An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation

scientific article

An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CELL.2009.10.014
P3181OpenCitations bibliographic resource ID247805
P932PMC publication ID2783826
P698PubMed publication ID19878981
P5875ResearchGate publication ID38057262

P2093author name stringKevin Struhl
Heather A Hirsch
Dimitrios Iliopoulos
P2860cites workLin28 mediates the terminal uridylation of let-7 precursor MicroRNAQ24308839
MicroRNAs: target recognition and regulatory functionsQ24609584
Selective blockade of microRNA processing by Lin28Q24609864
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancersQ24625794
The epithelial-mesenchymal transition generates cells with properties of stem cellsQ24650786
Suppression of non-small cell lung tumor development by the let-7 microRNA familyQ24651985
Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformationQ24658400
RAS is regulated by the let-7 microRNA familyQ27860522
MicroRNA expression profiles classify human cancersQ28032481
Inflammation and cancer: back to Virchow?Q28036756
Cancer genes and the pathways they controlQ28275089
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancerQ29614594
Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10Q29615921
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cellsQ29616498
Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell propertiesQ29636244
IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapyQ34048503
Rules for making human tumor cellsQ34159004
HLXB9 activates IL6 in Hodgkin lymphoma cell lines and is regulated by PI3K signalling involving E2F3.Q34403841
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remissionQ34611836
Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activityQ34680041
DNA methylation and gene silencing in cancerQ36338042
STAT3 as a central mediator of neoplastic cellular transformationQ36665485
Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cellsQ36787387
NF-kappaB and cancer-identifying targets and mechanismsQ36984251
Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesisQ37255168
Elevated biomarkers of inflammation are associated with reduced survival among breast cancer patientsQ37280710
Lin28 promotes transformation and is associated with advanced human malignanciesQ37377572
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesisQ38290076
Tumor necrosis factor-alpha activation of nuclear transcription factor-kappaB in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha.Q38331977
Src tyrosine kinases mediate activations of NF-kappaB and integrin signal during lipopolysaccharide-induced acute lung injuryQ38503682
Characterization of a subpopulation of colon cancer cells with stem cell-like propertiesQ39906634
An elaborate pathway required for Ras-mediated epigenetic silencingQ40062561
Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis.Q40105282
Interleukin-6 is a potent growth factor for ER-alpha-positive human breast cancerQ40116321
Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cellsQ40190617
MicroRNAs and cancer: short RNAs go a long way.Q41906288
Interleukin-6 activates PI3K/Akt pathway and regulates cyclin A1 to promote prostate cancer cell survival.Q46890187
Binding reactions: epigenetic switches, signal transduction and cancer.Q51751263
MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells.Q52582850
gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.Q53418407
Deletion of NEMO/IKKγ in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular CarcinomaQ58619568
Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomasQ59077136
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectmicroRNAQ310899
NF-κBQ411114
inflammationQ101991
P304page(s)693-706
P577publication date2009-11-13
P1433published inCellQ655814
P1476titleAn epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation
P478volume139

Reverse relations

cites work (P2860)
Q36369415A 3'-untranslated region KRAS variant and triple-negative breast cancer: a case-control and genetic analysis
Q38434103A Constitutive Intrinsic Inflammatory Signaling Circuit Composed of miR-196b, Meis2, PPP3CC, and p65 Drives Prostate Cancer Castration Resistance
Q50220279A New Concept of the Old Inhibitor NSC 74859 in Alleviating Cardiac Allograft Rejection and Extending Allograft Survival in Mice.
Q35557213A New Paradigm to Mitigate Osteosarcoma by Regulation of MicroRNAs and Suppression of the NF-κB Signaling Cascade
Q42504892A Rapid Induction Mechanism for Lin28a in Trophic Responses
Q64898796A Role for NF-κB in Organ Specific Cancer and Cancer Stem Cells.
Q35034064A Role for PML in Innate Immunity
Q24595689A Yin-Yang balancing act of the lin28/let-7 link in tumorigenesis
Q36519330A cardiac myocyte-restricted Lin28/let-7 regulatory axis promotes hypoxia-mediated apoptosis by inducing the AKT signaling suppressor PIK3IP1.
Q38241837A clinical perspective on the role of chronic inflammation in gastrointestinal cancer
Q27329871A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses
Q37264387A feedback loop consisting of microRNA 23a/27a and the β-like globin suppressors KLF3 and SP1 regulates globin gene expression
Q36188784A functional module-based exploration between inflammation and cancer in esophagus
Q34568201A mathematical model for microRNA in lung cancer
Q24602478A miR-19 regulon that controls NF-κB signaling
Q60959946A miRNA Host Response Signature Accurately Discriminates Acute Respiratory Infection Etiologies
Q38746340A miRNA signature for an environmental heterocyclic amine defined by a multi-organ carcinogenicity bioassay in the rat.
Q35471875A microRNA signature in pediatric ulcerative colitis: deregulation of the miR-4284/CXCL5 pathway in the intestinal epithelium.
Q37998956A mirror of two faces: Lin28 as a master regulator of both miRNA and mRNA.
Q31151086A model for the epigenetic switch linking inflammation to cell transformation: deterministic and stochastic approaches
Q28393278A multi-targeted approach to suppress tumor-promoting inflammation
Q36974721A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells
Q35831031A novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties.
Q35931759A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells
Q36989920A plasma microRNA signature of acute lentiviral infection: biomarkers of central nervous system disease
Q37329811A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways.
Q24615147A requirement for nuclear factor-kappaB in developmental and plasticity-associated synaptogenesis
Q33905329A retroviral mutagenesis screen identifies Cd74 as a common insertion site in murine B-lymphomas and reveals the existence of a novel IFNgamma-inducible Cd74 isoform
Q38863385A role of uridylation pathway for blockade of let-7 microRNA biogenesis by Lin28B.
Q96641372A single-cell landscape of high-grade serous ovarian cancer
Q52562647A step-by-step microRNA guide to cancer development and metastasis.
Q38434033A subset of microRNAs defining the side population of a human malignant mesothelioma cell line
Q33789567A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases
Q30558722A transient reversal of miRNA-mediated repression controls macrophage activation
Q35950161A two-SNP IL-6 promoter haplotype is associated with increased lung cancer risk
Q37185320ANTXR1, a stem cell-enriched functional biomarker, connects collagen signaling to cancer stem-like cells and metastasis in breast cancer.
Q35963779ARTD1 Suppresses Interleukin 6 Expression by Repressing MLL1-Dependent Histone H3 Trimethylation.
Q35626060ASK1 modulates the expression of microRNA Let7A in microglia under high glucose in vitro condition.
Q54120049ATM inhibition prevents interleukin-6 from contributing to the proliferation of glioblastoma cells after ionizing radiation.
Q38241292Aberrant regulation and function of microRNAs in cancer.
Q35881362Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancer
Q86049599Abrogation of galectin-4 expression promotes tumorigenesis in colorectal cancer
Q57073784Abundantly Present miRNAs in Milk-Derived Extracellular Vesicles Are Conserved Between Mammals
Q91795741Achillea Wilhelmsii C. KochHydroalcoholic Extract Induces Apoptosis and Alters LIN28B and p53 Gene Expression in Hela Cervical Cancer Cells
Q30852504Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells
Q36204104Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population.
Q64252260Acute Spinal Cord Injury: A Systematic Review Investigating miRNA Families Involved
Q36065109Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation
Q35085751Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation
Q38928108Alterations in microRNA expression profiles in inflamed and non-inflamed ascending colon mucosae of patients with active Crohn';s disease
Q35655840Alterations in microRNAs miR-21 and let-7a correlate with aberrant STAT3 signaling and downstream effects during cervical carcinogenesis
Q41659058Altered microRNA expression profiles in lung damage induced by nanosized SiO2.
Q37578724Alternative Interventions to Prevent Oxidative Damage following Ischemia/Reperfusion
Q35654340An HNF4α-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis
Q42182457An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses.
Q39793622An RNA element in human interleukin 6 confers escape from degradation by the gammaherpesvirus SOX protein
Q28592449An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates
Q41771642An autoinflammatory neurological disease due to interleukin 6 hypersecretion
Q90481740An evolving paradigm of cancer stem cell hierarchies: therapeutic implications
Q84758414An inflammatory proposal for hepatocarcinogenesis
Q36221885An integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell state
Q31125562Analysis of Mass Spectrometry Data for Nucleolar Proteomics Experiments
Q28308235Analysis of the host microRNA response to Salmonella uncovers the control of major cytokines by the let-7 family
Q35653619Anti-Warburg effect of rosmarinic acid via miR-155 in gastric cancer cells
Q28483751Anti-cancer activity of a novel small molecule compound that simultaneously activates p53 and inhibits NF-κB signaling
Q49446345Anti-inflammatory Effects of Phyllanthus emblica L on Benzopyrene-Induced Precancerous Lung Lesion by Regulating the IL-1β/miR-101/Lin28B Signaling Pathway.
