Parkin RBR E3 ubiquitin protein ligase

mammalian protein found in Homo sapiens

Wikidata entity: Q2472777



P682 biological process ... Q133500 (learning) learning
P682 biological process ... Q430986 (startle response) startle response
P682 biological process ... Q1806192 (autophagy of mitochondrion) autophagy of mitochondrion
P682 biological process ... Q3547638 (protein ubiquitination) protein ubiquitination
P682 biological process ... Q288322 (autophagy) autophagy
P682 biological process ... Q14914045 (positive regulation of proteasomal protein catabolic process) positive regulation of proteasomal protein catabolic process
P682 biological process ... Q14916304 (cellular response to manganese ion) cellular response to manganese ion
P682 biological process ... Q15323482 (proteasome-mediated ubiquitin-dependent protein catabolic process) proteasome-mediated ubiquitin-dependent protein catabolic process
P682 biological process ... Q21095242 (positive regulation of mitophagy in response to mitochondrial depolarization) positive regulation of mitophagy in response to mitochondrial depolarization
P682 biological process ... Q21097283 (positive regulation of autophagy of mitochondrion) positive regulation of autophagy of mitochondrion
P682 biological process ... Q21097289 (negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway) negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
P682 biological process ... Q21097308 (negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway) negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
P682 biological process ... Q21097326 (negative regulation of oxidative stress-induced cell death) negative regulation of oxidative stress-induced cell death
P682 biological process ... Q21097369 (protein K27-linked ubiquitination) protein K27-linked ubiquitination
P682 biological process ... Q21100431 (regulation of mitochondrion organization) regulation of mitochondrion organization
P682 biological process ... Q21100432 (positive regulation of mitochondrial fission) positive regulation of mitochondrial fission
P682 biological process ... Q21100604 (protein K11-linked ubiquitination) protein K11-linked ubiquitination
P682 biological process ... Q21100812 (negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator) negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
P682 biological process ... Q6881852 (mitochondrial fission) mitochondrial fission
P682 biological process ... Q14330676 (adult locomotory behavior) adult locomotory behavior
P682 biological process ... Q14330967 (central nervous system development) central nervous system development
P682 biological process ... Q14331055 (modulation of chemical synaptic transmission) modulation of chemical synaptic transmission
P682 biological process ... Q14599315 (response to oxidative stress) response to oxidative stress
P682 biological process ... Q21100880 (negative regulation of glucokinase activity) negative regulation of glucokinase activity
P682 biological process ... Q21101062 (ERAD pathway) ERAD pathway
P682 biological process ... Q21101105 (protein localization to mitochondrion) protein localization to mitochondrion
P682 biological process ... Q21101164 (negative regulation by host of viral genome replication) negative regulation by host of viral genome replication
P682 biological process ... Q21101599 (neuron cellular homeostasis) neuron cellular homeostasis
P682 biological process ... Q21104801 (positive regulation of tumor necrosis factor-mediated signaling pathway) positive regulation of tumor necrosis factor-mediated signaling pathway
P682 biological process ... Q21104834 (positive regulation of dendrite extension) positive regulation of dendrite extension
P682 biological process ... Q21106655 (regulation of protein targeting to mitochondrion) regulation of protein targeting to mitochondrion
P682 biological process ... Q21106681 (positive regulation of mitochondrial fusion) positive regulation of mitochondrial fusion
P682 biological process ... Q21106739 (cellular response to dopamine) cellular response to dopamine
P682 biological process ... Q21107887 (cellular response to toxic substance) cellular response to toxic substance
P682 biological process ... Q21109316 (regulation of synaptic vesicle transport) regulation of synaptic vesicle transport
P682 biological process ... Q21109505 (protein K29-linked ubiquitination) protein K29-linked ubiquitination
P682 biological process ... Q21109668 (free ubiquitin chain polymerization) free ubiquitin chain polymerization
P682 biological process ... Q21111447 (negative regulation of exosomal secretion) negative regulation of exosomal secretion
P682 biological process ... Q21112699 (negative regulation of mitochondrial fusion) negative regulation of mitochondrial fusion
P682 biological process ... Q21112700 (regulation of cellular response to oxidative stress) regulation of cellular response to oxidative stress
