In vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cells

scientific article

In vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.00437-06
P932PMC publication ID1635212
P698PubMed publication ID16940060
P5875ResearchGate publication ID6848779

P50authorJoan Carles Domingo PedrolQ64854203
Jesús Miguel López DuplaQ72279378
Tomáš CihlářQ88483170
Francesc VillarroyaQ41464646
Marta GiraltQ41652914
Francesc VidalQ42430887
Ferran TorresQ43088594
P2093author name stringPere Domingo
Maria Saumoy
Begoña Cordobilla
Maria Luisa Alvarez
Jordi Guallar
Rainel Sánchez de la Rosa
P2860cites workRole of purine nucleoside phosphorylase in interactions between 2',3'-dideoxyinosine and allopurinol, ganciclovir, or tenofovirQ24321512
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Biological effects of short-term or prolonged administration of 9-[2-(phosphonomethoxy)propyl]adenine (tenofovir) to newborn and infant rhesus macaquesQ28775900
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The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1.Q30759685
Long-term renal safety of tenofovir disoproxil fumarate in antiretroviral-naive HIV-1-infected patients. Data from a double-blind randomized active-controlled multicentre studyQ30983924
Tenofovir-related Fanconi syndrome with nephrogenic diabetes insipidus in a patient with acquired immunodeficiency syndrome: the role of lopinavir-ritonavir-didanosineQ33196165
Measurement of intracellular didanosine and tenofovir phosphorylated metabolites and possible interaction of the two drugs in human immunodeficiency virus-infected patientsQ33770032
Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1.Q33892331
Phase i/ii trial of the pharmacokinetics, safety, and antiretroviral activity of tenofovir disoproxil fumarate in human immunodeficiency virus-infected adultsQ33983070
Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity.Q33993644
Inducible expression of a dominant negative DNA polymerase-gamma depletes mitochondrial DNA and produces a rho0 phenotype.Q34184643
Effect of tenofovir on didanosine absorption in patients with HIV.Q34536261
Tenofovir disoproxil fumarate: a review of its use in the management of HIV infectionQ34554493
Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerationsQ34738805
Tenofovir-related nephrotoxicity: case report and review of the literatureQ35709802
Severe metabolic acidosis and renal failure in an HIV-1 patient receiving tenofovirQ35852636
Antiviral drug-induced nephrotoxicityQ36110651
Acute renal failure and Fanconi syndrome in an AIDS patient on tenofovir treatment--case report and review of literatureQ36204603
Fanconi syndrome associated with use of tenofovir in HIV-infected patients: a case report and review of the literatureQ36207487
Tenofovir-associated acute and chronic kidney disease: a case of multiple drug interactionsQ36342389
Tubulopathy consecutive to tenofovir-containing antiretroviral therapy in two patients infected with human immunodeficiency virus-1.Q38920848
Tenofovir DF, emtricitabine, and efavirenz vs. zidovudine, lamivudine, and efavirenz for HIV.Q46900196
Longitudinal study on mitochondrial effects of didanosine-tenofovir combinationQ46912883
96-week comparison of once-daily atazanavir/ritonavir and twice-daily lopinavir/ritonavir in patients with multiple virologic failuresQ46973541
Exploring mitochondrial nephrotoxicity as a potential mechanism of kidney dysfunction among HIV-infected patients on highly active antiretroviral therapyQ46976845
Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.Q50904345
Side-effects of ritonavir and its combination with saquinavir with special regard to renal functionQ73324130
The development of hypophosphataemic osteomalacia with myopathy in two patients with HIV infection receiving tenofovir therapyQ39340579
Greater and more rapid depletion of mitochondrial DNA in blood of patients treated with dual (zidovudine+didanosine or zidovudine+zalcitabine) vs. single (zidovudine) nucleoside reverse transcriptase inhibitorsQ39391662
In vitro antiviral interaction of lopinavir with other protease inhibitorsQ39652270
Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter.Q40499963
Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugsQ40688656
HIV protease inhibitor ritonavir induces cytotoxicity of human endothelial cellsQ40697876
Tenofovir exhibits low cytotoxicity in various human cell types: comparison with other nucleoside reverse transcriptase inhibitors.Q40745355
Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression systemQ40899458
Renal insufficiency induced by ritonavir in HIV-infected patients.Q42538007
Ritonavir and renal failureQ42551639
Renal failure after treatment with ritonavirQ42554381
Dideoxyinosine-associated nephrotoxicityQ42559031
Adefovir nephrotoxicity: possible role of mitochondrial DNA depletionQ43526884
Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogsQ43741891
Paradoxical CD4+ T-cell decline in HIV-infected patients with complete virus suppression taking tenofovir and didanosineQ43743810
Rapid communication: acute renal failure associated with tenofovir: evidence of drug-induced nephrotoxicity.Q43879910
Tenofovir DF in antiretroviral-experienced patients: results from a 48-week, randomized, double-blind studyQ44015302
Fanconi syndrome and renal failure induced by tenofovir: a first case reportQ44235015
First-line therapy and mitochondrial damage: different nucleosides, different findingsQ44309069
Renal lesions in HIV-1-positive patient treated with tenofovirQ44379167
Tenofovir-related nephrotoxicity in human immunodeficiency virus-infected patients: three cases of renal failure, Fanconi syndrome, and nephrogenic diabetes insipidusQ44396659
Fatal lactic acidosis and acute renal failure after addition of tenofovir to an antiretroviral regimen containing didanosineQ44396661
Acute renal failure associated with tenofovir treatment in a patient with acquired immunodeficiency syndromeQ44528008
Pancreatitis with didanosine and tenofovir disoproxil fumarate [corrected].Q44564512
Acute tubular necrosis in a patient receiving tenofovirQ44644295
Tenofovir-related nephrotoxicity in HIV-infected patientsQ44827267
Renal safety of tenofovir in HIV treatment-experienced patients.Q44851246
Didanosine-associated toxicity: a predictable complication of therapy with tenofovir and didanosine?Q44851404
Pancreatic toxic effects associated with co-administration of didanosine and tenofovir in HIV-infected adultsQ44964458
Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviral-naive patients: a 3-year randomized trialQ44975155
Proximal tubular kidney damage and tenofovir: a role for mitochondrial toxicity?Q44997975
Tenofovir-associated nephrotoxicity: Fanconi syndrome and renal failureQ45016447
Fatal lactic acidosis associated with coadministration of didanosine and tenofovir disoproxil fumarateQ45037788
Upregulatory mechanisms compensate for mitochondrial DNA depletion in asymptomatic individuals receiving stavudine plus didanosineQ45172095
Antiretroviral therapy with tenofovir is associated with mild renal dysfunctionQ45207624
Tenofovir-induced acute renal failure in an HIV patient with normal renal functionQ45240250
Serum hypophosphatemia in tenofovir disoproxil fumarate recipients is multifactorial in origin, questioning the utility of its monitoring in clinical practiceQ45285932
Acute renal failure, Fanconi syndrome and insipidus diabetes in a HIV-infected patient treated with TenofovirQ46528481
Assessment of renal abnormalities in 107 HIV patients treated with tenofovirQ46559081
Low frequency of renal function impairment during one-year of therapy with tenofovir-containing regimens in the real-world: a case-control studyQ46625896
High rate of virological failure in maintenance antiretroviral therapy with didanosine and tenofovirQ46720700
P433issue11
P407language of work or nameEnglishQ1860
P921main subjecttenofovirQ155954
cytotoxicityQ246181
anti-retroviral agentQ50430310
P304page(s)3824-3832
P577publication date2006-08-28
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleIn vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cells
P478volume50

Reverse relations

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