150 | Association Between Polymorphisms in the Promoter Region of microRNA-34b/c and the Chemoradiotherapy Efficacy for Locally Advanced Esophageal Squamous Cell Carcinoma in Chinese Han Population |
| Q37802011 | At the stem of youth and health |
| Q33627853 | Awakening p53 in senescent cells using nutlin-3. |
| Q36442900 | CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells |
| Q35947022 | Cellular senescence and cancer chemotherapy resistance |
| Q37574215 | Cellular senescence mediated by p16INK4A-coupled miRNA pathways |
| Q37392946 | Clinical impact of L1CAM expression measured on the transcriptome level in ovarian cancer. |
| Q35911210 | Converging miRNA functions in diverse brain disorders: a case for miR-124 and miR-126. |
| Q33627871 | Coupling transcriptional and post-transcriptional miRNA regulation in the control of cell fate. |
| Q37962577 | DNA methylation of tumor suppressor miRNA genes: a lesson from the miR-34 family |
| Q37914075 | Delaying vascular aging with Chinese medicine: implications from an overview of the p53 and miR-34s family |
| Q98177854 | Development of MicroRNAs as Potential Therapeutics against Cancer |
| Q39067988 | Differential effects of miR-34c-3p and miR-34c-5p on the proliferation, apoptosis and invasion of glioma cells |
| Q39321877 | E2F-1 promotes DAPK2-induced anti-tumor immunity of gastric cancer cells by targeting miR-34a |
| Q35353609 | E2F1-dependent oncogenic addiction of melanoma cells to MDM2. |
| Q39244957 | Efficient synthesis of RITA and its analogues: derivation of analogues with improved antiproliferative activity via modulation of p53/miR-34a pathway |
| Q37121346 | Elevated miR-34c-5p mediates dermal fibroblast senescence by ultraviolet irradiation |
| Q43515900 | Expression of miR-34c in response to overexpression of Boule and Stra8 in dairy goat male germ line stem cells (mGSCs). |
| Q38234418 | From experimental design to functional gene networks: DNA microarray contribution to skin ageing research |
| Q42611894 | Hyperoxia causes miR-34a-mediated injury via angiopoietin-1 in neonatal lungs |
| Q33574029 | ING proteins as potential anticancer drug targets |
| Q38081784 | ING1 and ING2: multifaceted tumor suppressor genes. |
| Q24312934 | ING2 controls the progression of DNA replication forks to maintain genome stability |
| Q37464728 | ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression. |
| Q38932782 | INGs are potential drug targets for cancer |
| Q38622840 | Identification of Four Oxidative Stress-Responsive MicroRNAs, miR-34a-5p, miR-1915-3p, miR-638, and miR-150-3p, in Hepatocellular Carcinoma |
| Q36805707 | Identifying microRNAs involved in degeneration of the organ of corti during age-related hearing loss. |
| Q35665389 | Ionizing radiation-induced microRNA expression changes in cultured RGC-5 cells |
| Q26859017 | Keep-ING balance: tumor suppression by epigenetic regulation |
| Q35998585 | Lamin B1 loss is a senescence-associated biomarker. |
| Q39548990 | MDM2 antagonists boost antitumor effect of androgen withdrawal: implications for therapy of prostate cancer |
| Q34412235 | Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease |
| Q36528255 | MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9. |
| Q36347188 | MiR-34c suppresses tumor growth and metastasis in nasopharyngeal carcinoma by targeting MET |
| Q53137197 | MicroRNA and cancer. |
| Q37827484 | MicroRNA epigenetics: a new avenue for wound healing research. |
| Q34268278 | MicroRNA expression and clinical outcomes in patients treated with adjuvant chemotherapy after complete resection of non-small cell lung carcinoma |
| Q24644251 | MicroRNA let-7: an emerging next-generation cancer therapeutic |
| Q39545068 | MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function |
| Q38832895 | MicroRNA-34c Downregulation Ameliorates Amyloid-β-Induced Synaptic Failure and Memory Deficits by Targeting VAMP2. |
| Q34221689 | MicroRNA-34c enhances murine male germ cell apoptosis through targeting ATF1. |
| Q37625829 | MicroRNAs in C. elegans Aging: Molecular Insurance for Robustness? |
| Q24652474 | MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8 |
| Q28478852 | Modeling of miRNA and drug action in the EGFR signaling pathway |
| Q34166515 | Necdin, a p53-target gene, is an inhibitor of p53-mediated growth arrest. |
| Q36997802 | New hope for Nutlin-3a therapy for pulmonary arterial hypertension |
| Q37446642 | Nutlin-3 affects expression and function of retinoblastoma protein: role of retinoblastoma protein in cellular response to nutlin-3. |
| Q30487407 | Open access to high-content clonogenic analysis |
| Q39701774 | Persistent p21 expression after Nutlin-3a removal is associated with senescence-like arrest in 4N cells |