Q33692555Anticancer Role of PPARgamma Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes.
Q36224715Association between IL6 -174G/C and cancer: A meta-analysis of 105,482 individuals.
Q40602555Association between tuberculosis and circulating microRNA hsa-let-7b and hsa-miR-30b: A pilot study in a Chinese population
Q36107142Association of MicroRNAs with Antibody Response to Mycoplasma bovis in Beef Cattle
Q37689058Autocrine interleukin-23 promotes self-renewal of CD133+ ovarian cancer stem-like cells
Q35711047BTB-Zinc Finger Oncogenes Are Required for Ras and Notch-Driven Tumorigenesis in Drosophila.
Q38952569Bidirectional effect of CD200 on breast cancer development and metastasis, with ultimate outcome determined by tumor aggressiveness and a cancer-induced inflammatory response
Q33855695Bistability and oscillations in gene regulation mediated by small noncoding RNAs
Q34487034Bistable switch in let-7 miRNA biogenesis pathway involving Lin28.
Q37294594Bone marrow mesenchymal stem cells for post-myocardial infarction cardiac repair: microRNAs as novel regulators
Q38237483Breaking the cycle: the role of omega-3 polyunsaturated fatty acids in inflammation-driven cancers
Q63365619Breast Cancer and miR-SNPs: The Importance of miR Germ-Line Genetics
Q38226597Breast cancer stem cells and the immune system: promotion, evasion and therapy.
Q38765793Breast cancer stem cells programs: enter the (non)-code.
Q35571904Breast cancer stem cells, cytokine networks, and the tumor microenvironment
Q38074394Breast cancer stem cells: an update
Q46260559Breast cancer stem cells: we've got them surrounded
Q37973821Breast-cancer stem cells-beyond semantics
Q64967681C/EBPβ-LIP induces cancer-type metabolic reprogramming by regulating the let-7/LIN28B circuit in mice.
Q36299728CCL18-mediated down-regulation of miR98 and miR27b promotes breast cancer metastasis
Q54222396CD200fc enhances anti-tumoral immune response and inhibits visceral metastasis of breast carcinoma.
Q39549719CPEB control of NF-kappaB nuclear localization and interleukin-6 production mediates cellular senescence
Q35590108Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress
Q26765342Cancer Stem Cells and Macrophages: Implications in Tumor Biology and Therapeutic Strategies
Q26747518Cancer Stem Cells: The Potential Targets of Chinese Medicines and Their Active Compounds
Q84408315Cancer and diabetes: are we ready for prime time?
Q36257990Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host
Q39171071Cancer metastasis - tricks of the trade
Q42540118Cancer stem cell and stromal microenvironment
Q37129887Cancer stem cells in breast cancer
Q26771651Cancer stem cells: a metastasizing menace!
Q38476034Cancer stem cells: a potential target for cancer therapy
Q84109267Cancer stem cells: nature versus nurture
Q35586803Canonical and non-canonical NF-κB signaling promotes breast cancer tumor-initiating cells
Q39140489Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells
Q36729403Caveolin-1 regulates cancer cell metabolism via scavenging Nrf2 and suppressing MnSOD-driven glycolysis
Q36409664Cell of origin determines clinically relevant subtypes of MLL-rearranged AML
Q37403811Cellular and urinary microRNA alterations in NZB/W mice with hydroxychloroquine or prednisone treatment
Q64051825Central role of IPR2-mediated Ca oscillation in self-renewal of liver cancer stem cells elucidated by high-signal ER sensor
Q36485209Characterization of autoimmune inflammation induced prostate stem cell expansion
Q38775227Chemopreventive effect of 18β-glycyrrhetinic acid via modulation of inflammatory markers and induction of apoptosis in human hepatoma cell line (HepG2).
Q34056549Chromatinized protein kinase C-θ directly regulates inducible genes in epithelial to mesenchymal transition and breast cancer stem cells
Q26801596Chronic inflammation and the development of malignancy in the GI tract
Q36055039Chronic inflammation, immune escape, and oncogenesis in the liver: a unique neighborhood for novel intersections
Q91018298Circulating inflammation signature predicts overall survival and relapse-free survival in metastatic colorectal cancer
Q47111006Circulating miR-125a but not miR-125b is decreased in active disease status and negatively correlates with disease severity as well as inflammatory cytokines in patients with Crohn's disease
Q41391829Circulating miRNAs as new activators of the JAK-STAT3 pathway
Q52912801Circulating miRNAs in Murine Experimental Endometriosis.
Q35806035Circulating microRNAs in Sera Correlate with Soluble Biomarkers of Immune Activation but Do Not Predict Mortality in ART Treated Individuals with HIV-1 Infection: A Case Control Study
Q35953283Clinical and subclinical endometritis induced alterations in bovine endometrial transcriptome and miRNome profile
Q89896570Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role
Q37970398Colorectal cancer mouse models: integrating inflammation and the stroma
Q36160774Combined application of anti-VEGF and anti-EGFR attenuates the growth and angiogenesis of colorectal cancer mainly through suppressing AKT and ERK signaling in mice model
Q26777882Common stemness regulators of embryonic and cancer stem cells
Q28943271Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma
Q35772708Concise Review: Targeting Cancer Stem Cells Using Immunologic Approaches
Q33975619Concise review: breast cancer stem cells: regulatory networks, stem cell niches, and disease relevance
Q41070980Concurrent treatment with simvastatin and NF-κB inhibitor in human castration-resistant prostate cancer cells exerts synergistic anti-cancer effects via control of the NF-κB/LIN28/let-7 miRNA signaling pathway.
Q33572246Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR.
Q39550421Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer
Q28727361Cooperative interaction between the MUC1-C oncoprotein and the Rab31 GTPase in estrogen receptor-positive breast cancer cells
Q64279791Critical role of Lin28-TNFR2 signalling in cardiac stem cell activation and differentiation
Q38567932Current position of TNF-α in melanomagenesis
Q36052395DNA damage induces NF-κB-dependent microRNA-21 up-regulation and promotes breast cancer cell invasion
Q38086764Deciphering microRNA code in pain and inflammation: lessons from bladder pain syndrome
Q90059367Deregulation of miR-27a may contribute to canine fibroblast activation after coculture with a mast cell tumour cell line
Q35191416Deregulation of microRNAs Let-7a and miR-21 mediate aberrant STAT3 signaling during human papillomavirus-induced cervical carcinogenesis: role of E6 oncoprotein
Q38777530Developments in miRNA gene signaling pathways in pancreatic cancer
Q36637909Diabetes and risk of cancer
Q41642286Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family
Q91650266Differences in the miRNA signatures of chronic musculoskeletal pain patients from neuropathic or nociceptive origins
Q41717573Differential Serum Cytokine Profiles in Patients with Chronic Hepatitis B, C, and Hepatocellular Carcinoma.
Q30408164Differential microRNA expression and virulence of avian, 1918 reassortant, and reconstructed 1918 influenza A viruses
Q34202869Differential motif enrichment analysis of paired ChIP-seq experiments
Q34467897Differentiation therapy: sesamin as an effective agent in targeting cancer stem-like side population cells of human gallbladder carcinoma
Q36574049Dimethyl Fumarate Inhibits the Nuclear Factor κB Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein
Q36673216Direct reprogramming by oncogenic Ras and Myc.
Q34569164Discovery and analysis of consistent active sub-networks in cancers
Q40036227Discriminating metastasised from non-metastasised seminoma based on transcriptional changes in primary tumours using NGS.
Q47138550Dissecting cellular senescence and SASP in Drosophila
Q35091322Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging.
Q35788952Disulfiram modulates stemness and metabolism of brain tumor initiating cells in atypical teratoid/rhabdoid tumors
Q50302643Donor-dependent variances of human adipose-derived stem cells in respect to the in-vitro endothelial cell differentiation capability.
Q24598592Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells
Q33705487Down-regulation of Forkhead box protein A1 (FOXA1) leads to cancer stem cell-like properties in tamoxifen-resistant breast cancer cells through induction of interleukin-6
Q37939734Drosophila as a model of wound healing and tissue regeneration in vertebrates
Q34458779Drosophila melanogaster as a model for human intestinal infection and pathology
Q35022538Dual roles of immune cells and their factors in cancer development and progression
Q37641700Dynamic Interactions Between Cancer Stem Cells And Their Stromal Partners
Q27025321Dynamic aberrant NF-κB spurs tumorigenesis: a new model encompassing the microenvironment
Q38038526Dynamic regulation of cancer stem cells and clinical challenges
Q36414449EBV-encoded RNA via TLR3 induces inflammation in nasopharyngeal carcinoma
Q35110754Early life ozone exposure results in dysregulated innate immune function and altered microRNA expression in airway epithelium
Q35956057Ectopic over-expression of tristetraprolin in human cancer cells promotes biogenesis of let-7 by down-regulation of Lin28
Q64104666Eicosapentaenoic Acid Improves Hepatic Metabolism and Reduces Inflammation Independent of Obesity in High-Fat-Fed Mice and in HepG2 Cells
Q35640263Elevated PI3K signaling drives multiple breast cancer subtypes
Q37254527Elevation of Il6 is associated with disturbed let-7 biogenesis in a genetic model of depression
Q38161379Emerging Evidence for MicroRNAs as Regulators of Cancer Stem Cells
Q37793651Emerging complexity of microRNA generation cascades.
