Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3

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Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3 is …
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scholarly articleQ13442814

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P819ADS bibcode2003PNAS..100.8880W
P356DOI10.1073/PNAS.1533186100
P8608Fatcat IDrelease_j7fkzkzjrngddl6fbjyog4r2fy
P3181OpenCitations bibliographic resource ID3594192
P932PMC publication ID166407
P698PubMed publication ID12840147
P5875ResearchGate publication ID10679336

P50authorJacek LubkowskiQ28360195
Wuyuan LuQ90908795
P2093author name stringZhibin Wu
De Yang
Joost J Oppenheim
Cyril Boulègue
David M Hoover
Fanny Santamaria
P2860cites workBeta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6Q22010648
Human neutrophil defensins selectively chemoattract naive T and immature dendritic cellsQ22254687
Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibioticQ24290539
Purification and characterization of human neutrophil peptide 4, a novel member of the defensin familyQ24300501
Discovery of five conserved beta -defensin gene clusters using a computational search strategyQ24529856
Antibacterial action of structurally diverse cationic peptides on gram-positive bacteriaQ24550625
Primary structures of three human neutrophil defensinsQ24563841
Defensins. Natural peptide antibiotics of human neutrophilsQ24563852
Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarityQ24644524
The structure of human beta-defensin-2 shows evidence of higher order oligomerizationQ27625482
Three-dimensional structure of RTD-1, a cyclic antimicrobial defensin from Rhesus macaque leukocytesQ27630954
The structure of human beta-defensin-1: new insights into structural properties of beta-defensinsQ27633872
The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureusQ27636772
Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilizationQ27658909
Antimicrobial peptides of multicellular organismsQ28131811
Discovery of new human beta-defensins using a genomics-based approachQ28202377
Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattractionQ28204611
Paneth cells--guardians of the gut cell hatcheryQ28204769
Principles that govern the folding of protein chainsQ28236872
A peptide antibiotic from human skinQ28242199
Structure, function, and membrane integration of defensinsQ28270856
Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophilsQ28277848
hBD-1: a novel beta-defensin from human plasmaQ28294850
Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosisQ28303994
Why and how are peptide-lipid interactions utilized for self-defense? Magainins and tachyplesins as archetypesQ33789700
Diversity of antimicrobial peptides and their mechanisms of actionQ33789705
Interaction of antimicrobial peptides with biological and model membranes: structural and charge requirements for activityQ33789711
Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptidesQ33789716
Lipid-induced conformation and lipid-binding properties of cytolytic and antimicrobial peptides: determination and biological specificityQ33789726
Innate antimicrobial peptide protects the skin from invasive bacterial infectionQ34102960
Defensins of vertebrate animalsQ34109303
Structure, function, and inhibition of chemokinesQ34110896
Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowelQ34359011
Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cellsQ34407161
Mechanism of interaction of different classes of cationic antimicrobial peptides with planar bilayers and with the cytoplasmic membrane of Escherichia coliQ34503697
[beta]-defensins in lung host defenseQ34516289
Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid.Q34732912
Paneth cells of the human small intestine express an antimicrobial peptide geneQ41099931
Cationic peptides: a new source of antibioticsQ41714967
Antimicrobial peptides of vertebratesQ41729805
Binding of amino acid side chains to preformed cavities: interaction of serine proteinases with turkey ovomucoid third domains with coded and noncoded P1 residuesQ42027179
Defensins promote fusion and lysis of negatively charged membranesQ42843138
Interaction of cationic antimicrobial peptides with model membranesQ43687963
Interactions of monomeric rabbit neutrophil defensins with bilayers: comparison with dimeric human defensin HNP-2.Q46241707
Engineered salt-insensitive alpha-defensins with end-to-end circularized structuresQ50122491
Design of Salt-Insensitive Glycine-Rich Antimicrobial Peptides with Cyclic Tricystine Structures†Q57236394
Marked Increase in Membranolytic Selectivity of Novel Cyclic Tachyplesins Constrained with an Antiparallel Two-β Strand Cystine Knot FrameworkQ57236397
Membranolytic selectivity of cystine-stabilized cyclic protegrinsQ57236398
Mutational Analysis of a Plant Defensin from Radish (Raphanus sativusL.) Reveals Two Adjacent Sites Important for Antifungal ActivityQ61052923
In situ neutralization in Boc-chemistry solid phase peptide synthesis. Rapid, high yield assembly of difficult sequencesQ67982257
A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migrationQ72133316
Peptide antibioticsQ73073957
Binding of amino acid side-chains to S1 cavities of serine proteinasesQ73104113
P433issue15
P407language of work or nameEnglishQ1860
P921main subjectchemotaxisQ658145
P304page(s)8880-5
P577publication date2003-07-22
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleEngineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3
P478volume100

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cites work (P2860)
Q53250989A New, High Yield, Rapid, and Cost-Effective Protocol to Deprotection of Cysteine-Rich Conopeptide, Omega-Conotoxin MVIIA.
