Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch

scientific article

Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VACCINE.2005.11.039
P932PMC publication ID2081151
P698PubMed publication ID16368167
P5875ResearchGate publication ID7403031

P50authorAnahit GhochikyanQ40272584
P2093author name stringDavid H Cribbs
Irina Petrushina
Michael G Agadjanyan
Mikayel Mkrtichyan
Nina Movsesyan
Adrine Karapetyan
P2860cites workThe amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeuticsQ27860914
Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunizationQ28185520
Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype productionQ70338857
Dosing in phase II trial of Alzheimer's vaccine suspendedQ73632329
QS-21: a water-soluble triterpene glycoside adjuvantQ94447746
Alzheimer's disease: the amyloid cascade hypothesisQ29547160
TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional propertiesQ29547848
High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formationQ29616564
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouseQ29619237
A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's diseaseQ33292093
A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's diseaseQ33292510
A portrait of Alzheimer secretases--new features and familiar facesQ34345559
Adjuvants for human vaccines--current status, problems and future prospectsQ34373525
Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.Q34417339
Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloidQ34698382
Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathologyQ34763076
Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginningQ34932593
Does my mouse have Alzheimer's disease?Q35186500
Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.Q35841991
Cytokine regulation of immunoglobulin isotype switching and expression.Q35999290
Lymphokine control of in vivo immunoglobulin isotype selection.Q36576188
Amyloid Protein and Alzheimer's DiseaseQ36938484
Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's diseaseQ37118356
Phase 1 trial of immunological adjuvant QS-21 with a GM2 ganglioside-keyhole limpet haemocyanin conjugate vaccine in patients with malignant melanomaQ40694541
Alzheimer's disease: a central role for amyloidQ40701623
Cellular and molecular biology of Alzheimer's disease and animal modelsQ40759701
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer diseaseQ41753192
Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer diseaseQ43860008
Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.Q44132564
Cytokine, chemokine and chemokine receptor mRNA expression in different strains of normal mice: implications for establishment of a Th1/Th2 biasQ44419196
Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasomeQ45007178
Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from beta-amyloid and promiscuous T cell epitope pan HLA DR-binding peptideQ45295828
Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68.Q46011081
A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's diseaseQ47583762
Safety, tolerability and immunogenicity of new formulations of the Plasmodium falciparum malaria peptide vaccine SPf66 combined with the immunological adjuvant QS-21.Q47904576
Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's diseaseQ48007049
Antibodies against beta-amyloid slow cognitive decline in Alzheimer's diseaseQ48300537
Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.Q48363055
Importance of IgG2c isotype in the immune response to beta-amyloid in amyloid precursor protein/transgenic mice.Q48396310
Abeta42 immunization in Alzheimer's disease generates Abeta N-terminal antibodiesQ48797820
Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease.Q48893777
Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivoQ48925662
Immunogenic properties of multiple antigen peptide systems containing defined T and B epitopesQ52088160
Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells.Q52112638
Set back to Alzheimer vaccine studies.Q53246987
Evaluation of the safety and immunogenicity of synthetic A 42 (AN1792) in patients with ADQ58005269
Integrating signals from IFN-gamma and IL-4 by B cells: positive and negative effects on CD40 ligand-induced proliferation, survival, and division-linked isotype switching to IgG1, IgE, and IgG2aQ61853750
P433issue13
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
antibodyQ79460
vaccineQ134808
infectious diseaseQ18123741
P304page(s)2275-2282
P577publication date2005-12-05
P1433published inVaccineQ7907941
P1476titlePrototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch
P478volume24

