Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors

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Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors is …
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scholarly articleQ13442814

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P819ADS bibcode2000PNAS...97.2814M
P356DOI10.1073/PNAS.050397097
P8608Fatcat IDrelease_kj72vsdyvbhgbebhdnya6hdr4y
P3181OpenCitations bibliographic resource ID4236211
P932PMC publication ID16012
P698PubMed publication ID10706619
P5875ResearchGate publication ID12608362

P50authorNai-Kong V CheungQ88954512
Brian H KushnerQ114536202
P2093author name stringP C Nowell
B J Lange
C A Felix
E F Rappaport
M D Megonigal
T M Williams
D H Jones
R B Wilson
D G Leonard
K Addya
P2860cites workMSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)Q22009898
gas7: A gene expressed preferentially in growth-arrested fibroblasts and terminally differentiated Purkinje neurons affects neurite formationQ24313245
Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemiaQ24317124
'Touchdown' PCR to circumvent spurious priming during gene amplificationQ24630793
t(11;22)(q23;q11.2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromesQ24641962
Panhandle PCR strategy to amplify MLL genomic breakpoints in treatment-related leukemiasQ24654907
Duplicated regions of AF-4 intron 4 at t(4;11) translocation breakpointsQ28144573
The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 geneQ28201279
Panhandle polymerase chain reaction amplifies MLL genomic translocation breakpoint involving unknown partner geneQ28255936
Secondary leukemia or myelodysplastic syndrome after treatment with epipodophyllotoxinsQ33855281
Rearrangement of the MLL gene confers a poor prognosis in childhood acute lymphoblastic leukemia, regardless of presenting age.Q34733137
Stem cell regulation, tissue ontogeny, and oncogenic eventsQ35757499
Association of CYP3A4 genotype with treatment-related leukemiaQ36643196
An interstitial 11q23 deletion proven to be a rearrangement interrupting the MLL gene in an infant with acute myeloblastic leukemia.Q36829667
Panhandle PCR: a technical advance to amplify MLL genomic translocation breakpointsQ38336232
Self-fusion of the ALL1 gene. A new genetic mechanism for acute leukemiaQ40580386
Highly effective induction therapy for stage 4 neuroblastoma in children over 1 year of age.Q41663772
Fine structure of translocation breakpoints in leukemic blasts with chromosomal translocation t(4;11): the DNA damage-repair model of translocationQ42819800
Association of germline p53 mutation with MLL segmental jumping translocation in treatment-related leukemia.Q48004867
The human MLL gene: nucleotide sequence, homology to the Drosophila trx zinc-finger domain, and alternative splicingQ48073409
High risk of leukemia after short-term dose-intensive chemotherapy in young patients with solid tumors.Q50866450
Characterization of immunoglobulin and T-cell receptor gene patterns in B-cell precursor acute lymphoblastic leukemia of childhood.Q51169322
ALL-1 gene rearrangements in DNA topoisomerase II inhibitor-related leukemia in children.Q52510288
Secondary acute myeloid leukemia in children previously treated with alkylating agents, intercalating topoisomerase II inhibitors, and irradiationQ70457573
Chromosome band 11q23 translocation breakpoints are DNA topoisomerase II cleavage sitesQ72050036
Do terminal deletions of 11q23 exist? Identification of undetected translocations with fluorescence in situ hybridizationQ72100930
Potential role for wild-type p53 in leukemias with MLL gene translocationsQ74452723
Hematological malignancies with a deletion of 11q23: cytogenetic and clinical aspects. European 11q23 Workshop participantsQ74566325
Partial tandem duplications of the MLL gene are detectable in peripheral blood and bone marrow of nearly all healthy donorsQ77145850
Anti-G(D2) antibody treatment of minimal residual stage 4 neuroblastoma diagnosed at more than 1 year of ageQ77302613
Secondary leukemias induced by topoisomerase-targeted drugsQ77333785
Cloning and sequence analysis of four t(9;11) therapy-related leukemia breakpointsQ77653606
Neuroblastoma and treatment-related myelodysplasia/leukemia: the Memorial Sloan-Kettering experience and a literature reviewQ77669936
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
chemotherapyQ974135
P304page(s)2814-9
P577publication date2000-03-14
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleDetection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors
P478volume97