Q35042179Emerging role of microRNA in hepatocellular carcinoma (Review)
Q64974925Endocrine Resistance in Hormone Receptor Positive Breast Cancer-From Mechanism to Therapy.
Q49735688Endurance training remodels sperm-borne small RNA expression and methylation at neurological gene hotspots.
Q36141832Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma
Q39077807Entangling Relation of Micro RNA-let7, miRNA-200 and miRNA-125 with Various Cancers
Q38771120Envisioning metastasis as a transdifferentiation phenomenon clarifies discordant results on cancer
Q50876226Epididymosomes convey different repertoires of microRNAs throughout the bovine epididymis.
Q35668617Epigenetic Regulation by Sulforaphane: Opportunities for Breast and Prostate Cancer Chemoprevention
Q90311523Epigenetic Regulation of Inflammatory Cytokine-Induced Epithelial-To-Mesenchymal Cell Transition and Cancer Stem Cell Generation
Q37830385Epigenetic aberrations during oncogenesis.
Q24629061Epigenetic control of the basal-like gene expression profile via Interleukin-6 in breast cancer cells
Q37823067Epigenetic mechanisms in inflammation
Q37983751Epigenetic memories: structural marks or active circuits?
Q26766149Epigenetic modulators, modifiers and mediators in cancer aetiology and progression
Q37591522Epigenetic regulation of miR-21 in colorectal cancer: ITGB4 as a novel miR-21 target and a three-gene network (miR-21-ITGΒ4-PDCD4) as predictor of metastatic tumor potential.
Q33965374Epigenetic response in mice mastitis: Role of histone H3 acetylation and microRNA(s) in the regulation of host inflammatory gene expression during Staphylococcus aureus infection
Q36820068Epigenetics: core misconcept
Q37149898Epstein-Barr Virus Infection of Mammary Epithelial Cells Promotes Malignant Transformation
Q35164627Essential role of Stat3 in PI3K-induced oncogenic transformation
Q36751314Exploring the RNA world in hematopoietic cells through the lens of RNA-binding proteins.
Q40256299Expression and associations of TRAF1, BMI-1, ALDH1, and Lin28B in oral squamous cell carcinoma
Q33918920Expression and interdependencies of pluripotency factors LIN28, OCT3/4, NANOG and SOX2 in human testicular germ cells and tumours of the testis.
Q92714867Expression of NF-κB and TLR-4 is associated with the occurrence, progression and prognosis of esophageal squamous cell carcinoma
Q39090949Expression of microRNA-1234 related signal transducer and activator of transcription 3 in patients with diffuse large B-cell lymphoma of activated B-cell like type from high and low infectious disease areas.
Q37179330Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism
Q91645573From Endogenous to Synthetic microRNA-Mediated Regulatory Circuits: An Overview
Q39045034From cell biology to immunology: Controlling metastatic progression of cancer via microRNA regulatory networks
Q28383729From hepatitis to hepatocellular carcinoma: a proposed model for cross-talk between inflammation and epigenetic mechanisms
Q35048239Functional analysis of microRNAs in human hepatocellular cancer stem cells
Q37171591Functional characteristics of a double negative feedback loop mediated by microRNAs
Q34034676Functional heterogeneity of breast fibroblasts is defined by a prostaglandin secretory phenotype that promotes expansion of cancer-stem like cells
Q28267167Functional screen analysis reveals miR-26b and miR-128 as central regulators of pituitary somatomammotrophic tumor growth through activation of the PTEN-AKT pathway
Q92759029G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis
Q47336078Gene silencing is an ancient means of producing multiple phenotypes from the same genotype: common mechanisms and functions in epigenetic processes can be seen throughout all life forms.
Q38198930Genetic Interactions of STAT3 and Anticancer Drug Development
Q36354844Genetic polymorphism directs IL-6 expression in fibroblasts but not selected other cell types.
Q39273903Genetic susceptibility to neuroblastoma
Q37736272Genetic variants in let-7/Lin28 modulate the risk of oral cavity cancer in a Chinese Han population.
Q34138157Genetic variants of the LIN28B gene predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy
Q59335750Genome-Wide Profiling of -Responsive MicroRNAs in the Exotic Whitefly, (Gennadius) Biotype Q
Q55362433Genome-scale identification of transcription factors that mediate an inflammatory network during breast cellular transformation.
Q36021530Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice
Q92015199Genome-wide characterization of cytosine-specific 5-hydroxymethylation in normal breast tissue
Q34412371Genomic DNA copy-number alterations of the let-7 family in human cancers
Q21144942Germline genetic variants disturbing the Let-7/LIN28 double-negative feedback loop alter breast cancer susceptibility
Q30417691Gestational diabetes mellitus: a positive predictor of type 2 diabetes?
Q40116157Glioblastoma cellular cross-talk converges on NF-κB to attenuate EGFR inhibitor sensitivity.
Q37368282Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8.
Q90013370H. pylori infection induced BMAL1 expression and rhythm disorder aggravate gastric inflammation
Q57283292HER2 in stemness and epithelial-mesenchymal plasticity of breast cancer
Q24598092HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis
Q49571851HER2 overexpression triggers an IL-1α pro-inflammatory circuit to drive tumorigenesis and promote chemotherapy resistance.
Q52632731HOXB7 overexpression in lung cancer is a hallmark of acquired stem-like phenotype.
Q42218400HPV16 E2-mediated potentiation of NF-κB activation induced by TNF-α involves parallel activation of STAT3 with a reduction in E2-induced apoptosis
Q59354958HTLV-1-Mediated Epigenetic Pathway to Adult T-Cell Leukemia-Lymphoma
Q37476039Harnessing the immune system for the treatment of breast cancer
Q30422950Helicobacter pylori infection induced gastric cancer; advance in gastric stem cell research and the remaining challenges
Q39210813Hepatitis B virus X protein upregulates Lin28A/Lin28B through Sp-1/c-Myc to enhance the proliferation of hepatoma cells.
Q27024630Hepatitis B virus and microRNAs: Complex interactions affecting hepatitis B virus replication and hepatitis B virus-associated diseases
Q41721730Heterochromatin Reduction Correlates with the Increase of the KDM4B and KDM6A Demethylases and the Expression of Pericentromeric DNA during the Acquisition of a Transformed Phenotype
Q92921699High Mobility Group A (HMGA): Chromatin Nodes Controlled by a Knotty miRNA Network
Q35889900High expression of Lin28 is associated with tumour aggressiveness and poor prognosis of patients in oesophagus cancer
Q36557288High throughput screening of cytokines, chemokines and matrix metalloproteinases in wound fluid induced by mammary surgery.
Q35309505Histone deacetylase 9 deficiency protects against effector T cell-mediated systemic autoimmunity
Q38271597Histone modifications: Targeting head and neck cancer stem cells
Q36204859How does Lin28 let-7 control development and disease?
Q38143961How should we define STAT3 as an oncogene and as a potential target for therapy?
Q33724285How to train your dragon: targeted delivery of microRNA to cancer cells in vivo
Q35683596Hsp27 participates in the maintenance of breast cancer stem cells through regulation of epithelial-mesenchymal transition and nuclear factor-κB.
Q28681257Human RGM249-derived small RNAs potentially regulate tumor malignancy
Q36127389IL-1β induces IL-6 production and increases invasiveness and estrogen-independent growth in a TG2-dependent manner in human breast cancer cells
Q39569042IL-1β-stimulated β-catenin up-regulation promotes angiogenesis in human lung-derived mesenchymal stromal cells through a NF-κB-dependent microRNA-433 induction
Q39255906IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development
Q38982850IL-6 enriched lung cancer stem-like cell population by inhibition of cell cycle regulators via DNMT1 upregulation
Q55262308IL-6 influences the polarization of macrophages and the formation and growth of colorectal tumor.
