Azathioprine and UVA light generate mutagenic oxidative DNA damage

scientific article

Azathioprine and UVA light generate mutagenic oxidative DNA damage is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1126/SCIENCE.1114233
P3181OpenCitations bibliographic resource ID1459365
P932PMC publication ID2426755
P698PubMed publication ID16166520
P5875ResearchGate publication ID7596214

P50authorYao-Zhong XuQ51136076
Beatriz MontanerQ55079979
Catherine HarwoodQ62662925
P2093author name stringFumio Hanaoka
Peter Karran
Susan L Walker
Xiaohong Zhang
Peter O'Donovan
Conal M Perrett
Jane M McGregor
P2860cites workThe XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase etaQ28115711
Replication of damaged DNA in mammalian cells: new solutions to an old problemQ30746296
Defective global genome repair in XPC mice is associated with skin cancer susceptibility but not with sensitivity to UVB induced erythema and edemaQ32068354
Photoactivation of DNA thiobases as a potential novel therapeutic optionQ34339210
Repair and genetic consequences of endogenous DNA base damage in mammalian cellsQ34371854
Pharmacogenetics and cancer therapyQ34572110
A role for ultraviolet A in solar mutagenesisQ34589316
Skin cancers after organ transplantationQ35113533
Oxidative damage to DNA: formation, measurement and biochemical features.Q35592841
Molecular basis of spontaneous mutation at the aprt locus of hamster cellsQ35597816
Synthetic activity of Sso DNA polymerase Y1, an archaeal DinB-like DNA polymerase, is stimulated by processivity factors proliferating cell nuclear antigen and replication factor C.Q38296309
Peripheral blood mononuclear cell DNA 6-thioguanine metabolite levels correlate with decreased interferon-gamma production in patients with Crohn's disease on AZA therapyQ40528442
Spontaneous development of drug resistance: mismatch repair and p53 defects in resistance to cisplatin in human tumor cellsQ40865504
Quantitation of 6-thioguanine residues in peripheral blood leukocyte DNA obtained from patients receiving 6-mercaptopurine-based maintenance therapyQ41350084
Incidence of skin cancer in 5356 patients following organ transplantationQ42492822
Non-melanoma skin cancer risk in the Queensland renal transplant population.Q42527482
Protection by ultraviolet A and B sunscreens against in situ dipyrimidine photolesions in human epidermis is comparable to protection against sunburn.Q43504839
Mechanisms of tolerance to DNA damaging therapeutic drugsQ43829355
Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumorsQ43871566
Fluorometric Assay of ThioguanineQ45116704
Replication of the base pair 6-thioguanine/5-methyl-2-pyrimidine with the large Klenow fragment of Escherichia coli DNA polymerase I.Q52398963
Photochemical sensitization by azathioprine and its metabolites--I. 6-MercaptopurineQ69499665
Immunosuppression and risk of non-melanoma skin cancer in renal transplant recipientsQ73073923
P433issue5742
P407language of work or nameEnglishQ1860
P921main subjectDNA damageQ5205747
azathioprineQ18939
P304page(s)1871-4
P577publication date2005-09-16
P1433published inScienceQ192864
P1476titleAzathioprine and UVA light generate mutagenic oxidative DNA damage
P478volume309

Reverse relations

cites work (P2860)
Q505768982-Thiouracil intersystem crossing photodynamics studied by wavelength-dependent photoelectron and transient absorption spectroscopies.
