Multiple kinase cascades mediate prolactin signals to activating protein-1 in breast cancer cells

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Multiple kinase cascades mediate prolactin signals to activating protein-1 in breast cancer cells is …
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scholarly articleQ13442814

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P356DOI10.1210/ME.2004-0187
P932PMC publication ID1634796
P698PubMed publication ID15319452
P5875ResearchGate publication ID8393058

P50authorJennifer H GutzmanQ42325976
P2093author name stringJyoti J Watters
Linda A Schuler
Matthew D Schroeder
Debra E Rugowski
P2860cites workFunctional characterization of the intermediate isoform of the human prolactin receptorQ22010878
BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2CQ24532869
cJun overexpression in MCF-7 breast cancer cells produces a tumorigenic, invasive and hormone resistant phenotypeQ28137770
Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesisQ28201509
Extracellular signal-regulated kinase 1/2-mediated phosphorylation of JunD and FosB is required for okadaic acid-induced activator protein 1 activationQ28292778
A cytoplasmic inhibitor of the JNK signal transduction pathwayQ28586970
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformationQ29400446
AP-1 as a regulator of cell life and deathQ29616558
The regulation of AP-1 activity by mitogen-activated protein kinasesQ29620431
AP-1: a double-edged sword in tumorigenesisQ30014831
A network of mitogen-activated protein kinases links G protein-coupled receptors to the c-jun promoter: a role for c-Jun NH2-terminal kinase, p38s, and extracellular signal-regulated kinase 5.Q33652314
Rapid activation of protein kinase C in isolated rat liver nuclei by prolactin, a known hepatic mitogenQ33671938
Should prolactin be reconsidered as a therapeutic target in human breast cancer?Q33690324
Reactivation of proliferin gene expression is associated with increased angiogenesis in a cell culture model of fibrosarcoma tumor progressionQ33949075
FosB is highly expressed in normal mammary epithelia, but down-regulated in poorly differentiated breast carcinomasQ34179474
Jun, the oncoprotein.Q34279331
The mammalian Jun proteins: redundancy and specificity.Q34279339
AP-1 in mouse development and tumorigenesisQ34279346
Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity.Q34279362
Promoter specificity and biological activity of tethered AP-1 dimersQ34282536
Signaling pathways in mammary gland development.Q34434909
Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout miceQ34471721
The role of prolactin in mammary carcinomaQ35067253
A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serumQ35200753
Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor.Q35923922
The association of breast mitogens with mammographic densitiesQ36646178
Accessory elements, flanking DNA sequence, and promoter context play key roles in determining the efficacy of insulin and phorbol ester signaling through the malic enzyme and collagenase-1 AP-1 motifsQ38288893
Prolactin-induced cell proliferation in PC12 cells depends on JNK but not ERK activationQ38312340
Increased AP-1 activity in drug resistant human breast cancer MCF-7 cellsQ38323749
Increased activator protein-1 DNA binding and c-Jun NH2-terminal kinase activity in human breast tumors with acquired tamoxifen resistanceQ38327743
c-JUN, JUN B, and JUN D differ in their binding affinities to AP-1 and CRE consensus sequences: effect of FOS proteinsQ38335918
Interaction of a bZip oligopeptide model with oligodeoxyribonucleotides modelling DNA binding sites. The effect of flanking sequences.Q38340729
Degradation of c-Fos by the 26S proteasome is accelerated by c-Jun and multiple protein kinasesQ40017378
c-fos proto-oncogene regulation and functionQ40567648
Inhibition of prolactin (PRL)-induced proliferative signals in breast cancer cells by a molecular mimic of phosphorylated PRL, S179D-PRL.Q40635267
c-Jun N-terminal kinase activation of activator protein-1 underlies homologous regulation of the gonadotropin-releasing hormone receptor gene in alpha T3-1 cells.Q40670692
AP-1 blockade inhibits the growth of normal and malignant breast cellsQ40700814
Prolactin stimulates activation of c-jun N-terminal kinase (JNK).Q40847193
Expression pattern of the AP-1 family in breast cancer: association of fosB expression with a well-differentiated, receptor-positive tumor phenotypeQ40926125
Dominant-negative c-Jun NH2-terminal kinase 2 sensitizes renal inner medullary collecting duct cells to hypertonicity-induced lethality independent of organic osmolyte transportQ41065579
Erythropoietin-dependent inhibition of apoptosis is supported by carboxyl-truncated receptor forms and blocked by dominant-negative forms of Jak2.Q41334500
Mechanism of action of a dominant-negative mutant of c-Jun.Q41483975
p38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun. The determinant roles of the isoforms in the p38 MAPK signal specificityQ42807486
Molecular interpretation of ERK signal duration by immediate early gene productsQ42812329
Cell cycle promoting activity of JunB through cyclin A activationQ42812587
Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathwayQ43691664
Src mediates prolactin-dependent proliferation of T47D and MCF7 cells via the activation of focal adhesion kinase/Erk1/2 and phosphatidylinositol 3-kinase pathwaysQ44542433
Alterations in the gene expression profile of MCF-7 breast tumor cells in response to c-JunQ44876378
PRL activates the cyclin D1 promoter via the Jak2/Stat pathway.Q52545721
Plasma Prolactin Levels and Subsequent Risk of Breast Cancer in Postmenopausal WomenQ56882445
Activation and inhibition of the AP-1 complex in human breast cancer cellsQ70992069
AP-1/jun is required for early Xenopus development and mediates mesoderm induction by fibroblast growth factor but not by activinQ71070377
Janus kinase 2-dependent activation of p38 mitogen-activated protein kinase by growth hormone. Resultant transcriptional activation of ATF-2 and CHOP, cytoskeletal re-organization and mitogenesisQ73357698
Biological and clinical associations of c-jun activation in human breast cancerQ73645110
Prolactin (PRL)-PRL receptor system increases cell proliferation involving JNK (c-Jun amino terminal kinase) and AP-1 activation: inhibition by glucocorticoidsQ73688138
AP-1 complexes containing cJun and JunB cause cellular transformation of Rat1a fibroblasts and share transcriptional targetsQ73876722
Expression of cell cycle-regulatory proteins rb, p16/MTS1, p27/KIP1, p21/WAF1, cyclin D1 and cyclin E in breast cancer: correlations with expression of activating protein-1 family membersQ74081695
PRL modulates cell cycle regulators in mammary tumor epithelial cellsQ77438791
P4510describes a project that usesImageQuantQ112270642
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)3064-3075
P577publication date2004-08-19
P1433published inMolecular EndocrinologyQ3319475
P1476titleMultiple kinase cascades mediate prolactin signals to activating protein-1 in breast cancer cells
P478volume18

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cites work (P2860)
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Q36629985Modeling prolactin actions in breast cancer in vivo: insights from the NRL-PRL mouse
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Q36998060PAK1 regulates breast cancer cell invasion through secretion of matrix metalloproteinases in response to prolactin and three-dimensional collagen IV.
Q30425265PAK1-Nck regulates cyclin D1 promoter activity in response to prolactin
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Q38667106Stat5 activation inhibits prolactin-induced AP-1 activity: distinct prolactin-initiated signals in tumorigenesis dependent on cell context.
Q36812402Stiff collagen matrices increase tumorigenic prolactin signaling in breast cancer cells
Q46826626The role of ERK5 in T-cell signalling.
Q37192034Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation.