Molecular and cellular targets

scientific article

Molecular and cellular targets is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1002/MC.20222
P932PMC publication ID2238808
P698PubMed publication ID16688728
P5875ResearchGate publication ID7092049

P50authorAnn M BodeQ91173532
Zigang DongQ91798724
P2860cites workBcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell deathQ24312211
The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2Q24561705
The retinoblastoma protein and cell cycle controlQ27860722
JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylationQ28243308
A receptor for green tea polyphenol EGCGQ28250787
Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4Q28266936
Green tea composition, consumption, and polyphenol chemistryQ28271284
Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosisQ28283313
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localizationQ28290083
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1Q28291340
The expanding role of mitochondria in apoptosisQ28609686
MAPKs: new JNK expands the groupQ28611010
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformationQ29400446
The phosphatidylinositol 3-Kinase AKT pathway in human cancerQ29547860
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cellsQ29618480
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-JunQ29620103
AP-1: a double-edged sword in tumorigenesisQ30014831
The intermediate filament protein vimentin is a new target for epigallocatechin gallateQ33211958
Tea and health.Q33851785
Tea and tea polyphenols in cancer preventionQ33866238
Intermediate filaments on the moveQ33994824
Apoptosis induction by arsenic: mechanisms of action and possible clinical applications for treating therapy-resistant cancersQ34332758
Inhibition of carcinogenesis by tea.Q34504013
Signal transduction pathways: targets for chemoprevention of skin cancerQ34571854
The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effectsQ34581717
Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cellsQ34987802
Signal transduction pathways: targets for green and black tea polyphenols.Q35051116
Mitogen-activated protein kinase activation in UV-induced signal transductionQ35055502
General keynote: the impact of cancer chemopreventionQ35065986
Cancer prevention by food factors through targeting signal transduction pathwaysQ35617546
Targeting signal transduction pathways by chemopreventive agentsQ35914334
Post-translational modification of p53 in tumorigenesisQ35930703
Inducible covalent posttranslational modification of histone H3.Q36108372
Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acidQ36159570
Signal transduction pathways in cancer development and as targets for cancer preventionQ36226855
Dissociation of mitogenesis and late-stage promotion of tumor cell phenotype by phorbol esters: mitogen-resistant variants are sensitive to promotionQ36378885
Theaflavin-3, 3'-digallate induces epidermal growth factor receptor downregulation.Q36430213
Effects of MAP kinase inhibitors on epidermal growth factor-induced neoplastic transformation of human keratinocytesQ36430224
Epigallocathechin-3 gallate selectively inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of sis-transfected NIH 3T3 fibroblasts and human glioblastoma cells (A172).Q36849886
Tea in chemoprevention of cancerQ37872214
Clinically relevant findingsQ39795395
Origins of G1 arrest in senescent human fibroblastsQ40422559
The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenols.Q40490329
Caffeine inhibits cell proliferation by G0/G1 phase arrest in JB6 cellsQ40559086
Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 activity by 1,2,3,4,6-Penta-O-galloyl-β-D-glucose in murine macrophage cellsQ40618107
Inhibition of Phorbol Ester–Induced COX-2 Expression by Epigallocatechin Gallate in Mouse Skin and Cultured Human Mammary Epithelial CellsQ40618173
Green tea constituent (-)-epigallocatechin-3-gallate inhibits Hep G2 cell proliferation and induces apoptosis through p53-dependent and Fas-mediated pathwaysQ40669278
Inhibitory mechanisms of tea polyphenols on the ultraviolet B-activated phosphatidylinositol 3-kinase-dependent pathwayQ40776146
Involvement of ERK and protein tyrosine phosphatase signaling pathways in EGCG-induced cyclooxygenase-2 expression in Raw 264.7 cellsQ40784170
Mechanisms of inhibition of the Ras-MAP kinase signaling pathway in 30.7b Ras 12 cells by tea polyphenols (-)-epigallocatechin-3-gallate and theaflavin-3,3'-digallateQ40785242
Green tea extracts decrease carcinogen-induced mammary tumor burden in rats and rate of breast cancer cell proliferation in culture.Q40786686
Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivoQ40817505
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced NF-kappaB activation by tea polyphenols, (-)-epigallocatechin gallate and theaflavinsQ40850635
Inhibition of ultraviolet B-induced AP-1 activation by theaflavins from black tea.Q40861539
Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophagesQ40904856
Tea and cancerQ40918996
Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved.Q40927921
Arsenic induces apoptosis through a c-Jun NH2-terminal kinase-dependent, p53-independent pathway.Q40943658
Inhibition of ultraviolet B--induced c-fos gene expression and p38 mitogen-activated protein kinase activation by (-)-epigallocatechin gallate in a human keratinocyte cell lineQ40966912
(-)-Epigallocatechin-3-gallate inhibition of ultraviolet B-induced AP-1 activityQ40981104
Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins.Q41087562
A dominant negative mutant of jun blocking 12-O-tetradecanoylphorbol-13-acetate-induced invasion in mouse keratinocytesQ41101178
Drug-induced reversion of progression phenotype is accompanied by reversion of AP-1 phenotype in JB6 cellsQ41208896
RB kinases and RB-binding proteins: new points of viewQ41341093
Transformation reversion induced in JB6 RT101 cells by AP-1 inhibitorsQ41353743
Inhibition of carcinogenesis by tea: the evidence from experimental studiesQ41691983
Progressive elevation of ap-1 activity during preneoplastic-to-neoplastic progression as modeled in mouse jb6 cell variantsQ42487840
Green tea polyphenol epigallocatechin-3 gallate inhibits Her-2/neu signaling, proliferation, and transformed phenotype of breast cancer cells.Q42516913
Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approachesQ42523881
Suppression of extracellular signals and cell proliferation by the black tea polyphenol, theaflavin-3,3'-digallateQ42816449
Apoptosis induction by epigallocatechin gallate involves its binding to Fas.Q43691451
Inhibitory effect of epigallocatechin gallate on adhesion of murine melanoma cells to lamininQ43752047
Direct effects of caffeine and theophylline on p110 delta and other phosphoinositide 3-kinases. Differential effects on lipid kinase and protein kinase activitiesQ44081143
Inhibitory effects of epigallocatechin-3-gallate on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in F344 rats.Q44215141
Inhibition of ultraviolet B-mediated activation of nuclear factor kappaB in normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallateQ44319791
Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cellsQ44486133
Role of p53 and NF-kappaB in epigallocatechin-3-gallate-induced apoptosis of LNCaP cellsQ44534508
Dual mechanisms of green tea extract (EGCG)-induced cell survival in human epidermal keratinocytesQ44535768
Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways.Q44542322
Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cellsQ44549283
Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skinQ46213216
Interaction between the carboxyl-terminal heparin-binding domain of fibronectin and (-)-epigallocatechin gallateQ47905548
Harvesting cells under anchorage-independent cell transformation conditions for biochemical analyses.Q53390497
Inhibition of tumor promoter-induced transformation by retinoids that transrepress AP-1 without transactivating retinoic acid response element.Q53457045
Tumour promoter induces anchorage independence irreversiblyQ53580945
Inhibition of carcinogenesis by teaQ59064127
Why drinking green tea could prevent cancerQ59064132
Inhibitory effects of perillyl alcohol on UVB-induced murine skin cancer and AP-1 transactivationQ63561123
Differential transformation efficiency but not AP-1 induction under anchorage-dependent and -independent conditionsQ72496882
Involvement of caspase-3 in epigallocatechin-3-gallate-mediated apoptosis of human chondrosarcoma cellsQ73693008
Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor kappaB in cancer cells versus normal cellsQ73699282
Inhibition of arsenite-induced apoptosis and AP-1 activity by epigallocatechin-3-gallate and theaflavinsQ74307110
Immunohistochemistry of Caspase3/CPP32 in human stomach and its correlation with cell proliferation and apoptosisQ77802495
Inhibitory effects of ascorbic acid on AP-1 activity and transformation of JB6 cellsQ84040122
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)422-30
P577publication date2006-06-01
P1433published inMolecular CarcinogenesisQ15724597
P1476titleMolecular and cellular targets
P478volume45