Q379517444-Thiothymidine sensitization of DNA to UVA offers potential for a novel photochemotherapy
Q371711586-Thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo
Q38693854A novel chalcone derivative S17 induces apoptosis through ROS dependent DR5 up-regulation in gastric cancer cells
Q38295916A practical guide to the use of thiopurines in oral medicine
Q42514247A surveillance model for skin cancer in organ transplant recipients: a 22-year prospective study in an ethnically diverse population
Q57399987An ab initio mechanism for efficient population of triplet states in cytotoxic sulfur substituted DNA bases: the case of 6-thioguanine
Q37447064Annotation of the Asian Citrus Psyllid Genome Reveals a Reduced Innate Immune System
Q37227694Association between Oxidative DNA Damage and Risk of Colorectal Cancer: Sensitive Determination of Urinary 8-Hydroxy-2'-deoxyguanosine by UPLC-MS/MS Analysis
Q36072486Associations between environmental factors and incidence of cutaneous melanoma. Review
Q38830835Azathioprine and Risk of Skin Cancer in Organ Transplant Recipients: Systematic Review and Meta-Analysis.
Q37164090Azathioprine prescribing in neurology
Q45289318Azathioprine treatment photosensitizes human skin to ultraviolet A radiation.
Q42447318Azathioprine-induced microsatellite instability is not observed in skin carcinomas of organ transplant recipients
Q39015006Basic aspects of the pathogenesis and prevention of non-melanoma skin cancer in solid organ transplant recipients: a review
Q26859216Burden of de novo malignancy in the liver transplant recipient
Q34520662Cancer Recurrence Following Immune-Suppressive Therapies in Patients With Immune-Mediated Diseases: A Systematic Review and Meta-analysis
Q99237566Cancer Risk in Pediatric-Onset Inflammatory Bowel Disease
Q48102349Cancer in ANCA-Associated Glomerulonephritis: A Registry-Based Cohort Study.
Q87796374Cancer in Solid Organ Transplant Recipients: There Is Still Much to Learn and Do
Q54187954Cancer in liver transplant recipients: management and outcomes.
Q64236185Cardiovascular, antidepressant and immunosuppressive drug use in relation to risk of cutaneous melanoma: a protocol for a prospective case-control study
Q37417605Cellular and sub-cellular responses to UVA in relation to carcinogenesis
Q50966306Clinical and immunological features of very long-term survivors with a single renal transplant.
Q26765172Clinical features, pathogenesis, and treatment of myasthenia gravis: a supplement to the Guidelines of the German Neurological Society
Q37811514Clinical insights for cancer outcomes in renal transplant patients
Q42174784Clinical lessons to be learned from patients developing chronic myeloid leukemia while on immunosuppressive therapy after solid organ transplantation: yet another case after orthotopic heart transplantation.
Q37771531Clinical recommendations for the use of everolimus in heart transplantation
Q53078388Communication: the dark singlet state as a doorway state in the ultrafast and efficient intersystem crossing dynamics in 2-thiothymine and 2-thiouracil.
Q38892578Comparing Outcomes between Antibody Induction Therapies in Kidney Transplantation
Q47572480Comprehensive review of post-organ transplant hematologic cancers
Q33844623Crosslinking of DNA repair and replication proteins to DNA in cells treated with 6-thioguanine and UVA
Q40012751CsA can induce DNA double-strand breaks: implications for BMT regimens particularly for individuals with defective DNA repair
Q35032846Cyclosporine a mediates pathogenesis of aggressive cutaneous squamous cell carcinoma by augmenting epithelial-mesenchymal transition: role of TGFβ signaling pathway
Q91663760DNA Repair Footprint Uncovers Contribution of DNA Repair Mechanism to Mutational Signatures
Q42735492DNA breakage and cell cycle checkpoint abrogation induced by a therapeutic thiopurine and UVA radiation
Q38052129DNA damage and repair in human cancer: molecular mechanisms and contribution to therapy-related leukemias.
Q38938690DNA repair inhibition by UVA photoactivated fluoroquinolones and vemurafenib
Q46451323Decoding the Molecular Basis for the Population Mechanism of the Triplet Phototoxic Precursors in UVA Light-Activated Pyrimidine Anticancer Drugs.