Q39790103A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa.
Q27319961A novel role for β2-microglobulin: a precursor of antibacterial chemokine in respiratory epithelial cells.
Q37393392AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense
Q51039745Alarmin-induced cell migration.
Q37404678Alarmins and antimicrobial immunity.
Q46819070Analysis and separation of residues important for the chemoattractant and antimicrobial activities of beta-defensin 3.
Q34463066Antibacterial activity of human neutrophil defensin HNP-1 analogs without cysteines
Q30848083Antifungal activities of human beta-defensins HBD-1 to HBD-3 and their C-terminal analogs Phd1 to Phd3.
Q38081821Antifungal proteins: More than antimicrobials?
Q42244810Antimicrobial activities of chemokines: not just a side-effect?
Q40013212Antimicrobial activity does not predict cytokine response to adrenomedullin or its shortened derivatives
Q42700440Antimicrobial and Antibiofilm Effects of Human Amniotic/Chorionic Membrane Extract on Streptococcus pneumoniae
Q35685623Antimicrobial characterization of human beta-defensin 3 derivatives
Q41348615Antimicrobial characterization of site-directed mutagenesis of porcine beta defensin 2.
Q45020337Antimicrobial efficacy of a human β-defensin-3 peptide using an Enterococcus faecalis dentine infection model
Q42275047Antimicrobial host defensins - specific antibiotic activities and innate defense modulation
Q57273088Antimicrobial peptides human β-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability
Q37034707Antimicrobial peptides in human skin disease.
Q34684398Antimicrobial peptides in the oral environment: expression and function in health and disease.
Q37954721Antimicrobial peptides: key components of the innate immune system
Q51145739Antiplasmodial activity of tick defensins in a mouse model of malaria.
Q43639700Artificial beta-defensin based on a minimal defensin template.
Q33686462Artificial disulfide-rich peptide scaffolds with precisely defined disulfide patterns and a minimized number of isomers.
Q37689800Avian antimicrobial host defense peptides: from biology to therapeutic applications.
Q28271109Avian defensins
Q52682316Beta-Defensin 2 and 3 Promote Bacterial Clearance of Pseudomonas aeruginosa by Inhibiting Macrophage Autophagy through Downregulation of Early Growth Response Gene-1 and c-FOS.
Q37844632Beta-defensins: what are they really doing in the oral cavity?
Q38162043Bovine β-defensin gene family: opportunities to improve animal health?
Q30151971Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections
Q93045538Characterization of host defense molecules in the human pancreas
Q46460554Characterization of the antimicrobial peptide family defensins in the Tasmanian devil (Sarcophilus harrisii), koala (Phascolarctos cinereus), and tammar wallaby (Macropus eugenii).
Q58771119Characterization of the β-defensin genes in giant panda
Q35794672Chemokine receptors and leukocyte trafficking in the mucosal immune system.
Q39203205Chimeric beta-defensin analogs, including the novel 3NI analog, display salt-resistant antimicrobial activity and lack toxicity in human epithelial cell lines
Q34660888Combining flagellin and human β-defensin-3 to combat bacterial infections
Q38788790Control of the Physical and Antimicrobial Skin Barrier by an IL-31-IL-1 Signaling Network.
Q42165308Covalent dimer species of beta-defensin Defr1 display potent antimicrobial activity against multidrug-resistant bacterial pathogens
Q24648026Crystal structures of human alpha-defensins HNP4, HD5, and HD6
Q57476688Cysteines and Disulfide-Bridged Macrocyclic Mimics of Teixobactin Analogues and Their Antibacterial Activity Evaluation against Methicillin-Resistant (MRSA)
Q33903419Defensin-related peptide 1 (Defr1) is allelic to Defb8 and chemoattracts immature DC and CD4+ T cells independently of CCR6.