Reverse relations

cites work (P2860)
Q36326816A Perspective on Roles Played by Innate and Adaptive Immunity in the Pathobiology of Neurodegenerative Disorders
Q28740910A cyclic undecamer peptide mimics a turn in folded Alzheimer amyloid β and elicits antibodies against oligomeric and fibrillar amyloid and plaques
Q35040016A dual vaccine against influenza & Alzheimer's disease failed to enhance anti-β-amyloid antibody responses in mice with pre-existing virus specific memory
Q37435886Active and passive immunization strategies based on the SDPM1 peptide demonstrate pre-clinical efficacy in the APPswePSEN1dE9 mouse model for Alzheimer's disease
Q37625591Adjuvants and autoimmunity
Q37438255Alternative Abeta immunotherapy approaches for Alzheimer's disease
Q33935251Amyloid beta immunization worsens iron deposits in the choroid plexus and cerebral microbleeds.
Q53318106Amyloid beta-HSP60 peptide conjugate vaccine treats a mouse model of Alzheimer's disease.
Q33954737Amyloid-beta immunotherapy for Alzheimer's disease
Q36677402An update on pharmacological approaches to neurodegenerative diseases
Q27024202CD4 T cells in immunity and immunotherapy of Alzheimer's disease
Q80633269Clinical evaluation of BCR-ABL peptide immunisation in chronic myeloid leukaemia: results of the EPIC study
Q45300233Comparison of Efficacy of Preventive and Therapeutic Vaccines Targeting the N Terminus of β-Amyloid in an Animal Model of Alzheimer's Disease
Q42610772Conformation-sensitive antibodies against alzheimer amyloid-beta by immunization with a thioredoxin-constrained B-cell epitope peptide
Q33957114DNA beta-amyloid(1-42) trimer immunization for Alzheimer disease in a wild-type mouse model.
Q37086973DNA epitope vaccine containing complement component C3d enhances anti-amyloid-beta antibody production and polarizes the immune response towards a Th2 phenotype
Q33647708DNA prime-protein boost increased the titer, avidity and persistence of anti-Abeta antibodies in wild-type mice.
Q36607324Early diagnostics and therapeutics for Alzheimer's disease--how early can we get there?
Q36026890Enhancing Th2 immune responses against amyloid protein by a DNA prime-adenovirus boost regimen for Alzheimer's disease
Q50776088Identification and mapping of linear antigenic determinants of human amyloid ß(1-42) peptide.
Q37209757Immune modulation by adjuvants combined with diphtheria toxoid administered topically in BALB/c mice after microneedle array pretreatment
Q24599108Immunization with the SDPM1 peptide lowers amyloid plaque burden and improves cognitive function in the APPswePSEN1(A246E) transgenic mouse model of Alzheimer's disease
Q38187861Immunogenicity of DNA- and recombinant protein-based Alzheimer disease epitope vaccines
Q36790089Immunogenicity, efficacy, safety, and mechanism of action of epitope vaccine (Lu AF20513) for Alzheimer's disease: prelude to a clinical trial
Q37634138Immunostimulant patches containing Escherichia coli LT enhance immune responses to DNA- and recombinant protein-based Alzheimer's disease vaccines.
Q22241491Immunotherapy as treatment for Alzheimer’s disease
Q48603497In vivo electroporation of a new gene vaccine encoding ten repeats of Aβ3-10 prevents brain Aβ deposition and delays cognitive impairment in young Tg-APPswe/PSEN1dE9 mice
Q41983452MER5101, a novel Aβ1-15:DT conjugate vaccine, generates a robust anti-Aβ antibody response and attenuates Aβ pathology and cognitive deficits in APPswe/PS1ΔE9 transgenic mice
Q34624985Oral administration of a fusion protein between the cholera toxin B subunit and the 42-amino acid isoform of amyloid-β peptide produced in silkworm pupae protects against Alzheimer's disease in mice
Q37438261Rationale for peptide and DNA based epitope vaccines for Alzheimer's disease immunotherapy
Q33332164Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy
Q37672845T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer's Disease: Potential Pools of New Biomarkers
Q36558485Tau-Directed Immunotherapy: A Promising Strategy for Treating Alzheimer's Disease and Other Tauopathies
Q54941797The antibody response in the bovine mammary gland is influenced by the adjuvant and the site of subcutaneous vaccination.
Q35183183The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer's disease
Q37896029The recent updates of therapeutic approaches against aβ for the treatment of Alzheimer's disease.
Q49138161The second-generation active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects.
Q37842339Therapeutic potential of vaccines for Alzheimer's disease
Q35844472Transcutaneous beta-amyloid immunization reduces cerebral beta-amyloid deposits without T cell infiltration and microhemorrhage
Q42655652UB-311, a novel UBITh® amyloid β peptide vaccine for mild Alzheimer's disease
Q38567072Vaccines, adjuvants and autoimmunity

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