Q45072650Dermatologist and gastroenterologist awareness of the potential of immunosuppressants used to treat inflammatory bowel disease to cause non-melanoma skin cancer
Q34815465Direct observation and quantitative characterization of singlet oxygen in aqueous solution upon UVA excitation of 6-thioguanines
Q41593052Discriminating patients with early-stage breast cancer from benign lesions by detection of oxidative DNA damage biomarker in urine
Q64111733Dissecting the Multiplicity of Immune Effects of Immunosuppressive Drugs to Better Predict the Risk of de novo Malignancies in Solid Organ Transplant Patients
Q38253832Does a personal or family history of malignancy preclude the use of immunomodulators and biologics in IBD.
Q38328785Does the nature of residual immune function explain the differential risk of non-melanoma skin cancer development in immunosuppressed organ transplant recipients?
Q28258977Drug Insight: pharmacology and toxicity of thiopurine therapy in patients with IBD
Q36662474Drug insight: maintenance immunosuppression in kidney transplant recipients
Q36436001Effects of 6-thioguanine and S6-methylthioguanine on transcription in vitro and in human cells
Q44983460Effects of light energy and reducing agents on C60-mediated photosensitizing reactions
Q55265769Effects of mTOR-Is on malignancy and survival following renal transplantation: A systematic review and meta-analysis of randomized trials with a minimum follow-up of 24 months.
Q53098481Effects of mammalian target of rapamycin inhibitors on cytokine production and differentiation in keratinocytes.
Q42516595Epidemiology of keratinocyte carcinomas after organ transplantation
Q40983397Exposure to moxifloxacin and cytomegalovirus replication is associated with skin squamous cell carcinoma development in lung transplant recipients.
Q39037391Formation and repair of oxidatively generated damage in cellular DNA.
Q35698913From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma
Q35128847Generation of reactive oxygen species by lethal attacks from competing microbes
Q48247468Growth rates of pulmonary metastases after liver transplantation for unresectable colorectal liver metastases
Q39843689Guanine sulphinate is a major stable product of photochemical oxidation of DNA 6-thioguanine by UVA irradiation
Q28540791Harmful effects of the azathioprine metabolite 6-mercaptopurine in vascular cells: induction of mineralization
Q38240647Human Beta-papillomavirus infection and keratinocyte carcinomas
Q34974648Human skin carcinoma arising from kidney transplant-derived tumor cells
Q35617246Identification of potentially cytotoxic lesions induced by UVA photoactivation of DNA 4-thiothymidine in human cells
Q39879692Immune effector cells produce lethal DNA damage in cells treated with a thiopurine
Q35050810Immune profiling and cancer post transplantation
Q38179468Immune-mediated inflammatory reactions and tumors as skin side effects of inflammatory bowel disease therapy
Q41645033Immunosuppressant-driven de novo malignant neoplasms after solid-organ transplant
Q35818080Immunosuppression and Multiple Primary Malignancies in Kidney-Transplanted Patients: A Single-Institute Study
Q38026406Immunosuppression-related lymphomas and cancers in IBD: how can they be prevented?
Q36830121Immunosuppressive therapy and malignancy in organ transplant recipients: a systematic review
Q37591675Immunosuppressive treatment after solid organ transplantation and risk of post-transplant cutaneous squamous cell carcinoma
Q35893844In vitro replication and thermodynamic studies of methylation and oxidation modifications of 6-thioguanine
Q35606909Incidence of Cancer in ANCA-Associated Vasculitis: A Meta-Analysis of Observational Studies
Q38413238Incidence of Malignancies in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Diagnosed Between 1991 and 2013.
Q36037651Incidence of malignancy after living kidney transplantation: a multicenter study from iran
Q27025406Incidence, risk factors and outcome of de novo tumors in liver transplant recipients focusing on alcoholic cirrhosis
Q26748580Incidence, risk factors and outcomes of de novo malignancies post liver transplantation
Q37624501Incidental adenocarcinoma in patients undergoing surgery for stricturing Crohn's disease.