Q34579734Defensins couple dysbiosis to primary immunodeficiency in Crohn's disease.
Q36488755Defensins in innate antiviral immunity
Q95840985Defensins: A Double-Edged Sword in Host Immunity
Q38201011Defensins: antifungal lessons from eukaryotes
Q91861171Defining the mobility range of a hinge-type connection using molecular dynamics and metadynamics
Q45303710Defining the native disulfide topology in the somatomedin B domain of human vitronectin
Q47979721Deleting the first disulphide bond in an arenicin derivative enhances its expression in Pichia pastoris
Q31015139Determining multiallelic complex copy number and sequence variation from high coverage exome sequencing data
Q57046321Did cis- and trans-defensins derive from a common ancestor?
Q30397736Different dynamics and pathway of disulfide bonds reduction of two human defensins, a molecular dynamics simulation study
Q36332730Diminished responsiveness to human β-defensin-3 and decreased TLR1 expression on monocytes and mDCs from HIV-1-infected patients.
Q37247514Disulfide cross-linking influences symbiotic activities of nodule peptide NCR247.
Q55604491Do β-defensins and other antimicrobial peptides play a role in neuroimmune function and neurodegeneration?
Q35006475Effect of selectively introducing arginine and D-amino acids on the antimicrobial activity and salt sensitivity in analogs of human beta-defensins
Q30179403Engineering disulfide bonds of the novel human beta-defensins hBD-27 and hBD-28: differences in disulfide formation and biological activity among human beta-defensins
Q53281868Engineering of a linear inactive analog of human β-defensin 4 to generate peptides with potent antimicrobial activity.
Q37780272Epithelial cell-derived antimicrobial peptides are multifunctional agents that bridge innate and adaptive immunity
Q42625994Equine beta-defensin-1: full-length cDNA sequence and tissue expression
Q24793732Expressed sequence tag profiling identifies developmental and anatomic partitioning of gene expression in the mouse prostate
Q37053063Functional consequences of retro-inverso isomerization of a miniature protein inhibitor of the p53-MDM2 interaction
Q24648799Functional structure of the somatomedin B domain of vitronectin
Q54368244Host defense (Antimicrobial) peptide, human β-defensin-3, improves the function of the epithelial tight-junction barrier in human keratinocytes.
Q35010044Host defense peptides as effector molecules of the innate immune response: a sledgehammer for drug resistance?
Q36276925Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2.
Q33753961Human Beta Defensin 2 Selectively Inhibits HIV-1 in Highly Permissive CCR6⁺CD4⁺ T Cells.
Q88954037Human Enteric α-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion
Q27649353Human Macrophage Inflammatory Protein 3 : Protein and Peptide Nuclear Magnetic Resonance Solution Structures, Dimerization, Dynamics, and Anti-Infective Properties
Q42089675Human alpha-defensins inhibit hemolysis mediated by cholesterol-dependent cytolysins
Q37053332Human antimicrobial proteins effectors of innate immunity
Q50335870Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2.
Q34737252Human beta-defensin 2 and beta-defensin 3 chimeric peptides reveal the structural basis of the pathogen specificity of their parent molecules
Q41837033Human beta-defensin 3 has immunosuppressive activity in vitro and in vivo
Q42013622Human beta-defensin 3 induces maturation of human langerhans cell-like dendritic cells: an antimicrobial peptide that functions as an endogenous adjuvant
Q41500846Human beta-defensin-3 producing cells in septic implant loosening.
Q34124118Human beta-defensins suppress human immunodeficiency virus infection: potential role in mucosal protection.
Q30032656Human defensin 5 disulfide array mutants: disulfide bond deletion attenuates antibacterial activity against Staphylococcus aureus
Q34727874Human defensins facilitate local unfolding of thermodynamically unstable regions of bacterial protein toxins
Q42285768Human β defensin-3 induces chemokines from monocytes and macrophages: diminished activity in cells from HIV-infected persons
Q27310039Human β-Defensin 3 [corrected] Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid
Q39496522Human β-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF
Q35580348Human β-defensin 4 with non-native disulfide bridges exhibit antimicrobial activity
Q54342786Human β-defensin-3 promotes intestinal epithelial cell migration and reduces the development of necrotizing enterocolitis in a neonatal rat model.