| Q36731603 | Pharmacologic activation of p53 by small-molecule MDM2 antagonists |
| Q33533630 | Protection of p53 wild type cells from taxol by nutlin-3 in the combined lung cancer treatment |
| Q33937376 | Rapid and efficient hydrophilicity tuning of p53/mdm2 antagonists |
| Q37957713 | Regulation of p53 by ING family members in suppression of tumor initiation and progression |
| Q35948994 | Regulation of senescence by microRNA biogenesis factors |
| Q49383418 | Relevance of the p53-MDM2 axis to aging |
| Q37464700 | Reviewing the current classification of inhibitor of growth family proteins. |
| Q37660308 | Role of miR-34a as a suppressor of L1CAM in endometrial carcinoma |
| Q33749954 | Role of miR-34c microRNA in the late steps of spermatogenesis |
| Q36903843 | Senescence in tumours: evidence from mice and humans |
| Q49654084 | Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype |
| Q39446764 | Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia. |
| Q24310863 | Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas |
| Q33858272 | The ING gene family in the regulation of cell growth and tumorigenesis |
| Q42084582 | The ING tumor suppressors in cellular senescence and chromatin |
| Q27326718 | The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration. |
| Q28245865 | The miR-34 family in cancer and apoptosis |
| Q34846077 | The multifunctional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell-cycle arrest. |
| Q28259725 | The p53 circuit board |
| Q36111707 | The predictive effect of overexpressed miR-34a on good survival of cancer patients: a systematic review and meta-analysis |
| Q38336979 | The rno-miR-34 family is upregulated and targets ACSL1 in dimethylnitrosamine-induced hepatic fibrosis in rats |
| Q37765520 | The role of MicroRNA in chemical carcinogenesis |
| Q57580223 | The tumor suppressor ING1 contributes to epigenetic control of cellular senescence |
| Q33927117 | Transcriptional and post-transcriptional mechanisms for oncogenic overexpression of ether à go-go K+ channel |
| Q37850681 | Transcriptional regulation of cellular senescence |
| Q39061155 | Truncation of inhibitor of growth family protein 5 effectively induces senescence, but not apoptosis in human tongue squamous cell carcinoma cell line |
| Q33764044 | Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylation |
| Q36234079 | Understanding drugs in breast cancer through drug sensitivity screening |
| Q37802195 | Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies |
| Q24646374 | miR-221 overexpression contributes to liver tumorigenesis |
| Q36064954 | miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis |
| Q39556727 | miR-34C Disrupts the Stemness of Purified CD133+ Prostatic Cancer Stem Cells |
| Q39382230 | miR-34a Inhibits Lung Fibrosis by Inducing Lung Fibroblast Senescence |
| Q89241143 | miR-34a directly targets tRNAiMet precursors and affects cellular proliferation, cell cycle, and apoptosis |
| Q37591525 | miR-34a expression, epigenetic regulation, and function in human placental diseases |
| Q35551925 | miR-34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c-Myc pathway |
| Q39342904 | miR-34a is downregulated in cis-diamminedichloroplatinum treated sinonasal squamous cell carcinoma patients with poor prognosis. |
| Q39465507 | miR-34a predicts survival of Ewing's sarcoma patients and directly influences cell chemo-sensitivity and malignancy |
| Q37681848 | miR-34c attenuates epithelial-mesenchymal transition and kidney fibrosis with ureteral obstruction. |
| Q43794094 | miR-34c works downstream of p53 leading to dairy goat male germline stem-cell (mGSCs) apoptosis |
| Q52686112 | miR-34c-5p promotes eradication of acute myeloid leukemia stem cells by inducing senescence through selective RAB27B targeting to inhibit exosome shedding. |
| Q39251230 | miRNA gene counts in chromosomes vary widely in a species and biogenesis of miRNA largely depends on transcription or post-transcriptional processing of coding genes |
| Q38110520 | miRNA in the regulation of ion channel/transporter expression |
| Q35186872 | microRNA profiling in three main stages during porcine spermatogenesis |
| Q28587920 | p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication |
| Q36401999 | p53 N-terminal phosphorylation: a defining layer of complex regulation |
| Q37714779 | p53 and NF-κB coregulate proinflammatory gene responses in human macrophages |
| Q33576299 | p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence |
| Q37010494 | p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation. |
| Q39810065 | p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC. |
| Q35190108 | p53: guardian of ploidy |
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