Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs (scientific article)

A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase

Q24313492

Cytidine 5?monophosphosialic acid synthetase *1Activity and localization in the nucleate fragments of the unfertilized sea urchin egg

Q70723019

Lec32 is a new mutation in Chinese hamster ovary cells that essentially abrogates CMP-N-acetylneuraminic acid synthetase activity

Q70808790

Biosynthesis of N-glycolylneuraminic acid-containing glycoconjugates. Purification and characterization of the key enzyme of the cytidine monophospho-N-acetylneuraminic acid hydroxylation system

Q72303109

Subcellular localization of sugar nucleotide synthetases

Q72862627

The subcellular distribution of cytidine 5'-monophosphosialic acid synthetase in rat liver

Q72878900

The biosynthesis of cytidine 5'-monophospho-n-acetylneuraminic acid by an enzyme from Neisseria meningitidis

Q79705374

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

Q24545170

Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen

Q24563666

Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure

Q24609771

Fitting a mixture model by expectation maximization to discover motifs in biopolymers

Q27860556

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

Q27860728

The sialic acids. X. Purification and properties of cytidine 5'-monophosphosialic acid synthetase

Q28238745

A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Purification and characterization of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

Q28249585

The biosynthesis of cell wall lipopolysaccharide in Escherichia coli. IV. Purification and properties of cytidine monophosphate 3-deoxy-d-manno-octulosonate synthetase

Q28251766

CMP-N-acetylneuraminic acid hydroxylase: the first cytosolic Rieske iron-sulphur protein to be described in Eukarya

Q28280402

Structural features in eukaryotic mRNAs that modulate the initiation of translation

Q29547921

Biological roles of oligosaccharides: all of the theories are correct

Q29616459

Purification and properties of UDP-N-acetylglucosamine 2'-epimerase from rat liver

Q34218462

Inhibition of CMP-sialic acid transport in human liver and colorectal cancer cell lines by a sialic acid nucleoside conjugate (KI-8110).

Q34359836

Genetic analysis of chromosomal mutations in the polysialic acid gene cluster of Escherichia coli K1.

Q36174523

Regulation of sialic acid metabolism in Escherichia coli: role of N-acylneuraminate pyruvate-lyase.

Q36279539

Enzymatic synthesis of cytidine 5'-mono-phospho-sialic acids

Q36394288

Sialic acid activation

Q36472452

Activation of two new alpha(1,3)fucosyltransferase activities in Chinese hamster ovary cells by 5-azacytidine

Q36746487

Expression cloning of the Golgi CMP-sialic acid transporter

Q37426960

NZB mouse system for production of monoclonal antibodies to weak bacterial antigens: isolation of an IgG antibody to the polysaccharide capsules of Escherichia coli K1 and group B meningococci

Q37678387

Structure and biosynthesis of the capsular antigens of Escherichia coli.

Q38139027

Sialylation and malignant potential in tumour cell glycosylation mutants

Q38303857

The immobilized leukoagglutinin from the seeds of Maackia amurensis binds with high affinity to complex-type Asn-linked oligosaccharides containing terminal sialic acid-linked alpha-2,3 to penultimate galactose residues

Q38347523

Properties and subcellular localization of CMP-N-acetylneuraminic acid hydrolase of calf kidney

Q39121171

NCAM (CD56)-positive malignant lymphoma

Q40388157

Sialic acids in molecular and cellular interactions

Q40912594

Biosynthesis of the polysialic acid capsule in Escherichia coli K1.

Q40972484

Autocatalytic polysialylation of polysialyltransferase-1.

Q41079025

Purification and characterization of the Escherichia coli K1 neuB gene product N-acetylneuraminic acid synthetase

Q41560241

Molecular analysis of the biosynthesis pathway of the alpha-2,8 polysialic acid capsule by Neisseria meningitidis serogroup B.