Q35369944IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells
Q37679965IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis
Q34346672IL6 genotype, tumour ER-status, and treatment predicted disease-free survival in a prospective breast cancer cohort
Q35869752IL6-mediated suppression of miR-200c directs constitutive activation of inflammatory signaling circuit driving transformation and tumorigenesis
Q37507920IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer
Q34578702Identification of a set of miRNAs differentially expressed in transiently TIA-depleted HeLa cells by genome-wide profiling
Q51380778Identification of key regulators and their controlling mechanism in a combinatorial apoptosis network: a systems biology approach.
Q33588191Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling
Q41889151Identification of mRNAs bound and regulated by human LIN28 proteins and molecular requirements for RNA recognition
Q33718927Identification of microRNAs regulating reprogramming factor LIN28 in embryonic stem cells and cancer cells.
Q35021710Identification of microRNAs that regulate TLR2-mediated trophoblast apoptosis and inhibition of IL-6 mRNA.
Q35675564Identification of small molecule inhibitors of Zcchc11 TUTase activity
Q33692886Identification of small molecule inhibitors of the Lin28-mediated blockage of pre-let-7g processing
Q36039259Identification of the MicroRNA Repertoire in TLR-Ligand Challenged Bubaline PBMCs as a Model of Bacterial and Viral Infection
Q38206386Immune regulation of therapy-resistant niches: emerging targets for improving anticancer drug responses
Q47653834Immune-pineal axis - acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes.
Q36082773Immunopathologic processes in sympathetic ophthalmia as signified by microRNA profiling
Q38787696Immunotherapy for breast cancer: past, present, and future
Q36502969Impact of single-nucleotide polymorphisms on radiation pneumonitis in cancer patients
Q36636779Impaired mitochondrial metabolism and mammary carcinogenesis
Q38840533Improving stem cell therapy in cardiovascular diseases: the potential role of microRNA.
Q37854175Impulse control: temporal dynamics in gene transcription
Q87264528In vitro screening of LPS-induced miRNAs in leukocytes derived from cord blood and their possible roles in regulating TLR signals
Q36370851Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.
Q35080717Increased expression of Lin28B associates with poor prognosis in patients with oral squamous cell carcinoma
Q34534217Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion
Q47672444Induction of cancer cell stemness by depletion of macrohistone H2A1 in hepatocellular carcinoma.
Q37956599Inflamm-aging of the stem cell niche: breast cancer as a paradigmatic example: breakdown of the multi-shell cytokine network fuels cancer in aged people
Q28396089Inflammation and skeletal metastasis
Q29620242Inflammation meets cancer, with NF-κB as the matchmaker
Q35024882Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms
Q41661114Inflammatory Diseases and Growth: Effects on the GH-IGF Axis and on Growth Plate
Q64234271Inflammatory cytokine-induced expression of MASTL is involved in hepatocarcinogenesis by regulating cell cycle progression
Q33889156Inflammatory networks during cellular senescence: causes and consequences
Q92614067Inflammatory regulatory network mediated by the joint action of NF-kB, STAT3, and AP-1 factors is involved in many human cancers
Q101403195Inhibition of inflammatory signaling in Pax5 mutant cells mitigates B-cell leukemogenesis
Q35141444Inhibition of miR-193a expression by Max and RXRα activates K-Ras and PLAU to mediate distinct aspects of cellular transformation
Q34295493Inhibition of specific NF-κB activity contributes to the tumor suppressor function of 14-3-3σ in breast cancer
Q35560558Inhibitory mechanism of FAT4 gene expression in response to actin dynamics during Src-induced carcinogenesis
Q35161634Innate inflammation and cancer: Is it time for cancer prevention?
Q34584599Integrated microRNA and mRNA signatures associated with survival in triple negative breast cancer
Q28661281Integrating microRNA and mRNA expression profiling in Symbiodinium microadriaticum, a dinoflagellate symbiont of reef-building corals
Q28477652Integration of transcriptomics, proteomics, and microRNA analyses reveals novel microRNA regulation of targets in the mammalian inner ear
Q60300784Integrin CD11b activation drives anti-tumor innate immunity
Q37220527Integrin-linked kinase as a novel molecular switch of the IL-6-NF-κB signaling loop in breast cancer.
Q39705279Interfering with inflammation: a new strategy to block breast cancer self-renewal and progression?
Q35918723Interferon-microRNA signalling drives liver precancerous lesion formation and hepatocarcinogenesis
Q41120985Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation
Q38675443Interleukin-1 activates synthesis of interleukin-6 by interfering with a KH-type splicing regulatory protein (KSRP)-dependent translational silencing mechanism
Q39041030Interleukin-17 produced by tumor microenvironment promotes self-renewal of CD133+ cancer stem-like cells in ovarian cancer
Q60916226Interleukin-6 Interweaves the Bone Marrow Microenvironment, Bone Loss, and Multiple Myeloma
Q38228079Interleukin-6 in renal disease and therapy.
Q28486177Interleukin-6 mediates epithelial-stromal interactions and promotes gastric tumorigenesis
Q34989590Interplay between DNA repair and inflammation, and the link to cancer
Q36973327Interplay between Reactive oxygen Species and MicroRNAs in Cancer
Q92668610Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis
Q38160108Interplay between microRNAs and the STAT3 signaling pathway in human cancers
Q35040373Intrinsic features in microRNA transcriptomes link porcine visceral rather than subcutaneous adipose tissues to metabolic risk
Q28079138Involvement of inflammation and its related microRNAs in hepatocellular carcinoma
Q24302544IκB kinases increase Myc protein stability and enhance progression of breast cancer cells
Q57244864KRAS 3′-UTR variants and stratification of breast-cancer risk
Q36483206Kaposi's sarcoma-associated herpesviral IL-6 and human IL-6 open reading frames contain miRNA binding sites and are subject to cellular miRNA regulation
Q34742851Kaposi's sarcoma-associated herpesvirus ORF57 promotes escape of viral and human interleukin-6 from microRNA-mediated suppression
Q36810185Knockdown of lncRNA-ATB suppresses autocrine secretion of TGF-β2 by targeting ZNF217 via miR-200c in keloid fibroblasts
Q47105619Knockdown of long non-coding RNA H19 inhibits multiple myeloma cell growth via NF-κB pathway
Q37724522LIN28 expression in rat spinal cord after injury
Q35963802LIN28A Modulates Splicing and Gene Expression Programs in Breast Cancer Cells
Q34119208LIN28A marks the spermatogonial progenitor population and regulates its cyclic expansion
Q37271808LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7
Q37696072LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer
Q37351155Leptin-cytokine crosstalk in breast cancer.
Q42420606Let-7 Represses Carcinogenesis and a Stem Cell Phenotype in the Intestine via Regulation of Hmga2.
Q38723917Let-7 Status Is Crucial for PARP1 Expression in HER2-Overexpressing Breast Tumors
Q93002451Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer
Q51703465Let-7a is differentially expressed in bronchial biopsies of patients with severe asthma.
Q36189380Let-7a regulates mammosphere formation capacity through Ras/NF-κB and Ras/MAPK/ERK pathway in breast cancer stem cells
Q34599323Let-7b is involved in the inflammation and immune responses associated with Helicobacter pylori infection by targeting Toll-like receptor 4.
Q37640216Let-7e modulates the inflammatory response in vascular endothelial cells through ceRNA crosstalk
Q92051349Let-7f-5p suppresses Th17 differentiation via targeting STAT3 in multiple sclerosis
Q47146221Let-7g suppresses both canonical and non-canonical NF-κB pathways in macrophages leading to anti-atherosclerosis
Q36562901Life after death: targeting high mobility group box 1 in emergent cancer therapies
Q36006947Lin-28 homologue A (LIN28A) promotes cell cycle progression via regulation of cyclin-dependent kinase 2 (CDK2), cyclin D1 (CCND1), and cell division cycle 25 homolog A (CDC25A) expression in cancer
Q43241505Lin28 and HER2: two stem cell regulators conspire to drive aggressive breast cancer
Q38211596Lin28 and let-7: ancient milestones on the road from pluripotency to neurogenesis
Q36955306Lin28 and let-7: roles and regulation in liver diseases.
Q38808170Lin28 induces resistance to anti-androgens via promotion of AR splice variant generation
Q36986508Lin28 promotes growth of prostate cancer cells and activates the androgen receptor
Q39328419Lin28 regulates HER2 and promotes malignancy through multiple mechanisms
Q34294456Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7).
Q38695098Lin28: an emerging important oncogene connecting several aspects of cancer
Q28288454Lin28: primal regulator of growth and metabolism in stem cells
Q37645034Lin28A activates androgen receptor via regulation of c-myc and promotes malignancy of ER-/Her2+ breast cancer
Q35583640Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.
Q38788785Lin28A and androgen receptor expression in ER-/Her2+ breast cancer
Q41694110Lin28B facilitates the progression and metastasis of pancreatic ductal adenocarcinoma
Q34121523Lin28B is a novel prognostic marker in gastric adenocarcinoma.
