Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways

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Efficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways is …
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scholarly articleQ13442814

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P356DOI10.1038/SJ.BJP.0706827
P932PMC publication ID1752021
P698PubMed publication ID16865095
P5875ResearchGate publication ID6921374

P2093author name stringPilar Pérez
Helmut Buschmann
Jörg Holenz
Gonzalo Romero
Xavier Codony
Marta Pujol
Petrus J Pauwels
Elisabeth Sánchez
P2860cites workSerotonin receptor ligands and the treatment of obesityQ35767986
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Stable expression of constitutively activated mutant h5HT6 and h5HT7 serotonin receptors: inverse agonist activity of antipsychotic drugsQ40436775
Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modelingQ40611704
Differentiation between partial and silent 5-HT1D beta receptor antagonists using rat C6-glial and Chinese hamster ovary cell lines permanently transfected with a cloned human 5-HT1D beta receptor geneQ41272104
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5-Hydroxytryptamine receptors with a 5-HT6 receptor-like profile stimulating adenylyl cyclase activity in pig caudate membranesQ42488807
5-HT(6) receptor antagonists: lead optimisation and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamidesQ43581196
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5-HT6 receptors positively coupled to adenylyl cyclase in striatal neurones in cultureQ72110315
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2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptorsQ28138501
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5-ht6 receptorsQ28245286
A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulationQ28263452
Characterization of Ro 04-6790 and Ro 63-0563: potent and selective antagonists at human and rat 5-HT6 receptorsQ28379597
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Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134).Q33930185
Efficacy as a vector: the relative prevalence and paucity of inverse agonismQ34289691
5-Chloro-N-(4-methoxy-3-piperazin-1-yl- phenyl)-3-methyl-2-benzothiophenesulfon- amide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonistQ34490069
Constitutive activity of G-protein coupled receptors: emphasis on serotonin receptorsQ34673695
Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonistQ35042511
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)1133-43
P577publication date2006-08-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleEfficacy of selective 5-HT6 receptor ligands determined by monitoring 5-HT6 receptor-mediated cAMP signaling pathways
P478volume148