Q42688458

Purification, cloning, and expression of a cytidine 5'-monophosphate N-acetylneuraminic acid synthetase from Haemophilus ducreyi

Q46698475

Molecular cloning of the hamster CMP-sialic acid transporter

Q48045929

Identification and characterization of genes required for post-translational modification of Campylobacter coli VC167 flagellin

Q48067414

Automated construction and graphical presentation of protein blocks from unaligned sequences

Q48069960

Molecular cloning and functional expression of bacteriophage PK1E-encoded endoneuraminidase Endo NE.

Q48074231

The subcellular localization of cytidine 5'-monophospho-N-acetylneuraminic acid synthetase in calf brain

Q48627151

Match-Box_server: a multiple sequence alignment tool placing emphasis on reliability

Q48749696

Purification and characterization of the nuclear cytidine 5'-monophosphate N-acetylneuraminic acid synthetase from rat liver.

Q50793324

Characterization of a post-translational modification of Campylobacter flagellin: identification of a sero-specific glycosyl moiety.

Q54596710

Demonstration of polysialic acid and N-CAM in neuroendocrine tumors

Q67688332

Translocation across Golgi vesicle membranes: a CHO glycosylation mutant deficient in CMP-sialic acid transport

Q70669682

P433

issue

P407

language of work or name

English

Q1860

P304

page(s)

9140-5

P577

publication date

1998-08-04

P1433

published in

Proceedings of the National Academy of Sciences of the United States of America

Q1146531

P1476

title

Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs

P478

volume

Reverse relations

cites work (P2860)

