Selective labelling of diazepam-insensitive GABAA receptors in vivo using [3H]Ro 15-4513

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Selective labelling of diazepam-insensitive GABAA receptors in vivo using [3H]Ro 15-4513 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SJ.BJP.0706392
P932PMC publication ID1751217
P698PubMed publication ID16184188
P5875ResearchGate publication ID7580439

P50authorJohn AtackQ63352032
P2093author name stringRuth M McKernan
Susan M Cook
Thomas Rosahl
Luanda J Pym
P2860cites workRelationship between benzodiazepine receptor occupancy and functional effects in vivo of four ligands of differing intrinsic efficaciesQ51690515
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Diazepam-insensitive [3H]Ro 15-4513 binding in intact cultured cerebellar granule cells.Q51747577
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Comparison of several benzodiazepine receptor ligands in two models of anxiolytic activity in the mouse: an analysis based on fractional receptor occupancies.Q52218225
Characterization of a benzodiazepine receptor site with exceptionally high affinity for Ro 15-4513 in the rat CNSQ71490919
No age-related changes in human benzodiazepine receptor binding measured by PET with [11C]Ro 15-4513Q72666885
Evaluation of [methyl-3H]L655,708 and [ethyl-3H]RY80 as putative PET ligands for central GABA(A) receptors containing alpha5 subunitQ73340077
Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptorsQ24311686
Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human [...]Q24316082
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionQ27860958
Pharmacological modulation of the diazepam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2Q28296477
A single histidine in GABAA receptors is essential for benzodiazepine agonist bindingQ28572645
Trace fear conditioning involves hippocampal alpha5 GABA(A) receptorsQ28594296
Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.Q33902217
Positioning of the alpha-subunit isoforms confers a functional signature to gamma-aminobutyric acid type A receptors.Q34337736
[123I]iomazenil SPECT imaging demonstrates significant benzodiazepine receptor reserve in human and nonhuman primate brainQ34356883
Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit.Q34395916
Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse geneticsQ35639173
The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalonQ38330309
Cloning, pharmacological characteristics and expression pattern of the rat GABAA receptor alpha 4 subunitQ38333425
Pharmacology of recombinant gamma-aminobutyric acidA receptors rendered diazepam-insensitive by point-mutated alpha-subunits.Q38334136
Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes.Q40417870
GABAA/Benzodiazepine receptor heterogeneity: Neurophysiological implicationsQ40457385
A significant part of native gamma-aminobutyric AcidA receptors containing alpha4 subunits do not contain gamma or delta subunitsQ40944598
Which GABAA-receptor subtypes really occur in the brain?Q41003268
GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain.Q42497057
Imaging the GABA-benzodiazepine receptor subtype containing the alpha5-subunit in vivo with [11C]Ro15 4513 positron emission tomographyQ44079767
11CRo 15-4513, a ligand for visualization of benzodiazepine receptor binding. Preparation, autoradiography and positron emission tomographyQ44135720
In vivo labeling of central benzodiazepine receptors with the partial inverse agonist [3H]Ro 15-4513.Q44263964
The benzodiazepine/alcohol antagonist Ro 15-4513: binding to a GABAA receptor subtype that is insensitive to diazepamQ46133985
In vivo labelling of alpha5 subunit-containing GABA(A) receptors using the selective radioligand [(3)H]L-655,708.Q46582343
Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for alpha 1 versus alpha 2 and alpha 3 subunit-containing GABAA receptors.Q48272085
Imaging of the super high affinity binding sites for [3H]Ro15-4513 in rat hippocampus: comparison between in vitro and in vivo bindingQ48409136
Comparative in vivo and in vitro regional selectivity of central omega (benzodiazepine) site ligands in inhibiting [3H]flumazenil binding in the rat central nervous systemQ48416552
In vivo binding of [11C]Ro15-4513 in human brain measured with PETQ48419920
Subunit composition and quantitative importance of hetero-oligomeric receptors: GABAA receptors containing alpha6 subunits.Q48493375
In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primatesQ48670838
A subclass of GABAA/benzodiazepine receptor exclusively localized in the limbic systemQ48827946
Molecular and neuronal substrate for the selective attenuation of anxiety.Q51376038
Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.Q51434685
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectdiazepamQ210402
P304page(s)817-825
P577publication date2005-11-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleSelective labelling of diazepam-insensitive GABAA receptors in vivo using [3H]Ro 15-4513
P478volume146

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cites work (P2860)
Q58554477A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive-compulsive disorder: Mapping the way forward
Q36243393Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment

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