P682 biological process ... Q21112702 (Unfolded Protein Response) Unfolded Protein Response
P682 biological process ... Q21112703 (zinc ion homeostasis) zinc ion homeostasis
P682 biological process ... Q21112704 (negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway) negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
P682 biological process ... Q21112705 (negative regulation of spontaneous neurotransmitter secretion) negative regulation of spontaneous neurotransmitter secretion
P682 biological process ... Q21112706 (positive regulation of neurotransmitter uptake) positive regulation of neurotransmitter uptake
P682 biological process ... Q21112707 (negative regulation of primary amine oxidase activity) negative regulation of primary amine oxidase activity
P682 biological process ... Q21112708 (positive regulation of protein linear polyubiquitination) positive regulation of protein linear polyubiquitination
P682 biological process ... Q21837024 (mitophagy) mitophagy
P682 biological process ... Q22282659 (parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization) parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
P682 biological process ... Q26250221 (positive regulation of retrograde transport, endosome to Golgi) positive regulation of retrograde transport, endosome to Golgi
P682 biological process ... Q27118160 (positive regulation of protein localization to membrane) positive regulation of protein localization to membrane
P682 biological process ... Q27119024 (negative regulation of intralumenal vesicle formation) negative regulation of intralumenal vesicle formation
P682 biological process ... Q27121922 (mitochondrion to lysosome transport) mitochondrion to lysosome transport
P682 biological process ... Q14633878 (negative regulation of transcription by RNA polymerase II) negative regulation of transcription by RNA polymerase II
P682 biological process ... Q14633883 (regulation of transcription, DNA-templated) regulation of transcription, DNA-templated
P682 biological process ... Q14633893 (positive regulation of gene expression) positive regulation of gene expression
P682 biological process ... Q14633911 (regulation of apoptotic process) regulation of apoptotic process
P682 biological process ... Q14633923 (protein stabilization) protein stabilization
P682 biological process ... Q14645719 (locomotory behavior) locomotory behavior
P682 biological process ... Q14763010 (transcription, DNA-templated) transcription, DNA-templated
P682 biological process ... Q14818068 (positive regulation of transcription by RNA polymerase II) positive regulation of transcription by RNA polymerase II
P682 biological process ... Q14818134 (negative regulation of reactive oxygen species metabolic process) negative regulation of reactive oxygen species metabolic process
P682 biological process ... Q14819847 (synaptic transmission, dopaminergic) synaptic transmission, dopaminergic
P682 biological process ... Q14819859 (negative regulation of gene expression) negative regulation of gene expression
P682 biological process ... Q14819896 (negative regulation of cell death) negative regulation of cell death
P682 biological process ... Q14820618 (negative regulation of neuron apoptotic process) negative regulation of neuron apoptotic process
P682 biological process ... Q14820684 (negative regulation of release of cytochrome c from mitochondria) negative regulation of release of cytochrome c from mitochondria
P682 biological process ... Q14821386 (positive regulation of protein binding) positive regulation of protein binding
P682 biological process ... Q14860027 (negative regulation of canonical Wnt signaling pathway) negative regulation of canonical Wnt signaling pathway
P682 biological process ... Q14860462 (protein autoubiquitination) protein autoubiquitination
P682 biological process ... Q14860865 (negative regulation of protein phosphorylation) negative regulation of protein phosphorylation
P682 biological process ... Q14860886 (regulation of dopamine secretion) regulation of dopamine secretion
P682 biological process ... Q14860896 (protein destabilization) protein destabilization
P682 biological process ... Q14862214 (protein K6-linked ubiquitination) protein K6-linked ubiquitination
P682 biological process ... Q14862258 (dopamine uptake involved in synaptic transmission) dopamine uptake involved in synaptic transmission
P682 biological process ... Q14862273 (dopamine metabolic process) dopamine metabolic process
P682 biological process ... Q14862274 (regulation of neurotransmitter secretion) regulation of neurotransmitter secretion
P682 biological process ... Q14863044 (synaptic transmission, glutamatergic) synaptic transmission, glutamatergic
P682 biological process ... Q14863113 (negative regulation of neuron death) negative regulation of neuron death