Q37318727Human β-defensin-3 structure motifs that are important in CXCR4 antagonism
Q28509274Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta-defensin 3
Q36010308Identification of a cell-penetrating peptide domain from human beta-defensin 3 and characterization of its anti-inflammatory activity
Q24644482Impact of pro segments on the folding and function of human neutrophil alpha-defensins
Q49852449Importance of phosphoinositide binding by human β-defensin 3 for Akt-dependent cytokine induction
Q38227832Importance of β-defensins in sperm function
Q42937024In vitro activation of the rhesus macaque myeloid alpha-defensin precursor proRMAD-4 by neutrophil serine proteinases
Q54365857In vitro antibacterial and hemolytic activities of crotamine, a small basic myotoxin from rattlesnake Crotalus durissus.
Q36954965Induction of group A Streptococcus virulence by a human antimicrobial peptide
Q33619244Insight into the mechanisms of adenovirus capsid disassembly from studies of defensin neutralization
Q91178592Integrated solid-state NMR and molecular dynamics modeling determines membrane insertion of human β-defensin analog
Q41149978Kinetic and thermodynamic studies reveal chemokine homologues CC11 and CC24 with an almost identical tertiary structure have different folding pathways
Q50070363Live Leishmania tarentolae secreting HNP1 as an immunotherapeutic tool against Leishmania infection in BALB/c mice.
Q33795132Macrocyclic Antimicrobial Peptides Engineered from ω-Conotoxin
Q36134856Mammalian defensins in the antimicrobial immune response
Q40478628Membrane damage and repair in primary monocytes exposed to human β-defensin-3
Q35027911Membrane disruptive antimicrobial activities of human β-defensin-3 analogs
Q50072115Modification of chicken avian beta-defensin-8 at positively selected amino acid sites enhances specific antimicrobial activity.
Q58746619Modification of the surface of titanium with multifunctional chimeric peptides to prevent biofilm formation via inhibition of initial colonizers
Q38824103Modulation of host defense peptide-mediated human mast cell activation by LPS.
Q40846156Modulation of neutrophil apoptosis by antimicrobial peptides
Q44976434Molecular and functional characterization of bovine beta-defensin-1.
Q42606648Molecular diversity of the antimicrobial domain of beta-defensin 3 and homologous peptides
Q33905204Multidimensional signatures in antimicrobial peptides
Q52368484Multifaceted immune functions of human defensins and underlying mechanisms.
Q34098551Multivalent Antimicrobial Peptides as Therapeutics: Design Principles and Structural Diversities
Q39709081Native thrombocidin-1 and unfolded thrombocidin-1 exert antimicrobial activity via distinct structural elements
Q35950558Nonviral human beta defensin-3 expression in a bioengineered human skin tissue: a therapeutic alternative for infected wounds
Q36288808Novel synthetic analogues of avian β-defensin-12: the role of charge, hydrophobicity, and disulfide bridges in biological functions
Q33876601Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity
Q46313866Osteoblasts participate in the innate immunity of the bone by producing human beta defensin-3.
Q58107788Overexpressing ovotransferrin and avian β-defensin-3 improves antimicrobial capacity of chickens and poultry products
Q33815422Paneth cell α-defensins in enteric innate immunity
Q33533544Peptide fragments of a beta-defensin derivative with potent bactericidal activity
Q40487333Perturbation of Lipopolysaccharide (LPS) Micelles by Sushi 3 (S3) antimicrobial peptide. The importance of an intermolecular disulfide bond in S3 dimer for binding, disruption, and neutralization of LPS.
Q21266611Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence
Q41916247Post-translational Modifications of Natural Antimicrobial Peptides and Strategies for Peptide Engineering
Q24310770Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense
Q33780738Psd1 Effects on Candida albicans Planktonic Cells and Biofilms
Q35998473Psoriatic scales: a promising source for the isolation of human skin-derived antimicrobial proteins
Q39766457Rattusin, an intestinal α-defensin-related peptide in rats with a unique cysteine spacing pattern and salt-insensitive antibacterial activities.