Q40724651	2',3'-Dialdehydo-UDP-N-acetylglucosamine inhibits UDP-N-acetylglucosamine 2-epimerase, the key enzyme of sialic acid biosynthesis
Q39462326	A transgenic insect cell line engineered to produce CMP-sialic acid and sialylated glycoproteins.
Q30039640	Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities
Q39250748	Biochemical, Cellular, Physiological, and Pathological Consequences of Human Loss of N-Glycolylneuraminic Acid.
Q40812143	Biosynthesis of N-acetylneuraminic acid in cells lacking UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
Q44762614	CMP-N-acetylneuraminic acid synthetase from Escherichia coli K1 is a bifunctional enzyme: identification of minimal catalytic domain for synthetase activity and novel functional domain for platelet-activating factor acetylhydrolase activity
Q28511421	Cloning and expression of human sialic acid pathway genes to generate CMP-sialic acids in insect cells
Q22253450	Cloning and expression of the human N-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-D-glycero- D-galacto-nononic acid biosynthetic ability
Q22254056	Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways
Q38567311	Comparative analysis of involvement of UGT1 and UGT2 splice variants of UDP-galactose transporter in glycosylation of macromolecules in MDCK and CHO cell lines
Q33269616	Construction and characterization of new piggyBac vectors for constitutive or inducible expression of heterologous gene pairs and the identification of a previously unrecognized activator sequence in piggyBac.
Q38353376	Correlation between the sialylation of cell surface Thomsen-Friedenreich antigen and the metastatic potential of colon carcinoma cells in a mouse model.
Q36109169	Deficits in sialylation impair podocyte maturation
Q35146270	Developing baculovirus-insect cell expression systems for humanized recombinant glycoprotein production
Q39093510	Diverse subcellular localizations of the insect CMP-sialic acid synthetases.
Q28569398	Domain-specific characteristics of the bifunctional key enzyme of sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
Q33804567	Enzymatic synthesis of nucleotide sugars
Q46990451	Expression of a functional Drosophila melanogaster CMP-sialic acid synthetase. Differential localization of the Drosophila and human enzymes
Q27637715	From structure to function: YrbI from Haemophilus influenzae (HI1679) is a phosphatase
Q48302185	Functional expression of a human GDP-L-fucose transporter in Escherichia coli.
Q39679452	Genetic variation at the O-antigen biosynthetic locus in Pseudomonas aeruginosa
Q28218950	GlcNAc 2-epimerase can serve a catabolic role in sialic acid metabolism
Q28362910	Glycoproteins from insect cells: sialylated or not?
Q24652891	Golgi targeting of Drosophila melanogaster beta4GalNAcTB requires a DHHC protein family-related protein as a pilot
Q44075276	High-level expression of recombinant Neisseria CMP-sialic acid synthetase in Escherichia coli
Q35921587	Identification and biochemical characterization of two functional CMP-sialic acid synthetases in Danio rerio
Q33982451	Identification and characterization of important residues in the catalytic mechanism of CMP-Neu5Ac synthetase from Neisseria meningitidis
Q42994786	Identification of Arg-12 in the active site of Escherichia coli K1 CMP-sialic acid synthetase
Q36730542	Isolation and analysis of a baculovirus vector that supports recombinant glycoprotein sialylation by SfSWT-1 cells cultured in serum-free medium
Q24533447	Kinetic properties of the acylneuraminate cytidylyltransferase from Pasteurella haemolytica A2
Q40625765	Lec3 Chinese Hamster Ovary Mutants Lack UDP-N-acetylglucosamine 2-Epimerase Activity Because of Mutations in the Epimerase Domain of the Gne Gene
Q45303152	Localization of UDP-GlcNAc 2-epimerase/ManAc kinase (GNE) in the Golgi complex and the nucleus of mammalian cells
Q59793793	Lysine at position 329 within a C-terminal dilysine motif is crucial for the ER localization of human SLC35B4
Q38902441	Metabolic Glycoengineering with N-Acyl Side Chain Modified Mannosamines
Q43728275	Metabolic control of recombinant monoclonal antibody N-glycosylation in GS-NS0 cells
Q43547015	Metabolic control of recombinant protein N-glycan processing in NS0 and CHO cells
Q28592468	Molecular characterization of N-acetylaspartylglutamate synthetase
Q42683096	Molecular cloning of the Leishmania major UDP-glucose pyrophosphorylase, functional characterization, and ligand binding analyses using NMR spectroscopy.
Q28205625	Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35)
Q64227114	N-acetylglucosaminyltransferases and nucleotide sugar transporters form multi-enzyme-multi-transporter assemblies in golgi membranes in vivo
Q34118424	Nuclear localization signal of murine CMP-Neu5Ac synthetase includes residues required for both nuclear targeting and enzymatic activity
Q28214896	Nucleotide sugar transporters: biological and functional aspects
Q36315969	Nutrient-deprived cancer cells preferentially use sialic acid to maintain cell surface glycosylation.
Q42648128	Point mutations identified in Lec8 Chinese hamster ovary glycosylation mutants that inactivate both the UDP-galactose and CMP-sialic acid transporters
Q93590818	Reassembled Biosynthetic Pathway for a Large-scale Synthesis of CMP-Neu5Ac
Q46305715	Regulation and function of endothelial glycocalyx layer in vascular diseases
Q37196285	Sialylation in protostomes: a perspective from Drosophila genetics and biochemistry
Q27628883	Structure of a sialic acid-activating synthetase, CMP-acylneuraminate synthetase in the presence and absence of CDP
Q27657733	Structure-based Mechanism of CMP-2-keto-3-deoxymanno-octulonic Acid Synthetase: CONVERGENT EVOLUTION OF A SUGAR-ACTIVATING ENZYME WITH DNA/RNA POLYMERASES
Q27642625	The crystal structure of murine CMP-5-N-acetylneuraminic acid synthetase
Q44456213	The nucleotide-sugar transporter family: a phylogenetic approach
Q38538651	The nutritional role of free sialic acid, a human milk monosaccharide, and its application as a functional food ingredient
Q73229636	The total synthesis of ganglioside GM3
Q37048424	UDP-N-acetylglucosamine transporter (SLC35A3) regulates biosynthesis of highly branched N-glycans and keratan sulfate.
Q35860624	UDP-galactose (SLC35A2) and UDP-N-acetylglucosamine (SLC35A3) Transporters Form Glycosylation-related Complexes with Mannoside Acetylglucosaminyltransferases (Mgats).

P819	ADS bibcode	1998PNAS...95.9140M
P356	DOI	10.1073/PNAS.95.16.9140
P932	PMC publication ID	21305
P698	PubMed publication ID	9689047
P5875	ResearchGate publication ID	13596270