Q36926139Lin28b promotes head and neck cancer progression via modulation of the insulin-like growth factor survival pathway
Q38699441Lipopolysaccharide-induced CCN1 production enhances interleukin-6 secretion in bronchial epithelial cells
Q89293146LncRNA H19-elevated LIN28B promotes lung cancer progression through sequestering miR-196b
Q93185119LncRNA-MALAT1 regulates proliferation and apoptosis of ovarian cancer cells by targeting miR-503-5p
Q54959875Long Non-Coding RNAs Dysregulation and Function in Glioblastoma Stem Cells.
Q51328387Long noncoding RNA-SRLR elicits intrinsic sorafenib resistance via evoking IL-6/STAT3 axis in renal cell carcinoma.
Q36512145Long-lived microRNA-Argonaute complexes in quiescent cells can be activated to regulate mitogenic responses.
Q38743303Loss of HDAC-Mediated Repression and Gain of NF-κB Activation Underlie Cytokine Induction in ARID1A- and PIK3CA-Mutation-Driven Ovarian Cancer
Q34971771Loss of let-7 microRNA upregulates IL-6 in bone marrow-derived mesenchymal stem cells triggering a reactive stromal response to prostate cancer
Q37609036Loss of methylation in CpG sites in the NF-κB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes.
Q24610880Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells
Q41932796Low concentration of S100A8/9 promotes angiogenesis-related activity of vascular endothelial cells: bridges among inflammation, angiogenesis, and tumorigenesis?
Q35204592MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC
Q26744410Mammalian microRNAs and long noncoding RNAs in the host-bacterial pathogen crosstalk
Q36310690Mammary epithelial cell phenotype disruption in vitro and in vivo through ERalpha36 overexpression
Q35460919Mammosphere formation assay from human breast cancer tissues and cell lines.
Q36539764Many lncRNAs, 5'UTRs, and pseudogenes are translated and some are likely to express functional proteins
Q37729638Maternal Low-Protein Diet Modulates Glucose Metabolism and Hepatic MicroRNAs Expression in the Early Life of Offspring †.
Q36910024Matrix metalloproteinase 8 (collagenase 2) induces the expression of interleukins 6 and 8 in breast cancer cells
Q37712385Mechanism of immune evasion in breast cancer
Q38128506Mechanisms of Lin28-mediated miRNA and mRNA regulation--a structural and functional perspective
Q58704736Mechanistic evidence that benzo[a]pyrene promotes an inflammatory microenvironment that drives the metastatic potential of human mammary cells
Q48140948Mesenchymal Stromal Cell-Derived Interleukin-6 Promotes Epithelial-Mesenchymal Transition and Acquisition of Epithelial Stem-Like Cell Properties in Ameloblastoma Epithelial Cells.
Q37015075Metabolic rescue of obese adipose-derived stem cells by Lin28/Let7 pathway.
Q38261030Metabostemness: a new cancer hallmark.
Q33971668Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells
Q92278973Metformin as an adjuvant in breast cancer treatment
Q50001260Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells.
Q34899382Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types
Q36545664Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth
Q91932738Metformin turns off the metabolic switch of pancreatic cancer
Q36902966Metformin: a case of divide and conquer.
Q37997926MiR-125 in normal and malignant hematopoiesis
Q36109677MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression
Q33913945MiR-146a negatively regulates dectin-1-induced inflammatory responses
Q42054741MiR-196a regulates heme oxygenase-1 by silencing Bach1 in the neonatal mouse lung
Q35791401MiR-27b targets PPARγ to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cells
Q37764166Micro-RNAs and breast cancer
Q38082379Micro-RNAs in inflammatory diseases and as a link between inflammation and cancer
Q27013841MicroRNA biogenesis pathways in cancer
Q53060711MicroRNA circuits regulate the cancer-inflammation link.
Q36661323MicroRNA control of bone formation and homeostasis
Q37601818MicroRNA dysregulation in spinal cord injury: causes, consequences and therapeutics.
Q27305161MicroRNA dysregulation in the spinal cord following traumatic injury
Q37802036MicroRNA functions in stress responses.
Q38103446MicroRNA in immunity and autoimmunity
Q37678651MicroRNA let-7 downregulates STAT3 phosphorylation in pancreatic cancer cells by increasing SOCS3 expression.
Q92544529MicroRNA let-7-TGFBR3 signalling regulates cardiomyocyte apoptosis after infarction
Q58580909MicroRNA let-7c Improves LPS-Induced Outcomes of Endometritis by Suppressing NF-κB Signaling
Q34221217MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth
Q41855099MicroRNA let-7c regulates macrophage polarization.
Q35668910MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells
Q41126784MicroRNA pharmacogenomics based integrated model of miR-17-92 cluster in sorafenib resistant HCC cells reveals a strategy to forestall drug resistance
Q41233695MicroRNA roles in the NF- κB signaling pathway during viral infections
Q34139023MicroRNA sponges: progress and possibilities
Q39139786MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
Q34821676MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis.
Q36864863MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice
Q37718263MicroRNA-22 negatively regulates poly(I:C)-triggered type I interferon and inflammatory cytokine production via targeting mitochondrial antiviral signaling protein (MAVS).
Q48144300MicroRNA-31 is required for astrocyte specification
Q39430328MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-κB and TGF-β signaling pathways.
Q36572465MicroRNA-feedback loop as a key modulator of liver tumorigenesis and inflammation.
Q35601698MicroRNA-let-7a expression is increased in the mesangial cells of NZB/W mice and increases IL-6 production in vitro
Q37626256MicroRNA-let-7a promotes E2F-mediated cell proliferation and NFκB activation in vitro
Q54982085MicroRNA-let-7e regulates the progression and development of allergic rhinitis by targeting suppressor of cytokine signaling 4 and activating Janus kinase 1/signal transducer and activator of transcription 3 pathway.
Q36096047MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice
Q88621594MicroRNAs and acute myeloid leukemia: therapeutic implications and emerging concepts
Q33953608MicroRNAs and gene regulatory networks: managing the impact of noise in biological systems
Q89287914MicroRNAs and liver disease
Q38819277MicroRNAs as regulatory elements in immune system logic
Q38795034MicroRNAs as therapeutics for future drug delivery systems in treatment of lung diseases.
Q37090412MicroRNAs implicated in the immunopathogenesis of lupus nephritis
Q24630097MicroRNAs in NF-kappaB signaling
Q36602107MicroRNAs in age-related diseases
Q86065522MicroRNAs in cancer
Q27027517MicroRNAs in stress signaling and human disease
Q26766336MicroRNAs in the Host-Apicomplexan Parasites Interactions: A Review of Immunopathological Aspects
Q37731180MicroRNAs in the etiology of colorectal cancer: pathways and clinical implications
Q37729606MicroRNAs in the regulation of TLR and RIG-I pathways
Q38095501MicroRNAs play a central role in molecular dysfunctions linking inflammation with cancer
Q26777313MicroRNAs, TGF-β signaling, and the inflammatory microenvironment in cancer
Q37995687MicroRNAs, new effectors and regulators of NF-κB.
Q35135542MicroRNAs: new players in IBD.
Q27010055MicroRNAs: new regulators of Toll-like receptor signalling pathways
Q37844405MicroRNAs: the fine-tuners of Toll-like receptor signalling
Q34562257Minireview: Basal-like breast cancer: from molecular profiles to targeted therapies
Q92238135Modeling the Dynamics of Let-7-Coupled Gene Regulatory Networks Linking Cell Proliferation to Malignant Transformation
Q47737123Modelling the propagation of a dynamical signature in gene expression mediated by the transport of extracellular microRNAs.
Q38049411Modulation of immune responses following solid organ transplantation by microRNA.
Q24633158Molecular basis for interaction of let-7 microRNAs with Lin28
Q46277416Molecular genetics and cellular events of K-Ras-driven tumorigenesis.
Q26780164Molecular mechanisms controlling asymmetric and symmetric self-renewal of cancer stem cells
Q47708421Molecular mechanisms of macrophage Toll-like receptor-Fc receptor synergy
Q40959067Monocyte MicroRNA Expression in Active Systemic Juvenile Idiopathic Arthritis Implicates MicroRNA-125a-5p in Polarized Monocyte Phenotypes
Q47153545Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis
Q36343400Multiple regulation pathways and pivotal biological functions of STAT3 in cancer.
Q37404422Multiscale models of breast cancer progression
Q35140027Mycobacterium bovis BCG triggered MyD88 induces miR-124 feedback negatively regulates immune response in alveolar epithelial cells
Q92604753NCAPG2 overexpression promotes hepatocellular carcinoma proliferation and metastasis through activating the STAT3 and NF-κB/miR-188-3p pathways
Q37615954NF-kappaB-dependent microRNA-425 upregulation promotes gastric cancer cell growth by targeting PTEN upon IL-1β induction
Q52717662NF-κB Activity Initiates Human ESC-Derived Neural Progenitor Cell Differentiation by Inducing a Metabolic Maturation Program.