Q97653000Recombinant expression, purification and PEGylation of Paneth cell peptide (cryptdin-2) with value added attributes against Staphylococcus aureus
Q34418988Reconstruction of the conserved beta-bulge in mammalian defensins using D-amino acids.
Q26864737Revealing the properties of plant defensins through dynamics
Q43958057Salt-resistant homodimeric bactenecin, a cathelicidin-derived antimicrobial peptide
Q52656373Simulating the antimicrobial mechanism of human β-defensin-3 with coarse-grained molecular dynamics.
Q28116444Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells
Q36492362Structural perspectives on antimicrobial chemokines
Q45022873Structure-activity relationships in defensin dimers: a novel link between beta-defensin tertiary structure and antimicrobial activity
Q24676176Structure-dependent functional properties of human defensin 5
Q36128939Structure-function analysis of Avian β-defensin-6 and β-defensin-12: role of charge and disulfide bridges
Q54452869Studies of the biological properties of human beta-defensin 1.
Q45156268Synthesis of cyclic peptides through an intramolecular amide bond rearrangement
Q92156594Synthetic Human β Defensin-3-C15 Peptide in Endodontics: Potential Therapeutic Agent in Streptococcus gordonii Lipoprotein-Stimulated Human Dental Pulp-Derived Cells
Q38919751Targeting bactoprenol-coupled cell envelope precursors
Q85282087The Alarmin HMGN1 contributes to antitumor immunity and is a potent immunoadjuvant
Q95840995The Antimicrobial Peptide Human Beta-Defensin 2 Inhibits Biofilm Production of Pseudomonas aeruginosa Without Compromising Metabolic Activity
Q27676502The Cyclic Cystine Ladder in  -Defensins Is Important for Structure and Stability, but Not Antibacterial Activity
Q37023132The Disulfide Bond of the Peptide Thanatin Is Dispensible for Its Antimicrobial Activity In Vivo and In Vitro
Q44221211The Toll-like receptor 1/2 agonists Pam(3) CSK(4) and human β-defensin-3 differentially induce interleukin-10 and nuclear factor-κB signalling patterns in human monocytes
Q33836880The antimicrobial activity of CCL28 is dependent on C-terminal positively-charged amino acids
Q36592239The changing of the guard: Molecular diversity and rapid evolution of beta-defensins
Q36508686The co-evolution of host cationic antimicrobial peptides and microbial resistance
Q36798766The conserved salt bridge in human alpha-defensin 5 is required for its precursor processing and proteolytic stability
Q37209150The drosomycin multigene family: three-disulfide variants from Drosophila takahashii possess antibacterial activity
Q37017370The role of antimicrobial peptides at the ocular surface
Q39903794The role of human beta-defensin-2 in bone
Q37361213The roles of antimicrobial peptides in innate host defense
Q50092750The synthetic form of a novel chicken beta-defensin identified in silico is predominantly active against intestinal pathogens
Q43470518The synthetic peptides bovine enteric β-defensin (EBD), bovine neutrophil β-defensin (BNBD) 9 and BNBD 3 are chemotactic for immature bovine dendritic cells
Q28828268Thermodynamic instability of viral proteins is a pathogen-associated molecular pattern targeted by human defensins
Q24652382Through the looking glass, mechanistic insights from enantiomeric human defensins
Q34122347Topology of the disulfide bonds in the antiviral lectin scytovirin
Q27644561Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs
Q47557198Towards the Application of Human Defensins as Antivirals
Q45883008Transplantation of BMSCs expressing hVEGF165 /hBD3 promotes wound healing in rats with combined radiation-wound injury
Q80501633Tumor-infiltrating dendritic cell precursors recruited by a beta-defensin contribute to vasculogenesis under the influence of Vegf-A
Q45023232Twin disulfides for orthogonal disulfide pairing and the directed folding of multicyclic peptides
Q34462507Why is the Arg5-Glu13 salt bridge conserved in mammalian alpha-defensins?
Q35173769Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals?
Q51972625beta-Defensins chemoattract macrophages and mast cells but not lymphocytes and dendritic cells: CCR6 is not involved.
Q37968296α-Defensins in human innate immunity
Q37996291β-Defensins: multifunctional modulators of infection, inflammation and more?

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