Q39043418Increased non-melanoma skin cancer risk in young patients with inflammatory bowel disease on immunomodulatory therapy: a retrospective single-centre cohort study
Q33727211Increased risk for non-melanoma skin cancer in patients with inflammatory bowel disease
Q84156294Increased risk of squamous-cell carcinoma in simultaneous pancreas kidney transplant recipients compared with kidney transplant recipients
Q26745456Inflammatory bowel disease and cancer: The role of inflammation, immunosuppression, and cancer treatment
Q39773210Inflammatory bowel disease, cancer and medication: Cancer risk in the Dutch population-based IBDSL cohort
Q64099701Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model
Q90315913Keratinocyte Carcinomas: Current Concepts and Future Research Priorities
Q36782544Keratotic skin lesions and other risk factors are associated with skin cancer in organ-transplant recipients: a case-control study in The Netherlands, United Kingdom, Germany, France, and Italy
Q39539469Known and potential new risk factors for skin cancer in European populations: a multicentre case-control study
Q34070112LC-MS/MS coupled with stable isotope dilution method for the quantification of 6-thioguanine and S(6)-methylthioguanine in genomic DNA of human cancer cells treated with 6-thioguanine
Q49722515Light-Induced Covalent Buffer Adducts to Histidine in a Model Protein.
Q40940707Long-term CD4 lymphopenia is associated with accelerated decline of kidney allograft function
Q47739192Long-term Change in the Risk of Skin Cancer After Organ Transplantation: A Population-Based Nationwide Cohort Study
Q41771210MUTYH mediates the toxicity of combined DNA 6-thioguanine and UVA radiation
Q38010633Management of non-melanoma skin cancer in immunocompromised solid organ transplant recipients
Q42456451Management of non-melanoma skin cancer in solid organ transplant recipients
Q27320787Melanoma Risk and Survival among Organ Transplant Recipients.
Q38118880Milestones in photocarcinogenesis
Q37049512Molecular and cellular mechanisms of photocarcinogenesis
Q34573854Molecular profiling of cutaneous squamous cell carcinomas and actinic keratoses from organ transplant recipients.
Q30835452More epidermal p53 patches adjacent to skin carcinomas in renal transplant recipients than in immunocompetent patients: the role of azathioprine
Q37955182Multiple forms of DNA damage caused by UVA photoactivation of DNA 6-thioguanine
Q40450769Mutagenic and cytotoxic properties of 6-thioguanine, S6-methylthioguanine, and guanine-S6-sulfonic acid.
Q37358453Mutagenicity and potential carcinogenicity of thiopurine treatment in patients with inflammatory bowel disease
Q38969032Myasthenia gravis: recent advances in immunopathology and therapy
Q38210623Non-melanoma skin cancer is reduced after switch of immunosuppression to mTOR-inhibitors in organ transplant recipients
Q35633626Non-targeting siRNA induces NPGPx expression to cooperate with exoribonuclease XRN2 for releasing the stress
Q34975612Nonmelanoma skin cancer in inflammatory bowel disease
Q35680367Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans
Q50519523Optical absorption and magnetic circular dichroism spectra of thiouracils: a quantum mechanical study in solution.
Q38228585Optimal management of skin cancer in immunosuppressed patients
Q35283173Oral azathioprine leads to higher incorporation of 6-thioguanine in DNA of skin than liver: the protective role of the Keap1/Nrf2/ARE pathway.
Q34609514Overall and cause-specific mortality in Crohn's disease: a meta-analysis of population-based studies
Q27863353Overexpression of selenoprotein H reduces Ht22 neuronal cell death after UVB irradiation by preventing superoxide formation
Q39042732Oxidatively-generated damage to DNA and proteins mediated by photosensitized UVA
Q46947476PDT as a cytotoxic agent and biological response modifier: Implications for cancer prevention and treatment in immunosuppressed and immunocompetent patients
Q36944052PTCH mutations in basal cell carcinomas from azathioprine-treated organ transplant recipients.