Q82619099NF-κB and STAT3 cooperatively induce IL6 in starved cancer cells
Q26830388NF-κB and STAT3 in glioblastoma: therapeutic targets coming of age
Q39400435NF-κB as the main node of resistance to receptor tyrosine kinase inhibitors in triple-negative breast cancer
Q39112160NF-κB non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtype
Q30417710NF-κB regulates mesenchymal transition for the induction of non-small cell lung cancer initiating cells
Q52663155NF-κB signaling in cancer stem cells: a promising therapeutic target?
Q34138728NF-κB, an active player in human cancers
Q49594691NF-κB, inflammation, immunity and cancer: coming of age.
Q35608668NF-κB, stem cells and breast cancer: the links get stronger
Q36090989NF-κB-DICER-miRs Axis Regulates TNF-α Expression in Responses to Endotoxin Stress
Q24338949NLR family member NLRC5 is a transcriptional regulator of MHC class I genes
Q64882652Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B.
Q58097633Network integration of multi-tumour omics data suggests novel targeting strategies
Q34687635Neuroimmune pathways in alcohol consumption: evidence from behavioral and genetic studies in rodents and humans
Q48043882Neuromedin U alters bioenergetics and expands the cancer stem cell phenotype in HER2-positive breast cancer.
Q39497062Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors
Q41430928New Frontiers in Genetics, Gut Microbiota, and Immunity: A Rosetta Stone for the Pathogenesis of Inflammatory Bowel Disease.
Q88682253New insights from the widening homogeneity perspective to target intratumor heterogeneity
Q33739200New insights into signalling networks regulating breast cancer stem cells.
Q38024125New insights into the roles of ncRNA in the STAT3 pathway
Q64951391Next Viable Routes to Targeting Pancreatic Cancer Stemness: Learning from Clinical Setbacks.
Q36235494Niche science: the aging stem cell.
Q26781414Non-autonomous overgrowth by oncogenic niche cells: Cellular cooperation and competition in tumorigenesis
Q42108249Noncoding RNAs and cancer.
Q27011225Noncoding RNAs in cancer and cancer stem cells
Q42560600Nonlinear growth kinetics of breast cancer stem cells: implications for cancer stem cell targeted therapy
Q34940971Novel therapeutic strategies for targeting liver cancer stem cells
Q36028488Nuclear receptors agonists exert opposing effects on the inflammation dependent survival of breast cancer stem cells.
Q64990607Nutrient Deprivation Elicits a Transcriptional and Translational Inflammatory Response Coupled to Decreased Protein Synthesis.
Q49489812OTUD7B upregulation predicts a poor response to paclitaxel in patients with triple-negative breast cancer.
Q41847735On oncogenes and tumor suppressor genes in the mammary gland
Q37068467Oncogenic herpesviruses sending mixed signals
Q33649015Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities.
Q38552480Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity.
Q58800992Onset and Progression of Human Osteoarthritis-Can Growth Factors, Inflammatory Cytokines, or Differential miRNA Expression Concomitantly Induce Proliferation, ECM Degradation, and Inflammation in Articular Cartilage?
Q41390560Overexpression of microRNA let-7 correlates with disease progression and poor prognosis in hepatocellular carcinoma
Q36549367PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness
Q35766755PATHOGENESIS OF HEPATOCELLULAR CARCINOMA DEVELOPMENT IN NON ALCOHOLIC FATTY LIVER DISEASE
Q90285576PBX3/MEK/ERK1/2/LIN28/let-7b positive feedback loop enhances mesenchymal phenotype to promote glioblastoma migration and invasion
Q47231969PCAF-mediated acetylation of Lin28B increases let-7 biogenesis in lung adenocarcinoma H1299 cells
Q34765897PHLDA1 expression is controlled by an estrogen receptor-NFκB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres
Q37986079PI3K and STAT3: a new alliance.
Q36544764PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth
Q37971590PPAR gamma, bioactive lipids, and cancer progression
Q47898509PSCA regulates IL-6 expression through p38/NF-κB signaling in prostate cancer.
Q39144695Perturbation of MicroRNA-370/Lin-28 homolog A/nuclear factor kappa B regulatory circuit contributes to the development of hepatocellular carcinoma
Q102326360Perversely expressed long noncoding RNAs can alter host response and viral proliferation in SARS-CoV-2 infection
Q24301920Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor
Q37711835Physiologically activated mammary fibroblasts promote postpartum mammary cancer
Q36419337Pinpointing RNA-Protein Cross-Links with Site-Specific Stable Isotope-Labeled Oligonucleotides
Q55239948Placental exosome-mediated Bta-miR-499-Lin28B/let-7 axis regulates inflammatory bias during early pregnancy.
Q90312093Potential Role of MSC/Cancer Cell Fusion and EMT for Breast Cancer Stem Cell Formation
Q36473875Precise let-7 expression levels balance organ regeneration against tumor suppression
Q41936990Predicted overlapping microRNA regulators of acetylcholine packaging and degradation in neuroinflammation-related disorders.
Q37622669Preliminary indications of the effect of a brief yoga intervention on markers of inflammation and DNA methylation in chronically stressed women
Q37694720Premalignant alteration assessment in liver-like tissue derived from embryonic stem cells by aristolochic acid I exposure
Q34983195Profiling microRNA expression in bovine alveolar macrophages using RNA-seq
Q24604272Proinflammatory role for let-7 microRNAS in experimental asthma
Q39546203Prolonged mammosphere culture of MCF-7 cells induces an EMT and repression of the estrogen receptor by microRNAs
Q58695612Promotion of tumor progression and cancer stemness by MUC15 in thyroid cancer via the GPCR/ERK and integrin-FAK signaling pathways
Q38643148Prostate Cancer Stem-like Cells Contribute to the Development of Castration-Resistant Prostate Cancer
Q33642321Prostate cancer and inflammation: the evidence
Q55153827Proteome-wide analysis of protein abundance and turnover remodelling during oncogenic transformation of human breast epithelial cells.
Q37334199Pseudomonas aeruginosa infection augments inflammation through miR-301b repression of c-Myb-mediated immune activation and infiltration
Q42030398Pulmonary microRNA profiling in a mouse model of ventilator-induced lung injury
Q39439242Quantitative Proteomic Analysis of the Human Nucleolus
Q60913070RNA sequencing identifies common pathways between cigarette smoke exposure and replicative senescence in human airway epithelia
Q91266655RNA-binding protein LIN28B inhibits apoptosis through regulation of the AKT2/FOXO3A/BIM axis in ovarian cancer cells
Q37665333Rab27A mediated by NF-κB promotes the stemness of colon cancer cells via up-regulation of cytokine secretion
Q41813196Radiation response and regulation of apoptosis induced by a combination of TRAIL and CHX in cells lacking mitochondrial DNA: a role for NF-κB-STAT3-directed gene expression
Q37063982Realization of tristability in a multiplicatively coupled dual-loop genetic network
Q38140023Recent progress in omics-driven analysis of MS to unravel pathological mechanisms
Q36110358Reciprocal control of miR-197 and IL-6/STAT3 pathway reveals miR-197 as potential therapeutic target for hepatocellular carcinoma
Q35840362Reduced DICER1 elicits an interferon response in endometrial cancer cells
Q90055152Reduced Let-7f in Bone Marrow-Derived Mesenchymal Stem Cells Triggers Treg/Th17 Imbalance in Patients With Systemic Lupus Erythematosus
Q91871978Regulation of TLR signaling pathways by microRNAs: implications in inflammatory diseases
Q35213333Regulation of apoptosis in human melanoma and neuroblastoma cells by statins, sodium arsenite and TRAIL: a role of combined treatment versus monotherapy
Q39737822Regulation of cancer stem cells by cytokine networks: attacking cancer's inflammatory roots
Q36076000Regulation of let-7 and its target oncogenes (Review)
Q36751949Regulation of signalling by microRNAs
Q36338775Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3
Q34163433Regulation of the let-7a-3 promoter by NF-κB.
Q39007185Regulatory roles of epigenetic modulators, modifiers and mediators in lung cancer
Q36187514Reinforcing targeted therapeutics with phenotypic stability factors
Q28587965Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway
Q35951840Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs
Q36486630Respiratory syncytial virus regulates human microRNAs by using mechanisms involving beta interferon and NF-κB.
Q26750380Retinoblastoma tumor suppressor functions shared by stem cell and cancer cell strategies
Q35133520Retracted: MicroRNA-424 Is Down-Regulated in Hepatocellular Carcinoma and Suppresses Cell Migration and Invasion through c-Myb
Q38262473Revisiting STAT3 signalling in cancer: new and unexpected biological functions
Q47137381Road to stemness in hepatocellular carcinoma
Q36461628Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation
Q57119043Role of family microRNA in breast cancer
Q36957249Role of interleukin 6 in innate immunity to Mycobacterium tuberculosis infection
Q38853625Role of interleukin-6 in cancer progression and therapeutic resistance
Q41890041Role of miRNA let-7 and its major targets in prostate cancer.