Reverse relations

cites work (P2860)
Q339673707,3',4'-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase
Q37151025A chrysin derivative suppresses skin cancer growth by inhibiting cyclin-dependent kinases.
Q88958715A new method to prepare and redefine black tea thearubigins
Q37815234Activation, regulation, and inhibition of DYRK1A.
Q34187311Activity and interactions of antibiotic and phytochemical combinations against Pseudomonas aeruginosa in vitro.
Q38093653Cancer chemoprevention by polyphenols and their potential application as nanomedicine
Q38897786Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K.
Q34551396Effects of the black tea polyphenol theaflavin‐2 on apoptotic and inflammatory pathways in vitro and in vivo
Q33655389Epigallocatechin 3-gallate and green tea catechins: United they work, divided they fail
Q34184286Functional protein pathway activation mapping of the progression of normal skin to squamous cell carcinoma
Q33696709Inhibitory effects of caffeine analogues on neoplastic transformation: structure-activity relationship
Q37083363Modulatory effects of polyphenols on apoptosis induction: relevance for cancer prevention
Q36945980Signal transduction and molecular targets of selected flavonoids
Q41766658Synergistic anticancer activity of biologicals from green and black tea on DU 145 human prostate cancer cells
Q89108747Targeting PRPK and TOPK for skin cancer prevention and therapy

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