Q34713840Pathogenesis of nonmelanoma skin cancers in organ transplant recipients
Q34413976Pharmacogenetics of azathioprine in inflammatory bowel disease: a role for glutathione-S-transferase?
Q37965984Photodynamic therapy for actinic keratosis in organ transplant patients.
Q38176091Photosensitizing medications and photocarcinogenesis
Q36081139Pleomorphic malignant histiocytoma: a rare skin cancer in a patient on azathioprine for ulcerative colitis
Q57750146Polygenic risk score as a determinant of risk of non-melanoma skin cancer in a European-descent renal transplant cohort
Q37863680Post-transplant malignancy: reducing the risk in kidney transplant recipients
Q38611709Post-transplantation malignancies: here today, gone tomorrow?
Q21261410Posttransplantation malignancy in a patient presenting with weight loss and changed bowel habits: a case report
Q60921182Practical guidance for the management of inflammatory bowel disease in patients with cancer. Which treatment?
Q34984571Procarcinogenic effects of cyclosporine A are mediated through the activation of TAK1/TAB1 signaling pathway
Q37876951Proliferation signal inhibitors and post-transplant malignancies in heart transplantation: practical clinical management questions
Q45136999Protein oxidation and DNA repair inhibition by 6-thioguanine and UVA radiation.
Q26744266Protein oxidation, UVA and human DNA repair
Q35534821Quantification of Thiopurine/UVA-Induced Singlet Oxygen Production
Q37149792Reactive oxygen species generated by thiopurine/UVA cause irreparable transcription-blocking DNA lesions
Q40068682Reactive oxygen-mediated damage to a human DNA replication and repair protein
Q42795506Recurrent Non-melanoma Skin Cancer: Remission of Field Cancerization after Conversion from Calcineurin Inhibitor- to Proliferation Signal Inhibitor-based Immunosuppression in a Cardiac Transplant Recipient
Q42499557Regression of BCC following immunosuppression withdrawal in a renal transplant recipient
Q90045000Reinvigoration of diploid strawberry (Fragaria vesca) during adventitious shoot regeneration
Q88848697Response to 'The importance of immunosuppression as risk and prognostic factor for periorbital non-melanoma skin cancers'
Q26822029Review article: dermatological complications of immunosuppressive and anti-TNF therapy in inflammatory bowel disease
Q39014703Risk of Aggressive Skin Cancers After Kidney Retransplantation in Patients With Previous Posttransplant Cutaneous Squamous Cell Carcinomas: A Retrospective Study of 53 Cases
Q38725469Risk of Second Malignancies in Solid Organ Transplant Recipients Who Develop Keratinocyte Cancers.
Q90737442Risk of lip cancer after solid organ transplantation in the United States
Q45943688Risk of melanoma and non-melanoma skin cancer in ulcerative colitis patients treated with thiopurines: a nationwide retrospective cohort.
Q33786255Risk of melanoma and nonmelanoma skin cancer among patients with inflammatory bowel disease
Q35029320Risk of merkel cell carcinoma after solid organ transplantation
Q82948889Risk of non-melanoma skin cancer in autoimmune hepatitis
Q45478307Risk of non-melanoma skin cancer in myasthenia patients treated with azathioprine
Q35403714Roles of the immune system in skin cancer.
Q40521435Rose Bengal-photosensitized oxidation of 4-thiothymidine in aqueous medium: evidence for the reaction of the nucleoside with singlet state oxygen
Q51206994S1-Guidelines on UV phototherapy and photochemotherapy.
Q42470631Skin cancer evaluation in transplant patients: a physician opinion survey with recommendations
Q26822549Skin cancer in organ transplant recipients: effects of immunosuppressive medications on DNA repair
Q26851436Skin cancer in solid organ transplant recipients: are mTOR inhibitors a game changer?
Q37053236Skin cancer in transplant recipients, out of the woods. Scientific retreat of the ITSCC and SCOPE.