Q38274949Role of microRNAs in maintaining cancer stem cells
Q55288642Role of nonresolving inflammation in hepatocellular carcinoma development and progression.
Q37596178Role of the tumor microenvironment in the pathogenesis of gastric carcinoma
Q92840453Role of β3 adrenoceptor in rat thoracic aorta contractility
Q35955737Roles for microRNAs in conferring robustness to biological processes
Q52722878Roles of NF-κB Signaling in the Regulation of miRNAs Impacting on Inflammation in Cancer.
Q37609032Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis.
Q47211731Roles of microRNAs and RNA-Binding Proteins in the Regulation of Colorectal Cancer Stem Cells
Q38086009Roles of microRNAs during prostatic tumorigenesis and tumor progression
Q34438487SCCA1/SERPINB3 promotes oncogenesis and epithelial-mesenchymal transition via the unfolded protein response and IL6 signaling
Q36968417SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b
Q33651685SLUG/SNAI2 and tumor necrosis factor generate breast cells with CD44+/CD24- phenotype.
Q28533971SNAI1-mediated epithelial-mesenchymal transition confers chemoresistance and cellular plasticity by regulating genes involved in cell death and stem cell maintenance
Q33640984SNPs in microRNA binding sites as prognostic and predictive cancer biomarkers
Q34850997SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model
Q61814939SP1 and STAT3 Functionally Synergize to Induce the Small GTPase and a Subclass of Non-canonical WNT Responsive Genes Correlating with Poor Prognosis in Breast Cancer
Q34088885STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer
Q35185463STAT3 acts through pre-existing nucleosome-depleted regions bound by FOS during an epigenetic switch linking inflammation to cancer
Q37362593STAT3 and NF-κB cooperatively control in vitro spontaneous apoptosis and poor chemo-responsiveness in patients with chronic lymphocytic leukemia.
Q90311460STAT3 and STAT5 Activation in Solid Cancers
Q37168124STAT3 as a new autophagy regulator
Q36901910STAT3 in the systemic inflammation of cancer cachexia.
Q34518047STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-κB to IL-6 signaling axis and STAT3-driven cancer phenotypes
Q103826160STAT3 phosphorylation at Ser727 and Tyr705 differentially regulates the EMT-MET switch and cancer metastasis
Q39540918STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.
Q37668555STAT3/NF-κB-Regulated Lentiviral TK/GCV Suicide Gene Therapy for Cisplatin-Resistant Triple-Negative Breast Cancer
Q92825339Senescence utilises inflammatory caspases to drive the SASP
Q41456647Serum Interleukin-6 Levels and Pulmonary Function in Ataxia-Telangiectasia
Q36589648Single-cell protein secretomic signatures as potential correlates to tumor cell lineage evolution and cell-cell interaction
Q38614827Small RNAs in the peripheral blood discriminate metastasized from non-metastasized seminoma
Q35803573Small ubiquitin-related modifier 2/3 interacts with p65 and stabilizes it in the cytoplasm in HBV-associated hepatocellular carcinoma
Q64945717Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28.
Q38900884Snail and Slug collaborate on EMT and tumor metastasis through miR-101-mediated EZH2 axis in oral tongue squamous cell carcinoma
Q94378277Snail and Slug collaborate on EMT and tumor metastasis through miR-101-mediated EZH2 axis in oral tongue squamous cell carcinoma
Q47189892Solexa sequencing and custom microRNA chip reveal repertoire of microRNAs in mammary gland of bovine suffering from natural infectious mastitis
Q90054655Src Inhibition Attenuates Neuroinflammation and Protects Dopaminergic Neurons in Parkinson's Disease Models
Q52775231Src kinase function controls progenitor cell pools during regeneration and tumor onset in the Drosophila intestine.
Q39210896Stat3-coordinated Lin-28-let-7-HMGA2 and miR-200-ZEB1 circuits initiate and maintain oncostatin M-driven epithelial-mesenchymal transition
Q37972656Stat3: linking inflammation to (gastrointestinal) tumourigenesis
Q33921803Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?
Q28079205Stem-like plasticity and heterogeneity of circulating tumor cells: current status and prospect challenges in liver cancer
Q42240229Streptococcus infantarius and carcinogenesis: a new chapter in colorectal pathology
Q35140542Stress and the epigenetic landscape: a link to the pathobiology of human diseases?
Q38017601Stromal biomarkers in breast cancer development and progression
Q35609967Stromal cells in tumor microenvironment and breast cancer
Q34340507Studying and modelling dynamic biological processes using time-series gene expression data
Q36033134Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3.
Q34227685Surgery-induced wound response promotes stem-like and tumor-initiating features of breast cancer cells, via STAT3 signaling
Q39216398Syndecan-1 modulates β-integrin-dependent and interleukin-6-dependent functions in breast cancer cell adhesion, migration, and resistance to irradiation
Q35080434Systematic identification of core transcription factors mediating dysregulated links bridging inflammatory bowel diseases and colorectal cancer
Q91792779TERC promotes cellular inflammatory response independent of telomerase
Q36194838TLR4 signaling induces the release of microparticles by tumor cells that regulate inflammatory cytokine IL-6 of macrophages via microRNA let-7b
Q36766514TNF-α-induced NF-κB activation upregulates microRNA-150-3p and inhibits osteogenesis of mesenchymal stem cells by targeting β-catenin
Q37694860TRIM71 suppresses tumorigenesis via modulation of Lin28B-let-7-HMGA2 signaling
Q38859693Tamoxifen induces a pluripotency signature in breast cancer cells and human tumors
Q39171958Tanshinone IIA inhibits breast cancer stem cells growth in vitro and in vivo through attenuation of IL-6/STAT3/NF-kB signaling pathways
Q39053707Targeted knock-in of the polymorphism rs61764370 does not affect KRAS expression but reduces let-7 levels
Q57050032Targeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteins
Q27003230Targeting CSC-related miRNAs for cancer therapy by natural agents
Q38033243Targeting CSCs within the tumor microenvironment for cancer therapy: a potential role of mesenchymal stem cells
Q57105625Targeting Crosstalk between Nrf-2, NF-κB and Androgen Receptor Signaling in Prostate Cancer
Q91451109Targeting LIN28B reprograms tumor glucose metabolism and acidic microenvironment to suppress cancer stemness and metastasis
Q49544368Targeting Stemness: Implications for Precision Medicine in Breast Cancer.
Q38149736Targeting cancer stem cells to suppress acquired chemotherapy resistance
Q39664369Targeting liver cancer: first steps toward a miRacle?
Q35067377Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality
Q64119664Targeting stem cells in the realm of drug-resistant breast cancer
Q37774852Targeting the ANGPT-TIE2 pathway in malignancy
Q92652651Targeting the Interplay Between Cancer Fibroblasts, Mesenchymal Stem Cells, and Cancer Stem Cells in Desmoplastic Cancers
Q26825658Targeting the tumor microenvironment: JAK-STAT3 signaling
Q38129926Targeting translational control as a novel way to treat inflammatory disease: the emerging role of microRNAs
Q36618973The Akt1/IL-6/STAT3 pathway regulates growth of lung tumor initiating cells
Q35602186The Assembly of EDC4 and Dcp1a into Processing Bodies Is Critical for the Translational Regulation of IL-6
Q39166548The Chromatin Assembly Factor Complex 1 (CAF1) and 5-Azacytidine (5-AzaC) Affect Cell Motility in Src-transformed Human Epithelial Cells.
Q49569445The DNA methyl-transferase protein DNMT1 enhances tumor-promoting properties of breast stromal fibroblasts.
Q37718285The ETS factor ESE3/EHF represses IL-6 preventing STAT3 activation and expansion of the prostate cancer stem-like compartment
Q92579938The Expression of Transforming Growth Factor Beta-1 and Interleukin-6 on Human Prostate: Prostate Hyperplasia and Prostate Cancer
Q35572396The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors
Q37723361The LIN28/let-7 Pathway in Cancer.
Q40645093The Minor MHC Class I Gene UDA of Ducks Is Regulated by Let-7 MicroRNA.
Q26750605The NF-κB Pathway and Cancer Stem Cells
Q46631178The NF-κB signalling pathway in colorectal cancer: associations between dysregulated gene and miRNA expression
Q41831013The Warburg effect version 2.0: metabolic reprogramming of cancer stem cells
Q37745788The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma.