P682 biological process ... Q14863376 (protein polyubiquitination) protein polyubiquitination
P682 biological process ... Q14863403 (regulation of protein stability) regulation of protein stability
P682 biological process ... Q14863429 (regulation of mitochondrial membrane potential) regulation of mitochondrial membrane potential
P682 biological process ... Q14863696 (positive regulation of DNA binding) positive regulation of DNA binding
P682 biological process ... Q14864026 (regulation of glucose metabolic process) regulation of glucose metabolic process
P682 biological process ... Q14864035 (positive regulation of I-kappaB kinase/NF-kappaB signaling) positive regulation of I-kappaB kinase/NF-kappaB signaling
P682 biological process ... Q14864117 (negative regulation of insulin secretion) negative regulation of insulin secretion
P682 biological process ... Q14864233 (ubiquitin-dependent protein catabolic process) ubiquitin-dependent protein catabolic process
P682 biological process ... Q14864234 (protein deubiquitination) protein deubiquitination
P682 biological process ... Q14864246 (protein monoubiquitination) protein monoubiquitination
P682 biological process ... Q14864247 (regulation of autophagy) regulation of autophagy
P682 biological process ... Q14864248 (negative regulation of actin filament bundle assembly) negative regulation of actin filament bundle assembly
P682 biological process ... Q14864250 (protein K63-linked ubiquitination) protein K63-linked ubiquitination
P682 biological process ... Q14864251 (aggresome assembly) aggresome assembly
P682 biological process ... Q14864252 (protein K48-linked ubiquitination) protein K48-linked ubiquitination
P682 biological process ... Q14864254 (regulation of reactive oxygen species metabolic process) regulation of reactive oxygen species metabolic process
P682 biological process ... Q14864262 (protein metabolic process) protein metabolic process
P682 biological process ... Q14864263 (norepinephrine metabolic process) norepinephrine metabolic process
P682 biological process ... Q14864932 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process) positive regulation of proteasomal ubiquitin-dependent protein catabolic process
P682 biological process ... Q14865069 (positive regulation of protein catabolic process) positive regulation of protein catabolic process
P682 biological process ... Q14865370 (regulation of dopamine metabolic process) regulation of dopamine metabolic process
P682 biological process ... Q14875873 (response to endoplasmic reticulum stress) response to endoplasmic reticulum stress
P682 biological process ... Q14882521 (mitochondrion organization) mitochondrion organization
P682 biological process ... Q14904552 (regulation of lipid transport) regulation of lipid transport
P682 biological process ... Q14905123 (macroautophagy) macroautophagy
P682 biological process ... Q14905468 (proteasomal protein catabolic process) proteasomal protein catabolic process
P682 biological process ... Q14906662 (regulation of protein ubiquitination) regulation of protein ubiquitination
P682 biological process ... Q14906918 (regulation of canonical Wnt signaling pathway) regulation of canonical Wnt signaling pathway
P682 biological process ... Q14913033 (negative regulation of JNK cascade) negative regulation of JNK cascade
P681 cell component ... Q79927 (endoplasmic reticulum) endoplasmic reticulum
P681 cell component ... Q83181 (Golgi apparatus) Golgi apparatus
P681 cell component ... Q79899 (cytoplasm) cytoplasm
P681 cell component ... Q1822234 (Lewy body) Lewy body
P681 cell component ... Q40260 (nucleus) nucleus
P681 cell component ... Q220599 (cytosol) cytosol
P681 cell component ... Q15323461 (SCF ubiquitin ligase complex) SCF ubiquitin ligase complex
P681 cell component ... Q39572 (mitochondrion) mitochondrion
P681 cell component ... Q4692265 (aggresome) aggresome
P681 cell component ... Q14330632 (perinuclear region of cytoplasm) perinuclear region of cytoplasm
P681 cell component ... Q21101945 (Parkin-FBXW7-Cul1 ubiquitin ligase complex) Parkin-FBXW7-Cul1 ubiquitin ligase complex
P681 cell component ... Q21112125 (LUBAC complex) LUBAC complex
P681 cell component ... Q22325163 (protein-containing complex) protein-containing complex
P681 cell component ... Q22327479 (presynapse) presynapse
P681 cell component ... Q27126305 (mitochondrion-derived vesicle) mitochondrion-derived vesicle
P681 cell component ... Q14645640 (neuron projection) neuron projection
P681 cell component ... Q14819271 (nuclear speck) nuclear speck
P681 cell component ... Q14860429 (ubiquitin ligase complex) ubiquitin ligase complex
P702 encoded by ... Q14864255 (PRKN) PRKN
P2888 exact match Url UniProt ???
P703 found in taxon ... Q15978631 (Homo sapiens) Homo sapiens
P692 Gene Atlas image CommonsMedia http://commons.wikimedia.org/wiki/Special:FilePath/PBB%20GE%20PARK2%20207058%20s%20at%20fs.png ???