Q37687958Skin changes following organ transplantation: an interdisciplinary challenge
Q43855889Skin tumors in organ-transplant recipients
Q40257939Spectrum of Immune-Related Conditions Associated with Risk of Keratinocyte Cancers among Elderly Adults in the United States
Q42149278Stimulus-responsive liquids for encapsulation storage and controlled release of drugs from nano-shell capsules
Q91707032Synthesis of Chalcone Derivatives: Inducing Apoptosis of HepG2 Cells via Regulating Reactive Oxygen Species and Mitochondrial Pathway
Q64253571The Role of the Immune System in Cutaneous Squamous Cell Carcinoma
Q52985758The Triplet State of 6-thio-2'-deoxyguanosine: Intrinsic Properties and Reactivity Toward Molecular Oxygen.
Q90104340The frequency of photosensitizing drug dispensings in Austria and Germany: a correlation with their photosensitizing potential based on published literature
Q58756343The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature
Q36435796The indirect antioxidant sulforaphane protects against thiopurine-mediated photooxidative stress
Q40237944The janus face of immunosuppression - de novo malignancy after renal transplantation: the experience of the Transplantation Center Munich
Q46934214The oncogene ATF3 is potentiated by cyclosporine A and ultraviolet light A.
Q46271884The pathogenesis of cutaneous squamous cell carcinoma in organ transplant recipients.
Q38883237The safety of treatment options for pediatric Crohn's disease
Q39171826The stress response resolution assay. I. Quantitative assessment of environmental agent/condition effects on cellular stress resolution outcomes in epithelium
Q36747429Thiopurine treatment in inflammatory bowel disease: clinical pharmacology and implication of pharmacogenetically guided dosing
Q28079644Thiopurines and inflammatory bowel disease: Current evidence and a historical perspective
Q34728470Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer
Q37087479Thiopurines related malignancies in inflammatory bowel disease: local experience in Granada, Spain
Q38443981Toxicity and response to thiopurines in patients with inflammatory bowel disease
Q37593739Translating translation into patient benefit for atopic eczema
Q38784067Treatment of moderate-to-severe atopic eczema in adults within the U.K.: results of a national survey of dermatologists.
Q36711033Treatment of post-transplant premalignant skin disease: a randomized intrapatient comparative study of 5-fluorouracil cream and topical photodynamic therapy.
Q44547715Tumor and transplantation
Q35680668Type VI Secretion System Transports Zn2+ to Combat Multiple Stresses and Host Immunity.
Q37921124UVA photosensitization of thiopurines and skin cancer in organ transplant recipients
Q64084989Understanding the burden of refractory myasthenia gravis
Q35677669Use of azathioprine for graft-vs-host disease is the major risk for development of secondary malignancies after haematopoietic stem cell transplantation: a nationwide population-based study
Q26750190Use of biologics and chemotherapy in patients with inflammatory bowel diseases and cancer
Q41481044Use of photodynamic therapy for treatment of actinic keratoses in organ transplant recipients.
Q33621267Use of thiopurines in inflammatory bowel disease: Safety issues
Q46397135Use of thiopurines in the treatment of inflammatory bowel disease is associated with an increased risk of non-melanoma skin cancer in an at-risk population: a cohort study
Q33383930Visible light regulates neurite outgrowth of nerve cells
Q37049515Waveband and dose dependency of sunlight-induced immunomodulation and cellular changes
Q33614146Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma
Q54690358[Cutaneous squamous cell carcinoma].
Q53301944[Immunosuppressive therapy after transplantation. Dermatologic relevance and pathomechanisms].
Q53254939[Phototherapy and carcinogenesis].
Q83004526[Primary and secondary prevention of skin cancer in organ transplant recipients]
Q91289588pH Controlled Intersystem Crossing and Singlet Oxygen Generation of 8-Azaadenine in Aqueous Solution

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