Q38913559The balance between cell cycle arrest and cell proliferation: control by the extracellular matrix and by contact inhibition
Q38192723The bifacial role of helminths in cancer: involvement of immune and non-immune mechanisms
Q39276429The breast cancer susceptibility gene product fibroblast growth factor receptor 2 serves as a scaffold for regulation of NF-κB signaling
Q38254181The cancer stem cell hypothesis: a guide to potential molecular targets
Q36205234The canonical NF-κB pathway differentially protects normal and human tumor cells from ROS-induced DNA damage
Q26799398The cnidarian origin of the proto-oncogenes NF-κB/STAT and WNT-like oncogenic pathway drives the ctenophores (Review)
Q38126565The complexity of NF-κB signaling in inflammation and cancer
Q37976939The diverse and complex roles of NF-κB subunits in cancer
Q33713934The effect of exercise training on the level of tissue IL-6 and vascular endothelial growth factor in breast cancer bearing mice
Q51085252The hidden switches underlying RORα-mediated circuits that critically regulate uncontrolled cell proliferation.
Q36834235The histone demethylase jumonji coordinates cellular senescence including secretion of neural stem cell-attracting cytokines
Q39560212The homeobox gene HLXB9 is upregulated in a morphological subset of poorly differentiated hepatocellular carcinoma
Q37520409The inflammatory/cancer-related IL-6/STAT3/NF-κB positive feedback loop includes AUF1 and maintains the active state of breast myofibroblasts
Q36924406The interaction between ER and NFκB in resistance to endocrine therapy.
Q38847554The involvement of mast cells in the irinotecan-induced enteric neurons loss and reactive gliosis.
Q36791167The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche
Q38910598The miR-199a/Brm/EGR1 axis is a determinant of anchorage-independent growth in epithelial tumor cell lines
Q92090605The miRNA bantam regulates growth and tumorigenesis by repressing the cell cycle regulator tribbles
Q92802709The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies
Q42827201The nucleotide excision repair protein XPC is essential for bulky DNA adducts to promote interleukin-6 expression via the activation of p38-SAPK.
Q34100815The nutritional phenome of EMT-induced cancer stem-like cells
Q39180960The oncoprotein HBXIP upregulates Lin28B via activating TF II D to promote proliferation of breast cancer cells
Q36168985The pluripotency factor LIN28B is involved in oral carcinogenesis and associates with tumor aggressiveness and unfavorable prognosis.
Q35685193The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancy
Q34920381The role of cytokines in breast cancer development and progression
Q38070334The role of genetic and epigenetic alterations in neuroblastoma disease pathogenesis
Q34419629The role of inflammation in inflammatory breast cancer.
Q37900640The role of inflammation in the pathogenesis of lung cancer
Q91707540The role of interleukin-6-STAT3 signalling in glioblastoma
Q38093468The role of intratumoral and systemic IL-6 in breast cancer
Q38164571The role of microRNAs in hepatocarcinogenesis: current knowledge and future prospects.
Q38712604The role of microRNAs in prostate cancer progression
Q35128540The role of non-coding RNAs in the regulation of stem cells and progenitors in the normal mammary gland and in breast tumors
Q34241137The role of the microenvironment in mammary gland development and cancer
Q35192233The second coming of epigenetic drugs: a more strategic and broader research framework could boost the development of new drugs to modify epigenetic factors and gene expression
Q92287618The spectraplakin Dystonin antagonizes YAP activity and suppresses tumourigenesis
Q27003938The structure, function and evolution of proteins that bind DNA and RNA
Q37674796The two faces of IL-6 in the tumor microenvironment
Q36030226Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer
Q38249091Therapeutic microRNAs targeting the NF-kappa B signaling circuits of cancers
Q37991391Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases.
Q38210867Therapeutic potential of microRNA let-7: tumor suppression or impeding normal stemness.
Q43237751Time-tuning cancer therapy.
Q33733518Tiny masking locked nucleic acids effectively bind to mRNA and inhibit binding of microRNAs in relation to thermodynamic stability
Q34470537Towards elucidating the connection between epithelial-mesenchymal transitions and stemness
Q35937176Transcriptional signature induced by a metastasis-promoting c-Src mutant in a human breast cell line
Q36777478Transcriptome-scale RNase-footprinting of RNA-protein complexes
Q35219539Translational horizons in the tumor microenvironment: harnessing breakthroughs and targeting cures
Q36237715Trastuzumab resistance induces EMT to transform HER2(+) PTEN(-) to a triple negative breast cancer that requires unique treatment options
Q92591815Trichosanthes tricuspidata Lour. Methanol Extract Exhibits Anti-Inflammatory Activity by Targeting Syk, Src, and IRAK1 Kinase Activity
Q36471435Tumor Cell-Derived Periostin Regulates Cytokines That Maintain Breast Cancer Stem Cells.
Q40049654Tumor necrosis factor‑α and interleukin‑6 suppress microRNA‑1275 transcription in human adipocytes through nuclear factor‑κB.
Q41718087Tumor suppression via inhibition of SWI/SNF complex-dependent NF-κB activation
Q35134007Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells
Q39236676Tumor-associated myeloid cells as guiding forces of cancer cell stemness
Q33668830Tumorigenic WAP-T Mouse Mammary Carcinoma Cells: A Model for a Self-Reproducing Homeostatic Cancer Cell System
Q24629299Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signalling
Q38327185Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop
Q41838932Uncapping NF-κB activity in pancreatic cancer
Q35878186Understanding Alcoholism Through microRNA Signatures in Brains of Human Alcoholics
Q35796886Understanding cancer stem cell heterogeneity and plasticity.
Q36284384Understanding the response to endurance exercise using a systems biology approach: combining blood metabolomics, transcriptomics and miRNomics in horses.
Q38673511Unlocking Doors without Keys: Activation of Src by Truncated C-terminal Intracellular Receptor Tyrosine Kinases Lacking Tyrosine Kinase Activity
Q37937424Unravelling the complexity of metastasis - molecular understanding and targeted therapies
Q35271198Ureteral involvement and diabetes increase the risk of subsequent bladder recurrence after nephroureterectomy for upper urinary tract urothelial carcinoma
Q33828973Whole blood gene expression profiling predicts therapeutic response at six months in patients with polyarticular juvenile idiopathic arthritis
Q37361584Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/let-7 miRNA-Dependent Pathway in Adult Mammalian Retinas
Q27023599Wound healing and cancer stem cells: inflammation as a driver of treatment resistance in breast cancer
Q35071581Wound healing-like immune program facilitates postpartum mammary gland involution and tumor progression
Q33926690XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway
Q38297935Xenopatients 2.0: reprogramming the epigenetic landscapes of patient-derived cancer genomes
Q35955360YM155 potently triggers cell death in breast cancer cells through an autophagy-NF-kB network
Q55465526[Antitumor mechanism of metformin via adenosine monophosphate-activated protein kinase (AMPK) activation].
Q85198781c-Myc-mediated epigenetic silencing of MicroRNA-101 contributes to dysregulation of multiple pathways in hepatocellular carcinoma
Q38591056lnflammation-induced epigenetic switches in cancer
Q37156750mTOR signaling feedback modulates mammary epithelial differentiation and restrains invasion downstream of PTEN loss
Q51314052miR-127 promotes EMT and stem-like traits in lung cancer through a feed-forward regulatory loop.
Q37652305miR-203 enhances let-7 biogenesis by targeting LIN28B to suppress tumor growth in lung cancer
Q37034009miR-20b, miR-98, miR-125b-1*, and let-7e* as new potential diagnostic biomarkers in ulcerative colitis
Q36917611miR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis.
Q34485753miR-301a as an NF-κB activator in pancreatic cancer cells
Q34180373miR-365, a novel negative regulator of interleukin-6 gene expression, is cooperatively regulated by Sp1 and NF-kappaB.
Q35014215miR-9 and let-7g enhance the sensitivity to ionizing radiation by suppression of NFκB1
Q33819951miR-Let7A Controls the Cell Death and Tight Junction Density of Brain Endothelial Cells under High Glucose Condition.
Q27025496miRNA Deregulation in Cancer Cells and the Tumor Microenvironment
Q24598174miRNA and vascular cell movement
Q35047068miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock
Q38114914miRNAs and HIV: unforeseen determinants of host-pathogen interaction.
Q36382382microRNA Function Is Limited to Cytokine Control in the Acute Response to Virus Infection
Q86900164microRNA and NF-kappa B
Q35078061microRNA as a potential vector for the propagation of robustness in protein expression and oscillatory dynamics within a ceRNA network
Q34245279microRNA regulation of inflammatory responses
Q38932823microRNAs and Colorectal Cancer
Q34683406p16 Protein and gigaxonin are associated with the ubiquitination of NFκB in cisplatin-induced senescence of cancer cells
Q34356907p38 MAPK inhibits breast cancer metastasis through regulation of stromal expansion.

Search more.