P527 has part(s) ... Q24773826 (Ubiquitin domain) Ubiquitin domain
P527 has part(s) ... Q24787246 (IBR domain) IBR domain
P31 instance of ... Q8054 (protein) protein
P680 molecular function ... Q167149 (protein binding) protein binding
P680 molecular function ... Q21095456 (ubiquitin protein ligase activity) ubiquitin protein ligase activity
P680 molecular function ... Q21096356 (cullin family protein binding) cullin family protein binding
P680 molecular function ... Q21097301 (ubiquitin-specific protease binding) ubiquitin-specific protease binding
P680 molecular function ... Q21097436 (DNA-binding transcription repressor activity, RNA polymerase II-specific) DNA-binding transcription repressor activity, RNA polymerase II-specific
P680 molecular function ... Q13667380 (metal ion binding) metal ion binding
P680 molecular function ... Q14599289 (enzyme binding) enzyme binding
P680 molecular function ... Q14633865 (zinc ion binding) zinc ion binding
P680 molecular function ... Q14633869 (ubiquitin protein ligase binding) ubiquitin protein ligase binding
P680 molecular function ... Q21107991 (ubiquitin conjugating enzyme binding) ubiquitin conjugating enzyme binding
P680 molecular function ... Q21112709 (F-box domain binding) F-box domain binding
P680 molecular function ... Q22312857 (protein-containing complex binding) protein-containing complex binding
P680 molecular function ... Q14633877 (chaperone binding) chaperone binding
P680 molecular function ... Q14762993 (tubulin binding) tubulin binding
P680 molecular function ... Q14762994 (identical protein binding) identical protein binding
P680 molecular function ... Q14817979 (DNA-binding transcription factor activity) DNA-binding transcription factor activity
P680 molecular function ... Q14817984 (protein kinase binding) protein kinase binding
P680 molecular function ... Q14819775 (G protein-coupled receptor binding) G protein-coupled receptor binding
P680 molecular function ... Q14840131 (transferase activity) transferase activity
P680 molecular function ... Q14860298 (PDZ domain binding) PDZ domain binding
P680 molecular function ... Q14860441 (ubiquitin-protein transferase activity) ubiquitin-protein transferase activity
P680 molecular function ... Q14860855 (Hsp70 protein binding) Hsp70 protein binding
P680 molecular function ... Q14860858 (phospholipase binding) phospholipase binding
P680 molecular function ... Q14863962 (actin binding) actin binding
P680 molecular function ... Q14864232 (ubiquitin binding) ubiquitin binding
P680 molecular function ... Q14864244 (kinase binding) kinase binding
P680 molecular function ... Q14864804 (transcription cis-regulatory region binding) transcription cis-regulatory region binding
P680 molecular function ... Q14865298 (SH3 domain binding) SH3 domain binding
P680 molecular function ... Q14865603 (histone deacetylase binding) histone deacetylase binding
P680 molecular function ... Q14872998 (beta-catenin binding) beta-catenin binding
P680 molecular function ... Q14905394 (heat shock protein binding) heat shock protein binding
P361 part of ... Q24719959 (E3 ubiquitin-protein ligase parkin) E3 ubiquitin-protein ligase parkin
P361 part of ... Q24725964 (Ubiquitin-like domain superfamily) Ubiquitin-like domain superfamily
P361 part of ... Q83141069 (Ubiquitin-like domain, protein family) Ubiquitin-like domain, protein family
P361 part of ... Q83166228 (IBR domain, protein family) IBR domain, protein family

External Ids
P705Ensembl protein IDENSP00000355863
P705Ensembl protein IDENSP00000355862
P705Ensembl protein IDENSP00000484112
P705Ensembl protein IDENSP00000355858
P705Ensembl protein IDENSP00000480716
P705Ensembl protein IDENSP00000355860
P705Ensembl protein IDENSP00000501207
P705Ensembl protein IDENSP00000355865
P705Ensembl protein IDENSP00000483773
P705Ensembl protein IDENSP00000478353
P705Ensembl protein IDENSP00000343589
P705Ensembl protein IDENSP00000434414
P646Freebase ID/m/03r3tb
P6366Microsoft Academic ID (discontinued)2777668072
P10283OpenAlex IDC2777668072
P638PDB structure ID4I1F
P638PDB structure ID4BM9
P638PDB structure ID5C23
P638PDB structure ID5C9V
P638PDB structure ID1IYF
P638PDB structure ID2JMO
P638PDB structure ID4I1H
P638PDB structure ID5C1Z
P637RefSeq protein IDNP_004553
P637RefSeq protein IDNP_054642
P637RefSeq protein IDNP_054643
P637RefSeq protein IDXP_011534165
P637RefSeq protein IDXP_016866397
P637RefSeq protein IDXP_016866398
P637RefSeq protein IDXP_024302217
P352UniProt protein IDO60260

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